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Data / Federal grants / RFA-AI-28-018

Improved Drug Susceptibility Testing (DST) for Mycobacteria

National Institutes of Health (Department of Health and Human Services) expects to post this opportunity around March 12, 2027, with applications due around May 28, 2027. It lists 3 awards expected, $3 million in total.

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Key facts

Opportunity number
RFA-AI-28-018
Status
Forecast
Posted
June 24, 2026
Closes
May 28, 2027
Expected awards
3
Total funding
$3,000,000
Cost sharing
Not required
Funding instrument
Cooperative Agreement
Category
Health
Assistance listing
93.855 Allergy and Infectious Diseases Research
Contact
NIAID DST (Division of Microbiology and Infectious Diseases) · [email protected] · Please contact via email.

Who can apply

  • Special district governments
  • Independent school districts
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • For profit organizations other than small businesses
  • Private institutions of higher education
  • Native American tribal governments (Federally recognized)
  • City or township governments
  • Public housing authorities/Indian housing authorities
  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
  • State governments
  • Public and State controlled institutions of higher education
  • County governments
  • Small businesses
  • Others (see text field entitled "Additional Information on Eligibility" for clarification)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

What the agency says

The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission by supporting research to develop improved drug susceptibility tests (DSTs) for mycobacterial drugs, including those currently used for treatment of tuberculosis (TB) and clinically important non-tuberculous mycobacterial (NTM) infections, new drugs and drugs in late-stage clinical development. TB is a leading cause of death from an infectious disease worldwide and drug-resistant strains of TB, including those resistant to new drug regimens, are increasing. In the United States, rates of NTM lung disease are rising, especially among women and older adults, while TB cases have surged to their highest level in ten years. Current assays utilize slow, culture-based processes that do not allow for the rapid testing of mycobacterial strains and their drug susceptibility. Improved DSTs are essential for guiding effective treatment, reducing drug-resistant mycobacterial rates, and preventing new transmissions. This program will support the development of innovative DST assays, including rapid genotypic and improved phenotypic methods that do not require full culture growth. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.

The notice on Grants.gov

Other open grants from the Department of Health and Human Services

All grants open to Special district governments · All grants open to Independent school districts · All grants open to Tribal organizations · Everything closing in May 2027

Read from the Grants.gov API, last updated 2026-10-23. The agency's notice on Grants.gov is the official record; check it before you apply.