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Data / Research funding / Prescription Drug Misuse

Prescription Drug Misuse: 231 NIH awards ($357.3M) to 121 organizations

231 NIH awards ($357.3M) in the NIH spending category Prescription Drug Misuse, to 121 organizations, read 2026-11-03. NIH fiscal years 2021 to 2025.

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Awards

231 awards in the window.

AwardAgencyInstitute or divisionFiscal yearAmount in windowStartEndPrincipal investigatorSource
Kentucky CAN HEAL (Communities and Networks Helping End Addiction Long-term)NIHNational Institute on Drug Abuse2021 to 2022$36,092,167April 17, 2019March 31, 2025WALSH, SHARON L.reporter.nih.gov
Arylepoxamides: A new class of potent, safer analgesicsNIHNational Institute on Drug Abuse2021 to 2023$13,729,307December 15, 2018August 31, 2025REICH, JEFFREYreporter.nih.gov
PF614-MPAR: clinical development of opioid with oral overdose protectionNIHNational Institute on Drug Abuse2024 to 2025$9,861,616September 1, 2024May 31, 2027KIRKPATRICK, LYNNreporter.nih.gov
Prevention Research Center: Parenting Among Women Who Are Opioid UsersNIHNational Institute on Drug Abuse2021 to 2023$8,972,150August 15, 2019May 31, 2025LEVE, LESLIE DIANEreporter.nih.gov
Development of cebranopadol, a potent dual MOP/NOP agonist, for the treatment of Opioid Use Disorder (OUD)NIHNational Institute on Drug Abuse2023 to 2024$6,654,182August 15, 2023July 31, 2025GRIECO, JOSEPHreporter.nih.gov
Hybrid Effectiveness-Implementation Trial of Guided Relaxation and Acupuncture for Chronic Sickle Cell Disease PainNIHNational Center for Complementary & Integrative Health2021 to 2024$6,352,490September 21, 2020August 31, 2025DOORENBOS, ARDITH Zreporter.nih.gov
PF614 MPAR Abuse Deterrent opioid prodrug with overdose protection: Pre-Clinical Development and Phase 1 Clinical TrialNIHNational Institute on Drug Abuse2021 to 2022$5,585,570September 15, 2018December 31, 2023KIRKPATRICK, LYNNreporter.nih.gov
Biased Mu-Opioid Receptor Analgesics to Prevent Overdose and Opioid Use DisordersNIHNational Institute on Drug Abuse2021 to 2023$4,306,927September 15, 2018August 31, 2023KUO, LAWRENCE Creporter.nih.gov
Antibody-based therapy for fentanyl-related opioid use disorderNIHNational Institute on Drug Abuse2023$4,202,550September 30, 2023August 31, 2025DESAI, RAJEEV INDRAJITreporter.nih.gov
Development of novel therapeutics for opioid dependenceNIHNational Institute on Drug Abuse2021 to 2022$3,944,970September 30, 2018August 31, 2024KENNY, PAUL J.reporter.nih.gov
Development and Implementation of a Culturally Centered Opioid Prevention Intervention for American Indian/Alaska Native Young Adults in CaliforniaNIHNational Institute on Drug Abuse2021 to 2023$3,791,983September 30, 2019August 31, 2025D'AMICO, ELIZABETH J.reporter.nih.gov
Community Randomized Trial in the Cherokee Nation: CONNECT and CMCA for Preventing Drug Misuse among Older AdolescentsNIHNational Institute on Drug Abuse2021 to 2023$3,708,886September 30, 2019August 31, 2025KOMRO, KELLI ANNreporter.nih.gov
Phase 1a/1b Clinical Trials of Multivalent Opioid Vaccine ComponentsNIHNational Institute on Drug Abuse2023$3,569,552September 15, 2018March 31, 2028COMER, SANDRA Dreporter.nih.gov
Prescription Opioid Misuse: A Pharmacist-Led Intervention at Point of Service Efficacy TrialNIHNational Institute on Drug Abuse2021 to 2025$3,513,979March 15, 2021January 31, 2027COCHRAN, GERALD T.reporter.nih.gov
Preclinical and clinical evaluation of the NMDA modulator NYX-783 for OUDNIHNational Institute on Drug Abuse2022$3,406,895September 30, 2019September 29, 2025SINHA, RAJITAreporter.nih.gov
Genetics of oxycodone intake in a hybrid rat diversity panel.NIHNational Institute on Drug Abuse2021 to 2025$3,392,750April 15, 2021January 31, 2027SHARP, BURT Mreporter.nih.gov
Perioperative Precision Medicine: Translating Science to Clinical Practice to Improve Safety and Efficacy of Opioids in Neonates, Children and Nursing MothersNIHNational Center for Advancing Translational Sciences2022 to 2024$3,295,714August 3, 2022April 30, 2027SADHASIVAM, SENTHILKUMARreporter.nih.gov
Functional and Genomic Signatures of Escalated Fentanyl UseNIHNational Institute on Drug Abuse2021 to 2025$3,237,608March 15, 2021December 31, 2026TURNER, JILL R.reporter.nih.gov
Aging, Polypharmacy and Neurotoxicity in Adults Living with HIVNIHNational Institute on Aging2021 to 2024$3,183,836May 1, 2020February 28, 2026MA, QINGreporter.nih.gov
Peripherally-restricted non-addictive cannabinoids for cancer pain treatmentNIHNational Institute of Neurological Disorders and Stroke2023$3,174,343August 1, 2023July 31, 2025SPIGELMAN, IGORreporter.nih.gov
HEAL - ASSESSMENT OF POTENTIAL SUBSTANCE ABUSE TREATMENT MEDICATIONS IN NONHUMAN PRIMATE MODELS. NIDA REF. NO. N01DA-19-8946; POP: 12/16/2018-12/15/2022.NIHNational Institute on Drug Abuse2022 to 2023$3,093,836December 16, 2018December 15, 2023BERGMAN, JACKreporter.nih.gov
Opioid and SUD Data Enclave (O-SUDDEn): Bringing real-time data to the opioid crisisNIHNational Institute on Drug Abuse2022 to 2025$2,921,106September 30, 2022August 31, 2027FERNANDEZ, SOLEDAD Areporter.nih.gov
Effects of Sleep Disruption on Subjective Responses to Opioid Administration in Patients with Chronic PainNIHNational Institute on Drug Abuse2021 to 2024$2,894,566May 1, 2019February 28, 2026SMITH, MICHAEL Treporter.nih.gov
Deterrents for prescription opioid abuseNIHNational Institute on Drug Abuse2021 to 2025$2,853,877September 15, 2015May 31, 2027FREEMAN, KEVIN B.reporter.nih.gov
Opioid and cannabinoid interactions in pain and rewardNIHNational Institute on Drug Abuse2021 to 2024$2,852,096September 30, 2020June 30, 2026NEUBERT, JOHN Kreporter.nih.gov
The Role of the Dopamine Transporter in Psychostimulant AbuseNIHNational Institute on Drug Abuse2021 to 2025$2,835,033July 1, 2014November 30, 2026GALLI, AURELIOreporter.nih.gov
Stress and Opioid Misuse Risk: The Role of Endogenous Opioid and Endocannabinoid MechanismsNIHNational Institute on Drug Abuse2021 to 2025$2,790,999May 1, 2021February 28, 2027BRUEHL, STEPHENreporter.nih.gov
Single-cell resolution analysis of chromatin accessibility and gene expression changes in a model of drug addictionNIHNational Institute on Drug Abuse2021 to 2024$2,772,633May 1, 2020February 28, 2026TELESE, FRANCESCAreporter.nih.gov
Benzodiazepine mediated mechanisms of transcriptional semi-quiescence in discrete myeloid populationsNIHNational Institute on Drug Abuse2022 to 2025$2,741,871September 15, 2022June 30, 2027GASKILL, PETER JESSEreporter.nih.gov
Decoding the grammar of transcriptional enhancers regulating different stages of opioid use disorderNIHNational Institute on Drug Abuse2021 to 2024$2,717,399September 30, 2020July 31, 2026TELESE, FRANCESCAreporter.nih.gov
Strategies to define and mitigate the placental and fetal alterations caused by maternal oxycodone exposureNIHNational Institute on Drug Abuse2023$2,655,006August 1, 2023July 31, 2026HARRIS, LYNDA KATHERINEreporter.nih.gov
Development of an Opioid Sparing Therapeutic to Minimize Opioid Use Disorderand Tolerance in the Treatment of PainNIHNational Institute on Drug Abuse2023$2,579,875September 1, 2023August 31, 2025MEYN, MALCOLM Areporter.nih.gov
Unintended Prolonged Opioid UseNIHNational Center for Advancing Translational Sciences2021 to 2022$2,552,781March 15, 2019August 31, 2024HOOTEN, W. MICHAELreporter.nih.gov
Research Examining Factors Associated with the Opioid Crisis among Underserved African Americans (REFOCUS)NIHNational Institute on Drug Abuse2021 to 2024$2,545,081September 30, 2020July 31, 2025STEVENS-WATKINS, DANELLE Jreporter.nih.gov
