Data / Drug companies / Methylxanthine
Methylxanthine drugs: 77 drugs from 202 companies in the FDA NDC directory
Methylxanthine is an FDA established pharmacologic class. The FDA National Drug Code Directory lists 562 products in this class from 202 companies, covering 77 drugs by generic name. The main marketing category is over the counter monograph drugs, and the newest product started marketing on October 30, 2026.
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- 202Companies
- 562Products
- 77Drugs by generic name
Drugs in the Methylxanthine class
Ranked by number of companies that list the drug.
| Drug | Products here | Companies listing it |
|---|---|---|
| Acetaminophen, aspirin, caffeine | 90 | 48 |
| Caffeine | 51 | 38 |
| Acetaminophen, caffeine, pyrilamine maleate | 31 | 26 |
| Acetaminophen, aspirin and caffeine | 29 | 26 |
| Theophylline | 43 | 24 |
| Butalbital, acetaminophen and caffeine | 37 | 23 |
| Butalbital, acetaminophen, and caffeine | 26 | 22 |
| Acetaminophen, caffeine | 20 | 14 |
| Acetaminophen, aspirin, and caffeine | 21 | 13 |
| Aspirin, caffeine | 12 | 11 |
| Aspirin and caffeine | 15 | 10 |
| Caffeine citrate | 15 | 8 |
| Acetaminophen, caffeine, and pyrilamine maleate | 8 | 7 |
| Aminophylline | 9 | 5 |
| Acetaminophen aspirin caffeine | 5 | 5 |
| Acetaminophen, caffeine and pyrilamine maleate | 5 | 5 |
| Butalbital, aspirin, and caffeine | 5 | 5 |
| Acetaminophen, aspirin (nsaid), caffeine | 6 | 4 |
| Butalbital, acetaminophen, caffeine and codeine phosphate | 5 | 4 |
| Theophylline anhydrous | 8 | 3 |
| Orphenadrine citrate, aspirin and caffeine | 5 | 3 |
| Acetaminophen and caffeine | 3 | 3 |
| Aspirin, acetaminophen, caffeine | 3 | 3 |
| Butalbital, aspirin, caffeine and codeine phosphate | 3 | 3 |
| Ergotamine tartrate and caffeine | 3 | 3 |
| Anhydrous citric acid, aspirin, and sodium bicarbonate | 1 | 3 |
| Acetaminophen, aspirin (nsaid), and caffeine | 5 | 2 |
| Aspirin,caffeine | 4 | 2 |
| Acetaminophen 250mg aspirin 250mg caffeine 65mg | 3 | 2 |
| Acetaminophen, aspirin (nsaid) and caffeine | 3 | 2 |
| Butalbital, acetaminophen, caffeine, and codeine phosphate | 3 | 2 |
| Acetaminophen and aspirin and caffeine | 2 | 2 |
| Menstrual complete | 2 | 2 |
| Pain reliever | 1 | 2 |
| Caffeinum | 8 | 1 |
| 5% minoxidil hair growth serum | 3 | 1 |
| Acetaminophen , caffeine and pyrilamine maleate | 2 | 1 |
| Acetaminophen, asprin, caffeine | 2 | 1 |
| Acetaminophen, pyrilamine maleate, caffeine | 2 | 1 |
| Acetaminophen/aspirin/caffeine tablet | 2 | 1 |
| Aspirin/caffeine oral powder | 2 | 1 |
| Tension headache relief | 2 | 1 |
| 5% minoxidil hair growth foam | 1 | 1 |
| Acetaminophen , aspirin and caffeine | 1 | 1 |
| Acetaminophen 250 mg aspirin 250 mg caffeine 65 mg | 1 | 1 |
| Acetaminophen 250 mg, aspirin 250 mg, and caffeine 65 mg | 1 | 1 |
| Acetaminophen 250mg, aspirin 250mg and caffeine 65mg | 1 | 1 |
| Acetaminophen 500 mg with caffeine 65mg | 1 | 1 |
| Acetaminophen 500mg caffeine 60mg pyrilamine maleate 15mg | 1 | 1 |
| Acetaminophen, aspirin, caffeine tablet | 1 | 1 |
| Acetaminophen, aspirin, caffeine tablet, film coated | 1 | 1 |
