Skip to the page

Data / Drug companies / Methylxanthine

Methylxanthine drugs: 77 drugs from 202 companies in the FDA NDC directory

Methylxanthine is an FDA established pharmacologic class. The FDA National Drug Code Directory lists 562 products in this class from 202 companies, covering 77 drugs by generic name. The main marketing category is over the counter monograph drugs, and the newest product started marketing on October 30, 2026.

SpecStream is the live web data engine for teams and agents. It reads the National Drug Code Directory that FDA publishes, and this page is that reading. Ask for the companies that make a drug, a class or a dosage form, with their headquarters, website and size added from the web, and new listings and discontinued products arrive in your sheet, CRM, Slack or agent as FDA posts them.

  • 202Companies
  • 562Products
  • 77Drugs by generic name

Drugs in the Methylxanthine class

Ranked by number of companies that list the drug.

DrugProducts hereCompanies listing it
Acetaminophen, aspirin, caffeine9048
Caffeine5138
Acetaminophen, caffeine, pyrilamine maleate3126
Acetaminophen, aspirin and caffeine2926
Theophylline4324
Butalbital, acetaminophen and caffeine3723
Butalbital, acetaminophen, and caffeine2622
Acetaminophen, caffeine2014
Acetaminophen, aspirin, and caffeine2113
Aspirin, caffeine1211
Aspirin and caffeine1510
Caffeine citrate158
Acetaminophen, caffeine, and pyrilamine maleate87
Aminophylline95
Acetaminophen aspirin caffeine55
Acetaminophen, caffeine and pyrilamine maleate55
Butalbital, aspirin, and caffeine55
Acetaminophen, aspirin (nsaid), caffeine64
Butalbital, acetaminophen, caffeine and codeine phosphate54
Theophylline anhydrous83
Orphenadrine citrate, aspirin and caffeine53
Acetaminophen and caffeine33
Aspirin, acetaminophen, caffeine33
Butalbital, aspirin, caffeine and codeine phosphate33
Ergotamine tartrate and caffeine33
Anhydrous citric acid, aspirin, and sodium bicarbonate13
Acetaminophen, aspirin (nsaid), and caffeine52
Aspirin,caffeine42
Acetaminophen 250mg aspirin 250mg caffeine 65mg32
Acetaminophen, aspirin (nsaid) and caffeine32
Butalbital, acetaminophen, caffeine, and codeine phosphate32
Acetaminophen and aspirin and caffeine22
Menstrual complete22
Pain reliever12
Caffeinum81
5% minoxidil hair growth serum31
Acetaminophen , caffeine and pyrilamine maleate21
Acetaminophen, asprin, caffeine21
Acetaminophen, pyrilamine maleate, caffeine21
Acetaminophen/aspirin/caffeine tablet21
Aspirin/caffeine oral powder21
Tension headache relief21
5% minoxidil hair growth foam11
Acetaminophen , aspirin and caffeine11
Acetaminophen 250 mg aspirin 250 mg caffeine 65 mg11
Acetaminophen 250 mg, aspirin 250 mg, and caffeine 65 mg11
Acetaminophen 250mg, aspirin 250mg and caffeine 65mg11
Acetaminophen 500 mg with caffeine 65mg11
Acetaminophen 500mg caffeine 60mg pyrilamine maleate 15mg11
Acetaminophen, aspirin, caffeine tablet11
Acetaminophen, aspirin, caffeine tablet, film coated11
Acetaminophen, caffeine anhydrous,11
Acetaminophen, caffeine, and pyrilamine maleate tablet11
Acetaminophen, caffeine, aspirin tablet11
Acetaminophen, caffeine, dihydrocodeine bitartrate11
Acetaminophen,caffeine11
Acetaminophen-aspirin-caffeine11
Acetaminophen-caffeine11
Anhydrous citric acid, aspirin11
Anti-aging eye mask11
Aspirin. caffeine11
Asprin and caffeine11
Butal/apap/caff11
Butal/apap/caffeine11
Butalbital, acetaminophen, and caffeine capsules11
Butalbital, aspirin, cafeine, and codeine phosphate11
Butalbital/acetaminophen/caffeine11
Caffeine and sodium benzoate11
Caffeine tablet, film-coated11
Caffeine, acetaminophen, aspirin11
Caffeine, choline salicylate11
Caffeine, magnesium salicylate11
Caffine11
Conditioner11
Eye cream11
Midol complete11
Sham poo11

