Data / Federal grants / PAR-28-009
A Holistic Approach to Study Non-Addictive Natural Products for Pain Management
National Institutes of Health (Department of Health and Human Services) expects to post this opportunity around February 2, 2027, with applications due around May 25, 2027.
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Key facts
- Opportunity number
- PAR-28-009
- Status
- Forecast
- Posted
- April 22, 2026
- Closes
- May 25, 2027
- Cost sharing
- Not required
- Funding instrument
- Grant
- Category
- Health
- Assistance listing
- 93.473 Complementary and Integrative Health - Research Projects
- Contact
- Division of Extramural Research (DER) Program Officer · [email protected] · Please contact via e-mail.
Who can apply
- Public and State controlled institutions of higher education
- Special district governments
- Others (see text field entitled "Additional Information on Eligibility" for clarification)
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- County governments
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Native American tribal governments (Federally recognized)
- Public housing authorities/Indian housing authorities
- For profit organizations other than small businesses
- Private institutions of higher education
- Independent school districts
- City or township governments
- Small businesses
- State governments
Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
What the agency says
The National Center for Complementary and Integrative Health (NCCIH) intends to publish a Notice of Funding Opportunity (NOFO) to support collaborative interdisciplinary research that advances foundational understanding of non-addictive natural products for chronic pain management through a holistic, system-oriented approach. This initiative aligns with the NIH Helping to End Addiction Long-term (HEAL) Initiative by promoting safe, non-addictive, and prevention-oriented strategies for pain relief. Chronic pain affects tens of millions of adults in the United States, contributing to disability, diminished quality of life, and significant healthcare costs. Despite widespread public use of natural products, such as botanicals, dietary supplements, and other naturally derived compounds for pain relief, scientific evidence has not kept pace with demand. Existing research often focuses on single molecular targets or isolated pathways, which fail to capture the complex, multisystem actions of these products. The scope of natural products under this NOFO includes those commonly used by the public as well as those with emerging usage or therapeutic potential. Research is expected to take a holistic approach that examines how these products influence pain through coordinated biological pathways across the multiple organ systems, such as digestive, immune, vascular, musculoskeletal, lymphatic, metabolic/adipose tissues, and nervous system. Studies should also explore dose optimization based on the principle of hormesis, where low doses may elicit beneficial or adaptive effects while higher doses could be ineffective or harmful. In addition, investigators are encouraged to identify optimal intervention timing that aligns with the dynamic phases of pain and inflammation, thereby maximizing therapeutic outcomes and supporting physiological recovery. This program emphasizes rigorous mechanistic studies that generate foundational insights to inform future translational research and guide the development of safe, evidence-based, non-addictive strategies for pain management.
Other open grants from the Department of Health and Human Services
| Opportunity | Status | Closes | Award ceiling | Total funding | Record |
|---|---|---|---|---|---|
| Long-term health outcomes of people living with spina bifida CDC-RFA-DD-26-0222 | Open | Oct 26 | $300,000 | $3,000,000 | grants.gov |
| GREGoRi Data Coordination and Outreach Center (U01, Clinical Trials Not Allowed) RFA-HG-27-011 | Open | Oct 30 | $1,250,000 | $2,000,000 | grants.gov |
| GREGoRi Innovation Projects (U01 Clinical Trial Optional) RFA-HG-27-013 | Open | Oct 30 | $500,000 | $7,500,000 | grants.gov |
| GREGoRi Technology Integration Center (U01, Clinical Trials Optional) RFA-HG-27-012 | Open | Oct 30 | $2,250,000 | $3,000,000 | grants.gov |
| HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required) PAR-27-045 | Open | Oct 30 | grants.gov | ||
| Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases (R01 Clinical Trial Not Allowed) PAR-24-280 | Open | Nov 2 | grants.gov |
All grants open to Public colleges and universities · All grants open to Special district governments · All grants open to Tribal organizations · Everything closing in May 2027
Read from the Grants.gov API, last updated 2026-10-23. The agency's notice on Grants.gov is the official record; check it before you apply.