Development of an oral analgesic with reduced liabilitiesNIHNational Institute on Drug Abuse2022 to 2023$2,500,000April 15, 2022March 31, 2025GEHLERT, DONALD Rreporter.nih.gov
Multiomic profiling of cell types mediating opioid use disorder in ratsNIHNational Institute on Drug Abuse2022 to 2025$2,491,424August 15, 2022April 30, 2027TELESE, FRANCESCAreporter.nih.gov
Integrative Modeling of HIV-Associated Neurocognitive Disorder in Human Brain OrganoidsNIHNational Institute on Drug Abuse2021 to 2024$2,456,170August 1, 2020May 31, 2025NOVITCH, BENNETT Greporter.nih.gov
Ventral pallidal transcriptional adaptations underlying punishment-resistant opioid intakeNIHNational Institute on Drug Abuse2023 to 2025$2,423,094September 30, 2023May 31, 2028CREED, MEAGHAN Creporter.nih.gov
Multi-organ-on-chip device for modeling opioid reinforcement and withdrawal, and the negative affective component of pain: a therapeutic screening tool.NIHNational Center for Advancing Translational Sciences2022 to 2024$2,380,820September 26, 2019July 31, 2025MAIDMENT, NIGEL Treporter.nih.gov
Integrative single-cell spatial transcriptomic, anatomical, and functional profiling of brain-wide ensembles engaged by opioid relapseNIHNational Institute on Drug Abuse2023 to 2025$2,359,515September 30, 2023June 30, 2028GOLDEN, SAMreporter.nih.gov
The impact of early life opioid exposure on the molecular and functional trajectories of septal cell typesNIHNational Institute on Drug Abuse2023 to 2025$2,334,521September 30, 2023June 30, 2028HARWELL, COREY Creporter.nih.gov
Examining the synergistic effects of cannabis and prescription opioid policies on chronic pain, opioid prescribing, and opioid overdoseNIHNational Institute on Drug Abuse2021 to 2023$2,319,128January 1, 2019November 30, 2025CERDA, MAGDALENAreporter.nih.gov
Non-opiate topical formulations for treating pain associated with molar extractionsNIHNational Institute of Dental & Craniofacial Research2021 to 2022$2,257,823September 18, 2018February 29, 2024PARR, ALANreporter.nih.gov
Neuroimaging response inhibition and salience attribution changes during mindfulness-based treatment of human heroin addictionNIHNational Center for Complementary & Integrative Health2021 to 2023$2,253,926August 15, 2019June 30, 2024GOLDSTEIN, RITA Zreporter.nih.gov
Impact of prescription stimulants on the drug overdose epidemicNIHNational Institute on Drug Abuse2023 to 2025$2,253,245May 1, 2023March 31, 2028DE NADAI, ALESSANDRO STEVENSreporter.nih.gov
Increased CNS Opioid Exposure by an Acetaminophen-Induced Blood-Brain Barrier MechanismNIHNational Institute on Drug Abuse2021 to 2024$2,240,104July 1, 2020May 31, 2026DAVIS, THOMAS PAULreporter.nih.gov
Endocannabinoid Targeting for Opioid Induced Respiratory DepressionNIHNational Institute on Drug Abuse2022 to 2025$2,190,554July 1, 2022June 30, 2027MILNES, TALLY MARIEreporter.nih.gov
Sex-specific mechanisms underlying the effects of pain on opioid seekingNIHNational Institute on Drug Abuse2022 to 2025$2,163,671September 15, 2022June 30, 2027MORON-CONCEPCION, JOSE Areporter.nih.gov
Enhancing Infrastructure for Clinical and Translational Research to Address the Opioid EpidemicNIHNational Center for Advancing Translational Sciences2021 to 2023$2,152,222August 6, 2019June 30, 2024LENERT, LESLIE A.reporter.nih.gov
Development of cannabinoid-opioid combination with opioid sparing and synergistic analgesic effects to prevent opioid use disorder and overdose.NIHNational Institute on Drug Abuse2021 to 2022$2,110,556September 30, 2019August 31, 2025BRIONES, MARISAreporter.nih.gov
Benzodiazepine Choice and Polydrug UseNIHNational Institute on Drug Abuse2022 to 2025$2,074,200April 1, 2022January 31, 2027HUSKINSON, SALLY Lreporter.nih.gov
A Reduced Complexity Cross in BALB/c substrains to identify the genetic basis of oxycodone dependence phenotypesNIHNational Institute on Drug Abuse2021 to 2023$2,072,058September 1, 2020June 30, 2024ZACHARIOU, VENETIAreporter.nih.gov
A Novel Opioid-Free Targeted Pain Control Method for Acute Post-Operative Localized Pain Related to Oral Surgical ProceduresNIHNational Institute of Dental & Craniofacial Research2023$2,050,357September 19, 2019September 18, 2025JADIA, RAHULreporter.nih.gov
Influence of Orexin Antagonism on Opioid and Methamphetamine DemandNIHNational Institute on Drug Abuse2023 to 2025$2,047,388April 15, 2023December 1, 2025STRICKLAND, JUSTIN CHARLESreporter.nih.gov
Empowering dentists to reduce opioid prescriptions to young peopleNIHNational Institute of Dental & Craniofacial Research2024 to 2025$2,035,344January 1, 2023December 31, 2028OYLER, DOUGLASreporter.nih.gov
Oxycodone, Neonatal Opioid Withdrawal Syndrome, and Adult Abuse LiabilityNIHNational Institute on Drug Abuse2021 to 2024$2,030,768August 1, 2020May 31, 2026BYRNES, ELIZABETH Mreporter.nih.gov
Evaluating Policy Interventions to Decrease Excessive and Risky Perioperative Opioid PrescribingNIHNational Institute on Drug Abuse2022 to 2024$2,027,866September 1, 2022October 31, 2024WALJEE, JENNIFER FILIPreporter.nih.gov
Identifying Genetic Variants Associated with Opioid Overdose MortalityNIHNational Institute on Drug Abuse2021 to 2022$2,020,602July 1, 2018April 30, 2024NELSON, ELLIOT Creporter.nih.gov
Integrated Treatment for Veterans with Co-Occurring Chronic Pain and Opioid Use DisorderNIHNational Institute on Drug Abuse2021 to 2024$1,994,995September 30, 2019August 31, 2025WITKIEWITZ, KATIE Areporter.nih.gov
Developing and Evaluating a Machine-Learning Opioid Prediction & Risk-Stratification E-Platform (DEMONSTRATE)NIHNational Institute on Drug Abuse2021 to 2023$1,991,133July 1, 2021November 1, 2023LO-CIGANIC, WEI-HSUANreporter.nih.gov
Determinants of Drug Preference in HumansNIHNational Institute on Drug Abuse2021 to 2024$1,905,360January 1, 1981January 31, 2026DE WIT, HARRIETreporter.nih.gov
Abuse-deterrence and prevention of respiratory depression by an oral opioid analgesic and doxapram combinationNIHNational Institute on Drug Abuse2022 to 2023$1,904,562September 1, 2022February 28, 2026RIX, PETER JEFFREYreporter.nih.gov
Tolerance and Physical Dependence after Chronic Benzodiazepine TreatmentNIHNational Institute on Drug Abuse2021 to 2025$1,872,481June 1, 2002February 29, 2028ROWLETT, JAMES Kreporter.nih.gov
Opioid/benzodiazepine polydrug abuse: Integrating research on mechanisms, treatment and policiesNIHNational Institute on Drug Abuse2021 to 2023$1,868,751September 30, 2018August 31, 2025GREENWALD, MARK Kreporter.nih.gov
Dissecting ventral pallidal plasticity in punishment-resistant opioid self-administrationNIHNational Institute on Drug Abuse2023 to 2025$1,862,776June 15, 2023March 31, 2028CREED, MEAGHAN Creporter.nih.gov
The Symptom-Associated Pathway to Substance Use and Misuse during AdolescenceNIHNational Institute on Drug Abuse2021 to 2025$1,852,500September 1, 2021July 31, 2027VOEPEL-LEWIS, TERRI DIANEreporter.nih.gov
Nonaddictive opioid prodrug nanomedicine for musculoskeletal painNIHNational Institute of Arthritis and Musculoskeletal and Skin Diseases2022 to 2025$1,851,532September 7, 2022July 31, 2027WANG, DONGreporter.nih.gov
Sleep deficiency and opioid use/misuse in adolescents following surgeryNIHNational Heart, Lung, and Blood Institute2023 to 2025$1,850,649September 10, 2023August 31, 2028GROENEWALD, CORNELIUS BOTHAreporter.nih.gov
Endocannabinoid Metabolism in Acute PainNIHNational Institute on Drug Abuse2021 to 2024$1,844,228April 15, 2020February 28, 2026KACZOCHA, MARTINreporter.nih.gov
