Data / Research funding / Rett Syndrome
Rett Syndrome: 70 NIH awards ($64.3M) to 40 organizations
70 NIH awards ($64.3M) in the NIH spending category Rett Syndrome, to 40 organizations, read 2026-11-03. NIH fiscal years 2021 to 2025.
SpecStream is the live web data engine for teams and agents. It reads the NIH and NSF award files each time the agencies update them, and this page is that reading, joined to the open federal funding opportunities on Grants.gov. Ask for the awards you track by topic, organization or state and new awards arrive in your sheet, CRM, Slack or agent as the agencies publish them.
- Topic
- NIH spending category
Awards
70 awards in the window.
| Award | Agency | Institute or division | Fiscal year | Amount in window | Start | End | Principal investigator | Source |
|---|---|---|---|---|---|---|---|---|
| Multi-site validation of biomarkers and core clinical outcome measures for clinical trial readiness in CDKL5 Deficiency Disorder - Supplement | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $4,693,682 | February 15, 2021 | January 31, 2027 | BENKE, TIMOTHY A | reporter.nih.gov |
| Advancing an XIST ASO candidate for the treatment of Rett Syndrome | NIH | National Institute of Mental Health | 2021 to 2025 | $3,842,186 | July 1, 2019 | February 28, 2029 | LEE, JEANNIE T | reporter.nih.gov |
| Dense Analysis of Cortical Circuit Dysfunction in the MECP2-duplication Syndrome of Autism | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $3,332,806 | January 1, 2021 | December 31, 2025 | SMIRNAKIS, STELIOS MANOLIS | reporter.nih.gov |
| Proteogenetics of Autism Spectrum Disorders | NIH | National Institute of Mental Health | 2021 to 2025 | $3,288,305 | August 1, 2013 | June 30, 2027 | YATES III, JOHN R | reporter.nih.gov |
| Elucidating the molecular mechanisms behind human neurodevelopmental disorders using brain organoids | NIH | National Institute of Mental Health | 2022 to 2025 | $2,876,812 | February 16, 2022 | December 31, 2026 | NOVITCH, BENNETT G | reporter.nih.gov |
| Development of mGlu7 receptor allosteric modulators for neurological and psychiatric disorders | NIH | National Institute of Mental Health | 2021 to 2024 | $2,788,139 | September 21, 2020 | June 30, 2026 | NISWENDER, COLLEEN M | reporter.nih.gov |
| Transcriptional condensates, epigenetic editing and Rett Syndrome | NIH | National Institute of Mental Health | 2021 to 2023 | $2,677,396 | September 15, 2014 | July 31, 2025 | JAENISCH, RUDOLF | reporter.nih.gov |
| Noradrenergic mechanisms in breathing and respiratory pathophysiologies | NIH | National Heart, Lung, and Blood Institute | 2021 to 2024 | $2,520,373 | January 15, 2016 | July 31, 2025 | RAY, RUSSELL S | reporter.nih.gov |
| Development of Translatable Neurophysiological Biomarkers to Accelerate Therapeutic Development in Rett Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2025 | $2,464,143 | April 1, 2023 | March 31, 2026 | MARSH, ERIC D | reporter.nih.gov |
| MeCP2 reactivation from the inactive X chromosome as treatment for Rett syndrome | NIH | National Institute of Mental Health | 2023 to 2025 | $2,456,289 | September 15, 2023 | June 30, 2028 | LIU, X. SHAWN | reporter.nih.gov |
| Glial chemosensitivity and control of breathing in Rett syndrome | NIH | National Heart, Lung, and Blood Institute | 2021 to 2024 | $2,155,960 | August 1, 2010 | December 31, 2025 | MULKEY, DANIEL K | reporter.nih.gov |
| MOLECULAR PATHOGENESIS STUDIES OF RETT SYNDROME | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $1,994,213 | September 4, 2006 | April 30, 2026 | ZOGHBI, HUDA Y | reporter.nih.gov |
| Early developmental mechanisms of Rett Syndrome | NIH | National Institute of Mental Health | 2021 to 2025 | $1,936,688 | December 1, 2009 | January 31, 2027 | SUR, MRIGANKA | reporter.nih.gov |
| Understanding the effects of motor learning in wild-type and Mecp2-deficient mice | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2025 | $1,912,399 | April 1, 2022 | March 31, 2027 | LU, HUI | reporter.nih.gov |
| Studying the effects and mechanisms of deep brain stimulation in Rett syndrome mice | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $1,884,390 | April 1, 2018 | July 31, 2027 | TANG, JIANRONG | reporter.nih.gov |
| Understanding the Pathogenic Mechanisms of Rett Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2025 | $1,672,155 | September 1, 2013 | April 30, 2030 | ZHOU, ZHAOLAN | reporter.nih.gov |
