Data / Research funding / Frontotemporal Dementia (FTD)
Frontotemporal Dementia (FTD): 601 NIH awards ($942.9M) to 139 organizations
601 NIH awards ($942.9M) in the NIH spending category Frontotemporal Dementia (FTD), to 139 organizations, read 2026-11-03. NIH fiscal years 2021 to 2025.
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Awards
The 500 largest of 601 awards in the window.
| Award | Agency | Institute or division | Fiscal year | Amount in window | Start | End | Principal investigator | Source |
|---|---|---|---|---|---|---|---|---|
| ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration, Cycle 2 (ALLFTD2) | NIH | National Institute on Aging | 2021 to 2025 | $56,766,232 | September 15, 2019 | August 31, 2030 | BOEVE, BRADLEY F | reporter.nih.gov |
| The Progressive Supranuclear Palsy Clinical Trial Platform (PTP) | NIH | National Institute on Aging | 2024 to 2025 | $30,281,212 | August 15, 2024 | July 31, 2029 | BOXER, ADAM L. | reporter.nih.gov |
| Center without Walls for Imaging Proteinopathies with PET | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $24,457,384 | September 24, 2019 | July 31, 2029 | MACH, ROBERT H | reporter.nih.gov |
| Frontotemporal Dementia: Genes, Images, and Emotions | NIH | National Institute on Aging | 2021 to 2025 | $20,694,825 | September 1, 2002 | April 30, 2028 | GORNO TEMPINI, MARIA LUISA | reporter.nih.gov |
| Investigating regional and cellular vulnerabilities to tau pathology in young-onset Alzheimer's disease | NIH | National Institute on Aging | 2022 to 2025 | $12,536,106 | February 15, 2022 | November 30, 2026 | MURRAY, MELISSA ERIN | reporter.nih.gov |
| Pre-Symptomatic Familial ALS (Pre-fALS) Study: From Prodrome and Biomarkers to ALS/FTD Prevention | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $11,282,768 | September 15, 2018 | July 31, 2029 | BENATAR, MICHAEL | reporter.nih.gov |
| Uncovering the Genetic Mechanisms of the Chromosome 17q21.31 Tau Haplotype on Neurodegeneration Risk in FTD and PSP | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $9,418,230 | September 1, 2021 | August 31, 2026 | GOATE, ALISON M | reporter.nih.gov |
| Identification of TDP-43 Modifiers Through Single-Cell Transcriptional and Epigenomic Dissection of ALS and FTLD-MND | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $9,106,321 | September 29, 2021 | August 31, 2026 | DONNELLY, CHRISTOPHER JAMES | reporter.nih.gov |
| ASYMMETRIC NEURODEGENERATION AND LANGUAGE IN PRIMARY PROGRESSIVE APHASIA | NIH | National Institute on Aging | 2022 to 2025 | $8,306,361 | June 15, 2022 | March 31, 2027 | MESULAM, MAREK-MARSEL M | reporter.nih.gov |
| The Physical Biology of Neurodegeneration in Sporadic Amyotrophic Lateral Sclerosis/Frontotemporal Dementia | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $8,227,499 | September 1, 2021 | August 31, 2027 | PHATNANI, HEMALI | reporter.nih.gov |
| Discovery of novel TDP-43 splicing targets: the Achilles heel for FTD and towards sensitive biomarkers and therapeutic targets | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $8,189,971 | September 15, 2024 | August 31, 2026 | GITLER, AARON D. | reporter.nih.gov |
| Communication Bridge: Optimizing an evidence-based intervention for individuals with primary progressive aphasia | NIH | National Institute on Aging | 2023 to 2025 | $7,878,167 | September 15, 2017 | August 31, 2028 | ROGALSKI, EMILY J | reporter.nih.gov |
| Interdisciplinary Research Network on Biologically Active Tau Aggregate Polymorphs from Alzheimer's Disease and Related Dementias | NIH | National Institute on Aging | 2021 to 2025 | $7,757,977 | July 1, 2021 | June 30, 2027 | KAYED, RAKEZ | reporter.nih.gov |
| Precision Editing of Granulin Mutations that Cause Frontotemporal Dementia | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $6,580,415 | August 15, 2025 | July 31, 2029 | SONTHEIMER, ERIK J. | reporter.nih.gov |
| Expanding insights into FTD disease mechanisms | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $6,199,699 | December 1, 2016 | November 30, 2024 | PETRUCELLI, LEONARD | reporter.nih.gov |
| Phase II clinical trial of transcranial direct current stimulation in the treatment of primary progressive aphasia | NIH | National Institute on Aging | 2022 to 2025 | $5,516,416 | September 30, 2022 | May 31, 2027 | HAMILTON, ROY H | reporter.nih.gov |
| An automated machine learning approach to language changes in Alzheimer’s disease and frontotemporal dementia across Latino and English-speaking populations | NIH | National Institute on Aging | 2023 to 2025 | $5,455,529 | August 15, 2023 | June 30, 2028 | GORNO TEMPINI, MARIA LUISA | reporter.nih.gov |
| Investigating the Benefits of Remotely-supervised Neuromodulation in Primary Progressive Aphasia | NIH | National Institute on Aging | 2025 | $5,343,452 | September 15, 2025 | August 31, 2029 | HENRY, MAYA | reporter.nih.gov |
| Clinical Features and Neuropathological Basis of Sleep Wake Behavior in Alzheimer's and PSP | NIH | National Institute on Aging | 2021 to 2025 | $5,284,458 | June 1, 2019 | March 31, 2029 | NEYLAN, THOMAS C | reporter.nih.gov |
| Digital Health Technologies for Monitoring Motor Function in Progressive Supranuclear Palsy and Dementia with Lewy Bodies | NIH | National Institute on Aging | 2025 | $5,174,076 | September 1, 2025 | August 31, 2029 | VAZIRI, ASHKAN | reporter.nih.gov |
| Targeting Dysregulated RNA Splicing in Neurodegenerative Diseases | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2025 | $5,093,143 | September 1, 2023 | August 31, 2028 | LAGIER-TOURENNE, CLOTILDE | reporter.nih.gov |
| Investigations of the protein aggregation inhibitor NU-9 and its derivatives: mode of action and impact on Alzheimer’s disease and related dementias | NIH | National Institute on Aging | 2021 to 2025 | $4,851,218 | August 1, 2019 | July 31, 2029 | OZDINLER, PEMBE HANDE | reporter.nih.gov |
| Web-based Automated Imaging Differentiation of Parkinsonism | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $4,837,150 | April 1, 2021 | March 31, 2027 | VAILLANCOURT, DAVID E | reporter.nih.gov |
| Primary Progressive Aphasia: Cognition, Anatomy and Progression | NIH | National Institute of Neurological Disorders and Stroke | 2022 | $4,705,247 | July 15, 2004 | August 31, 2025 | GORNO TEMPINI, MARIA LUISA | reporter.nih.gov |
| Development of a MT-stabilizing agent for the treatment of tauopathies | NIH | National Institute on Aging | 2024 to 2025 | $4,559,463 | September 1, 2024 | August 31, 2027 | CAFFREY, CONOR | reporter.nih.gov |
| Innovating Yeast and Human Genetics Approaches to Define Mechanisms of Neurodegenerative Disease | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $4,359,590 | December 1, 2016 | November 30, 2024 | GITLER, AARON D. | reporter.nih.gov |
| Spreading Tau Pathology in Non-Amnestic Alzheimer's Disease | NIH | National Institute on Aging | 2021 to 2025 | $4,306,312 | July 1, 2018 | June 30, 2028 | PHILLIPS, JEFFREY S | reporter.nih.gov |
| Microglia contribution to disease pathogenesis in C9orf72 ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $4,229,195 | September 1, 2021 | August 31, 2027 | SATTLER, RITA | reporter.nih.gov |
| Peripheral Tissue Biomarker for Premortem Diagnosis of Lewy Body Dementia | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2025 | $4,170,328 | December 15, 2021 | June 30, 2026 | CHEN, SHU G. | reporter.nih.gov |
| Investigating the Temperature Dependence of Age-related Tau Pathology Relevant to Early Alzheimer's Disease | NIH | National Institute on Aging | 2021 to 2025 | $4,104,231 | August 15, 2021 | April 30, 2027 | BLESSING, ESTHER MARIAN | reporter.nih.gov |
| Nuclear pore complex quality control in ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $4,005,112 | May 1, 2021 | April 30, 2026 | ROTHSTEIN, JEFFREY D | reporter.nih.gov |
| Regulation of mRNA processing: Mechanisms and Consequences | NIH | National Institute of General Medical Sciences | 2021 to 2025 | $3,993,090 | June 8, 2016 | May 31, 2026 | MANLEY, JAMES L. | reporter.nih.gov |
| Discovery of Multimodal Biomarkers for Parkinsonian Syndromes, Their Progression, and Pathological Relevance | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2023 | $3,985,569 | June 1, 2019 | May 31, 2025 | MAILMAN, RICHARD B | reporter.nih.gov |
| Frontotemporal dementia and related disorders: transcriptomic profiling, biomarker discovery, and mechanistic insight | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $3,904,675 | April 15, 2021 | March 31, 2027 | VAN BLITTERSWIJK, MARKA | reporter.nih.gov |
| Skin biomarkers for diagnosing and characterizing AD and ADRD | NIH | National Institute on Aging | 2021 to 2025 | $3,834,262 | September 30, 2021 | June 30, 2027 | KRAUS, ALLISON L | reporter.nih.gov |
| Emotion network dysfunction and decline in early frontotemporal dementia | NIH | National Institute on Aging | 2021 to 2025 | $3,811,261 | December 15, 2016 | February 28, 2027 | STURM, VIRGINIA EMILY | reporter.nih.gov |
| tRNA fragments and their role in tau pathology in Alzheimer's disease and tauopathies | NIH | National Institute on Aging | 2025 | $3,672,952 | September 1, 2025 | August 31, 2029 | KRICHEVSKY, ANNA M. | reporter.nih.gov |
| Single-Cell Transcriptional and Epigenomic Dissection to Identify Therapeutic Targets for ALS and FTD | NIH | National Institute on Aging | 2021 to 2025 | $3,657,244 | March 1, 2021 | November 30, 2026 | KELLIS, MANOLIS | reporter.nih.gov |
| Nuclear and Glial Dysfunction in Neurodegeneration | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2025 | $3,647,532 | May 16, 2023 | April 30, 2031 | ROTHSTEIN, JEFFREY D | reporter.nih.gov |