Microglia and Epigenetic Regulation in Opioid AddictionNIHNational Institute on Drug Abuse2021 to 2024$1,842,000July 1, 2020May 31, 2025TUESTA, LUIS MIGUELreporter.nih.gov
Identification of genes and genetic networks contributing to opioid use disorder traits in the Hybrid Rat Diversity PanelNIHNational Institute on Drug Abuse2021 to 2024$1,834,833August 1, 2020May 31, 2026EHRINGER, MARISSA Areporter.nih.gov
Validation of the TAPS-Electronic Spanish Platform (TAPS-ESP): A Technology to Improve Access to Substance Use Screening and Reduce Behavioral Health Disparities in Hispanic Primary Care PatientsNIHNational Institute on Minority Health and Health Disparities2021 to 2022$1,833,979September 19, 2018May 31, 2025CARSWELL, STEVEN BERNARDreporter.nih.gov
An augmented reality platform to reduce post-operative and chronic opioid use in pediatric cancerNIHNational Institute on Drug Abuse2021 to 2022$1,828,326June 1, 2020August 31, 2024YORK, CHRISTINAreporter.nih.gov
Title: Pharmacokinetic, pharmacodynamic , and toxicological interactions among Opioids and CabotegravirNIHNational Institute on Drug Abuse2022 to 2025$1,790,275September 1, 2022July 31, 2027EL-HAGE, NAZIRAreporter.nih.gov
Mining Social Media Big Data for Toxicovigilance: Studying Substance Use via Natural Language Processing and Machine Learning MethodsNIHNational Institute on Drug Abuse2022 to 2025$1,773,166September 30, 2022July 31, 2027SARKER, ABEED Hreporter.nih.gov
Bench-top Reader and Aptamer-based Assay for Rapid, High-sensitivity Drug/Opiate DetectionNIHNational Institute of Biomedical Imaging and Bioengineering2023 to 2025$1,763,772September 15, 2023July 31, 2027JACKSON, GEORGE Wreporter.nih.gov
Buprenorphine analogs for the treatment of opioid abuseNIHNational Institute on Drug Abuse2021 to 2023$1,731,161March 1, 2021January 31, 2027KO, MEI-CHUANreporter.nih.gov
The Genetic Basis of Opioid Dependence Vulnerablility in a Rodent ModelNIHNational Institute on Drug Abuse2021 to 2022$1,704,402September 30, 2018July 31, 2024KALIVAS, PETER Wreporter.nih.gov
Preventing prescription opioid misuse among employees working in high risk industries.NIHNational Institute on Drug Abuse2022 to 2023$1,626,195September 30, 2019April 30, 2026HEBARD, STEPHENreporter.nih.gov
The Role of Microbiome Composition in Amphetamine AbuseNIHNational Institute on Drug Abuse2023 to 2025$1,621,263August 15, 2023May 31, 2028GALLI, AURELIOreporter.nih.gov
Anxiolytic Effects and Abuse of BZ Receptor LigandsNIHNational Institute on Drug Abuse2021 to 2024$1,607,424June 15, 1998April 30, 2026ROWLETT, JAMES Kreporter.nih.gov
CB2 Cannabinoid Mechanisms for Suppressing Opioid Tolerance and DependenceNIHNational Institute on Drug Abuse2021 to 2023$1,551,552April 15, 2019February 28, 2026HOHMANN, ANDREA GRACEreporter.nih.gov
Opioid Treatment of Pain in People with Cancer: Intended and unintended consequences of state policies addressing opioid prescribingNIHNational Cancer Institute2022 to 2025$1,523,785September 20, 2022August 31, 2026BAO, YUHUAreporter.nih.gov
Fentanyl use during pregnancy: impact on dam, placenta, and offspring development.NIHNational Institute on Drug Abuse2023$1,509,492August 1, 2023July 31, 2026RÜEDI-BETTSCHEN, DANIELAreporter.nih.gov
Reduced complexity mapping of oxycodone self-administration and stress responsiveness in ratsNIHNational Institute on Drug Abuse2021 to 2024$1,379,892May 1, 2020February 28, 2026CHEN, HAOreporter.nih.gov
Mechanisms of Variability in the Analgesic Response to Ibuprofen Following Third Molar ExtractionNIHNational Institute of Dental & Craniofacial Research2024 to 2025$1,374,754July 16, 2024April 30, 2029THEKEN, KATHERINE NICOLEreporter.nih.gov
Using opioid industry documents to understand marketing of addictive medicationsNIHNational Institute on Drug Abuse2024 to 2025$1,361,397September 15, 2024May 31, 2029APOLLONIO, DOROTHY ELINORreporter.nih.gov
The Opioid Crisis: The Effects and Unintended Consequences of State Policies on Opioid Analgesic PrescribingNIHNational Institute on Drug Abuse2021 to 2022$1,288,703March 15, 2019December 31, 2023STEIN, BRADLEY Dreporter.nih.gov
Risk for opioid abuse and misuse in adolescenceNIHNational Institute on Drug Abuse2021 to 2022$1,287,806March 15, 2018December 31, 2024WILSON, ANNA CAMILLEreporter.nih.gov
Reducing morbidity and mortality from overdose, HIV, and hepatitis C in opioid-using personsNIHNational Institute on Drug Abuse2021 to 2022$1,262,543September 1, 2018June 30, 2024BRAITHWAITE, RONALD SCOTTreporter.nih.gov
Single cell multi-omics of iPSC-derived brain organoids from patients with opioid use disorder: synthetic opioids as molecular probesNIHNational Institute on Drug Abuse2023 to 2025$1,252,839July 15, 2023May 31, 2028HO, MING-FENreporter.nih.gov
Delineating the role of serotonin 5-HT2 receptors in opioid use disorders: Development of novel 5-HT2 modulators with translational studies in rodents and primatesNIHNational Institute on Drug Abuse2021 to 2022$1,219,349August 1, 2018May 31, 2026BOOTH, RAYMOND G.reporter.nih.gov
Developing and Evaluating a Machine-Learning Opioid Prediction & Risk-Stratification E-Platform (DEMONSTRATE)NIHNational Institute on Drug Abuse2024 to 2025$1,212,241July 1, 2021April 30, 2027LO-CIGANIC, WEI-HSUAN JENNYreporter.nih.gov
Trajectories of Prescription Nonmedical Drug MisuseNIHNational Institute on Drug Abuse2021 to 2025$1,194,681April 1, 2011March 31, 2028MCCABE, SEAN ESTEBANreporter.nih.gov
Substance Use in Reservists: Social and Environmental InfluencesNIHNational Institute on Drug Abuse2021 to 2022$1,192,691June 1, 2013July 31, 2025HOMISH, GREGORY G.reporter.nih.gov
Molecular and Cellular Profiling of the Habenulointerpeduncular Circuit in Opioid Tolerance and WithdrawalNIHNational Institute on Drug Abuse2024 to 2025$1,188,822September 15, 2024May 31, 2029ABLES, JESSICAreporter.nih.gov
Implementation, Outcomes, and Cost of a Novel Medicaid Policy to Reduce Opioids for Back PainNIHNational Institute on Drug Abuse2021 to 2022$1,181,590August 15, 2018May 31, 2024CHOO, ESTHER Kreporter.nih.gov
Incubation of oxycodone craving and nucleus accumbens plasticityNIHNational Institute on Drug Abuse2024 to 2025$1,166,080September 30, 2024May 31, 2029WOLF, MARINA ELIZABETHreporter.nih.gov
DAT-Regulation of Nucleus Accumbens Microcircuitry by Oxycodone Exposure and WithdrawalNIHNational Institute on Drug Abuse2021 to 2023$1,155,000September 1, 2019July 31, 2025ROTHWELL, PATRICKreporter.nih.gov
Effects of State Laws to Reduce Opioid Diversion on Transitions to Injection Drug Use and HIV/HCV TransmissionNIHNational Institute on Drug Abuse2021 to 2022$1,137,366April 1, 2018December 31, 2023DICKSON-GOMEZ, JULIA Breporter.nih.gov
Licit and Illicit Opioids: Comparative Studies in HumansNIHNational Institute on Drug Abuse2021 to 2023$1,134,119July 10, 2004July 31, 2025WALSH, SHARON L.reporter.nih.gov
MyTPill: A Novel Strategy to Monitor Antiretroviral Adherence among HIV+ Prescription Opioid UsersNIHNational Institute on Drug Abuse2021 to 2022$1,133,812June 1, 2019April 30, 2025BOYER, EDWARD Wreporter.nih.gov
Harnessing big data to arrest the HIV/HCV/opioid syndemic in the rural and urban SouthNIHNational Institute on Drug Abuse2023 to 2025$1,115,625June 1, 2023March 31, 2028REBEIRO, PETER Freporter.nih.gov
Opioid-induced dysregulation of cortico-striatal circuitsNIHNational Institute on Drug Abuse2023 to 2025$1,083,671July 1, 2023April 30, 2028HEARING, MATTHEW CARLreporter.nih.gov
