Data / Federal grants / PAR-25-378

Intervention Research to Improve Native American Health (R34 Clinical Trial Optional)

National Institutes of Health (Department of Health and Human Services) is accepting applications until January 7, 2027.

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Key facts

Opportunity number

PAR-25-378

Status

Posted, open

Posted

January 22, 2025

Closes

January 7, 2027

Cost sharing

Not required

Funding instrument

Grant

Category

Education, Environment, Health, Income Security and Social Services

Assistance listing

93.113 Environmental Health; 93.121 Oral Diseases and Disorders Research; 93.213 Research and Training in Complementary and Integrative Health; 93.242 Mental Health Research Grants; 93.273 Alcohol Research Programs; 93.279 Drug Use and Addiction Research Programs; 93.310 Trans-NIH Research Support; 93.313 NIH Office of Research on Women's Health; 93.361 Nursing Research; 93.865 Child Health and Human Development Extramural Research; 93.866 Aging Research; None None

Contact

National Institutes of Health · [email protected] · 301-402-2541

Who can apply

• City or township governments
• Independent school districts
• Small businesses
• Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
• Special district governments
• For profit organizations other than small businesses
• Private institutions of higher education
• County governments
• Native American tribal governments (Federally recognized)
• State governments
• Native American tribal organizations (other than Federally recognized tribal governments)
• Public and State controlled institutions of higher education
• Public housing authorities/Indian housing authorities
• Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
• Others (see text field entitled "Additional Information on Eligibility" for clarification)

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

What the agency says

The purpose of this notice of funding opportunity (NOFO) is to support research on interventions to improve health in Native American (NA) populations. This includes 1) etiologic research, where there is a significant gap in knowledge, that will directly inform intervention development or adaptations, 2) research that develops, adapts, or tests the efficacy or effectiveness of health promotion and disease prevention interventions, 3) research that tests culturally informed treatment or recovery interventions and 4) where a sufficient body of knowledge on intervention efficacy exists, research on dissemination and implementation that develops and tests strategies to overcome barriers to the adoption, integration, scale-up, and sustainability of effective interventions. Existing data suggest that significant acute and chronic disease inequities exist for NA populations. Concurrently, NA populations experience unique sociopolitical, historical, and environmental stressors and risks that may exacerbate health conditions and/or impact the effectiveness of existing solutions to address the conditions. They also possess unique strengths and resiliencies that can mitigate stressors or inform intervention strategies. Through this initiative, intervention and related research is sought to build upon community knowledge, resources, and resilience to test science-based, culturally appropriate solutions to reduce morbidity and mortality through identification and remediation of precursors to diseases and disorders and through culturally informed treatment. Interventions should be designed with a consideration for sustainability within the communities where they are tested, and have the flexibility to be readily adapted, disseminated, and scaled up to other communities where culturally appropriate. For the purposes of this NOFO, NA includes the following populations: Alaska Natives, American Indians (whose ancestral lands fall at least partially within the U.S. main land).

The notice on Grants.gov Full announcement

Other open grants from the Department of Health and Human Services

All grants open to City or township governments · All grants open to Independent school districts · All grants open to Small businesses · Everything closing in January 2027

Read from the Grants.gov API, last updated 2026-10-23. The agency's notice on Grants.gov is the official record; check it before you apply.