| A precision medicine approach to Rett Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $1,388,394 | May 1, 2020 | April 30, 2026 | GOGLIOTTI, ROCCO GEORGE | reporter.nih.gov |
| The Pathophysiological Role of Cerebellar Glia in Rett Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $1,366,769 | April 1, 2021 | August 15, 2025 | LI, WEI | reporter.nih.gov |
| Repair of neurological disorders through RNA editing | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $1,337,395 | December 1, 2019 | November 30, 2024 | MANDEL, GAIL | reporter.nih.gov |
| Targeted Therapies for Rett Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2023 | $1,175,897 | May 1, 2019 | April 30, 2025 | KANNAN, SUJATHA | reporter.nih.gov |
| Neuroimmune interactions in Rett syndrome | NIH | National Institute on Alcohol Abuse and Alcoholism | 2021 to 2022 | $1,146,682 | September 10, 2018 | June 30, 2024 | LASALLE, JANINE M | reporter.nih.gov |
| Restoration of Homeostasis of Downstream Targets of MeCP2 as a Potential Therapeutic Avenue for Rett Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2023 | $984,375 | March 1, 2019 | January 31, 2025 | MACDONALD, JESSICA L. | reporter.nih.gov |
| Elucidating the role of MeCP2 in the pathophysiology of obesity | NIH | National Institute of General Medical Sciences | 2022 to 2024 | $886,350 | July 8, 2022 | May 31, 2026 | NA, ELISA S | reporter.nih.gov |
| Role of the Hippocampal-mPFC Pathway in Social Memory Deficits in Autism | NIH | National Institute of Mental Health | 2021 to 2022 | $851,655 | April 1, 2019 | January 31, 2024 | POZZO-MILLER, LUCAS D | reporter.nih.gov |
| Comprehensive Deep Phenotyping and Multi-omics to Develop Clinical and Molecular Biomarkers for MeCP2-related Diseases | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2025 | $841,256 | August 15, 2022 | June 30, 2027 | PEHLIVAN, DAVUT | reporter.nih.gov |
| Investigating mitochondrial dysfunction in human astrocytes with RTT-causing MECP2 mutations | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $797,500 | May 5, 2024 | April 30, 2029 | BALLAS, NURIT | reporter.nih.gov |
| Preclinical development of novel site blocking ASOs for the treatment of Rett syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $774,361 | August 1, 2025 | July 31, 2027 | GOGLIOTTI, ROCCO GEORGE | reporter.nih.gov |
| High Fidelity Genome Editing for the Correction of MECP2 Mutations and Physiologic Regulation of Expression in Rett Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $738,182 | April 15, 2025 | February 28, 2030 | CHATTERJEE, SASWATI | reporter.nih.gov |
| Application of a novel dCasNano-based Epigenetic Editing to Treat Rett Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2024 | $698,459 | September 15, 2024 | February 28, 2026 | TSAI, YI-TING | reporter.nih.gov |
| Disruption of lateralized auditory cortical function in a mouse model of Rett Syndrome | NIH | National Institute on Deafness and Other Communication Disorders | 2024 | $530,706 | March 1, 2024 | February 28, 2025 | OVIEDO, HYSELL VIVIANA | reporter.nih.gov |
| Contribution of astrocytes to Rett syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2024 | $522,500 | June 1, 2024 | May 31, 2026 | ALLEN, NICOLA J | reporter.nih.gov |
| Restoring Cortical Network Function in Rett Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $515,462 | January 1, 2024 | December 31, 2028 | MIERAU, SUSANNA | reporter.nih.gov |
| Role of the Rett Syndrome-causing gene MeCP2 in 3D chromosomal organization and rescue of cellular disease phenotypes | NIH | National Institute of Mental Health | 2021 to 2022 | $491,612 | April 1, 2020 | January 31, 2023 | LIU, X. SHAWN | reporter.nih.gov |
| Clinical validation of at-home methods of sleep assessment in Rett Syndrome | NIH | National Center for Advancing Translational Sciences | 2021 to 2022 | $457,700 | July 1, 2021 | April 30, 2024 | PETERS, SARIKA U | reporter.nih.gov |
| High dimensional motor coding and motor dysfunction in Rett syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2024 | $450,000 | July 9, 2024 | June 30, 2027 | SHEW, WOODROW L. | reporter.nih.gov |
| Dissecting functional roles of MeCP2 condensates in neurons with chemogenetic tools | NIH | National Institute on Drug Abuse | 2022 to 2023 | $444,125 | August 1, 2022 | July 31, 2024 | SHEN, YIN | reporter.nih.gov |