Improving pain management and opioid safety through a systemwide, data driven evaluation of the CDC opioid prescribing guideline best practices and the use of Clinical Decision SupportNIHNational Institute on Drug Abuse2022$1,072,844September 30, 2022September 29, 2024HOPPE, JASONreporter.nih.gov
Effectiveness, toxicity and safety of opioid and benzodiazepine substitutesNIHNational Institute on Drug Abuse2021 to 2023$1,066,500September 15, 2016April 30, 2026KUO, YONG-FANGreporter.nih.gov
Psychological Risk Factors for Persistent Opioid Use and Prevention of Chronic Opioid Use and Misuse After Surgery: Postoperative Motivational Interviewing and Guided Opioid WeaningNIHNational Institute on Drug Abuse2021 to 2022$1,041,294September 1, 2018June 30, 2024HAH, JENNIFERreporter.nih.gov
Using a Novel Comprehensive Linked Dataset to Determine Early Predictors of Opioid OverdoseNIHNational Institute on Drug Abuse2021 to 2022$1,016,161September 30, 2018August 31, 2024WEINER, SCOTT GORDONreporter.nih.gov
Serotonin receptors that potentiate addiction-related behavioral and molecular effects induced by methylphenidate plus SSRI exposureNIHNational Institute on Drug Abuse2021 to 2023$1,013,596April 1, 2019January 31, 2024STEINER, HEINZreporter.nih.gov
Optopharmacology and Sensors for Dissecting Opioid Action In VivoNIHNational Institute on Drug Abuse2023 to 2024$1,005,835September 30, 2020August 31, 2025BRUCHAS, MICHAEL R.reporter.nih.gov
Structure and Function of GABA-A ReceptorsNIHNational Institute on Drug Abuse2021 to 2022$995,664February 1, 2019December 31, 2023HIBBS, RYAN Ereporter.nih.gov
Opioid-Sparing pain management for Chronic Low Back Pain patients using TMC-CP01 - A VANISH (Virtual Autonomic Neuromodulation Induced Systemic Healing) based programNIHNational Institute on Drug Abuse2022$989,571September 30, 2019December 31, 2024TIEN, CELINEreporter.nih.gov
Optimization of novel thioesters as a therapeutic strategy for combating opioid overdoses and abuseNIHNational Institute on Drug Abuse2021 to 2022$956,514September 1, 2020July 31, 2023LEWIS, STEPHEN JOHNreporter.nih.gov
Community-based, client-centered prevention homes to address the rural opioid epidemicNIHNational Institute on Drug Abuse2021 to 2022$941,278August 15, 2017July 31, 2023WESTERGAARD, RYAN PATRICKreporter.nih.gov
Longitudinal Changes in Prescription Drug Misuse and Polysubstance Use in Adolescents and Young AdultsNIHNational Institute on Drug Abuse2023 to 2025$939,705June 1, 2017July 31, 2027SCHEPIS, TY STEPHENreporter.nih.gov
Molecular and Dynamic Insights into the Function of GPCRs Involved in Drug AbuseNIHNational Institute on Drug Abuse2021 to 2022$932,192August 1, 2018May 31, 2025FILIZOLA, MARTAreporter.nih.gov
Thalamic Circuits Underlying Opioid SeekingNIHNational Institute on Drug Abuse2021 to 2022$913,114September 30, 2018June 30, 2024CHEN, XIAOKEreporter.nih.gov
Chemical biology tools for illuminating cannabinoid signaling pathways in opioid use disorder.NIHNational Institute on Drug Abuse2024 to 2025$842,400August 15, 2024May 31, 2029FRANK, JAMES ALLENreporter.nih.gov
Research and Mentoring in Innovative Patient Oriented Pain and Opioid ScienceNIHNational Institute on Drug Abuse2021 to 2025$837,632May 1, 2021April 30, 2026DARNALL, BETH DENISEreporter.nih.gov
Discovery of GPR52 ligand probes for cocaine use disorderNIHNational Institute on Drug Abuse2025$795,090September 1, 2025May 31, 2030ALLEN, JOHN Areporter.nih.gov
RELIEPH for Interstitial CystitisNIHNational Institute of Diabetes and Digestive and Kidney Diseases2021 to 2022$769,386July 1, 2018March 31, 2024XU, YANreporter.nih.gov
Leveraging Integrative Modeling and AI-Based Tools to Develop Safer OpioidsNIHNational Institute on Drug Abuse2025$767,506July 1, 2025March 31, 2030FILIZOLA, MARTAreporter.nih.gov
Optopharmacology and Sensors for Dissecting Opioid Action In VivoNIHNational Institute on Drug Abuse2021 to 2022$761,628September 30, 2020August 31, 2023BRUCHAS, MICHAEL R.reporter.nih.gov
The role of central amylin receptor in opioid-mediated behaviorsNIHNational Institute on Drug Abuse2025$759,339July 1, 2025March 31, 2030SCHMIDT, HEATH Dreporter.nih.gov
Improving the Safety of Treatment for Hospitalized Patients with Alcohol Withdrawal SyndromeNIHNational Institute on Alcohol Abuse and Alcoholism2022 to 2025$752,112September 20, 2022August 31, 2027STEEL, TESSA LYNNEreporter.nih.gov
The Role of HIV Proteins in Psychostimulant AbuseNIHNational Institute on Drug Abuse2025$751,112May 1, 2025March 31, 2030GALLI, AURELIOreporter.nih.gov
Cucurbituril Type Receptors as Sequestration Agents for Drugs of AbuseNIHNational Institute of General Medical Sciences2021 to 2022$747,910April 15, 2019January 31, 2024ISAACS, LYLE Dreporter.nih.gov
Elucidating behavior and neural circuits underlying opioid addiction and dependenceNIHNational Institute on Drug Abuse2023 to 2025$747,000September 1, 2019January 31, 2027NGUYEN, JACQUES DUCHUYreporter.nih.gov
Discovery of novel pharmacotherapeutic targets for opioid addictionNIHNational Institute on Drug Abuse2022 to 2024$746,999August 1, 2020March 31, 2026SMITH, ALEXANDER WANLESSreporter.nih.gov
Prescription Stimulant Supply Shocks: Assessing the Impacts on Health Outcomes and DisparitiesNIHNational Institute of Mental Health2025$729,367December 18, 2024November 30, 2028SMART, ROSANNAreporter.nih.gov
Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect DeterminationNIHNational Institute on Drug Abuse2022 to 2025$723,453January 1, 2022December 31, 2026BERRY, MEREDITHreporter.nih.gov
Explicating Vulnerability and Resilience in Opioid Self-Administration in Middle Aged RatsNIHNational Institute on Drug Abuse2024 to 2025$715,500September 15, 2024June 30, 2029TAFFE, MICHAEL A.reporter.nih.gov
Multivariate genome-wide association analysis of opioid-related traits in half a million diverse individualsNIHNational Institute on Drug Abuse2025$715,238January 15, 2025November 30, 2029SANCHEZ ROIGE, SANDRAreporter.nih.gov
Affective and Inflammatory Reactivity to Pain in Opioid Use DisorderNIHNational Institute on Drug Abuse2021 to 2022$714,008September 30, 2019July 31, 2025MCHUGH, REBECCA KATHRYNreporter.nih.gov
Co-Use of Opioid Medications and Alcohol Prevention Study (COAPS)NIHNational Institute on Alcohol Abuse and Alcoholism2022 to 2024$708,250May 26, 2022April 30, 2026COCHRAN, GERALD T.reporter.nih.gov
Screening and Brief Intervention for Prescription Stimulant Misuse and Diversion: Refining and Piloting a Curriculum for College Health ProvidersNIHNational Institute on Drug Abuse2023 to 2025$672,656July 15, 2023May 31, 2027BAVARIAN, NILOOFARreporter.nih.gov
Pain Medication Prescriptions and Misuse Following Treatment for Alcohol Use DisordersNIHNational Institute on Alcohol Abuse and Alcoholism2021 to 2022$652,259August 1, 2020December 31, 2024LEONARD, KENNETH Ereporter.nih.gov
Benzodiazepine-related harms in young people: Informing policy, interventions, and prescribingNIHNational Institute on Drug Abuse2023 to 2025$647,316March 15, 2021February 28, 2027BUSHNELL, GRETAreporter.nih.gov
Using Default Opioid Prescription Settings to Limit Excessive Opioid Prescribing to Adolescents and Young AdultsNIHNational Institute on Drug Abuse2021 to 2023$589,680May 1, 2019April 30, 2024CHUA, KAO-PINGreporter.nih.gov
Modeling weekly and daily processes of a high-risk feedback cycle of alcohol, cannabis, and nonmedical use of prescription stimulants in college students: Impacts on use, academics, and sleepNIHNational Institute on Drug Abuse2025$589,440May 15, 2025February 28, 2030FAIRLIE, ANNE MARIEreporter.nih.gov
