Data / Federal grants / RFA-DA-27-004
BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed)
National Institutes of Health (Department of Health and Human Services) is accepting applications until November 8, 2027.
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Key facts
- Opportunity number
- RFA-DA-27-004
- Status
- Posted, open
- Posted
- September 16, 2025
- Closes
- November 8, 2027
- Cost sharing
- Not required
- Funding instrument
- Grant
- Category
- Education, Health, Income Security and Social Services
- Assistance listing
- 93.173 Research Related to Deafness and Communication Disorders; 93.213 Research and Training in Complementary and Integrative Health; 93.242 Mental Health Research Grants; 93.273 Alcohol Research Programs; 93.279 Drug Use and Addiction Research Programs; 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health; 93.372 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies; 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders; 93.865 Child Health and Human Development Extramural Research; 93.866 Aging Research; 93.867 Vision Research; None None
- Contact
- National Institutes of Health · [email protected] · 301-402-2541
Who can apply
- Small businesses
- City or township governments
- For profit organizations other than small businesses
- Private institutions of higher education
- Public housing authorities/Indian housing authorities
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Independent school districts
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- State governments
- Special district governments
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- County governments
- Public and State controlled institutions of higher education
- Native American tribal organizations (other than Federally recognized tribal governments)
- Native American tribal governments (Federally recognized)
Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; U.S. Territory or Possession.
What the agency says
The Theories, Models and Methods (TMM) initiative will support the development of computational tools for understanding dynamic brain circuits that are made broadly accessible to the greater research community. This program supports applications focused on tool building and dissemination in the domain of theories about neural circuit mechanisms, models of circuit structure and function, and/or computational methods of analysis spanning across scales from neurons to behavior. The development of novel theories, computational models and methods for understanding brain function will help characterize fundamental principles of brain function and organization, characterize cellular and circuit-level neural computations over time in different regions, and understand how interactions of multiple brain circuits enable flexible behaviors and contribute to brain-wide neural dynamics. These tools will be critical for developing treatments such as closed loop systems for brain disorders including Parkinsons disease and major depressive disorder.
Other open grants from the Department of Health and Human Services
| Opportunity | Status | Closes | Award ceiling | Total funding | Record |
|---|---|---|---|---|---|
| Long-term health outcomes of people living with spina bifida CDC-RFA-DD-26-0222 | Open | Oct 26 | $300,000 | $3,000,000 | grants.gov |
| GREGoRi Data Coordination and Outreach Center (U01, Clinical Trials Not Allowed) RFA-HG-27-011 | Open | Oct 30 | $1,250,000 | $2,000,000 | grants.gov |
| GREGoRi Innovation Projects (U01 Clinical Trial Optional) RFA-HG-27-013 | Open | Oct 30 | $500,000 | $7,500,000 | grants.gov |
| GREGoRi Technology Integration Center (U01, Clinical Trials Optional) RFA-HG-27-012 | Open | Oct 30 | $2,250,000 | $3,000,000 | grants.gov |
| HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required) PAR-27-045 | Open | Oct 30 | grants.gov | ||
| Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed) PAR-24-280 | Open | Nov 2 | grants.gov |
All grants open to Small businesses · All grants open to City or township governments · All grants open to For profit organizations other than small businesses · Everything closing in November 2027
Read from the Grants.gov API, last updated 2026-10-23. The agency's notice on Grants.gov is the official record; check it before you apply.