| Acetaminophen, caffeine anhydrous, | 1 | 1 |
| Acetaminophen, caffeine, and pyrilamine maleate tablet | 1 | 1 |
| Acetaminophen, caffeine, aspirin tablet | 1 | 1 |
| Acetaminophen, caffeine, dihydrocodeine bitartrate | 1 | 1 |
| Acetaminophen,caffeine | 1 | 1 |
| Acetaminophen-aspirin-caffeine | 1 | 1 |
| Acetaminophen-caffeine | 1 | 1 |
| Anhydrous citric acid, aspirin | 1 | 1 |
| Anti-aging eye mask | 1 | 1 |
| Aspirin. caffeine | 1 | 1 |
| Asprin and caffeine | 1 | 1 |
| Butal/apap/caff | 1 | 1 |
| Butal/apap/caffeine | 1 | 1 |
| Butalbital, acetaminophen, and caffeine capsules | 1 | 1 |
| Butalbital, aspirin, cafeine, and codeine phosphate | 1 | 1 |
| Butalbital/acetaminophen/caffeine | 1 | 1 |
| Caffeine and sodium benzoate | 1 | 1 |
| Caffeine tablet, film-coated | 1 | 1 |
| Caffeine, acetaminophen, aspirin | 1 | 1 |
| Caffeine, choline salicylate | 1 | 1 |
| Caffeine, magnesium salicylate | 1 | 1 |
| Caffine | 1 | 1 |
| Conditioner | 1 | 1 |
| Eye cream | 1 | 1 |
| Midol complete | 1 | 1 |
| Sham poo | 1 | 1 |
Companies with the most products in this class
| Company | Products | Main dosage forms | Main marketing category | Newest product started |
|---|---|---|---|---|
| Walgreen Company | 21 | tablet; tablet, film coated | Over the counter monograph drugs | May 1, 2026 |
| Opmx LLC | 17 | tablet, film coated; tablet | Over the counter monograph drugs | March 11, 2026 |
| Lil' Drug Store Products, Inc. | 16 | tablet, film coated; tablet | Over the counter monograph drugs | August 1, 2023 |
| Haleon US Holdings LLC | 13 | tablet, film coated; tablet, coated | Over the counter monograph drugs | January 1, 2024 |
| Medtech Products Inc. | 12 | powder | Over the counter monograph drugs | February 2, 2026 |
| Dolgencorp, Inc. (dollar General & Rexall) | 10 | tablet, film coated; tablet | Over the counter monograph drugs | February 21, 2024 |
| Bayer HealthCare LLC. | 9 | tablet; powder | Over the counter monograph drugs | February 5, 2026 |
| Bryant Ranch Prepack | 9 | tablet; solution | Generic drugs (ANDA) | May 1, 2024 |
| Cardinal Health 110, LLC. DBA Leader | 8 | tablet, film coated; tablet | Over the counter monograph drugs | October 30, 2026 |
| Carolina Cannabis Creations LLC | 8 | chewable gel | Over the counter monograph drugs | November 14, 2025 |
| Hahnemann Laboratories, Inc. | 8 | pellet | Unapproved homeopathic products | May 9, 2022 |
| Kroger Company | 8 | tablet; tablet, film coated | Over the counter monograph drugs | May 5, 2025 |
| Newton Laboratories, Inc. | 8 | liquid; pellet | Unapproved homeopathic products | September 25, 2023 |
| Rite Aid Corporation | 8 | tablet, film coated; tablet | Over the counter monograph drugs | September 27, 2024 |
| CVS Pharmacy | 7 | tablet; tablet, film coated | Over the counter monograph drugs | July 5, 2021 |
| Safeway | 7 | tablet; tablet, film coated | Over the counter monograph drugs | April 29, 2024 |
| Bryant Ranch Prepack | 6 | capsule; solution | Generic drugs (ANDA) | May 1, 2024 |
| Target Corporation | 6 | tablet, film coated; tablet | Over the counter monograph drugs | April 7, 2025 |
| United Natural Foods, Inc. DBA Unfi | 6 | tablet, film coated; tablet | Over the counter monograph drugs | September 3, 2024 |