A Tailored Behavioral Intervention To Increase Engagement in Opioid Tapering in Primary Care SettingsNIHNational Institute on Drug Abuse2021 to 2023$582,473July 1, 2019December 31, 2024LAGISETTY, POOJAreporter.nih.gov
Empowering dentists to reduce opioid prescriptions to young peopleNIHNational Institute of Dental & Craniofacial Research2023$580,179January 1, 2023December 31, 2023OYLER, DOUGLASreporter.nih.gov
Expanding the Youth Opioid Recovery Support (YORS) Intervention for MOUD adherence to adolescents with OUDNIHNational Institute on Drug Abuse2024$576,675September 30, 2024August 31, 2027WENZEL, KEVIN R.reporter.nih.gov
Variable brain oxycodone metabolism alters drug effectNIHNational Institute on Drug Abuse2021 to 2022$576,531September 30, 2018July 31, 2024TYNDALE, RACHEL FYNVOLAreporter.nih.gov
Polydrug Abuse: Opioid-Alcohol CombinationsNIHNational Institute on Alcohol Abuse and Alcoholism2025$571,673September 23, 2025July 31, 2030PLATT, DONNA Mreporter.nih.gov
PrEP and substance use among sexual minority young adultsNIHNational Institute on Drug Abuse2021 to 2023$571,335April 1, 2019March 31, 2025WATSON, RYAN Jreporter.nih.gov
Nicotinic and Insular Cortical Mechanisms Contributing to Opiate MisuseNIHNational Institute on Drug Abuse2021 to 2024$547,022May 1, 2024July 31, 2025LONEY, GREGORY CARLreporter.nih.gov
Low-dose buccal buprenorphine: Relative abuse potential and postoperative analgesic acceptabilityNIHNational Institute on Drug Abuse2023 to 2025$526,926March 15, 2023February 29, 2028LARACH, DANIELreporter.nih.gov
Reducing Unused Prescribed Opioids After Cesarean BirthNIHNational Institute on Drug Abuse2021 to 2023$508,978August 1, 2019July 31, 2024OSMUNDSON, SARAH SCHEIDERICHreporter.nih.gov
Development and Pilot Randomized Control Trial of a Text Message Intervention to Facilitate Secure Storage and Disposal of Prescription Opioids to Prevent Diversion and MisuseNIHNational Institute on Drug Abuse2021 to 2022$503,877August 1, 2021July 31, 2023EGAN, KATHLEEN LOUISEreporter.nih.gov
Safety Assessment of Perioperative Pain Medications for Children (SAPPhire)NIHEunice Kennedy Shriver National Institute of Child Health & Human Development2021 to 2022$489,697August 20, 2021July 31, 2024RAVAL, MEHUL V.reporter.nih.gov
EpiCenter - EPIdemiology of opioid prescribing in community health CENTERsNIHNational Institute on Drug Abuse2022$483,221August 1, 2018April 30, 2023HARTUNG, DANIEL Mreporter.nih.gov
Changes to which Drugs and Drug Combinations are Prescribed in Response to Opioid Supply-side PoliciesNIHNational Institute on Drug Abuse2021 to 2022$478,166September 30, 2021August 31, 2025PEET, EVAN DAVIDreporter.nih.gov
Single Session Pain Catastrophizing Class: Efficacy & Mechanisms for Reducing Opioid Use Among Chronic Pain PatientsNIHNational Institute on Drug Abuse2021 to 2023$477,657May 15, 2019November 30, 2024ZIADNI, MAISAreporter.nih.gov
Impact of cannabis legalization on prescription drug use and health outcomes in ConnecticutNIHNational Institute on Drug Abuse2023 to 2024$475,440April 1, 2023March 31, 2025RADHAKRISHNAN, RAJIVreporter.nih.gov
Understanding and Addressing Opioid and Benzodiazepine Co-prescribing among Older Adults with CancerNIHNational Institute on Aging2022 to 2023$466,440February 15, 2022November 30, 2024CHECK, DEVONreporter.nih.gov
Role of lateral hypothalamus projections in opioid withdrawal-induced sleep deficitsNIHNational Institute on Drug Abuse2022 to 2023$466,310July 1, 2022June 30, 2025CARLEZON, WILLIAM A.reporter.nih.gov
Evaluating Policy Interventions to Decrease Excessive and Risky Perioperative Opioid PrescribingNIHNational Institute on Drug Abuse2025$465,336February 28, 2025April 30, 2027WALJEE, JENNIFER FILIPreporter.nih.gov
Spinal Manipulative Therapy vs. Prescription Drug Therapy for Care of Aged Medicare Beneficiaries with Neck PainNIHNational Center for Complementary & Integrative Health2022$459,595August 1, 2018April 30, 2025WHEDON, JAMES M.reporter.nih.gov
Effect of pain catastrophizing on prescription opioid cravingNIHNational Institute on Drug Abuse2021 to 2023$454,533July 1, 2019December 31, 2024YOU, DOKYOUNG SOPHIAreporter.nih.gov
Long-term Opioid Therapy, Depression and Suicide Mortality Risk in Patients with Head and Neck CancerNIHNational Institute of Dental & Craniofacial Research2022$447,950September 15, 2022September 14, 2025OSAZUWA-PETERS, NOSAYABAreporter.nih.gov
Resolving differences between clinical opioids at single neuronsNIHNational Institute on Drug Abuse2021 to 2022$444,125March 1, 2021February 29, 2024MARGOLIS, ELYSSAreporter.nih.gov
Functional consequences of the interactions between tau protein and opioidsNIHNational Institute on Drug Abuse2024 to 2025$441,176September 15, 2024August 31, 2026ATWOOD, BRADYreporter.nih.gov
Spillover Effects of Policies Targeting Opioid Abuse on Intimate Partner ViolenceNIHNational Institute on Drug Abuse2024 to 2025$438,703June 1, 2024May 31, 2026DAVE, DHAVAL M.reporter.nih.gov
Early cannabis use and later opioid use disorder - the role of adverse childhood experiences, genetic liability and comorbid stimulant useNIHNational Institute on Drug Abuse2024 to 2025$427,625August 1, 2024July 31, 2027AGRAWAL, ARPANAreporter.nih.gov
Consequences of fentanyl self-administration during pregnancyNIHNational Institute on Drug Abuse2021 to 2022$426,250April 1, 2021March 31, 2024RÜEDI-BETTSCHEN, DANIELAreporter.nih.gov
Macrocyclic Arenes as Sequestrants for Drugs of AbuseNIHNational Institute on Drug Abuse2024 to 2025$425,976June 15, 2024May 31, 2027ISAACS, LYLE Dreporter.nih.gov
The potential of oxytocin to reduce opioid abuse liability and pain among older adultsNIHNational Institute on Drug Abuse2023 to 2024$419,375May 1, 2023April 30, 2026BERRY, MEREDITHreporter.nih.gov
Transcriptional silencing of HIV by LTR targeting RNAiNIHNational Institute on Drug Abuse2025$418,625July 15, 2025June 30, 2027KLASE, ZACHARY ALANreporter.nih.gov
Providers and Older Pain Patients with Prescription Opioid Dependence: A Qualitative Study to Understand Barriers to Opioid Taper, Cessation, and Transition to Buprenorphine.NIHNational Institute on Aging2023$416,625September 19, 2023September 18, 2025GRUCZA, RICHARD Areporter.nih.gov
Counterfeit Pharmaceuticals: Increased Risks in the Era of Novel Synthetic Opioids and Other Designer DrugsNIHNational Institute on Drug Abuse2022 to 2023$415,340April 1, 2022March 31, 2025DANIULAITYTE, RAMINTAreporter.nih.gov
An Examination of Concomitant Non-Medical Use of Gabapentin and Opioids.NIHNational Institute on Drug Abuse2022 to 2023$412,363September 30, 2022August 31, 2025BUTTRAM, MANCE E.reporter.nih.gov
Brain Development after Early-Life Antipsychotic TreatmentNIHNational Institute of General Medical Sciences2023 to 2025$411,000June 1, 2023April 30, 2027BARDGETT, MARK EDWARDreporter.nih.gov
March5 and Associated Mitochondrial Dynamics in Incubation of Oxycodone CravingNIHNational Institute on Drug Abuse2023 to 2024$410,136May 15, 2023April 30, 2026LI, XUAN ANNAreporter.nih.gov
Subcellular Proteomics in Orbitostriatal Circuits in Incubation of Oxycodone CravingNIHNational Institute on Drug Abuse2024$403,542September 15, 2024August 31, 2026LI, XUAN ANNAreporter.nih.gov
Short-term Outcome of Stimulant Use Disorder Treatment TrialsNIHNational Institute on Drug Abuse2024$403,206July 1, 2024June 30, 2026MOJTABAI, RAMINreporter.nih.gov
The use of DNA-encoded library (DEL) technology for the identification of therapeutic molecules to treat opioid use disorders (OUDs)NIHNational Institute on Drug Abuse2024$399,884September 1, 2024August 31, 2025FLAJOLET, MARCreporter.nih.gov