| Targeted Cerebral Spinal Fluid (CSF) Drug Delivery - Enclear Precision System | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $3,564,917 | January 1, 2024 | December 31, 2026 | GLICKSMAN, MARCIE A | reporter.nih.gov |
| Endolysosomal defects in secretory autophagy and microglial toxicity in FTD | NIH | National Institute on Aging | 2021 to 2025 | $3,491,522 | September 15, 2017 | March 31, 2027 | HUANG, ERIC J | reporter.nih.gov |
| Resolving the function of progranulin in lysosomal lipid metabolism and the etiology of Alzheimer's disease and frontotemporal dementia | NIH | National Institute on Aging | 2022 to 2025 | $3,471,933 | September 1, 2022 | August 31, 2027 | KUKAR, THOMAS L | reporter.nih.gov |
| Biological drivers of sex differences in frontotemporal dementia | NIH | National Institute on Aging | 2025 | $3,427,292 | September 15, 2025 | August 31, 2029 | CASALETTO, KAITLIN B | reporter.nih.gov |
| Protein aggregation in inclusion body and myofibrillar myopathies | NIH | National Institute on Aging | 2021 to 2025 | $3,388,405 | January 1, 2009 | March 31, 2029 | WEIHL, CONRAD C | reporter.nih.gov |
| Defining short RNA therapeutics that combat TDP-43 proteinopathy connected to AD and ADRDs. | NIH | National Institute on Aging | 2025 | $3,360,074 | September 15, 2025 | August 31, 2029 | SHORTER, JAMES | reporter.nih.gov |
| Small Molecule Ligands Targeting Pathological Tau Signaling In AD And Related Dementias | NIH | National Institute on Aging | 2025 | $3,336,256 | September 1, 2025 | August 31, 2029 | BRADY, SCOTT THOMAS | reporter.nih.gov |
| MAP4K3 regulation of cellular stress response pathways in health and disease | NIH | National Institute on Aging | 2022 to 2025 | $3,333,247 | December 1, 2008 | August 31, 2027 | LA SPADA, ALBERT R | reporter.nih.gov |
| Drivers of Pathological Tau Aggregation | NIH | National Institute on Aging | 2021 to 2025 | $3,324,711 | April 15, 2017 | March 31, 2027 | KOSIK, KENNETH STEPHEN | reporter.nih.gov |
| Investigating aberrant vesicular degradation and lipid metabolism in neurodegeneration | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $3,323,710 | August 15, 2025 | July 31, 2029 | BOSCO, DARYL ANGELA | reporter.nih.gov |
| Neurodevelopment in children from families with genetic frontotemporal dementia and Alzheimer’s disease | NIH | National Institute on Aging | 2022 to 2025 | $3,300,813 | February 15, 2022 | January 31, 2027 | LEE, SUZEE EURIE | reporter.nih.gov |
| Patient-Based Structural Biology of Tauopathies and TDP-43 Proteinopathies using Cryo-Electron Microscopy and Mass Spectrometry | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $3,258,324 | September 30, 2018 | August 31, 2024 | FITZPATRICK, ANTHONY WILLIAM PAUL | reporter.nih.gov |
| Investigating Dysregulation of Stress-related Ribonucleoprotein Granules and Functions of Associated RNA-binding Proteins in ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $3,254,207 | February 1, 2019 | November 30, 2028 | WANG, JIOU | reporter.nih.gov |
| Investigating the role of TMEM106b genetics and pathology in Alzheimer’s disease, LATE and FTLD | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2025 | $3,221,644 | September 22, 2023 | August 31, 2028 | PETRUCELLI, LEONARD | reporter.nih.gov |
| Longitudinal multi-modality imaging in non-fluent/agrammatic primary progressive aphasia | NIH | National Institute on Deafness and Other Communication Disorders | 2021 to 2025 | $3,217,385 | July 1, 2013 | June 30, 2028 | WHITWELL, JENNIFER LOUISE | reporter.nih.gov |
| Characterization of Antigen-Specific Immune Response in ALS | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $3,213,011 | August 11, 2025 | July 31, 2029 | ELYAMAN, WASSIM | reporter.nih.gov |
| Genetic Contributions to Phenotypic Heterogeneity in the ALS-FTD Spectrum | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $3,204,260 | August 1, 2025 | July 31, 2029 | MCMILLAN, COREY T | reporter.nih.gov |
| Diagnostic and prognostic certainty in behavioral variant frontotemporal dementia | NIH | National Institute on Aging | 2021 to 2025 | $3,196,474 | August 15, 2020 | April 30, 2027 | PERRY, DAVID C | reporter.nih.gov |
| Upstream pathogenesis in familial and sporadic frontotemporal dementia and motor neuron disease | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $3,153,019 | July 1, 2018 | July 31, 2029 | SEELEY, WILLIAM W | reporter.nih.gov |
| Longitudinal Multi-modal Imaging in Progressive Supranuclear Palsy Syndromes | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $3,134,730 | September 15, 2015 | August 31, 2025 | WHITWELL, JENNIFER LOUISE | reporter.nih.gov |
| Integrating Spatial Multi-omics and Clinical Covariates to Identify Mechanisms of Disease in ALS-FTD | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $3,108,178 | August 15, 2020 | April 30, 2026 | PHATNANI, HEMALI | reporter.nih.gov |
| Single molecule study of C9ORF72 repeat RNA metabolisms in ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $3,085,325 | March 1, 2020 | May 31, 2029 | SUN, SHUYING | reporter.nih.gov |
| Mechanism of ALS/FTD determined by multimodal single cell spatial transcriptomics | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $3,081,936 | September 12, 2025 | June 30, 2029 | CLEVELAND, DON W | reporter.nih.gov |
| Disease Mechanism and Therapy in TDP-43 Proteinopathies and Dementias | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2025 | $3,081,573 | April 1, 1989 | August 31, 2027 | CLEVELAND, DON W | reporter.nih.gov |
| Molecular characterization of extracellular vesicles for the spread of misfolded tau protein | NIH | National Institute on Aging | 2021 to 2025 | $3,058,838 | May 15, 2021 | April 30, 2027 | IKEZU, TSUNEYA | reporter.nih.gov |
| Regulation of human tau expression and tauopathy by alpha-synuclein | NIH | National Institute on Aging | 2022 to 2025 | $3,043,872 | June 1, 2022 | March 31, 2027 | LEE, MICHAEL K | reporter.nih.gov |
| Molecular Genetic Insight into Neurodegenerative Disease from Drosophila | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $3,032,672 | December 1, 2016 | November 30, 2025 | BONINI, NANCY M | reporter.nih.gov |
| Investigating the Novel Disease Pathways Associated with C9orf72-Linked ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $2,951,882 | May 15, 2015 | April 30, 2030 | WANG, JIOU | reporter.nih.gov |
| Cell and Network Disruptions and Associated Pathogenenesis in Tauopathy and Down Syndrome | NIH | National Institute on Aging | 2021 to 2024 | $2,943,744 | April 15, 2020 | March 31, 2026 | FINKBEINER, STEVEN M | reporter.nih.gov |
| Functional and Pathological Interactions of TDP-43 | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $2,925,557 | April 1, 2020 | March 31, 2025 | FAWZI, NICOLAS LUX | reporter.nih.gov |
| Molecular Neurobiology of Human Opioid Use Disorder | NIH | National Institute on Drug Abuse | 2021 to 2025 | $2,918,959 | July 15, 2021 | March 31, 2027 | HURD, YASMIN L. | reporter.nih.gov |
| Defining mechanisms underlying C9orf72-associated frontotemporal dementia with C. elegans and mammalian models | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2025 | $2,904,236 | February 1, 2022 | January 31, 2027 | KALB, ROBERT G | reporter.nih.gov |
| Development of a SYF2 antisense oligonucleotide treatment for ALS and FTD | NIH | National Institute on Aging | 2023 to 2024 | $2,894,619 | August 1, 2023 | July 31, 2025 | ALWORTH, SAMUEL V | reporter.nih.gov |
| Single Cell Characterization of FTLD-GRN | NIH | National Institute of Neurological Disorders and Stroke | 2022 | $2,891,009 | September 15, 2022 | August 31, 2025 | HUANG, ERIC J | reporter.nih.gov |
| Investigation of the role of ATXN1 in oligodendroglia and neurodegenerative diseases | NIH | National Institute on Aging | 2022 to 2025 | $2,847,875 | March 1, 2022 | December 31, 2026 | LIM, JANGHOO | reporter.nih.gov |
| The interplay between Tau and ncRNAs – genomic and epigenomic clues to early AD pathogenesis | NIH | National Institute on Aging | 2022 to 2025 | $2,845,617 | June 15, 2022 | March 31, 2027 | KOLDAMOVA, RADOSVETA | reporter.nih.gov |
| The role of a metazoan-specific PQC system in protecting against TDP-43 proteinopathies | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $2,817,215 | August 7, 2025 | July 31, 2029 | YANG, XIAOLU | reporter.nih.gov |
| Reinforcement Mechanisms for Learning Vocal Behaviors - Renewal - 1 | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $2,764,385 | April 1, 2018 | August 31, 2028 | ROBERTS, TODD F | reporter.nih.gov |
| Validating Secretory Autophagy as a Therapeutic Strategy for Diverse Forms of ALS and FTD | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $2,714,836 | July 1, 2017 | June 30, 2026 | ICHIDA, JUSTIN KAWIKA | reporter.nih.gov |
| Regulation of Pathological Tau Transmission by Soluble Tau Post-Translational Modifications | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2025 | $2,714,628 | July 1, 2022 | April 30, 2027 | PENG, CHAO | reporter.nih.gov |
| Role of TRIM11 in regulating TDP-43 and FUS | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $2,709,695 | September 5, 2025 | August 31, 2029 | YANG, XIAOLU | reporter.nih.gov |
| Concordance of TDP-43 Inclusions with Cortical Atrophy and Clinical Phenotype | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $2,671,684 | August 1, 2014 | March 31, 2026 | GEULA, CHANGIZ | reporter.nih.gov |
| Development of an UNC13A antisense oligonucleotide treatment for ALS and FTD | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2024 | $2,670,896 | August 1, 2023 | July 31, 2025 | CHANG, WEN-HSUAN | reporter.nih.gov |
