Data / Federal rules / 2025-22927

SpCas9 Protein; Exemption From the Requirement of a Tolerance

The Environmental Protection Agency published this final rule in the Federal Register on December 16, 2025. It took effect on December 16, 2025.

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What the agency says

This regulation establishes an exemption from the requirement of a tolerance for residues of the SpCas9 protein in or on the food and feed commodities of citrus when used as a plant-incorporated protectant (PIP) in citrus. Soil Culture Solutions LLC (d/b/a Soilcea) submitted a petition to EPA under the Federal Food, Drug, and Cosmetic Act (FFDCA), requesting an exemption from the requirement of a tolerance. This regulation eliminates the need to establish a maximum permissible level for residues of SpCas9 protein.

Key facts

Document number: 2025-22927
Type: Final rule
Action: Final rule
Agency: Environmental Protection Agency
Published: December 16, 2025
Takes effect: December 16, 2025
Dates: This regulation is effective December 16, 2025. Objections and requests for hearings must be received on or before February 17, 2026, and must be filed in accordance with the instructions provided in 40 CFR part 178 (see also Unit I.C. of the SUPPLEMENTARY INFORMATION).
Docket: EPA-HQ-OPP-2025-0212; FRL-13100-01-OCSPP
Code of Federal Regulations: 40 CFR 174
Topics: Administrative practice and procedure; Agricultural commodities; Environmental protection; Pesticides and pests; Reporting and recordkeeping requirements
Pages: 4

The document on federalregister.gov PDF

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Everything from the Environmental Protection Agency · Rules on administrative practice and procedure · Rules on agricultural commodities · Rules on environmental protection · Published in December 2025

Read from the Federal Register API, last updated 2026-10-24. The document on federalregister.gov is the official record; dates and dockets can change through later corrections. Free to reuse with credit to SpecStream under CC BY 4.0.