Companies with the most products in this class

CompanyProductsMain dosage formsMain marketing categoryNewest product started
Walgreen Company21tablet; tablet, film coatedOver the counter monograph drugsMay 1, 2026
Opmx LLC17tablet, film coated; tabletOver the counter monograph drugsMarch 11, 2026
Lil' Drug Store Products, Inc.16tablet, film coated; tabletOver the counter monograph drugsAugust 1, 2023
Haleon US Holdings LLC13tablet, film coated; tablet, coatedOver the counter monograph drugsJanuary 1, 2024
Medtech Products Inc.12powderOver the counter monograph drugsFebruary 2, 2026
Dolgencorp, Inc. (dollar General & Rexall)10tablet, film coated; tabletOver the counter monograph drugsFebruary 21, 2024
Bayer HealthCare LLC.9tablet; powderOver the counter monograph drugsFebruary 5, 2026
Bryant Ranch Prepack9tablet; solutionGeneric drugs (ANDA)May 1, 2024
Cardinal Health 110, LLC. DBA Leader8tablet, film coated; tabletOver the counter monograph drugsOctober 30, 2026
Carolina Cannabis Creations LLC8chewable gelOver the counter monograph drugsNovember 14, 2025
Hahnemann Laboratories, Inc.8pelletUnapproved homeopathic productsMay 9, 2022
Kroger Company8tablet; tablet, film coatedOver the counter monograph drugsMay 5, 2025
Newton Laboratories, Inc.8liquid; pelletUnapproved homeopathic productsSeptember 25, 2023
Rite Aid Corporation8tablet, film coated; tabletOver the counter monograph drugsSeptember 27, 2024
CVS Pharmacy7tablet; tablet, film coatedOver the counter monograph drugsJuly 5, 2021
Safeway7tablet; tablet, film coatedOver the counter monograph drugsApril 29, 2024
Bryant Ranch Prepack6capsule; solutionGeneric drugs (ANDA)May 1, 2024
Target Corporation6tablet, film coated; tabletOver the counter monograph drugsApril 7, 2025
United Natural Foods, Inc. DBA Unfi6tablet, film coated; tabletOver the counter monograph drugsSeptember 3, 2024
Walmart Inc.6tablet, film coated; tabletOver the counter monograph drugsAugust 19, 2024
Allegiant Health5tablet, film coated; capsuleOver the counter monograph drugsNovember 5, 2024
Amazon.com Services LLC5tablet, film coatedGeneric drugs (ANDA)September 11, 2026
CVS Pharmacy5tablet, film coatedOver the counter monograph drugsMarch 13, 2008
Family Dollar (family Wellness)5tablet; tablet, film coatedOver the counter monograph drugsJanuary 25, 2024
Kobayashi Healthcare International, Inc.5tablet, film coated; tablet, coatedOver the counter monograph drugsOctober 31, 2024
Navajo Manufacturing Company Inc.5tablet, film coated; tabletOver the counter monograph drugsMarch 13, 2025
Proficient Rx LP5tablet, film coated; tablet, extended releaseGeneric drugs (ANDA)November 25, 2025
Actavis Pharma, Inc.4capsule; tabletGeneric drugs (ANDA)July 29, 2013
Advanced Rx of Tennessee, LLC4capsule; tabletGeneric drugs (ANDA)January 8, 2026
Bryant Ranch Prepack4capsule; tabletGeneric drugs (ANDA)December 17, 2019
Chain Drug Marketing Association4tablet, film coated; powderOver the counter monograph drugsMarch 25, 2021
Chain Drug Marketing Association, Inc.4tablet, film coated; tabletOver the counter monograph drugsSeptember 2, 2025
Chartwell RX, LLC4capsule; tablet, extended releaseGeneric drugs (ANDA)June 27, 2022
Endo USA, Inc.4capsule, extended releaseGeneric drugs (ANDA)August 25, 2014