| Mechanisms of Novel Regulators of Proteotoxicity and Quality Control Associated with ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $2,659,547 | August 15, 2011 | February 28, 2027 | WANG, JIOU | reporter.nih.gov |
| Development of a PIKFYVE Antisense Oligonucleotide Treatment for FTD | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $2,612,154 | March 1, 2022 | August 31, 2023 | ALWORTH, SAMUEL V | reporter.nih.gov |
| Veri-T: A phase 1 Placebo-Controlled Trial of Verdiperstat in Semantic Variant Primary Progressive Aphasia Due to Underlying FTLD-TDP | NIH | National Institute on Aging | 2021 to 2024 | $2,589,914 | August 1, 2021 | July 31, 2026 | LJUBENKOV, PETER ALEXANDER | reporter.nih.gov |
| Biomarker discovery for parkinsonian diseases in extracellular vesicles from iPSC-derived neurons | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2024 | $2,555,369 | April 1, 2023 | March 31, 2026 | BITAN, GAL | reporter.nih.gov |
| A Multi-Modal Remote Monitoring Platform for Frontotemporal Lobar Degeneration Syndromes | NIH | National Institute on Aging | 2022 to 2024 | $2,546,364 | September 30, 2022 | August 31, 2025 | VAZIRI, ASHKAN | reporter.nih.gov |
| Investigating Pathogenic Mechanisms of Frontotemporal Dementia Caused by Mutations in CHMP2B and TBK1 | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $2,537,267 | January 1, 2018 | November 30, 2025 | GAO, FEN-BIAO | reporter.nih.gov |
| Toward Personalized Prognosis and Outcomes in Primary Progressive Aphasia | NIH | National Institute of Neurological Disorders and Stroke | 2023 | $2,515,977 | April 17, 2023 | March 31, 2026 | DICKERSON, BRADFORD C | reporter.nih.gov |
| In vivo modelling and therapy development for stathmin-2 loss in TDP-43 proteinopathies | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $2,507,311 | August 1, 2021 | July 31, 2024 | LAGIER-TOURENNE, CLOTILDE | reporter.nih.gov |
| Novel Approaches for Tau PROTAC Drug Discovery | NIH | National Institute on Aging | 2023 to 2024 | $2,499,622 | September 15, 2020 | March 31, 2026 | BUTT, TAUSEEF R. | reporter.nih.gov |
| Microglial regulation of Progranulin levels | NIH | National Institute on Aging | 2021 to 2024 | $2,492,948 | February 1, 2020 | December 31, 2025 | LIM, JANGHOO | reporter.nih.gov |
| Robust detection of atrophy over short intervals in AD and FTLD | NIH | National Institute on Aging | 2023 to 2025 | $2,487,385 | May 15, 2023 | March 31, 2028 | DICKERSON, BRADFORD C | reporter.nih.gov |
| Function of TMEM106B in Neurodegeneration | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $2,485,615 | April 1, 2021 | March 31, 2027 | HU, FENGHUA | reporter.nih.gov |
| Chemical approaches to selectively target beta-rich amyloids | NIH | National Institute on Aging | 2021 to 2025 | $2,477,656 | August 15, 2021 | May 31, 2026 | DEL VALLE, JUAN R | reporter.nih.gov |
| Closing the gap between structural biology and translational science for amyloid diseases | NIH | National Heart, Lung, and Blood Institute | 2021 to 2024 | $2,469,735 | September 1, 2021 | August 31, 2026 | SAELICES GOMEZ, LORENA | reporter.nih.gov |
| Molecular Basis of Pathogenic Cascades in ALS/FTD Initiated from C9orf72 Hexanucleotide Repeat Expansion | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2025 | $2,469,291 | July 15, 2022 | May 31, 2027 | WANG, JIOU | reporter.nih.gov |
| Disruption of Nucleocytoplasmic Transport in FUS-related Neurodegenerative Diseases | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2023 | $2,460,641 | May 15, 2019 | September 30, 2024 | BOSCO, DARYL ANGELA | reporter.nih.gov |
| Early Detection and Treatment of Emerging Cognitive-Linguistic Impairment in Minority Cognitive Aging and Primary Progressive Aphasia | NIH | National Institute on Deafness and Other Communication Disorders | 2021 to 2025 | $2,454,933 | February 1, 2014 | January 31, 2029 | REILLY, JAMES JOSEPH | reporter.nih.gov |
| RNA-based regulation of TDP-43 nuclear export in ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $2,447,618 | August 1, 2021 | June 30, 2026 | HOKE, AHMET | reporter.nih.gov |
| Role of central and peripheral immune crosstalk in FTD-Grn neurodegeneration | NIH | National Institute of Neurological Disorders and Stroke | 2022 | $2,446,942 | August 17, 2022 | July 30, 2025 | TANSEY, MARIA DE LOURDES GAMEZ | reporter.nih.gov |
| Cell-Type Specific Vulnerability to Tauopathy and Its Prevention in Multiple Models | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $2,438,130 | February 1, 2021 | January 31, 2024 | SIGURDSSON, EINAR M | reporter.nih.gov |
| Alzheimer's tauopathy phenotype and the microRNA22-3p: implication for pathogenesis | NIH | National Institute on Aging | 2021 to 2025 | $2,431,481 | September 1, 2021 | June 30, 2027 | PRATICO, DOMENICO | reporter.nih.gov |
| The Contribution of Age-Related Tauopathies to Alzheimer's Disease | NIH | National Institute on Aging | 2023 | $2,430,703 | September 30, 2018 | August 31, 2026 | MCKEE, ANN C. | reporter.nih.gov |
| Biochemical and molecular heterogeneity of human TDP-43 proteinopathies in age-related dementias | NIH | National Institute on Aging | 2022 to 2025 | $2,424,308 | July 15, 2022 | April 30, 2027 | PORTA ANTOLINEZ, SILVIA | reporter.nih.gov |
| Lysosomal Function of Progranulin and Neurodegeneration | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $2,421,653 | August 1, 2017 | February 28, 2027 | HU, FENGHUA | reporter.nih.gov |
| TMEM106B in neurodegenerative disease | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $2,390,842 | July 15, 2013 | February 28, 2025 | CHEN-PLOTKIN, ALICE S | reporter.nih.gov |
| Reward processing in genetic frontotemporal dementia and mood disorders | NIH | National Institute on Aging | 2021 to 2023 | $2,382,005 | March 1, 2019 | December 31, 2025 | PERRY, DAVID C | reporter.nih.gov |
| Alzheimer Pathology and Neurovascular Dysfunction | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $2,375,220 | July 1, 1998 | December 31, 2027 | IADECOLA, COSTANTINO | reporter.nih.gov |
| Dynamic Brain Imaging of Speech in Primary Progressive Aphasia | NIH | National Institute of Neurological Disorders and Stroke | 2023 | $2,373,138 | September 15, 2017 | June 30, 2026 | NAGARAJAN, SRIKANTAN S. | reporter.nih.gov |
| Validating remote digital assessments for familial frontotemporal dementia | NIH | National Institute on Aging | 2022 | $2,371,437 | May 1, 2022 | April 30, 2025 | STAFFARONI, ADAM MARK | reporter.nih.gov |
| C9orf72 frontotemporal dementia (FTD) and amyotrophic lateral sclerosis(ALS): using patient cells and CRISPR to reveal therapeutic approaches | NIH | National Institute on Aging | 2021 to 2022 | $2,365,559 | May 1, 2021 | April 30, 2024 | CONKLIN, BRUCE R | reporter.nih.gov |
| Synaptopathy and Pathogenesis in Frontotemporal Dementia: Role of CYLD | NIH | National Institute on Aging | 2023 | $2,364,013 | June 1, 2023 | May 31, 2026 | YAO, WEI-DONG | reporter.nih.gov |
| Loss of VCP Function in Frontotemporal Lobar Degeneration | NIH | National Institute on Aging | 2022 | $2,356,099 | June 1, 2022 | May 31, 2025 | LEE, EDWARD BYUNG-HA | reporter.nih.gov |
| C9orf72-mediated features, transcriptomic signatures, and translational studies for frontotemporal dementia and related disorders | NIH | National Institute of Neurological Disorders and Stroke | 2022 | $2,351,241 | June 15, 2022 | May 31, 2025 | VAN BLITTERSWIJK, MARKA | reporter.nih.gov |
| Poly(ADP-ribose) promotes the condensation and toxicity of C9orf72 arginine-rich dipeptide repeat proteins | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $2,345,590 | July 15, 2021 | June 30, 2027 | ZHANG, YONGJIE | reporter.nih.gov |
| Tau Conformation in Tauopathies and Neuronal Function | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2023 | $2,326,506 | April 15, 2014 | April 30, 2025 | BRADY, SCOTT THOMAS | reporter.nih.gov |
| Overlapping Molecular Dysregulation of Endolysosomal Function in Alzheimer's Disease and FTLD-TDP | NIH | National Institute on Aging | 2021 to 2023 | $2,325,777 | September 15, 2019 | May 31, 2025 | STRITTMATTER, STEPHEN M | reporter.nih.gov |
| Contributions of tau-mediated translational dysregulation to pathogenesis and progression of fronto-temporal dementia | NIH | National Institute on Aging | 2022 to 2025 | $2,310,587 | February 1, 2022 | January 31, 2027 | ABISAMBRA, JOSE FRANCISCO | reporter.nih.gov |
| Microscopic and Large-Scale Networks of Molecular Pathology in Frontotemporal Lobar Degeneration | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2023 | $2,282,984 | August 1, 2019 | June 30, 2025 | IRWIN, DAVID JOHN | reporter.nih.gov |
| Full human gene-replacement mouse models of ADRDs | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $2,280,898 | September 18, 2019 | August 31, 2025 | KOOB, MICHAEL D | reporter.nih.gov |
| Investigating the Contribution of ALS/FTD-Associated Mutations in the NEK1 Kinase to Disease Pathophysiology | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2025 | $2,276,048 | July 15, 2023 | April 30, 2028 | KISKINIS, EVANGELOS | reporter.nih.gov |
| Excitability Dysfunction Mechanisms Underlying the TDP43-Dependent ALS and FTD Pathogenesis | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2025 | $2,264,232 | August 1, 2023 | July 31, 2028 | ELBASIOUNY, SHERIF M | reporter.nih.gov |
| Primary Progressive Aphasia: Cognition, Anatomy and Progression | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $2,249,522 | July 15, 2004 | August 31, 2027 | GORNO TEMPINI, MARIA LUISA | reporter.nih.gov |