iPSC-derived human neurons and OUD medications developmentNIHNational Institute on Drug Abuse2025$399,536March 15, 2025February 28, 2027GOMEZ-GALENO, JORGE E.reporter.nih.gov
Collaborative Care Office-Based Opioid Treatment for Adolescents and Young AdultsNIHNational Institute on Drug Abuse2021 to 2022$398,423October 5, 2021December 31, 2023HADLAND, SCOTT EVANreporter.nih.gov
Behavior Change Components to Enhance Opioid Disposal After SurgeryNIHNational Institute on Drug Abuse2024 to 2025$397,440May 1, 2024April 30, 2028HUANG, LYEN CAMILLEreporter.nih.gov
Benzodiazepine-related harms in young people: Informing policy, interventions, and prescribingNIHNational Institute on Drug Abuse2021 to 2022$392,212March 15, 2021February 28, 2023BUSHNELL, GRETAreporter.nih.gov
Multi-level associations between opioid use and overdose: Individual, clinical, and population-based risk factors for fatalityNIHNational Institute on Drug Abuse2021 to 2022$392,212July 1, 2020June 30, 2023SAMPLES, HILLARYreporter.nih.gov
Multi-level associations between opioid use and overdose: Individual, clinical, and population-based risk factors for fatalityNIHNational Institute on Drug Abuse2023 to 2024$392,212July 1, 2020June 30, 2026SAMPLES, HILLARYreporter.nih.gov
Opioid-induced dysregulation of lateral mesolimbic dopamine circuits and motivated behaviorNIHNational Institute on Drug Abuse2021 to 2022$381,587September 30, 2021August 31, 2023HEARING, MATTHEW CARLreporter.nih.gov
Facilitating supervised self-management of stimulant medications among adolescents: improving adherence, reducing stigma, and supporting caregiversNIHNational Institute on Drug Abuse2021 to 2022$379,072June 1, 2021May 31, 2022PERSE, ARTINreporter.nih.gov
SPOiLER: towards Safer Prescribing of Legal Opioids from the Emergency RoomNIHNational Institute on Drug Abuse2021 to 2022$370,793March 1, 2018August 31, 2023SOARES, WILLIAM EDWARDreporter.nih.gov
Postpartum Neurobiological Sequelae of Prescription Opioid Use During PregnancyNIHNational Institute on Drug Abuse2024 to 2025$369,930March 1, 2024May 30, 2025LUJAN PEREZ, MIGUEL ANGELreporter.nih.gov
Development of compound RUEC2-118, a novel partial GABAAR positive modulator, a fast-acting treatment for general anxiety and panic disorder, to prevent opioid and benzodiazepine overdose fatalities.NIHNational Institute on Drug Abuse2023 to 2024$368,300February 1, 2024September 30, 2024CARRY, EILEENreporter.nih.gov
Using machine learning to analyze integrated clinical and geo-contextual data to inform the design of a decision support system to reduce the risk of stimulant therapyNIHNational Institute on Drug Abuse2024 to 2025$361,792July 15, 2024June 30, 2029TUAN, WEN-JANreporter.nih.gov
Augmenting the Efficacy of Benzodiazepine Taper with Telehealth-Delivered Cognitive Behavioral Therapy for Anxiety Disorders in Patients Using Prescription OpioidsNIHNational Institute on Drug Abuse2022 to 2023$360,141September 15, 2022August 31, 2025WOLITZKY-TAYLOR, KATE BASIAreporter.nih.gov
Quantifying health policy impacts on substance use and treatment among women with and at risk for HIV: a longitudinal multilevel analysis using the Women's Interagency HIV StudyNIHNational Institute on Drug Abuse2021 to 2022$349,741July 18, 2020June 30, 2024HALEY, DANIELLE FRANCESreporter.nih.gov
Leveraging large-scale national data to understand, reduce, and prevent benzodiazepine-related harms among older adultsNIHNational Institute on Drug Abuse2022$348,477May 15, 2018February 29, 2024MAUST, DONOVAN Treporter.nih.gov
Dementia and the opioid epidemic: The impact of the 2016 CDC guidelines on disparities in pain managementNIHNational Institute on Aging2024$338,000September 17, 2024August 31, 2026RODIN, REBECCA ANNEreporter.nih.gov
Functional and molecular characterization of the central amygdala in the context of oxycodone withdrawalNIHNational Institute on Drug Abuse2024 to 2025$331,822May 1, 2024April 30, 2027SLIVICKI, RICHARDreporter.nih.gov
Harnessing Placebo Analgesia to Address the Opioid EpidemicNIHNational Institute on Drug Abuse2022 to 2023$330,981April 1, 2019September 30, 2024BERNSTEIN, MICHAEL HARRISONreporter.nih.gov
Nucleus accumbens fast-spiking interneurons regulate opioid reward and addictionNIHNational Institute on Drug Abuse2022 to 2023$329,130March 1, 2022February 29, 2024LEFEVRE, EMILIA Mreporter.nih.gov
SafeMedWaste At-Home, Environmentally-Friendly Opioid Disposal Kit for Orthopedic Post-Operative Surgical Patients to Reduce Opioids Available for DiversionNIHNational Institute on Drug Abuse2023$323,698September 1, 2023August 31, 2025STAS, JUSTINreporter.nih.gov
An oral therapeutic to treat intoxication by prescription and illicit stimulantsNIHNational Institute on Drug Abuse2022$319,946September 30, 2022March 31, 2023LI, XINHUAreporter.nih.gov
Theory-based social media intervention for non-medical use of prescription opioids (NMUPO) in young adultsNIHNational Institute on Drug Abuse2024 to 2025$311,558May 1, 2024April 30, 2029TAM, CHEUK CHIreporter.nih.gov
Feasibility of a dual English/Spanish mobile augmented reality pain assessment app to reduce postoperative prescription opioid use in Hispanic/Latino pediatric and adolescent cancer patientsNIHNational Institute on Drug Abuse2022 to 2023$310,996March 6, 2023September 30, 2023YORK, CHRISTINAreporter.nih.gov
Meeting the cost and privacy demands for detecting Anabolic Androgenic Steroid doping in youth athletics with rationally designed nuclear receptor BioAssaysNIHNational Institute on Drug Abuse2025$306,872February 1, 2025December 31, 2026SCHAUFELE, FRED Jreporter.nih.gov
Preventing Prescription Stimulant Diversion and Medication Misuse Via a Web-Based Simulation InterventionNIHNational Institute on Drug Abuse2021 to 2022$306,592July 15, 2020May 31, 2024HOLT, LAURAreporter.nih.gov
A Hybrid Program to Prevent Substance Use Risk among Upper Elementary School Students Using a Positive Youth Development ApproachNIHNational Institute on Drug Abuse2024$305,046September 15, 2024August 31, 2025WILLIAMS, CHRISTOPHERreporter.nih.gov
Extending duration of an injectable long-acting local anesthetic formulation using novel saltsNIHNational Institute on Drug Abuse2024$295,921September 1, 2024August 31, 2025DAVIS, BRETTreporter.nih.gov
Feasibility of Electronic Screening to Identify Risk of Opioid Misuse and OverdoseNIHNational Institute on Drug Abuse2024$295,876September 15, 2024August 31, 2025FERRARESE, NICKreporter.nih.gov
Technologies for OUD Prevention, Control and Supportive Care - Development of Patient/Caregiver mobile application and Provider DashboardNIHNational Institute on Drug Abuse2021 to 2022$276,150September 15, 2021August 31, 2022ELUMALAI, SATHYAreporter.nih.gov
Developing a novel epigenetic regulator as a treatment for opioid use disorderNIHNational Institute on Drug Abuse2024$275,253September 30, 2024September 29, 2025KIM, THOMASreporter.nih.gov
An mHealth Approach to Decreasing Opioid Abuse and Other Diseases of Despair in Rural PopulationsNIHNational Institute on Drug Abuse2023$274,791September 15, 2023July 31, 2024DEITZ, DIANE K.reporter.nih.gov
Neurocognitive Impairments Resulting from Adolescent Prescription Opioid Use Disorder: Longitudinal Impact, Neural Mechanisms, and ComorbiditiesNIHNational Institute on Drug Abuse2022 to 2023$262,289April 1, 2022March 31, 2024MCLAURIN, KRISTEN ADDIEreporter.nih.gov
Sedative-Hypnotic Use Patterns and Risk for Cognitive Decline and Alzheimer's DiseaseNIHNational Institute on Aging2022 to 2023$255,420February 15, 2019January 31, 2025KAUFMANN, CHRISTOPHER NORFLEETreporter.nih.gov