| Walmart Inc. | 6 | tablet, film coated; tablet | Over the counter monograph drugs | August 19, 2024 |
| Allegiant Health | 5 | tablet, film coated; capsule | Over the counter monograph drugs | November 5, 2024 |
| Amazon.com Services LLC | 5 | tablet, film coated | Generic drugs (ANDA) | September 11, 2026 |
| CVS Pharmacy | 5 | tablet, film coated | Over the counter monograph drugs | March 13, 2008 |
| Family Dollar (family Wellness) | 5 | tablet; tablet, film coated | Over the counter monograph drugs | January 25, 2024 |
| Kobayashi Healthcare International, Inc. | 5 | tablet, film coated; tablet, coated | Over the counter monograph drugs | October 31, 2024 |
| Navajo Manufacturing Company Inc. | 5 | tablet, film coated; tablet | Over the counter monograph drugs | March 13, 2025 |
| Proficient Rx LP | 5 | tablet, film coated; tablet, extended release | Generic drugs (ANDA) | November 25, 2025 |
| Actavis Pharma, Inc. | 4 | capsule; tablet | Generic drugs (ANDA) | July 29, 2013 |
| Advanced Rx of Tennessee, LLC | 4 | capsule; tablet | Generic drugs (ANDA) | January 8, 2026 |
| Bryant Ranch Prepack | 4 | capsule; tablet | Generic drugs (ANDA) | December 17, 2019 |
| Chain Drug Marketing Association | 4 | tablet, film coated; powder | Over the counter monograph drugs | March 25, 2021 |
| Chain Drug Marketing Association, Inc. | 4 | tablet, film coated; tablet | Over the counter monograph drugs | September 2, 2025 |
| Chartwell RX, LLC | 4 | capsule; tablet, extended release | Generic drugs (ANDA) | June 27, 2022 |
| Endo USA, Inc. | 4 | capsule, extended release | Generic drugs (ANDA) | August 25, 2014 |
| Glenmark Pharmaceuticals Inc., USA | 4 | tablet, extended release | Generic drugs (ANDA) | June 3, 2021 |
| Guangzhou Ariel Biotech Co., Ltd. | 4 | liquid | Other unapproved drugs | April 2, 2026 |
| L.N.K. International, Inc. | 4 | tablet, film coated; tablet | Over the counter monograph drugs | July 19, 2023 |
| LGM Pharma Solutions, LLC | 4 | capsule; tablet | Generic drugs (ANDA) | October 18, 2021 |
| Lannett Company, Inc. | 4 | capsule; tablet | Generic drugs (ANDA) | December 17, 2019 |
| Pioneer Life Sciences, LLC | 4 | tablet | Over the counter monograph drugs | October 2, 2024 |
| Time Cap Laboratories, Inc | 4 | tablet, film coated; tablet | Over the counter monograph drugs | June 16, 2021 |
| Topco Associates LLC | 4 | tablet, film coated | Over the counter monograph drugs | June 16, 2022 |
| Unifirst First Aid Corporation | 4 | tablet, film coated | Over the counter monograph drugs | September 26, 2022 |
| Westminster Pharmaceuticals, LLC | 4 | tablet, extended release; capsule | Generic drugs (ANDA) | November 25, 2025 |
| WinCo Foods, LLC | 4 | tablet, film coated; tablet | Over the counter monograph drugs | March 8, 2024 |
| A-S Medication Solutions | 3 | tablet; tablet, film coated | Generic drugs (ANDA) | September 30, 2020 |
| Aurohealth LLC | 3 | tablet, film coated; tablet | Generic drugs (ANDA) | July 4, 2024 |
| Discount Drug Mart | 3 | tablet; tablet, film coated | Over the counter monograph drugs | January 11, 2024 |