| Pathogenesis of Tauopathies | NIH | National Institute on Aging | 2023 to 2025 | $2,247,913 | March 1, 2023 | February 29, 2028 | LEE, VIRGINIA M | reporter.nih.gov |
| Functional Validation of TDP-43 splicing repression for frontotemporal degeneration | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $2,237,856 | September 1, 2021 | August 31, 2023 | WONG, PHILIP C | reporter.nih.gov |
| Molecular Chaperones and Small Molecules | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $2,229,230 | February 1, 2008 | July 31, 2028 | GESTWICKI, JASON E | reporter.nih.gov |
| Peripheral Biomarkers for Early Diagnosis of Mixed Pathologies in AD/ADRD | NIH | National Institute on Aging | 2023 to 2025 | $2,219,859 | June 1, 2023 | February 29, 2028 | CHEN, SHU G. | reporter.nih.gov |
| Mechanistic studies and therapeutics for ALS/FTD linked to UBQLN2 mutations | NIH | National Institute of Neurological Disorders and Stroke | 2022 | $2,200,770 | January 15, 2017 | January 31, 2025 | MONTEIRO, MERVYN J | reporter.nih.gov |
| A microphysiologic multicellular organ-on-chip to inform clinical trials in FTD/ALS | NIH | National Center for Advancing Translational Sciences | 2022 to 2024 | $2,198,065 | July 1, 2020 | November 30, 2025 | SVENDSEN, CLIVE NIELS | reporter.nih.gov |
| Treating primary progressive aphasia and elucidating neurodegeneration in the language network using transcranial direct current stimulation | NIH | National Institute on Aging | 2021 to 2024 | $2,194,544 | August 15, 2019 | June 30, 2025 | HAMILTON, ROY H | reporter.nih.gov |
| Communication Bridge: A person-centered Internet-based intervention for individuals with primary progressive aphasia | NIH | National Institute on Aging | 2022 | $2,184,811 | September 15, 2017 | August 31, 2023 | ROGALSKI, EMILY J | reporter.nih.gov |
| Targeting MSUT2 with small molecules to ameliorate pathological tau | NIH | National Institute on Aging | 2023 | $2,181,250 | September 1, 2023 | August 31, 2026 | KRAEMER, BRIAN C. | reporter.nih.gov |
| Novel patient-derived 3D platform for detecting TDP-43 proteinopathy and associated biomarkers for ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2023 | $2,175,360 | February 15, 2022 | January 31, 2025 | GHAFFARI, LAYLA | reporter.nih.gov |
| Tau-seed protein interactome and its role in neurodegenerative tauopathies | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $2,175,152 | September 30, 2020 | February 16, 2025 | LASAGNA-REEVES, CRISTIAN | reporter.nih.gov |
| Molecular effects of metformin, PKR and TBI on C9orf72 ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2022 | $2,152,606 | August 1, 2016 | August 31, 2025 | RANUM, LAURA P.W | reporter.nih.gov |
| Assessing skin biomarkers for preclinical diagnosis of PD and non-PD Parkinsonism | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2023 | $2,147,422 | August 15, 2019 | May 31, 2025 | KONG, QINGZHONG | reporter.nih.gov |
| The Role of Abnormal Inter-Organelle Communication in the Pathogenesis of Tauopathy | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $2,140,089 | September 1, 2014 | December 31, 2029 | CAI, QIAN | reporter.nih.gov |
| RNA Surveillance and Protein Translation in FTD | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $2,139,216 | August 1, 2021 | July 31, 2026 | ZHU, HAINING | reporter.nih.gov |
| Nuclear import receptors as modifiers of TDP-43 phase transition and toxicity in FTD/ALS | NIH | National Institute on Aging | 2023 to 2025 | $2,130,126 | December 1, 2022 | November 30, 2027 | ROSSOLL, WILFRIED | reporter.nih.gov |
| Protection from pathological tau by activation of the ER unfolded protein response | NIH | National Institute on Aging | 2021 to 2024 | $2,127,765 | February 1, 2020 | January 31, 2026 | KRAEMER, BRIAN C. | reporter.nih.gov |
| Multidimensional Approaches to Understanding Consequences and Mechanisms of Apathy in Frontotemporal Degeneration | NIH | National Institute on Aging | 2022 to 2025 | $2,126,527 | September 30, 2022 | July 31, 2027 | MASSIMO, LAUREN M | reporter.nih.gov |
| Human Retinal Imaging Biomarkers for FTLD-Tau in Relation to FTLD-TDP and Nonamnestic AD | NIH | National Institute on Aging | 2023 | $2,126,420 | September 1, 2023 | August 31, 2026 | KIM, BENJAMIN J. | reporter.nih.gov |
| Fibrillar polymorphs in human brain tissue | NIH | National Institute on Aging | 2023 | $2,112,290 | September 1, 2023 | August 31, 2026 | MAKOWSKI, LEE | reporter.nih.gov |
| Cell Type and Regional Vulnerability in Frontotemporal Dementia | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $2,094,351 | August 1, 2021 | July 31, 2024 | TEMPLE, SALLY | reporter.nih.gov |
| Understanding Frontotemporal Dementia Using Drosophila and iPSC Models | NIH | National Institute of Neurological Disorders and Stroke | 2022 | $2,086,468 | April 15, 2017 | March 31, 2025 | GAO, FEN-BIAO | reporter.nih.gov |
| Resolving the Role of Neuronal STING in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia | NIH | National Institute of Neurological Disorders and Stroke | 2023 | $2,085,362 | January 5, 2023 | December 31, 2025 | WAINGER, BRIAN JASON | reporter.nih.gov |
| S-Nitrosylation-Dependent Pathological Spread of Abnormal Proteins in Frontotemporal Dementia and Lewy Body Dementia | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $2,081,944 | August 1, 2021 | July 31, 2024 | NAKAMURA, TOMOHIRO | reporter.nih.gov |
| Bilingual Factors Associated with Cognitive Reserve and Linguistic Resilience in Hispanics with Primary Progressive Aphasia | NIH | National Institute on Aging | 2023 to 2025 | $2,072,077 | December 1, 2022 | November 30, 2027 | GRASSO, STEPHANIE M | reporter.nih.gov |
| Optimization of microtubule-stabilizing triazolopyrimidines as therapeutics for Alzheimer's disease and related tauopathies | NIH | National Institute on Aging | 2021 to 2022 | $2,069,299 | March 1, 2019 | February 29, 2024 | BRUNDEN, KURT R. | reporter.nih.gov |
| Role of Ataxin-2 polyglutamine expansion on TDP-43 transport and post-transcriptional RNA regulation in neurons | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $2,057,651 | July 15, 2021 | June 30, 2027 | GOPAL, PALLAVI P. | reporter.nih.gov |
| Neuronal quality control and neuroprotection in tauopathies | NIH | National Institute on Aging | 2021 to 2024 | $2,040,301 | August 1, 2007 | April 30, 2026 | CHU, CHARLEEN T | reporter.nih.gov |
| Identification of novel four repeat tauopathies through analysis of network vulnerability, tau structure and propagation. | NIH | National Institute on Aging | 2023 to 2025 | $2,011,551 | December 1, 2022 | November 30, 2027 | VIDAL, RUBEN | reporter.nih.gov |
| Investigating the role of TDP-43 mislocalization, structure, and post-translational modifications in the neuropathologically heterogeneous TDP-43 proteinopathies | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $2,010,088 | April 16, 2024 | March 31, 2029 | NEWELL, KATHY L | reporter.nih.gov |
| Immunotherapy Targeting Tau Aggregate Polymorphs | NIH | National Institute on Aging | 2022 | $2,009,600 | June 1, 2022 | May 31, 2025 | KAYED, RAKEZ | reporter.nih.gov |
| Subcellular mechanisms of subtype-specific neuron vulnerability in ALS and FTD: dysregulation of synapse-localized RNA, protein, and translation in mouse models and human cortico-spinal assembloids | NIH | National Institute on Aging | 2023 | $2,001,864 | September 1, 2023 | August 31, 2026 | MACKLIS, JEFFREY D | reporter.nih.gov |
| Pathological Signatures of CHCHD10 Dysfunction in ADRDs | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $2,000,425 | August 1, 2021 | June 30, 2027 | KANG, DAVID E | reporter.nih.gov |
| Hexanucleotide repeat translation in ALS and Frontotemporal Dementia | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2025 | $1,976,676 | September 1, 2016 | March 31, 2028 | TODD, PETER K | reporter.nih.gov |
| Cell Death Regulation by Pro-Apoptotic BOK in Tauopathies | NIH | National Institute of Neurological Disorders and Stroke | 2024 | $1,969,620 | September 17, 2024 | August 31, 2027 | KATZ, SAMUEL G | reporter.nih.gov |
| The role of m6A RNA methylation in C9ORF72-ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2024 | $1,953,392 | September 23, 2024 | April 30, 2025 | SUN, SHUYING | reporter.nih.gov |
| Epigenetic Mechanisms Contributing to the Pathogenesis of ALS/FTD with GGGGCC Repeat Expansion Mutation at the C9orf72 Locus | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2025 | $1,949,974 | July 15, 2022 | June 30, 2027 | LIU, X. SHAWN | reporter.nih.gov |
| Formation of Tau RNA Complexes disrupts tau function and drives tau neuropathology | NIH | National Institute on Aging | 2023 to 2025 | $1,947,127 | September 30, 2023 | December 31, 2028 | KRAEMER, BRIAN C. | reporter.nih.gov |
| Role of SUMOylation in Mitochondrial/Synaptic Axis Dysfunction Induced by Abnormal Tau in FTD | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $1,941,311 | September 19, 2023 | August 31, 2028 | QUINZII, CATARINA M. | reporter.nih.gov |
| Novel repeat associated non-AUG (RAN) proteins in sALS, sFTD and SBMA: shared pathological features and unifying therapeutic opportunities | NIH | National Institute of Neurological Disorders and Stroke | 2022 | $1,930,065 | July 1, 2022 | June 30, 2025 | RANUM, LAURA P.W | reporter.nih.gov |
| Mechanistic insights into the link between the A152T risk variant and tauopathy | NIH | National Institute on Aging | 2021 to 2024 | $1,923,008 | April 15, 2020 | March 31, 2026 | COOK, CASEY N | reporter.nih.gov |
