Data / Federal grants / PAR-25-383

Blueprint MedTech Translator (UG3/UH3 - Clinical Trial Optional)

National Institutes of Health (Department of Health and Human Services) is accepting applications until January 28, 2028.

SpecStream is the live web data engine for teams and agents. It reads every open and forecast federal opportunity on Grants.gov each morning, and this page is that reading. Describe your organization once and the grants that fit arrive in your sheet, CRM, Slack or agent as they are posted.

Get grants like this one

Key facts

Opportunity number: PAR-25-383
Status: Posted, open
Posted: June 17, 2025
Closes: January 28, 2028
Cost sharing: Not required
Funding instrument: Cooperative Agreement
Category: Education, Health, Income Security and Social Services
Assistance listing: 93.121 Oral Diseases and Disorders Research; 93.213 Research and Training in Complementary and Integrative Health; 93.242 Mental Health Research Grants; 93.273 Alcohol Research Programs; 93.279 Drug Use and Addiction Research Programs; 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health; 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders; 93.865 Child Health and Human Development Extramural Research; 93.866 Aging Research; 93.867 Vision Research; None None
Contact: National Institutes of Health · [email protected] · 301-402-2541

Who can apply

Independent school districts
Others (see text field entitled "Additional Information on Eligibility" for clarification)
For profit organizations other than small businesses
Public and State controlled institutions of higher education
State governments
Small businesses
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Public housing authorities/Indian housing authorities
Native American tribal governments (Federally recognized)
City or township governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Private institutions of higher education
County governments
Special district governments

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

What the agency says

The purpose of this announcement is to encourage investigators to pursue translational activities and clinical feasibility studies to advance the development of therapeutic, and diagnostic devices for disorders that affect the nervous or neuromuscular systems. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, obtaining an Investigational Device Exemption (IDE) for a Significant Risk (SR) study or Institutional Review Board (IRB) approval for a Non-Significant Risk (NSR) study, as well as a subsequent clinical feasibility study. The clinical study is expected to provide information about the device function or final design that cannot be practically obtained through additional non-clinical assessments (e.g., bench top or animal studies) due to the novelty of the device or its intended use. This FOA is a milestone-driven cooperative agreement program and will involve participation of NIH program staff in negotiating the final project plan before award and monitoring of research progress. Participants in Blueprint MedTech receive funding for all activities to be conducted in their own laboratories. In addition, applicants will collaborate with NIH-funded consultants to receive assistance with specialty areas including regulatory, reimbursement, intellectual property, commercialization, and strategic partnerships. Participants can also augment their project with NIH contract research organizations that specialize in large animal testing, sterilization testing, biocompatibility assessment, manufacturing, and medical monitoring. Individuals, institutions, or businesses developing their own devices or that already have established collaborations with device manufacturers are welcome to apply directly to this NOFO or any of the companion opportunities. For more information see BP MedTech website.

The notice on Grants.gov Full announcement

Other open grants from the Department of Health and Human Services

Opportunity	Status	Closes	Award ceiling	Total funding	Record
Long-term health outcomes of people living with spina bifida CDC-RFA-DD-26-0222	Open	Oct 26	$300,000	$3,000,000	grants.gov
GREGoRi Data Coordination and Outreach Center (U01, Clinical Trials Not Allowed) RFA-HG-27-011	Open	Oct 30	$1,250,000	$2,000,000	grants.gov
GREGoRi Innovation Projects (U01 Clinical Trial Optional) RFA-HG-27-013	Open	Oct 30	$500,000	$7,500,000	grants.gov
GREGoRi Technology Integration Center (U01, Clinical Trials Optional) RFA-HG-27-012	Open	Oct 30	$2,250,000	$3,000,000	grants.gov
HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required) PAR-27-045	Open	Oct 30			grants.gov
Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed) PAR-24-280	Open	Nov 2			grants.gov

All grants open to Independent school districts · All grants open to For profit organizations other than small businesses · All grants open to Public colleges and universities · Everything closing in January 2028

Read from the Grants.gov API, last updated 2026-10-23. The agency's notice on Grants.gov is the official record; check it before you apply.