Data / Store locations / The Home Depot / South Carolina
The Home Depot locations in South Carolina: 26 stores, with addresses and phone numbers
The Home Depot has 26 locations in South Carolina, 1.3% of its 2,028 in the United States, in 20 cities. The most are in Columbia, with 3. Each row links to the brand's own store locator, as read on October 24, 2026.
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- 26Locations
- 20Cities
- 1.3%Share of the brand
- October 24, 2026Run date
The Home Depot locations in South Carolina
All 26 locations, ordered by city.
| Address | City | ZIP | Phone | Opening hours | Source |
|---|---|---|---|---|---|
| 1785 Whiskey Rd | Aiken | 29803 | (803) 648-6291 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
| 3427 Clemson Blvd | Anderson | 29621 | (864) 964-0820 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
| 20 Gateway Village Road | Bluffton | 29910 | (843) 815-7000 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
| 2008 Magwood Dr | Charleston | 29414 | (843) 556-2447 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
| 7554 Northwood Blvd | Charleston | 29406 | (843) 569-3773 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
| 285 Forum Drive | Columbia | 29229 | (803) 419-9336 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
| 5200 Fernandina Rd | Columbia | 29212 | (803) 781-0877 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
| 7701 Two Notch Rd | Columbia | 29223 | (803) 736-1666 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
| 6607 Calhoun Memorial Hwy | Easley | 29640 | (864) 306-0137 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
| 3051 West Radio Drive | Florence | 29501 | (843) 661-2597 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
| 1339 S Pleasantburg Dr | Greenville | 29605 | (864) 236-0197 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
| 2490 N Pleasantburg Dr | Greenville | 29609 | (864) 232-0510 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
| 79 Woodruff Industrial Ln | Greenville | 29607 | (864) 284-0991 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
| 1385 W Wade Hampton Blvd | Greer | 29650 | (864) 848-6083 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
| 1116 Highway 9 Byp W | Lancaster | 29720 | (803) 286-9700 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
| 5600 Sunset Blvd | Lexington | 29072 | (803) 359-1194 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
| 2213 North Highway 17 | Mount Pleasant | 29466 | (843) 972-6800 | Mo-Sa 06:00-21:00; Su 08:00-20:00 | homedepot.com |
| 12262 Hwy 17 Bypass | Murrells Inlet | 29576 | (843) 357-3777 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
| 951 Oak Forest Ln | Myrtle Beach | 29577 | (843) 916-2229 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
| 620 Hwy 17 N | North Myrtle Beach | 29582 | (843) 280-9908 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
| 2815 Home Depot Blvd | Rock Hill | 29730 | (803) 909-2420 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
| 1614 Sandifer Blvd | Seneca | 29678 | (864) 886-0633 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
| 669 Fairview Road | Simpsonville | 29680 | (864) 963-7732 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
| 121 Dorman Center Drive | Spartanburg | 29301 | (864) 574-2922 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
| 2300 E Main Street | Spartanburg | 29307 | (864) 579-0382 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
| 190 Marymeade Dr | Summerville | 29483 | (843) 851-0468 | Mo-Sa 06:00-22:00; Su 08:00-20:00 | homedepot.com |
Cities
| City | Locations |
|---|---|
| Columbia | 3 |
| Greenville | 3 |
| Charleston | 2 |
| Spartanburg | 2 |
| Aiken | 1 |
| Anderson | 1 |
| Bluffton | 1 |
| Easley | 1 |
| Florence | 1 |
| Greer | 1 |
| Lancaster | 1 |
| Lexington | 1 |
| Mount Pleasant | 1 |
| Murrells Inlet | 1 |
| Myrtle Beach | 1 |
| North Myrtle Beach | 1 |
| Rock Hill | 1 |
| Seneca | 1 |
| Simpsonville | 1 |
| Summerville | 1 |
Also on SpecStream
Updated November 7, 2026. Read from All the Places. All the Places data is CC0-1.0, a public domain dedication. Each location is read from the brand's own store locator by the All the Places project, which runs about once a week, so a location can have opened or closed since the run date. A brand is keyed on its Wikidata item when the project gives one, else on the project's own name for that brand's locator; two brands are never merged on a name. A repeated address of one brand counts once. Locations named for a private person are left out. Opening hours are shown as the brand lists them. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.