| RNA decay in amyotrophic lateral sclerosis and frontotemporal lobar degeneration | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $1,900,827 | August 1, 2016 | April 30, 2026 | BARMADA, SAMI | reporter.nih.gov |
| Defining the Mechanisms and Consequences of Nuclear Defects in ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $1,888,756 | April 1, 2021 | March 31, 2027 | FALLINI, CLAUDIA | reporter.nih.gov |
| Super-Resolution Fluorescence Microscopy of Synaptic Plasticity on Unmodified Brain Slices in Health and Tauopathy | NIH | National Institute on Aging | 2023 | $1,870,822 | September 1, 2023 | August 31, 2026 | SELVIN, PAUL R | reporter.nih.gov |
| Determine the neurotoxicity of RNA metabolism dysfunction caused by cytoplasmic TDP-43 aggregates | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2025 | $1,859,204 | September 19, 2023 | August 31, 2028 | SHAHMORADIAN, SARAH H | reporter.nih.gov |
| Modeling Alzheimer's Disease Related Dementias in the Marmoset | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2023 | $1,851,822 | September 16, 2019 | August 31, 2025 | LEE, KUO-FEN | reporter.nih.gov |
| Treating neurotoxicity and cognitive deficits due to hyperphosphorylated tau. | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2025 | $1,840,283 | September 22, 2023 | August 31, 2028 | KUAN, CHIA-YI | reporter.nih.gov |
| SPOP drives neurodegenerative tauopathy | NIH | National Institute on Aging | 2023 | $1,823,353 | September 1, 2023 | August 31, 2026 | KRAEMER, BRIAN C. | reporter.nih.gov |
| Developing new conditional models to study tauopathy, amyloidosis, and their interaction | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $1,817,356 | September 17, 2019 | August 31, 2025 | LEWIS, JADA M | reporter.nih.gov |
| Targeting Tau Proteoforms in Frontotemporal Dementia | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $1,815,043 | August 1, 2021 | July 31, 2024 | KARCH, CELESTE MARIE | reporter.nih.gov |
| Tau accumulation in the pedunculopontine tegmentum as an early node in Progressive Supranuclear Palsy pathogenesis | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $1,808,406 | August 1, 2021 | July 31, 2024 | CLARK, STEWART DONALDSON | reporter.nih.gov |
| Investigation of UBQLN2 in neuronal dysfunction and ALS-FTD | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2025 | $1,803,720 | June 15, 2023 | May 31, 2028 | WHITELEY, ALEXANDRA | reporter.nih.gov |
| Brain aging and Alzheimer's related dementias: convergence onto retrotransposons and endogenous retroviruses | NIH | National Institute on Aging | 2022 | $1,797,870 | May 1, 2022 | April 30, 2025 | DUBNAU, JOSHUA T | reporter.nih.gov |
| Regulation and impact of shortened TDP43 isoforms in FTD and ALS | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $1,794,354 | December 1, 2019 | August 31, 2029 | BARMADA, SAMI | reporter.nih.gov |
| Modeling Frontotemporal Dementia in Rhesus Macaques | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2024 | $1,789,771 | September 30, 2019 | May 31, 2026 | EMBORG, MARINA | reporter.nih.gov |
| Deubiquitinase USP19 in TDP-43 pathogenesis. | NIH | National Institute of Neurological Disorders and Stroke | 2022 | $1,785,220 | May 1, 2022 | April 30, 2025 | KANG, DAVID E | reporter.nih.gov |
| BIOMARKER DISCOVERY AND VALIDATION IN PSP | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $1,775,155 | August 1, 2018 | April 30, 2025 | PANTELYAT, ALEXANDER Y. | reporter.nih.gov |
| Mechanisms of impaired ESCRT-III nuclear surveillance in ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2025 | $1,736,889 | August 1, 2023 | May 31, 2028 | COYNE, ALYSSA | reporter.nih.gov |
| Deep Pathological Phenotyping in Frontotemporal Dementia and Motor Neuron Disease. | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $1,708,426 | July 1, 2018 | June 30, 2025 | SEELEY, WILLIAM W | reporter.nih.gov |
| Clinical, Neuroanatomic, and Pathologic Signatures of FTLD-tau in Dementia Phenotypes - Diversity Supplement (Antwan Howard) | NIH | National Institute on Aging | 2021 to 2024 | $1,697,140 | January 15, 2020 | December 31, 2025 | GEFEN, TAMAR D | reporter.nih.gov |
| Residue-by-residue details of FUS protein phase separation and aggregation | NIH | National Institute of General Medical Sciences | 2022 to 2025 | $1,694,269 | September 23, 2022 | August 31, 2026 | FAWZI, NICOLAS LUX | reporter.nih.gov |
| Determining stathmin-2 function and potential as a therapeutic target in ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2024 | $1,692,971 | April 1, 2020 | March 31, 2025 | CLEVELAND, DON W | reporter.nih.gov |
| Effects of TDP-43 Proteinopathy on Retrotransposon Activation and Cell-Type Specific Vulnerability in a Mammalian Model of Alzheimer's and Related Dementias | NIH | National Institute on Aging | 2023 to 2025 | $1,671,733 | December 1, 2022 | November 30, 2027 | SHER, ROGER B | reporter.nih.gov |
| Developing Splicing-Targeted Therapeutic Strategies for Neurological Diseases | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2025 | $1,667,400 | August 1, 2022 | April 30, 2026 | MORINI, ELISABETTA | reporter.nih.gov |
| Impact of coding and non-coding variation in progressive supranuclear palsy | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $1,664,308 | September 25, 2017 | July 31, 2023 | GESCHWIND, DANIEL H | reporter.nih.gov |
| Antisocial Behavior in Frontotemporal Dementia: Behavioral Phenotypes, Neural Markers, and Decision-Making Mechanisms | NIH | National Institute on Aging | 2024 to 2025 | $1,653,888 | July 15, 2024 | March 31, 2029 | DARBY, RICHARD RYAN | reporter.nih.gov |
| In vivo modelling and therapy development for stathmin-2 loss in TDP-43 proteinopathies | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $1,648,874 | August 1, 2021 | July 31, 2026 | LAGIER-TOURENNE, CLOTILDE | reporter.nih.gov |
| Clinical performance testing of neuropacs in Parkinsonism diagnosis | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $1,647,650 | June 15, 2023 | August 31, 2026 | BARMPOUTIS, ANGELOS | reporter.nih.gov |
| Mechanisms of Thalamocortical Dysfunction and Social Deficits in FTD due to GRN Mutations | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2025 | $1,646,918 | July 1, 2022 | June 30, 2027 | ARRANT, ANDREW EMMETT | reporter.nih.gov |
| Diversity Supplement - Progranulin, Prosaposin and Lipid Biology in FTD | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2023 | $1,641,237 | April 1, 2023 | March 31, 2025 | KAO, AIMEE | reporter.nih.gov |
| Cell-type-specific toxicity of C9orf72 repeat expansions in FTD and ALS | NIH | National Institute on Aging | 2021 to 2024 | $1,637,016 | September 15, 2020 | May 31, 2025 | JIANG, JIE | reporter.nih.gov |
| CHCHD10 Frontotemporal Dementia, Molecular Mechanisms and Therapeutic Strategies | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $1,635,738 | August 22, 2024 | July 31, 2029 | FUJITA, HIBIKI | reporter.nih.gov |
| Comprehensive Harmonization and Analysis of Case/Control Whole Genome Sequencing Data from the ALS/FTD Compute Project | NIH | National Institute of Neurological Disorders and Stroke | 2023 | $1,630,264 | February 1, 2023 | July 31, 2025 | LANDERS, JOHN E | reporter.nih.gov |
| Cell-Type Specific Vulnerability to Tauopathy and Its Prevention in Multiple Models | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $1,625,424 | February 1, 2021 | January 31, 2026 | SIGURDSSON, EINAR M | reporter.nih.gov |
| Progranulin deficiency and microglia senescence in neurodegeneration | NIH | National Institute on Aging | 2021 to 2024 | $1,615,000 | August 1, 2020 | July 31, 2025 | HUANG, ERIC J | reporter.nih.gov |
| Validation of Modulators of PGRN as Novel Therapeutics for Frontotemporal Dementi | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $1,601,862 | September 30, 2018 | July 31, 2024 | HERZ, JOACHIM J | reporter.nih.gov |
| Determining stathmin-2 function and potential as a therapeutic target in ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $1,595,758 | April 1, 2020 | March 31, 2025 | CLEVELAND, DON W | reporter.nih.gov |
| Tau Conformation in Tauopathies and Neuronal Function | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $1,592,854 | June 1, 2025 | May 31, 2027 | BRADY, SCOTT THOMAS | reporter.nih.gov |
| Pathology-guided biofluid biomarker strategies for classification and progression of frontotemporal lobar degeneration (FTLD) | NIH | National Institute on Aging | 2024 to 2025 | $1,592,279 | September 30, 2024 | June 30, 2029 | COUSINS, KATHERYN ALEXANDRA QUILICO | reporter.nih.gov |
| Automated speech assessment for diagnosis of FTD spectrum disorders | NIH | National Institute on Aging | 2024 to 2025 | $1,592,166 | May 1, 2024 | January 31, 2029 | BOTHA, HUGO | reporter.nih.gov |
| Stathmin-2 and TDP-43 neurodegeneration in Alzheimer’s and multi-etiology dementias | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $1,583,390 | April 1, 2021 | April 30, 2027 | JOSEPHS, KEITH A | reporter.nih.gov |
| Atypical TDP43 isoforrms driving neurodegeneration in FTD/ALS | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $1,560,000 | December 1, 2019 | November 30, 2025 | BARMADA, SAMI | reporter.nih.gov |
| Defining TBK1-associated autophagy networks in neurons | NIH | National Institute on Aging | 2024 to 2025 | $1,557,479 | August 15, 2024 | April 30, 2029 | MORDES, DANIEL ADAM | reporter.nih.gov |
| Deubiquitinase USP11 in tau regulation and age-related tauopathy | NIH | National Institute on Aging | 2021 to 2024 | $1,549,030 | June 1, 2020 | March 31, 2026 | KANG, DAVID E | reporter.nih.gov |
