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Data / Federal grants / PAR-25-101

Cutting-Edge Basic Research Awards (CEBRA) (R21 Clinical Trial Optional)

National Institutes of Health (Department of Health and Human Services) is accepting applications until August 11, 2027. It lists awards of up to $150,000, $150,000 in total.

SpecStream is the live web data engine for teams and agents. It reads every open and forecast federal opportunity on Grants.gov each morning, and this page is that reading. Describe your organization once and the grants that fit arrive in your sheet, CRM, Slack or agent as they are posted.

Key facts

Opportunity number
PAR-25-101
Status
Posted, open
Posted
December 30, 2024
Closes
August 11, 2027
Award ceiling
$150,000
Total funding
$150,000
Cost sharing
Not required
Funding instrument
Grant
Category
Education, Health
Assistance listing
93.279 Drug Use and Addiction Research Programs; None None
Contact
National Institutes of Health · [email protected] · 301-402-2541

Who can apply

  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • City or township governments
  • Public housing authorities/Indian housing authorities
  • State governments
  • Public and State controlled institutions of higher education
  • For profit organizations other than small businesses
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • County governments
  • Private institutions of higher education
  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
  • Special district governments
  • Small businesses
  • Others (see text field entitled "Additional Information on Eligibility" for clarification)

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

What the agency says

The National Institute on Drug Abuse (NIDA) Cutting-Edge Basic Research Award (CEBRA) is designed to foster highly innovative or conceptually creative research related to the etiology, pathophysiology, prevention, or treatment of substance use disorders (SUDs). It supports high-risk and potentially high-impact research that is sparse or not included in NIDA's current portfolio that has the potential to transform SUD research. The proposed research should: 1. develop, and/or adapt, revolutionary techniques or methods for addiction research or that show promising future applicability to SUD research; and /or 2. test an innovative and significant hypothesis for which there are scant precedent or preliminary data and which, if confirmed, would transform current thinking.

The notice on Grants.gov Full announcement

Other open grants from the Department of Health and Human Services

All grants open to Independent school districts · All grants open to Tribal governments · All grants open to City or township governments · Everything closing in August 2027

Read from the Grants.gov API, last updated 2026-10-23. The agency's notice on Grants.gov is the official record; check it before you apply.