Elucidating behavior and neural circuits underlying opioid addiction and dependenceNIHNational Institute on Drug Abuse2022$234,963September 1, 2019August 31, 2022NGUYEN, JACQUES DUCHUYreporter.nih.gov
Mechanism and Efficacy of a Novel Opioid AdjuvantNIHNational Institute on Drug Abuse2024$220,668August 1, 2024August 31, 2025MEYN, MALCOLM Areporter.nih.gov
Harnessing Placebo Analgesia to Address the Opioid EpidemicNIHNational Institute on Drug Abuse2021 to 2022$211,519April 1, 2019July 31, 2022BERNSTEIN, MICHAEL HARRISONreporter.nih.gov
Development and Pilot Randomized Control Trial of a Text Message Intervention to Facilitate Secure Storage and Disposal of Prescription Opioids to Prevent Diversion and MisuseNIHNational Institute on Drug Abuse2023$195,173August 1, 2021May 31, 2026EGAN, KATHLEEN LOUISEreporter.nih.gov
Cross-state validation of a novel prescription-based model to predict new long-term opioid useNIHNational Institute on Drug Abuse2022 to 2023$173,286July 1, 2022June 30, 2025TSEREGOUNIS, IRAKLIS ERIKreporter.nih.gov
Adolescent Oxycodone Exposure on Oxycodone Reinforcement and Reward Neurocircuitry in AdulthoodNIHNational Institute on Drug Abuse2021 to 2022$158,500July 15, 2021June 30, 2024HAUSER, SHEKETHA RENAYreporter.nih.gov
Quantification and Characterization of Opioid Prescription, Overdose, and Fatalities in People with Cancer: A Massive Nationwide, Multi-Cohort StudyNIHNational Institute on Drug Abuse2021 to 2022$157,938April 1, 2021March 31, 2023MURPHY, JAMES Dreporter.nih.gov
Assessing Implementation of Pharmacy-Based Medication Disposal Programs: National Estimates, Neighborhood Inequities, and Determinants of ImplementationNIHNational Institute on Drug Abuse2023 to 2024$155,000August 15, 2023July 31, 2025EGAN, KATHLEEN LOUISEreporter.nih.gov
Using electronic medical record (EMR) data to examine the impact of prenatal drug exposure: Evaluating availability, accuracy and utilty of exposure informationNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2022 to 2023$146,500August 25, 2022July 31, 2025BAILEY, BETH Areporter.nih.gov
The role of Zhx2 in CYP2D regulation, oxycodone metabolism, and opioid addiction model behaviors.NIHNational Institute on Drug Abuse2023 to 2024$96,668August 8, 2023July 31, 2026LYNCH, WILLIAMreporter.nih.gov
Disentangling unique etiologies of prescription opioid misuse and heroin use: Analysis of longitudinal, twin, and genomic dataNIHNational Institute on Drug Abuse2021 to 2022$92,311August 1, 2021July 31, 2023DASH, GENEVIEVE FULLERTONreporter.nih.gov
Drug-drug interactions between cannabis and hydrocodone.NIHNational Institute on Drug Abuse2022 to 2024$77,985August 16, 2022August 17, 2024COATES, SHELBYreporter.nih.gov
Drug-induced plasticity in mesolimbic dopamine circuits in opioid dependenceNIHNational Institute on Drug Abuse2021 to 2022$77,106September 1, 2020August 31, 2023GOODING, SARAH WARRENreporter.nih.gov
Assessing the dose- and sex-dependent effects of oxytocin on opioid demand and reinstatementNIHNational Institute on Drug Abuse2025$76,250December 15, 2024November 30, 2026SCHWENDT, MAREKreporter.nih.gov
Bacteriophage virus-like particle based vaccines against oxycodoneNIHNational Institute on Drug Abuse2023 to 2024$75,468September 1, 2023August 31, 2025ROMANO, ISABELLAreporter.nih.gov
Exploring Reactivity Among Patients with Chronic Pain Using Cannabis and Opioids: Mixed-Method Evidence of Promising Intervention StrategiesNIHNational Institute on Drug Abuse2024$73,828September 15, 2024September 14, 2026STONE, BRYANT MICHAELreporter.nih.gov
Oxytocin regulation of intravenous oxycodone demand: a role for nucleus accumbensNIHNational Institute on Drug Abuse2023 to 2024$73,125May 16, 2023August 15, 2024WILKINSON, COURTNEYreporter.nih.gov
Computational analysis of single-nucleus sequencing data for studying the cell type-specific basis of opioid use disordersNIHNational Institute on Drug Abuse2022 to 2023$67,699April 1, 2022September 30, 2023ZHOU, JESSICA LUreporter.nih.gov
Delta Opioid Receptor Regulation of Parvalbumin Interneuron Transmission and Oxycodone-Related BehaviorNIHNational Institute on Drug Abuse2025$49,538May 1, 2025April 30, 2028COLE, REBECCAreporter.nih.gov
Evaluating the Multiscale Effects of Fentanyl-Induced Dependence and Abstinence within the Mouse Basolateral AmygdalaNIHNational Institute on Drug Abuse2025$45,982August 1, 2025July 31, 2028DESFOR, SHANEreporter.nih.gov
Molecular target and circuitry underlying the preclinical effects of psychedelics in models of opioid use disorderNIHNational Institute on Drug Abuse2023$39,388July 1, 2023May 10, 2024JASTER, ALAINAreporter.nih.gov

Organizations

OrganizationPlaceNIH awardsNIH amountNSF awardsNSF amount
University of KentuckyLexington, KY6$45.6 million0$0
Ensysce Biosciences, Inc.La Jolla, CA2$15.4 million0$0
Sparian Biosciences, Inc.New York City, NY1$13.7 million0$0
University of Mississippi Med CTRJackson, MS7$10.9 million0$0
Mclean HospitalBelmont, MA5$10.7 million0$0
University of California, San DiegoLa Jolla, CA8$9.9 million0$0
Icahn School of Medicine at Mount SinaiNew York, NY6$9.4 million0$0
Washington UniversitySaint Louis, MO6$9.2 million0$0
University of Oregon EugeneEugene, OR1$9 million0$0
University of California Los AngelesLos Angeles, CA4$8.4 million0$0
Park Therapeutics, Inc.Morristown, NJ1$6.7 million0$0
University of Michigan at Ann ArborAnn Arbor, MI6$6.6 million0$0
University of FloridaGainesville, FL7$6.4 million0$0
University of Illinois at ChicagoChicago, IL1$6.4 million0$0
Rand CorporationSanta Monica, CA4$6.3 million0$0
SUNY at BuffaloAmherst, NY4$5.6 million0$0
Stanford UniversityStanford, CA6$5.6 million0$0
Emory UniversityAtlanta, GA2$5.5 million0$0
University of WashingtonSeattle, WA5$5.5 million0$0
University of Pittsburgh at PittsburghPittsburgh, PA4$5.3 million0$0
University of Alabama at BirminghamBirmingham, AL3$5.2 million0$0
Johns Hopkins UniversityBaltimore, MD3$5 million0$0
Vanderbilt University Medical CenterNashville, TN4$4.9 million0$0
University of Tennessee Health Sci CTRMemphis, TN2$4.8 million0$0
University of UtahSalt Lake City, UT3$4.6 million0$0
Medical University of South CarolinaCharleston, SC3$4.6 million0$0
University of Nebraska Medical CenterOmaha, NE2$4.5 million0$0
Oregon Health & Science UniversityPortland, OR4$4.5 million0$0
University of ArizonaTucson, AZ2$4.4 million0$0
Mebias Discovery, Inc.Philadelphia, PA1$4.3 million0$0
University of California, San FranciscoSan Francisco, CA3$4.1 million0$0
Ohio State UniversityColumbus, OH2$4.1 million0$0
Yale UniversityNew Haven, CT2$3.9 million0$0
Mayo Clinic RochesterRochester, MN2$3.8 million0$0
New York University School of MedicineNew York, NY2$3.6 million0$0
New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INCNew York, NY1$3.6 million0$0
Drexel UniversityPhiladelphia, PA2$3.2 million0$0
Amalgent Therapeutics, Inc.Greenville, NC2$2.8 million0$0
Boston University Medical CampusBoston, MA3$2.5 million0$0
Epiodyne, Inc.San Francisco, CA1$2.5 million0$0
Arcato Laboratories, Inc.Greenville, NC1$2.3 million0$0
Altality, Inc.Ann Arbor, MI2$2.1 million0$0
University of PennsylvaniaPhiladelphia, PA2$2.1 million0$0
BDH Pharma, LLCStudio City, CA1$2.1 million0$0
Wake Forest University Health SciencesWinston-Salem, NC3$2.1 million0$0
Revbio, Inc.Lowell, MA1$2.1 million0$0
Tufts University BostonBoston, MA1$2 million0$0
University of New MexicoAlbuquerque, NM1$2 million0$0
University of Maryland, College ParkCollege Park, MD4$2 million0$0