| iPSC-based Model to Study Frontotemporal Dementia Due to MAPT Mutation | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $1,540,579 | June 1, 2025 | May 31, 2027 | TEMPLE, SALLY | reporter.nih.gov |
| SSH1-Nrf2 nexus in tipping the balance between degeneration and protection in tauopathies. | NIH | National Institute on Aging | 2023 to 2025 | $1,519,726 | December 1, 2022 | November 30, 2027 | KANG, DAVID E | reporter.nih.gov |
| Role of oligomeric TDP-43 aggregate intermediates in ALS and frontotemporal dementia | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $1,517,828 | February 1, 2020 | January 31, 2026 | AYALA, YUNA | reporter.nih.gov |
| PASK-regulated genes and proteins as therapeutic targets for ALS and FTD | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $1,516,783 | September 19, 2024 | July 31, 2029 | SCOLES, DANIEL R | reporter.nih.gov |
| Defining modifiers and mechanisms of RAN translation | NIH | National Institute on Aging | 2024 to 2025 | $1,516,148 | May 1, 2019 | April 30, 2028 | PUGLISI, JOSEPH D | reporter.nih.gov |
| Environmental risk factors linked to TDP-43 proteinopathies | NIH | National Institute on Aging | 2024 to 2025 | $1,507,263 | August 15, 2024 | April 30, 2029 | COHEN, TODD JONATHAN | reporter.nih.gov |
| Staging primary tauopathies with tau proteoforms | NIH | National Institute on Aging | 2024 to 2025 | $1,504,704 | June 15, 2024 | May 31, 2029 | SATO, CHIHIRO | reporter.nih.gov |
| A Chemical Footprinting Approach towards Poly-ADP-Ribosylation-regulated Biomolecular Condensation | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2025 | $1,502,609 | September 1, 2022 | November 30, 2026 | YU, YONGHAO | reporter.nih.gov |
| Discovery of novel tau proteoforms as biomarker candidates for AD and PSP | NIH | National Institute on Aging | 2024 to 2025 | $1,501,253 | August 15, 2024 | April 30, 2029 | DAGE, JEFFREY | reporter.nih.gov |
| Multiplexed Quantification of the Protein Poly-ADP-Ribosylation Landscape in C9ORF72-ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $1,495,087 | May 1, 2024 | April 30, 2029 | YU, YONGHAO | reporter.nih.gov |
| Role of T cells in tau-mediated neurodegeneration | NIH | National Institute on Aging | 2024 to 2025 | $1,486,244 | February 1, 2024 | January 31, 2029 | HOLTZMAN, DAVID M. | reporter.nih.gov |
| Structural analysis of tau associated with parenchymal and vascular prion protein amyloidosis | NIH | National Institute on Aging | 2024 to 2025 | $1,476,148 | April 1, 2021 | March 31, 2026 | VIDAL, RUBEN | reporter.nih.gov |
| Frontotemporal dementia in rhesus macaques | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $1,471,318 | May 1, 2024 | January 31, 2029 | EMBORG, MARINA | reporter.nih.gov |
| Soluble adenylyl cyclases in lung endothelial tauopathy | NIH | National Heart, Lung, and Blood Institute | 2023 to 2025 | $1,451,396 | March 20, 2023 | February 28, 2027 | STEVENS, TROY | reporter.nih.gov |
| Novel Tau-Targeted Radiohalogenated Agents for Alzheimer's Disease | NIH | National Institute on Aging | 2024 to 2025 | $1,435,768 | February 15, 2024 | November 30, 2028 | MUKHERJEE, JOGESHWAR | reporter.nih.gov |
| S-Nitrosylation-Dependent Pathological Spread of Abnormal Proteins in Frontotemporal Dementia and Lewy Body Dementia | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $1,431,052 | August 1, 2021 | July 31, 2027 | NAKAMURA, TOMOHIRO | reporter.nih.gov |
| PREDICT-FTD: Multimodal Imaging Prediction of FTLD Subtypes. | NIH | National Institute on Aging | 2023 | $1,408,318 | September 30, 2017 | September 29, 2025 | WANG, LEI | reporter.nih.gov |
| C9orf72 frontotemporal dementia (FTD) and amyotrophic lateral sclerosis(ALS): using patient cells and CRISPR to reveal therapeutic approaches | NIH | National Institute on Aging | 2024 to 2025 | $1,403,325 | May 1, 2021 | April 30, 2026 | CONKLIN, BRUCE R | reporter.nih.gov |
| Development of a topical tracer to detect TDP43 in ALS, LATE and FTD retinas for AI-powered disease insights | NIH | National Institute on Aging | 2025 | $1,388,697 | August 15, 2022 | May 31, 2027 | SARRAF, STELLA | reporter.nih.gov |
| Single Cell Analyses of Neuroimmune Dysfunctions in the Thalamocortical Circuit in FTLD | NIH | National Institute on Alcohol Abuse and Alcoholism | 2021 to 2022 | $1,385,282 | September 15, 2018 | June 30, 2023 | HUANG, ERIC J | reporter.nih.gov |
| Role of SUMOylation in Mitochondrial/Synaptic Axis Dysfunction Induced by Abnormal Tau in FTD | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2024 | $1,376,782 | September 19, 2023 | August 31, 2028 | QUINZII, CATARINA M. | reporter.nih.gov |
| Defining mechanisms of AAA+ disaggregases | NIH | National Institute of General Medical Sciences | 2021 to 2024 | $1,366,630 | January 1, 2013 | May 31, 2025 | SHORTER, JAMES | reporter.nih.gov |
| Defining trajectories of dynamic biomarkers for C9ORF72 repeat expansion carriers | NIH | National Institute on Aging | 2021 to 2022 | $1,365,380 | August 15, 2018 | April 30, 2026 | LEE, SUZEE EURIE | reporter.nih.gov |
| Protein Homeostasis and Proteotoxicity Mechanisms | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $1,365,060 | February 1, 2015 | May 31, 2026 | LIN, JONATHAN | reporter.nih.gov |
| Atomic models of human tau filaments and development of tau ligands | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $1,361,315 | September 30, 2018 | August 31, 2023 | VIDAL, RUBEN | reporter.nih.gov |
| Role of the TE-cGAS-STING pathway in C9orf72-ALS/FTD pathogenesis | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $1,360,696 | September 18, 2024 | August 31, 2029 | TROTTI, DAVIDE | reporter.nih.gov |
| Endolysosomal trafficking and lipid metabolism defects in FTLD | NIH | National Institute on Aging | 2023 to 2024 | $1,341,154 | May 15, 2023 | December 31, 2024 | HUANG, ERIC J | reporter.nih.gov |
| Hyperphosphorylated tau and the molecular mechanisms of tauopathy | NIH | National Institute on Aging | 2022 | $1,337,894 | June 1, 2022 | May 31, 2025 | KUO, MIN-HAO | reporter.nih.gov |
| Cell Type and Regional Vulnerability in Frontotemporal Dementia | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $1,326,924 | August 1, 2021 | July 31, 2027 | TEMPLE, SALLY | reporter.nih.gov |
| STELLA-FTD: Examination of a Behavior Change Intervention for FTD Family Care Partners | NIH | National Institute on Aging | 2024 to 2025 | $1,299,534 | July 15, 2024 | June 30, 2029 | LINDAUER, ALLISON | reporter.nih.gov |
| Mechanisms of FUS Toxicity in Animal and Cellular Models of ALS/FTD. | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $1,296,000 | June 15, 2019 | February 29, 2024 | SHNEIDER, NEIL ALAN | reporter.nih.gov |
| Deciphering the structural basis of repeat-associated non-AUG (RAN) translation in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $1,288,272 | September 18, 2024 | August 31, 2029 | BRITO QUERIDO, JAILSON | reporter.nih.gov |
| Mechanisms of chimeric DPR production and toxicity in c9ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $1,283,766 | July 1, 2024 | April 30, 2029 | MCEACHIN, ZACHARY THOMAS | reporter.nih.gov |
| The impact of progranulin species on TDP-43 proteolysis and pathobiology | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $1,275,512 | June 1, 2025 | May 31, 2027 | KAO, AIMEE | reporter.nih.gov |
| Generation and characterization of a mouse model exhibiting beta-amyloidosis and tauopathy with nuclear depletion of TDP-43 | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2023 | $1,267,418 | September 17, 2019 | August 31, 2024 | WONG, PHILIP C | reporter.nih.gov |
| 3D in vitro model of genetic and sporadic FTD: accelerating novel therapeutic development | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $1,253,527 | May 9, 2025 | April 30, 2027 | GHAFFARI, LAYLA | reporter.nih.gov |
| TDP-43 Proteinopathy in ALS-FTD: Mechanism, Target Validation and Biomarker | NIH | National Institute of Neurological Disorders and Stroke | 2023 | $1,245,777 | February 1, 2016 | February 28, 2026 | WONG, PHILIP C | reporter.nih.gov |
| Mechanistic studies and therapeutics for ALS/FTD linked to UBQLN2 mutations | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $1,242,686 | January 15, 2017 | January 31, 2027 | MONTEIRO, MERVYN J | reporter.nih.gov |
| Identifying T cell determinants of heritable Frontotemporal dementia | NIH | National Institute on Aging | 2024 to 2025 | $1,236,405 | April 1, 2024 | March 31, 2029 | BURBERRY, AARON | reporter.nih.gov |
| Neural Mechanisms of Empathy Loss in Frontotemporal Dementia | NIH | National Institute on Aging | 2024 to 2025 | $1,236,010 | May 1, 2024 | April 30, 2029 | YAO, WEI-DONG | reporter.nih.gov |
| Structural profiling of tauopathy seeds | NIH | National Institute on Aging | 2023 | $1,230,000 | February 15, 2023 | January 31, 2026 | JOACHIMIAK, LUKASZ A. | reporter.nih.gov |
| Whole genome sequencing consortium on Frontotemporal dementia with underlying TDP-43 pathology | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $1,213,868 | September 25, 2017 | August 31, 2024 | RADEMAKERS, ROSA | reporter.nih.gov |
| Phase Transition-Mediated Tau Function and Dysfunction | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2023 | $1,200,000 | August 15, 2019 | July 31, 2025 | FERREON, ALLAN CHRIS | reporter.nih.gov |
| Flortaucipir PET and histopathology in frontotemporal lobar degeneration and Alzheimer’s disease | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $1,192,500 | February 15, 2021 | January 31, 2024 | JOSEPHS, KEITH A | reporter.nih.gov |
| Development of Mass Spectrometry Strategies to Decipher Dynamic Lysosomal Dysfunctions in Frontotemporal Dementia | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $1,188,229 | April 15, 2021 | August 31, 2024 | HAO, LING | reporter.nih.gov |