Glenmark Pharmaceuticals Inc., USA4tablet, extended releaseGeneric drugs (ANDA)June 3, 2021
Guangzhou Ariel Biotech Co., Ltd.4liquidOther unapproved drugsApril 2, 2026
L.N.K. International, Inc.4tablet, film coated; tabletOver the counter monograph drugsJuly 19, 2023
LGM Pharma Solutions, LLC4capsule; tabletGeneric drugs (ANDA)October 18, 2021
Lannett Company, Inc.4capsule; tabletGeneric drugs (ANDA)December 17, 2019
Pioneer Life Sciences, LLC4tabletOver the counter monograph drugsOctober 2, 2024
Time Cap Laboratories, Inc4tablet, film coated; tabletOver the counter monograph drugsJune 16, 2021
Topco Associates LLC4tablet, film coatedOver the counter monograph drugsJune 16, 2022
Unifirst First Aid Corporation4tablet, film coatedOver the counter monograph drugsSeptember 26, 2022
Westminster Pharmaceuticals, LLC4tablet, extended release; capsuleGeneric drugs (ANDA)November 25, 2025
WinCo Foods, LLC4tablet, film coated; tabletOver the counter monograph drugsMarch 8, 2024
A-S Medication Solutions3tablet; tablet, film coatedGeneric drugs (ANDA)September 30, 2020
Aurohealth LLC3tablet, film coated; tabletGeneric drugs (ANDA)July 4, 2024
Discount Drug Mart3tablet; tablet, film coatedOver the counter monograph drugsJanuary 11, 2024
Fresenius Kabi USA, LLC3injection, solution; solutionGeneric drugs (ANDA)November 19, 2009
Golden State Medical Supply, Inc.3tablet, extended release; tabletGeneric drugs (ANDA)December 1, 2008
H E B3tablet, film coated; tabletOver the counter monograph drugsMay 3, 2024
L. Perrigo Company3tablet, film coatedGeneric drugs (ANDA)June 24, 2022
Lil' Drug Store Products, Inc.3tabletOver the counter monograph drugsAugust 25, 2021
Meijer Distribution Inc3tablet, film coatedOver the counter monograph drugsApril 12, 2014
Pharmadel LLC3tablet; tablet, coatedOver the counter monograph drugsAugust 12, 2025
Preferred Pharmaceuticals Inc.3tabletGeneric drugs (ANDA)June 9, 2026
Proficient Rx LP3tablet; capsuleGeneric drugs (ANDA)December 1, 2014
Publix Super Markets Inc3tablet; tablet, film coatedOver the counter monograph drugsFebruary 23, 2024
Quagen Pharmaceuticals LLC3capsule; tabletGeneric drugs (ANDA)May 1, 2024
Remedyrepack Inc.3tabletGeneric drugs (ANDA)April 16, 2026
Salado Sales, Inc.3tablet, film coated; tabletOver the counter monograph drugsMarch 13, 2008
Select Consumer Group3tablet, film coated; tabletOver the counter monograph drugsJanuary 1, 2024
Shield Pharmaceuticals Corp3tablet, film coated; tablet, coatedOver the counter monograph drugsMay 18, 2026
Softgel Healthcare Pvt Ltd3capsule; capsule, liquid filledOver the counter monograph drugsFebruary 9, 2026
Strive Pharmaceuticals Inc.3tablet; tablet, coatedOver the counter monograph drugsApril 6, 2023
Valu Merchandisers Company3tablet, film coated; powderOver the counter monograph drugsJune 17, 2022
Wal-Mart Stores Inc3tablet; tablet, film coatedOver the counter monograph drugsFebruary 28, 2018
Aaa Pharmaceutical, Inc.2tabletGeneric drugs (ANDA)April 1, 2024
Ajanta Pharma USA Inc.2tablet, extended releaseGeneric drugs (ANDA)March 26, 2025
Alembic Pharmaceuticals Inc.2tablet, extended releaseGeneric drugs (ANDA)January 29, 2016
Alembic Pharmaceuticals Limited2tablet, extended releaseGeneric drugs (ANDA)November 1, 2010
Amerisource Bergen2tablet; tablet, film coatedOver the counter monograph drugsMarch 11, 2021