University of MinnesotaMinneapolis, MN3$1.9 million0$0
University of ChicagoChicago, IL1$1.9 million0$0
Quivive Pharma, INCRowland Heights, CA1$1.9 million0$0
Wayne State UniversityDetroit, MI1$1.9 million0$0
University of Texas Med BR GalvestonGalveston, TX2$1.9 million0$0
SUNY at Stony BrookStony Brook, NY1$1.8 million0$0
University of Miami School of MedicineCoral Gables, FL1$1.8 million0$0
University of Colorado at BoulderBoulder, CO1$1.8 million0$0
Cog Analytics, LLCPotomac, MD1$1.8 million0$0
Florida International UniversityMiami, FL1$1.8 million0$0
Base Pair Biotechnologies, Inc.Pearland, TX1$1.8 million0$0
Prevention Strategies, LLCGreensboro, NC1$1.6 million0$0
Indiana UniversityBloomington, IN1$1.6 million0$0
Weill Medical Coll of Cornell UnivNew York, NY1$1.5 million0$0
Marquette UniversityMilwaukee, WI2$1.5 million0$0
Northeastern UniversityBoston, MA1$1.2 million0$0
Medical College of WisconsinMilwaukee, WI1$1.1 million0$0
University of Colorado DenverAurora, CO1$1.1 million0$0
Rutgers Biomedical and Health SciencesNewark, NJ2$1 million0$0
Brigham and Women's HospitalBoston, MA1$1 million0$0
Rosalind Franklin Univ of Medicine & SciNorth Chicago, IL1$1 million0$0
Ut Southwestern Medical CenterDallas, TX1$995,6640$0
Tamade, LLCPasadena, CA1$989,5710$0
Case Western Reserve UniversityCleveland, OH1$956,5140$0
University of Wisconsin-MadisonMadison, WI1$941,2780$0
Texas State University - San MarcosSan Marcos, TX1$939,7050$0
Duke UniversityDurham, NC2$914,3900$0
Rutgers Biomedical/health Sciences-RbhsNew Brunswick, NJ2$784,4240$0
Baylor UniversityWaco, TX1$747,0000$0
California State University-Long Beach FoundationLong Beach, CA1$672,6560$0
Indiana University IndianapolisIndianapolis, IN2$623,8360$0
Maryland Treatment Centers, Inc.Baltimore, MD1$576,6750$0
University of TorontoToronto1$576,5310$0
University of South Carolina at ColumbiaColumbia, SC2$573,8470$0
University of ConnecticutStorrs, CT1$571,3350$0
East Carolina UniversityGreenville, NC1$503,8770$0
Northwestern University at ChicagoChicago, IL1$489,6970$0
Oregon State UniversityCorvallis, OR1$483,2210$0
Southern California Univ of Health ScisWhittier, CA1$459,5950$0
National Bureau of Economic Research IncCambridge, MA1$438,7030$0
Saint Louis UniversitySaint Louis, MO1$416,6250$0
Arizona State UniversityScottsdale, AZ1$415,3400$0
University of ArkansasFayetteville, AR1$412,3630$0
Northern Kentucky UniversityHighland Heights, KY1$411,0000$0
Tulane University of LouisianaNew Orleans, LA1$403,2060$0
Jillion Therapeutics Inc.New York, NY1$399,8840$0
Chemregen INCSan Diego, CA1$399,5360$0
Massachusetts General HospitalBoston, MA1$398,4230$0
Pillsmart Inc.Brooklyn, NY1$379,0720$0
Baystate Medical Center, Inc.Springfield, MA1$370,7930$0
University of Maryland BaltimoreBaltimore, MD1$369,9300$0

Funding by fiscal year

Fiscal yearNIH awardsNIH amountNSF awardsNSF amount
202573$38,920,1780$0
2024103$51,165,5560$0
2023124$80,662,0850$0
2022141$94,911,1760$0
2021101$91,688,1860$0

Open federal funding opportunities

From Grants.gov: notices that funded awards in this table, and open notices on the same agency and assistance listing.

Open opportunityNumberAgencyListingClosesAward ceilingWhy it matches
Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)PA-24-254NIHJuly 12, 2027Not listedNotice number printed on 1 award here
NIDA Mentored Clinical Scientist Development Program Award in Substance Use and Substance Use Disorder Research (K12 Clinical Trial Optional)PAR-24-089NIH93.279November 13, 2026$750,000Same assistance listing 93.279 as 197 awards here
Ethical, Legal and Social Implications (ELSI) Small Research Grant (R03 Clinical Trial Optional)PAR-25-370NIH93.279November 16, 2026$50,000Same assistance listing 93.279 as 197 awards here
Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant (R21 Clinical Trial Optional)PAR-25-369NIH93.279November 18, 2026Not listedSame assistance listing 93.279 as 197 awards here
Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)PAR-25-371NIH93.279November 18, 2026Not listedSame assistance listing 93.279 as 197 awards here
Competing Revisions to Existing NIH Single Project Research Grants and Cooperative Agreements (Clinical Trial Optional)PA-23-317NIH93.279November 24, 2026Not listedSame assistance listing 93.279 as 197 awards here
Emerging Global Leader Award (K43 Independent Clinical Trial Required)PAR-24-295NIH93.279December 3, 2026Not listedSame assistance listing 93.279 as 197 awards here
Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed)PAR-24-296NIH93.279December 3, 2026Not listedSame assistance listing 93.279 as 197 awards here
NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)RFA-OD-24-011NIH93.279December 4, 2026Not listedSame assistance listing 93.279 as 197 awards here
Small Business Transition Grant for New Entrepreneurs (Parent R43/R44 Clinical Trial Optional)PAR-27-039NIH93.279January 5, 2027Not listedSame assistance listing 93.279 as 197 awards here
Small Business Transition Grant for New Entrepreneurs (Parent R41/R42 Clinical Trial Optional)PAR-27-040NIH93.279January 5, 2027Not listedSame assistance listing 93.279 as 197 awards here
Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required)PAR-24-214NIH93.279January 7, 2027$375,000Same assistance listing 93.279 as 197 awards here
Intervention Research to Improve Native American Health (R34 Clinical Trial Optional)PAR-25-378NIH93.279January 7, 2027Not listedSame assistance listing 93.279 as 197 awards here
Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)PAR-25-379NIH93.279January 7, 2027Not listedSame assistance listing 93.279 as 197 awards here
HEAL Initiative: Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required)RFA-DA-28-011NIH93.279January 26, 2027Not listedSame assistance listing 93.279 as 197 awards here
HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR) - Building Engagement, Assistance, Capacity, Outreach, and Networks (BEACON) Center (U2C Clinical Trial Not Allowed)RFA-DA-28-012NIH93.279January 26, 2027Not listedSame assistance listing 93.279 as 197 awards here
Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program (UC2- Clinical Trial Not Allowed)PAR-24-268NIH93.279January 27, 2027$500,000Same assistance listing 93.279 as 197 awards here
BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS (R18 - Clinical Trial Not Allowed)RFA-NS-24-031NIH93.279January 28, 2027$750,000Same assistance listing 93.279 as 197 awards here
Neural Ensembles & Used Substances (NExUS) Collaboratory: Building a Multimodal Inventory of Cell Ensembles Encoding the Effects of Addictive Substances (U01 Clinical Trial Not Allowed)RFA-DA-28-013NIH93.279February 8, 2027Not listedSame assistance listing 93.279 as 197 awards here
BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed)RFA-MH-26-170NIH93.279February 8, 2027Not listedSame assistance listing 93.279 as 197 awards here

Updated November 3, 2026. Read from NIH RePORTER ExPORTER and NSF Award Search. Published by NIH and NSF as U.S. government data. NIH awards are fiscal years 2021 to 2025 (NIH files published to 2026-07-09); NSF awards are fiscal years 2022 to 2026 (NSF files published to 2026-11-02). NIH amounts are the total cost of each fiscal year in the window; NSF amounts are the funds obligated in the window. Organizations are matched on the UEI. Open opportunities come from Grants.gov and match on agency and assistance listing number, and on the notice number NIH prints on an award. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.