| Engineering Anti-Tau Intrabodies that Reduce Tauopathy by Either the Proteasome, Lysosome, or Chaperone Mediated Autophagy | NIH | National Institute on Aging | 2021 to 2023 | $1,181,250 | August 1, 2019 | April 30, 2025 | GALLARDO, GILBERT | reporter.nih.gov |
| A video intervention to improve decision making in early-onset dementia caregivers | NIH | National Institute on Aging | 2021 to 2022 | $1,179,500 | September 30, 2018 | May 31, 2024 | DICKERSON, BRADFORD C | reporter.nih.gov |
| Developing RNA Oligonucleotides to Mitigate Abberant FUS Phase Transition in FTD/ALS | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $1,170,000 | April 1, 2021 | March 31, 2024 | GUO, LIN | reporter.nih.gov |
| Architecture, dynamics and cell-specific behavior of tau condensates | NIH | National Institute on Aging | 2023 to 2025 | $1,166,793 | May 15, 2023 | April 30, 2028 | ELBAUM, SHANA | reporter.nih.gov |
| Cellular and Molecular Mechanisms of FUS-related ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2023 | $1,161,739 | April 15, 2013 | January 31, 2025 | PANDEY, UDAI B | reporter.nih.gov |
| Alterations in somatodendritic bioenergetics in Drosophila models of tauopathy | NIH | National Institute on Aging | 2021 | $1,159,932 | May 15, 2021 | April 30, 2025 | VENKATACHALAM, KARTIK | reporter.nih.gov |
| Regulated energy metabolism in ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2022 | $1,157,896 | May 1, 2022 | April 30, 2025 | WHARTON, KRISTI A | reporter.nih.gov |
| Expanding insights into FTD disease mechanisms | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $1,138,538 | December 15, 2024 | November 30, 2032 | PETRUCELLI, LEONARD | reporter.nih.gov |
| Antisense Oligonucleotides for Targeting Nonsense-mediated mRNA Decay in Frontotemporal Dementia | NIH | National Institute on Aging | 2021 to 2023 | $1,136,250 | August 1, 2019 | April 30, 2024 | NGUYEN, ANDREW D. | reporter.nih.gov |
| Impeding transcription of expanded microsatellite repeats using deactivated Cas9 | NIH | National Institute on Aging | 2021 to 2023 | $1,133,433 | February 15, 2019 | December 31, 2023 | WANG, ERIC T | reporter.nih.gov |
| Self-assembling Nanofiber Vaccines for Neurodegeneration | NIH | National Institute on Aging | 2024 to 2025 | $1,123,861 | September 30, 2024 | May 31, 2029 | RUDRA, JAI | reporter.nih.gov |
| Understanding Frontotemporal Dementia Using Drosophila and iPSC Models | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $1,095,779 | April 15, 2017 | March 31, 2027 | GAO, FEN-BIAO | reporter.nih.gov |
| Imaging Iron-Rich Pathology to Monitor and Diagnose FLTD Subtypes | NIH | National Institute on Aging | 2023 to 2025 | $1,089,563 | April 15, 2023 | January 31, 2028 | TISDALL, MATTHEW DYLAN | reporter.nih.gov |
| Dysregulation of p97/VCP disease mutants in IBM and FTLD-U | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $1,088,809 | July 1, 2018 | April 30, 2024 | CHOU, TSUI-FEN | reporter.nih.gov |
| Developing Neuroprotective Strategies for Tau and TDP-43 Proteinopathy in FTLD | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $1,087,993 | February 15, 2009 | December 31, 2025 | KRAEMER, BRIAN C. | reporter.nih.gov |
| The TMEM106B-GRN-TDP43 triad: leveraging human samples and humanized models to unravel FTLD-TDP disease mechanisms | NIH | National Institute on Aging | 2024 to 2025 | $1,065,992 | September 30, 2024 | August 31, 2029 | RADEMAKERS, ROSA | reporter.nih.gov |
| Probing the Influence of Oxygen Toxicity on Tau Hyperphosphorylation caused by Mitochondrial Dysfunction | NIH | National Institute on Aging | 2024 to 2025 | $1,058,875 | June 15, 2024 | February 28, 2029 | GRILLO, ANTHONY STEVEN | reporter.nih.gov |
| ROLE OF TFEB IN TAUOPATHY | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $997,908 | July 1, 2015 | May 31, 2027 | ZHENG, HUI | reporter.nih.gov |
| Elucidating the Role of Microglia and Neurotrophin Receptor p75 on Neuronal Degeneration in Frontotemporal Dementia | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $967,680 | January 15, 2021 | December 31, 2025 | HARGUS, GUNNAR | reporter.nih.gov |
| Single Cell Characterization of FTLD-GRN | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $965,344 | September 15, 2022 | August 31, 2027 | HUANG, ERIC J | reporter.nih.gov |
| CRISPR-Cas9 editing in C9orf72 patient derived iPSC | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $961,200 | July 1, 2020 | June 30, 2025 | CLELLAND, CLAIRE | reporter.nih.gov |
| Training program in the neurology of language and neurodegenerative aphasias | NIH | National Institute on Deafness and Other Communication Disorders | 2021 to 2025 | $944,145 | July 1, 2016 | June 30, 2026 | GORNO TEMPINI, MARIA LUISA | reporter.nih.gov |
| Unraveling the Aggregation of TDP43 Fragments Associated with ALS and FTD: Insights into Protein Quality Control Mechanisms and Cellular Vulnerability | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $934,383 | May 15, 2016 | July 31, 2028 | BROWER, CHRISTOPHER SCOTT | reporter.nih.gov |
| Communication Bridge: Optimizing an evidence-based intervention for individuals with primary progressive aphasia | NIH | National Institute on Aging | 2021 to 2023 | $924,107 | September 15, 2017 | September 2, 2023 | ROGALSKI, EMILY J | reporter.nih.gov |
| Dynamic neural systems underlying socioemotional function | NIH | National Institute on Aging | 2022 to 2024 | $898,471 | August 1, 2020 | May 31, 2026 | PASQUINI, LORENZO | reporter.nih.gov |
| Determinants of neurodegenerative decline in the aphasic variant of Alzheimer's disease | NIH | National Institute on Aging | 2021 to 2022 | $886,422 | March 15, 2012 | August 31, 2023 | ROGALSKI, EMILY J | reporter.nih.gov |
| Connecting TDP-43 Pathology to the Molecular Profiles of Neurodegeneration | NIH | National Institute of Neurological Disorders and Stroke | 2024 | $879,816 | August 15, 2020 | July 31, 2025 | GALE HAMMELL, MOLLY | reporter.nih.gov |
| Optimization of CRISPR genome editor and its delivery strategy for C9orf72 frontotemporal dementia | NIH | National Institute of Neurological Disorders and Stroke | 2023 | $869,959 | August 18, 2023 | July 31, 2025 | CLELLAND, CLAIRE | reporter.nih.gov |
| Cognitive and Neural Mechanisms of Antisocial Behavior in Frontotemporal Dementia | NIH | National Institute on Aging | 2021 to 2025 | $856,746 | June 1, 2021 | November 30, 2026 | DARBY, RICHARD RYAN | reporter.nih.gov |
| Intervention to promote communication quality of life for persons with language‐led dementia and their partners: A randomized pilot trial | NIH | National Institute on Aging | 2025 | $856,024 | September 15, 2025 | August 31, 2027 | HENRY, MAYA | reporter.nih.gov |
| Comprehensive Harmonization and Analysis of Case/Control Whole Genome Sequencing Data from the ALS/FTD Compute Project | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $817,388 | February 1, 2023 | July 31, 2028 | LANDERS, JOHN E | reporter.nih.gov |
| Aberrant proteomes in tauopathy: revealing functional consequences via multimodal proteomics | NIH | National Institute on Aging | 2025 | $816,661 | June 1, 2025 | February 28, 2030 | SWANEY, DANIELLE L | reporter.nih.gov |
| Novel role of β-arrestins in Tauopathy | NIH | National Institute on Aging | 2022 to 2023 | $805,000 | May 15, 2019 | January 31, 2025 | WOO, JUNGA "ALEXA" | reporter.nih.gov |
| Defining the pathogenic relationship of TDP-43 inclusions and cytoplasmic double stranded RNA in AD and FTD | NIH | National Institute on Aging | 2025 | $804,740 | August 2, 2022 | July 31, 2027 | ALBERS, MARK W | reporter.nih.gov |
| Glial-mediated Inflammation and Iron Accumulation in Frontotemporal Dementia | NIH | National Institute on Aging | 2025 | $803,111 | December 15, 2024 | November 30, 2029 | IRWIN, DAVID JOHN | reporter.nih.gov |
| A Cytochrome P450 Therapeutic Space for Tauopathies | NIH | National Institute on Aging | 2021 | $801,925 | September 30, 2021 | August 31, 2023 | DAR, ARVIN | reporter.nih.gov |
| A microphysiologic multicellular organ-on-chip to inform clinical trials in FTD/ALS | NIH | National Center for Advancing Translational Sciences | 2021 | $800,773 | July 1, 2020 | May 31, 2022 | SVENDSEN, CLIVE NIELS | reporter.nih.gov |
| Systems Genetics Analysis of Resilience to Tauopathy in ADRD | NIH | National Institute on Aging | 2025 | $799,700 | January 1, 2025 | December 31, 2029 | DUFF, KAREN | reporter.nih.gov |
| Validating remote digital assessments for familial frontotemporal dementia | NIH | National Institute on Aging | 2025 | $798,073 | May 1, 2022 | April 30, 2027 | STAFFARONI, ADAM MARK | reporter.nih.gov |
| Neuroinflammation, white matter integrity, AD biomarkers and pathology in corticobasal syndrome | NIH | National Institute on Aging | 2025 | $798,032 | April 1, 2025 | January 31, 2030 | WHITWELL, JENNIFER LOUISE | reporter.nih.gov |
| Primary Progressive Aphasia: Beyond the Clinical Variants | NIH | National Institute on Deafness and Other Communication Disorders | 2021 to 2024 | $796,392 | April 1, 2020 | March 31, 2025 | DELEON, JESSICA ANNE | reporter.nih.gov |
| Age-related TDP-43 neuropathology: using disease-driving mechanisms to guide classification | NIH | National Institute of Neurological Disorders and Stroke | 2024 | $790,914 | September 15, 2020 | March 31, 2026 | CYKOWSKI, MATTHEW DANIEL | reporter.nih.gov |
| C9orf72-mediated features transcriptomic signatures and translational studies for frontotemporal dementia and related disorders | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $788,248 | June 15, 2022 | May 31, 2027 | VAN BLITTERSWIJK, MARKA | reporter.nih.gov |