Amneal Pharmaceuticals NY LLC2tablet, extended releaseGeneric drugs (ANDA)March 27, 2023
Armas Pharmaceuticals Inc.2solution; injectionGeneric drugs (ANDA)March 1, 2020
Army and Air Force Exchange Service2tablet; tablet, film coatedOver the counter monograph drugsMarch 13, 2008
Atland Pharmaceuticals, LLC2tabletGeneric drugs (ANDA)March 1, 2023
AvKARE2capsule; tablet, extended releaseGeneric drugs (ANDA)April 13, 2023
Beijing Junge Technology Co., Ltd.2creamOver the counter monograph drugsOctober 1, 2024
Bell Pharmaceuticals, Inc.2tablet, coatedOver the counter monograph drugsJuly 27, 2016
Belmora LLC2tablet; powderOver the counter monograph drugsJune 30, 2024
Breckenridge Pharmaceutical, Inc.2capsuleGeneric drugs (ANDA)May 1, 2009
Camber Pharmaceuticals, Inc.2tablet, extended releaseGeneric drugs (ANDA)September 8, 2023
Direct_Rx2tabletGeneric drugs (ANDA)January 2, 2025
Dr. Reddy's Laboratories Inc.2tablet; capsuleGeneric drugs (ANDA)September 25, 2026
Energetix Corporation2liquidUnapproved homeopathic productsNovember 3, 2017
Exela Pharma Sciences, LLC2injection; solutionGeneric drugs (ANDA)March 30, 2015
Galt Pharmaceuticals, LLC2tabletGeneric drugs (ANDA)May 16, 2022
Granules Pharmaceuticals Inc.2capsule; tabletGeneric drugs (ANDA)June 29, 2022
Guangdong Bisutang Biotechnology Co., LTD2pasteOver the counter monograph drugsSeptember 22, 2026
Guangdong Joyan Biological Technology Co.,Ltd2liquid; creamOther unapproved drugsJune 10, 2025
Guangzhou Yapeng Refinement Chemical Co., Ltd.2gel; creamOver the counter monograph drugsJune 20, 2025
HF Acquisition Co LLC, DBA HealthFirst2injection, solutionGeneric drugs (ANDA)February 10, 2019
Harman Finochem Limited2tablet, extended releaseGeneric drugs (ANDA)May 31, 2024
Harris Teeter2tabletGeneric drugs (ANDA)August 30, 2023
Health Pharma USA LLC2tablet, film coatedOver the counter monograph drugsMarch 7, 2024
Henry Schein, Inc.2injection, solutionGeneric drugs (ANDA)January 8, 2022
Heritage Pharmaceuticals Inc. D/B/A Avet Pharmaceuticals Inc.2tablet, extended releaseGeneric drugs (ANDA)June 27, 2022
Hi-Tech Nutraceuticals, LLC2tabletOver the counter monograph drugsNovember 9, 2020
Hikma Pharmaceuticals USA Inc.2capsuleGeneric drugs (ANDA)May 9, 2022
Hospira, Inc.2injection, solutionGeneric drugs (ANDA)May 10, 2005

Dosage forms

Dosage formProductsShare
Tablet16629.5%
Tablet, film coated16529.4%
Capsule458%
Tablet, extended release396.9%
Tablet, coated305.3%
Powder234.1%
Liquid193.4%
Solution162.8%
Injection, solution142.5%
Pellet112%
Chewable gel81.4%
Cream40.7%

Updated November 6, 2026. Read from US Food and Drug Administration, National Drug Code Directory (openFDA). CC0 1.0 public domain dedication (openFDA). Counts are products in the FDA National Drug Code Directory on November 6, 2026: 138,262 products in commercial distribution, meaning without a marketing end date in the past. A company is a labeler code; one company can hold several codes, and the directory carries no address. Inclusion in the directory is not FDA approval, and the marketing category says under which kind of application or rule a product is sold. This page uses openFDA data and is not endorsed or certified by FDA. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.