| Fresenius Kabi USA, LLC | 3 | injection, solution; solution | Generic drugs (ANDA) | November 19, 2009 |
| Golden State Medical Supply, Inc. | 3 | tablet, extended release; tablet | Generic drugs (ANDA) | December 1, 2008 |
| H E B | 3 | tablet, film coated; tablet | Over the counter monograph drugs | May 3, 2024 |
| L. Perrigo Company | 3 | tablet, film coated | Generic drugs (ANDA) | June 24, 2022 |
| Lil' Drug Store Products, Inc. | 3 | tablet | Over the counter monograph drugs | August 25, 2021 |
| Meijer Distribution Inc | 3 | tablet, film coated | Over the counter monograph drugs | April 12, 2014 |
| Pharmadel LLC | 3 | tablet; tablet, coated | Over the counter monograph drugs | August 12, 2025 |
| Preferred Pharmaceuticals Inc. | 3 | tablet | Generic drugs (ANDA) | June 9, 2026 |
| Proficient Rx LP | 3 | tablet; capsule | Generic drugs (ANDA) | December 1, 2014 |
| Publix Super Markets Inc | 3 | tablet; tablet, film coated | Over the counter monograph drugs | February 23, 2024 |
| Quagen Pharmaceuticals LLC | 3 | capsule; tablet | Generic drugs (ANDA) | May 1, 2024 |
| Remedyrepack Inc. | 3 | tablet | Generic drugs (ANDA) | April 16, 2026 |
| Salado Sales, Inc. | 3 | tablet, film coated; tablet | Over the counter monograph drugs | March 13, 2008 |
| Select Consumer Group | 3 | tablet, film coated; tablet | Over the counter monograph drugs | January 1, 2024 |
| Shield Pharmaceuticals Corp | 3 | tablet, film coated; tablet, coated | Over the counter monograph drugs | May 18, 2026 |
| Softgel Healthcare Pvt Ltd | 3 | capsule; capsule, liquid filled | Over the counter monograph drugs | February 9, 2026 |
| Strive Pharmaceuticals Inc. | 3 | tablet; tablet, coated | Over the counter monograph drugs | April 6, 2023 |
| Valu Merchandisers Company | 3 | tablet, film coated; powder | Over the counter monograph drugs | June 17, 2022 |
| Wal-Mart Stores Inc | 3 | tablet; tablet, film coated | Over the counter monograph drugs | February 28, 2018 |
| Aaa Pharmaceutical, Inc. | 2 | tablet | Generic drugs (ANDA) | April 1, 2024 |
| Ajanta Pharma USA Inc. | 2 | tablet, extended release | Generic drugs (ANDA) | March 26, 2025 |
| Alembic Pharmaceuticals Inc. | 2 | tablet, extended release | Generic drugs (ANDA) | January 29, 2016 |
| Alembic Pharmaceuticals Limited | 2 | tablet, extended release | Generic drugs (ANDA) | November 1, 2010 |
| Amerisource Bergen | 2 | tablet; tablet, film coated | Over the counter monograph drugs | March 11, 2021 |
| Amneal Pharmaceuticals NY LLC | 2 | tablet, extended release | Generic drugs (ANDA) | March 27, 2023 |
| Armas Pharmaceuticals Inc. | 2 | solution; injection | Generic drugs (ANDA) | March 1, 2020 |
| Army and Air Force Exchange Service | 2 | tablet; tablet, film coated | Over the counter monograph drugs | March 13, 2008 |
| Atland Pharmaceuticals, LLC | 2 | tablet | Generic drugs (ANDA) | March 1, 2023 |
| AvKARE | 2 | capsule; tablet, extended release | Generic drugs (ANDA) | April 13, 2023 |
| Beijing Junge Technology Co., Ltd. | 2 | cream | Over the counter monograph drugs | October 1, 2024 |
| Bell Pharmaceuticals, Inc. | 2 | tablet, coated | Over the counter monograph drugs | July 27, 2016 |
