Data / Federal grants / RFA-ES-28-002
Health and Extreme Weather Solutions-Focused Research Hubs (U54 - Clinical Trial Optional)
National Institutes of Health (Department of Health and Human Services) expects to post this opportunity around November 27, 2026, with applications due around January 29, 2027. It lists awards of up to $2 million, 6 awards expected, $18 million in total.
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Key facts
- Opportunity number
- RFA-ES-28-002
- Status
- Forecast
- Posted
- June 26, 2026
- Closes
- January 29, 2027
- Award ceiling
- $2,000,000
- Expected awards
- 6
- Total funding
- $18,000,000
- Cost sharing
- Not required
- Funding instrument
- Cooperative Agreement
- Category
- Health
- Assistance listing
- 93.113 Environmental Health
- Contact
- NIEHS Division of Extramural Research and Training · [email protected] · Please contact via e-mail
Who can apply
- Public housing authorities/Indian housing authorities
- Private institutions of higher education
- Public and State controlled institutions of higher education
- Native American tribal governments (Federally recognized)
- City or township governments
- Special district governments
- Small businesses
- Independent school districts
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- County governments
- Native American tribal organizations (other than Federally recognized tribal governments)
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- State governments
- For profit organizations other than small businesses
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations
What the agency says
The National Institute of Environmental Health Sciences (NIEHS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications that propose translational research hubs with multiple highly integrated components focused on research, capacity building, and community/public health translation for regionally relevant topics related to the health impacts of extreme weather and cumulative exposures, including but not limited to wildfire smoke, extreme heat, flooding, hurricanes, drought, and other climate-related hazards affecting populations at heightened risk across the lifespan. Responsive applications will be led by a multidisciplinary team of investigators with non-academic partners, such as state and local public health departments, community-based organizations, Tribal entities, health care systems, and emergency preparedness agencies. Consortia of multiple institutions are encouraged, particularly those that demonstrate meaningful community engagement and balanced, mutually beneficial partnership structures. Research can be situated at different nodes on the translational research continuum, spanning from fundamental to implementation research with a focus on being problem-based and solutions oriented, and should clearly inform pathways to support implementation, scalability, and measurable public health impact. Award recipients will be expected to collaborate with the HEW Research Coordination and Data Center(s) and other members of the HEW Community of Practice, including participation in data harmonization efforts, shared metrics development, and cross-site dissemination activities. This NOFO will utilize the U54 activity code, that supports specialized centers that function as regional resources for targeted research initiatives, including support for infrastructure development, pilot projects, and partnerships with affected communities throughout the research lifecycle. The U54 is a cooperative agreement that anticipates substantial federal programmatic staff involvement to assist investigators in the achievement of project objectives , including coordination across funded hubs, strategic alignment with NIH priorities, and facilitation of cross-institute collaboration . Grant authorities that allow NIEHS to forecast this opportunity are as follows: 42 USC 285l (NIEHS specific); 42 USC sections 241 (NIH grant authorities).
Other open grants from the Department of Health and Human Services
| Opportunity | Status | Closes | Award ceiling | Total funding | Record |
|---|---|---|---|---|---|
| Long-term health outcomes of people living with spina bifida CDC-RFA-DD-26-0222 | Open | Oct 26 | $300,000 | $3,000,000 | grants.gov |
| GREGoRi Data Coordination and Outreach Center (U01, Clinical Trials Not Allowed) RFA-HG-27-011 | Open | Oct 30 | $1,250,000 | $2,000,000 | grants.gov |
| GREGoRi Innovation Projects (U01 Clinical Trial Optional) RFA-HG-27-013 | Open | Oct 30 | $500,000 | $7,500,000 | grants.gov |
| GREGoRi Technology Integration Center (U01, Clinical Trials Optional) RFA-HG-27-012 | Open | Oct 30 | $2,250,000 | $3,000,000 | grants.gov |
| HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required) PAR-27-045 | Open | Oct 30 | grants.gov | ||
| Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed) PAR-24-280 | Open | Nov 2 | grants.gov |
All grants open to Public housing authorities/Indian housing authorities · All grants open to Private colleges and universities · All grants open to Public colleges and universities · Everything closing in January 2027
Read from the Grants.gov API, last updated 2026-10-23. The agency's notice on Grants.gov is the official record; check it before you apply.