| The cellular and molecular signatures of postnatal human RTT astrocytes | NIH | National Institute of Mental Health | 2021 to 2022 | $438,625 | April 1, 2021 | March 31, 2025 | BALLAS, NURIT | reporter.nih.gov |
| Single-cell approaches to probe the function of the unique neuronal epigenome | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2023 | $433,125 | March 1, 2022 | February 28, 2025 | EDWARDS, JOHN R. | reporter.nih.gov |
| miRNA site-blocking ASOs as MeCP2 targeted therapeutics | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2023 to 2024 | $423,500 | April 4, 2023 | March 31, 2026 | GOGLIOTTI, ROCCO GEORGE | reporter.nih.gov |
| Role of GABAergic interneurons in developmental dysregulation of cortical function | NIH | National Institute of Mental Health | 2021 | $418,210 | August 3, 2017 | May 31, 2023 | CARDIN, JESSICA A | reporter.nih.gov |
| How MeCP2 discriminates epigenetic marks is still a mystery | NIH | National Institute of General Medical Sciences | 2021 | $334,000 | July 1, 2018 | June 30, 2023 | BRENOWITZ, MICHAEL D. | reporter.nih.gov |
| Mitochondrial ROS and Microglia in Rett Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 | $314,989 | August 10, 2017 | May 31, 2022 | JIN, LEE-WAY | reporter.nih.gov |
| Function of stimulus-induced MeCP2 phosphorylation | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 | $311,125 | April 1, 2010 | April 30, 2024 | CHANG, QIANG | reporter.nih.gov |
| Developing multimodal biomarkers of cognitive ability in a genetic model of neurodevelopment | NIH | National Institute of Mental Health | 2023 to 2025 | $232,923 | December 3, 2020 | July 31, 2026 | CAZARES, CHRISTIAN | reporter.nih.gov |
| Development of a reliable, valid, and sensitive outcome measure in Rett syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 | $219,524 | September 1, 2020 | August 31, 2023 | NEUL, JEFFREY L | reporter.nih.gov |
| CONTROL OF LONG GENE EXPRESSION AS A NOVEL THERAPEUTIC APPROACH FOR RETT SYNDROME | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $197,640 | December 11, 2019 | June 30, 2022 | RENTHAL, WILLIAM RUSSELL | reporter.nih.gov |
| Genetic enhancement of CREB signaling in Rett Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $194,375 | August 1, 2020 | June 30, 2023 | TIBBETTS, RANDAL SCOT | reporter.nih.gov |
| Single-molecule Investigation of the Interaction Between MeCP2 and Chromatin | NIH | National Institute of Mental Health | 2022 to 2024 | $143,420 | September 1, 2022 | August 31, 2025 | CHUA, GABRIELLA N. L. | reporter.nih.gov |
| Examining adult hippocampal neurogenesis and cognitive function in Rett syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2023 | $139,374 | May 1, 2022 | April 30, 2024 | ANDERSON, ASHLEY GRACE | reporter.nih.gov |
| Contributions of Astrocyte Kir4.1/5.1 Channels to Disordered Breathing in Rett Syndrome | NIH | National Heart, Lung, and Blood Institute | 2023 to 2025 | $137,266 | January 6, 2023 | January 5, 2027 | STRAIN, MONICA | reporter.nih.gov |
| Targeting MeCP2-Associated Disorders with miRNA Site-Blocking Oligonucleotides | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 to 2025 | $136,336 | May 1, 2024 | January 6, 2026 | VANDERPLOW, AMANDA | reporter.nih.gov |
| Astrocyte-neuron interactions in Rett Syndrome and Fragile X Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $118,395 | August 7, 2025 | February 28, 2027 | LYON, KRISTINE ANNE | reporter.nih.gov |
| Circulating Organ-enriched microRNAs as biomarkers of Rett Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $110,956 | September 30, 2020 | March 30, 2023 | UMANSKY, SAMUIL R | reporter.nih.gov |
| Epigenetic and Neuronal Mechanisms of MECP2 Reactivation to rescue Rett Syndrome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 to 2025 | $101,915 | September 16, 2024 | September 15, 2028 | PAN, RICHARD LI CHENG | reporter.nih.gov |
| Characterization of functional molecular domains of MeCP2 | NIH | National Institute of Mental Health | 2021 to 2022 | $96,176 | August 1, 2020 | May 12, 2023 | COLLINS, BRIDGET E | reporter.nih.gov |
| Characterization of MeCP2-dependent gene regulation with temporal and mechanistic precision | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $89,370 | June 1, 2021 | May 31, 2022 | BOXER, LISA D. | reporter.nih.gov |