| Belmora LLC | 2 | tablet; powder | Over the counter monograph drugs | June 30, 2024 |
| Breckenridge Pharmaceutical, Inc. | 2 | capsule | Generic drugs (ANDA) | May 1, 2009 |
| Camber Pharmaceuticals, Inc. | 2 | tablet, extended release | Generic drugs (ANDA) | September 8, 2023 |
| Direct_Rx | 2 | tablet | Generic drugs (ANDA) | January 2, 2025 |
| Dr. Reddy's Laboratories Inc. | 2 | tablet; capsule | Generic drugs (ANDA) | September 25, 2026 |
| Energetix Corporation | 2 | liquid | Unapproved homeopathic products | November 3, 2017 |
| Exela Pharma Sciences, LLC | 2 | injection; solution | Generic drugs (ANDA) | March 30, 2015 |
| Galt Pharmaceuticals, LLC | 2 | tablet | Generic drugs (ANDA) | May 16, 2022 |
| Granules Pharmaceuticals Inc. | 2 | capsule; tablet | Generic drugs (ANDA) | June 29, 2022 |
| Guangdong Bisutang Biotechnology Co., LTD | 2 | paste | Over the counter monograph drugs | September 22, 2026 |
| Guangdong Joyan Biological Technology Co.,Ltd | 2 | liquid; cream | Other unapproved drugs | June 10, 2025 |
| Guangzhou Yapeng Refinement Chemical Co., Ltd. | 2 | gel; cream | Over the counter monograph drugs | June 20, 2025 |
| HF Acquisition Co LLC, DBA HealthFirst | 2 | injection, solution | Generic drugs (ANDA) | February 10, 2019 |
| Harman Finochem Limited | 2 | tablet, extended release | Generic drugs (ANDA) | May 31, 2024 |
| Harris Teeter | 2 | tablet | Generic drugs (ANDA) | August 30, 2023 |
| Health Pharma USA LLC | 2 | tablet, film coated | Over the counter monograph drugs | March 7, 2024 |
| Henry Schein, Inc. | 2 | injection, solution | Generic drugs (ANDA) | January 8, 2022 |
| Heritage Pharmaceuticals Inc. D/B/A Avet Pharmaceuticals Inc. | 2 | tablet, extended release | Generic drugs (ANDA) | June 27, 2022 |
| Hi-Tech Nutraceuticals, LLC | 2 | tablet | Over the counter monograph drugs | November 9, 2020 |
| Hikma Pharmaceuticals USA Inc. | 2 | capsule | Generic drugs (ANDA) | May 9, 2022 |
| Hospira, Inc. | 2 | injection, solution | Generic drugs (ANDA) | May 10, 2005 |
Dosage forms
| Dosage form | Products | Share |
|---|---|---|
| Tablet | 166 | 29.5% |
| Tablet, film coated | 165 | 29.4% |
| Capsule | 45 | 8% |
| Tablet, extended release | 39 | 6.9% |
| Tablet, coated | 30 | 5.3% |
| Powder | 23 | 4.1% |
| Liquid | 19 | 3.4% |
| Solution | 16 | 2.8% |
| Injection, solution | 14 | 2.5% |
| Pellet | 11 | 2% |
| Chewable gel | 8 | 1.4% |
| Cream | 4 | 0.7% |
Updated November 6, 2026. Read from US Food and Drug Administration, National Drug Code Directory (openFDA). CC0 1.0 public domain dedication (openFDA). Counts are products in the FDA National Drug Code Directory on November 6, 2026: 138,262 products in commercial distribution, meaning without a marketing end date in the past. A company is a labeler code; one company can hold several codes, and the directory carries no address. Inclusion in the directory is not FDA approval, and the marketing category says under which kind of application or rule a product is sold. This page uses openFDA data and is not endorsed or certified by FDA. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.