| The Pathophysiological Role of Cerebellar Glia in Rett Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $89,132 | April 1, 2021 | December 31, 2026 | LI, WEI | reporter.nih.gov |
| The role of skull bone marrow-derived CNS macrophages in Rett syndrome. | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2023 to 2025 | $87,881 | November 1, 2023 | October 31, 2025 | MAZZITELLI PEREZ, JOSE ALEJANDRO | reporter.nih.gov |
| The interplay of the heat shock cascade and Rett syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $85,712 | April 15, 2024 | August 31, 2026 | GONZALEZ, SONIA | reporter.nih.gov |
| MeCP2 and non-CG methylation regulation of neuronal cell-type specific transcription | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 to 2022 | $83,722 | March 1, 2021 | February 28, 2023 | MOORE, JAMES RUSSELL | reporter.nih.gov |
| BDNF signaling via astrocyte Trkb.T1 drives morphogenesis and maturation of astrocytes, a dysregulated feature of Rett syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $82,705 | July 10, 2021 | July 9, 2023 | HERNANDEZ, RAYMUNDO DANIEL | reporter.nih.gov |
| Exploring the role of hippocampal hypervascularization in Rett syndrome pathogenesis | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $75,520 | September 1, 2025 | August 31, 2028 | BRENNER, JOSHUA | reporter.nih.gov |
| Establishing and Optimizing a Prime Editing Method in Neurons for Treatment of Rett Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2025 | $73,206 | January 15, 2023 | February 3, 2025 | KEENER, DAVID G. | reporter.nih.gov |
| Lipid dysregulation as a mediator of Rett syndrome disease progression | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 | $65,994 | April 24, 2021 | April 23, 2022 | NEIER, KARI ELIZABETH | reporter.nih.gov |
| Identifying potential therapeutics for neurodevelopmental disorders using artificial intelligence and transcriptional data | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2024 | $49,362 | December 1, 2024 | May 31, 2028 | DEISSEROTH, COLE | reporter.nih.gov |
| Investigating the role of Growth-differentiation factor 11 in neurodevelopmental and MECP2-related disorders | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2021 | $35,229 | September 10, 2019 | March 9, 2022 | BAJIKAR, SAMEER | reporter.nih.gov |
| Uncovering functional nodes of the Rett syndrome transcriptome | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2022 | $34,290 | March 1, 2023 | February 28, 2024 | CONNOLLY, DANIEL | reporter.nih.gov |
| Aberrant parvalbumin-positive interneuron regulation of maternal behavior in a Rett Syndrome mouse model | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2022 | $32,410 | September 20, 2022 | May 31, 2023 | PAGLIARO, ALEXA | reporter.nih.gov |
| Stratifying Rett syndrome patient populations to evaluate the efficacy of genetic and pharmacological therapeutic interventions | NIH | National Institute of Mental Health | 2021 | $30,751 | August 1, 2019 | July 31, 2022 | VERMUDEZ, SHERYL ANNE DAGUIMOL | reporter.nih.gov |
| Functional Connectivity Across Development in a Mouse Model of Rett Syndrome | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $8,191 | July 1, 2019 | August 19, 2021 | RAHN, RACHEL M | reporter.nih.gov |
Organizations
Funding by fiscal year
| Fiscal year | NIH awards | NIH amount | NSF awards | NSF amount |
|---|---|---|---|---|
| 2025 | 28 | $10,676,893 | 0 | $0 |
| 2024 | 33 | $13,454,697 | 0 | $0 |
| 2023 | 32 | $13,575,461 | 0 | $0 |
| 2022 | 35 | $13,418,068 | 0 | $0 |
| 2021 | 37 | $13,195,546 | 0 | $0 |
Open federal funding opportunities
From Grants.gov: notices that funded awards in this table, and open notices on the same agency and assistance listing.
Updated November 3, 2026. Read from NIH RePORTER ExPORTER and NSF Award Search. Published by NIH and NSF as U.S. government data. NIH awards are fiscal years 2021 to 2025 (NIH files published to 2026-07-09); NSF awards are fiscal years 2022 to 2026 (NSF files published to 2026-11-02). NIH amounts are the total cost of each fiscal year in the window; NSF amounts are the funds obligated in the window. Organizations are matched on the UEI. Open opportunities come from Grants.gov and match on agency and assistance listing number, and on the notice number NIH prints on an award. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.