| Deciphering TDP-43 Proteinopathy: Unveiling the Consequences on Oligodendrocyte Dysfunction | NIH | National Institute on Aging | 2024 | $787,095 | June 15, 2024 | May 31, 2026 | PORTA ANTOLINEZ, SILVIA | reporter.nih.gov |
| Anatomic, Pathologic, and Molecular Signatures of FTLD-TDP type C | NIH | National Institute on Aging | 2025 | $786,632 | December 1, 2024 | November 30, 2029 | GEFEN, TAMAR D | reporter.nih.gov |
| Role of central and peripheral immune crosstalk in FTD-Grn neurodegeneration | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $782,364 | August 17, 2022 | July 31, 2027 | TANSEY, MARIA DE LOURDES GAMEZ | reporter.nih.gov |
| Molecular mechanisms of Progranulin in Neurodegeneration | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $770,547 | May 1, 2018 | February 28, 2025 | KUKAR, THOMAS L | reporter.nih.gov |
| Flortaucipir PET and histopathology in frontotemporal lobar degeneration and Alzheimer’s disease | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $766,650 | February 15, 2021 | January 31, 2027 | JOSEPHS, KEITH A | reporter.nih.gov |
| Deconstructing and challenging TDP-43 proteinopathies: from FTLD/ALS to Alzheimer's disease | NIH | National Institute on Aging | 2021 to 2022 | $762,500 | August 15, 2018 | April 30, 2024 | RINCON-LIMAS, DIEGO E | reporter.nih.gov |
| Shared Mechanisms of Tau Toxicity Among Neurodegenerative Diseases | NIH | National Institute on Aging | 2025 | $762,144 | June 1, 2025 | April 30, 2030 | LU, BINGWEI | reporter.nih.gov |
| Mechanisms of Gait and Balance Impairment in Progressive Supranuclear Palsy | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2025 | $761,756 | September 1, 2022 | August 31, 2027 | ALI, FARWA | reporter.nih.gov |
| Development of Emergent PET Tracers in Frontotemporal Lobar Degeneration | NIH | National Institute on Aging | 2022 to 2025 | $760,536 | August 5, 2022 | April 30, 2027 | SOLEIMANI-MEIGOONI, DAVID NIMA | reporter.nih.gov |
| Targeting Ceramide Signaling: Enhancing Healthy Aging and Combating Tauopathy in Mammals | NIH | National Institute on Aging | 2025 | $753,728 | December 1, 2024 | November 30, 2029 | SUN, LIOU Y. | reporter.nih.gov |
| Loss of VCP Function in Frontotemporal Lobar Degeneration | NIH | National Institute on Aging | 2025 | $753,559 | June 1, 2022 | May 31, 2027 | LEE, EDWARD BYUNG-HA | reporter.nih.gov |
| Mechanisms of nuclear pore complex homeostasis and injury in ALS/FTD and related neurodegenerative diseases | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2024 | $747,000 | July 15, 2021 | July 31, 2025 | COYNE, ALYSSA | reporter.nih.gov |
| Exploring Mechanisms of Pathogenicity in C9ORF72 Frontotemporal Dementia and Amyotrophic Lateral Sclerosis | NIH | National Institute on Aging | 2021 to 2023 | $746,997 | July 1, 2021 | March 31, 2024 | BURBERRY, AARON | reporter.nih.gov |
| Determining How Defective Nucleo-Cytoplasmic Trafficking Leads To Neurodegeneration In C9orf72-Related ALS And FTD | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $746,849 | March 1, 2018 | February 28, 2025 | KISKINIS, EVANGELOS | reporter.nih.gov |
| Cerebellar TMS for postural instability in progressive supranuclear palsy | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2025 | $745,023 | May 1, 2022 | April 30, 2027 | DALE, MARIAN LIVINGSTON | reporter.nih.gov |
| An optogenetic approach to establish the interplay between stress granules and TDP-43 proteinopathy in ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $744,882 | March 15, 2018 | February 28, 2023 | DONNELLY, CHRISTOPHER JAMES | reporter.nih.gov |
| Developing RNA Oligonucleotides to Mitigate Abberant FUS Phase Transition in FTD/ALS | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $741,000 | April 1, 2021 | March 31, 2026 | GUO, LIN | reporter.nih.gov |
| Identifying and understanding the role of repeat RNAs and RAN proteins in Alzheimer's disease | NIH | National Institute on Aging | 2023 to 2025 | $740,057 | July 1, 2023 | March 31, 2026 | NGUYEN, LIEN | reporter.nih.gov |
| Regulation of ATAD3A in TDP43-associated ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $737,720 | July 1, 2025 | March 31, 2030 | QI, XIN | reporter.nih.gov |
| Loss of TDP-43 disrupts the prefrontal neural activity and circuitry: relevance for TDP-43 linked ADRD | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $736,565 | September 19, 2022 | August 31, 2027 | LI, YUN | reporter.nih.gov |
| The Role of RNA Binding Protein Networks in Tauopathy and Related Dementia | NIH | National Institute on Aging | 2024 | $735,836 | September 15, 2020 | August 31, 2025 | VASSAR, ROBERT J | reporter.nih.gov |
| Hyperphosphorylated tau aggregation kit to identify tauopathy risk factor | NIH | National Institute on Aging | 2021 | $734,479 | September 30, 2017 | May 31, 2024 | MORANO, MARIA INES | reporter.nih.gov |
| Decision-Making in Genetic FTD | NIH | National Institute on Aging | 2021 | $731,351 | September 1, 2004 | February 29, 2024 | CHIONG, WINSTON | reporter.nih.gov |
| Capturing the molecular complexity of tau pathology-associated proteomes involved in the etiology of Alzheimer's disease and related dementias | NIH | National Institute on Aging | 2025 | $722,870 | September 15, 2022 | August 31, 2027 | ROSSOLL, WILFRIED | reporter.nih.gov |
| Behavioral and physiological linkage in people with frontotemporal dementia and spousal caregivers | NIH | National Institute on Aging | 2023 to 2025 | $722,719 | June 15, 2019 | December 31, 2025 | CHEN, KUAN-HUA | reporter.nih.gov |
| Mapping proteomic changes of tauopathy in human neurons | NIH | National Institute on Aging | 2025 | $717,709 | June 1, 2025 | March 31, 2030 | GAN, LI | reporter.nih.gov |
| Molecular mechanism of dipeptide repeat protein production from hexanucleotide repeats in C9ORF72-related ALS and FTD | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $716,406 | July 1, 2018 | March 31, 2024 | SUN, SHUYING | reporter.nih.gov |
| Frontotemporal Dementias: Genotypes and Phenotypes | NIH | National Institute on Aging | 2021 | $711,440 | March 15, 2000 | February 28, 2022 | LEE, VIRGINIA M | reporter.nih.gov |
| Understanding cleaved granulin production, protease inhibition and effects on protein homeostasis | NIH | National Institute on Aging | 2021 to 2022 | $710,600 | April 1, 2018 | December 31, 2023 | KAO, AIMEE | reporter.nih.gov |
| Rare Genetic Risk and Gene Networks in Tauopathy | NIH | National Institute on Aging | 2021 to 2024 | $709,776 | September 15, 2020 | May 31, 2025 | CHANG, TIMOTHY S | reporter.nih.gov |
| Translation dysregulation in neurodegeneration | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $707,634 | June 1, 2025 | May 31, 2027 | ZARNESCU, DANIELA C | reporter.nih.gov |
| Molecular effects of metformin, PKR and TBI on C9orf72 ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $705,919 | August 1, 2016 | August 31, 2027 | RANUM, LAURA P.W | reporter.nih.gov |
| A Novel Blood Test for Early Diagnosis of Frontotemporal Lobar Degeneration | NIH | National Institute of Neurological Disorders and Stroke | 2024 | $700,000 | August 15, 2024 | July 31, 2026 | FANGER, NEIL A | reporter.nih.gov |
| Prodrugs of potent and selective protease inhibitors as tauopathy therapeutics | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2024 | $699,984 | September 20, 2023 | August 31, 2025 | ASHE, KAREN H | reporter.nih.gov |
| Developing an Anti-proteotoxicity Therapy for Neurodegenerative Diseases | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $694,318 | September 17, 2024 | August 31, 2027 | ZHANG, TAO | reporter.nih.gov |
| Novel repeat associated non-AUG (RAN) proteins in sALS sFTD and SBMA: shared pathological features and unifying therapeutic opportunities | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $693,663 | July 1, 2022 | June 30, 2027 | RANUM, LAURA P.W | reporter.nih.gov |
| Single cell and tissue level functional genomic analysis of astrocyte-related mechanisms in tauopathy | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2023 | $691,714 | September 15, 2019 | August 31, 2024 | REXACH, JESSICA E | reporter.nih.gov |
| Molecular mechanisms that match lysosome function to cellular demand | NIH | National Institute of General Medical Sciences | 2021 to 2022 | $686,750 | September 1, 2013 | January 31, 2024 | FERGUSON, SHAWN | reporter.nih.gov |
| CYLD in Synapse Pruning and Pathogenesis of FTD | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $682,211 | August 1, 2021 | July 31, 2023 | YAO, WEI-DONG | reporter.nih.gov |
| Endolysosomal trafficking and lipid metabolism defects in FTLD | NIH | National Institute on Aging | 2025 | $669,477 | May 1, 2023 | March 31, 2028 | HUANG, ERIC J | reporter.nih.gov |
| Small molecule inhibitors of hyperphosphorylated tau aggregation in Alzheimer's disease: lead optimization, and proof of concept in a rodent model | NIH | National Institute on Aging | 2022 to 2025 | $657,093 | May 15, 2022 | April 30, 2027 | FORTIN, JESSICA | reporter.nih.gov |
| Defining the Role of Poly ADP-ribose in Biomolecular Condensation in ALS and FTLD | NIH | National Institute on Aging | 2024 | $654,638 | September 30, 2020 | August 31, 2025 | MYONG, SUA | reporter.nih.gov |
| Establishing Evidence-based Treatment for Speech and Language in Primary Progressive Aphasia | NIH | National Institute on Deafness and Other Communication Disorders | 2021 | $650,149 | July 1, 2017 | June 30, 2023 | HENRY, MAYA | reporter.nih.gov |
| Disease mechanism in ALS and frontotemporal dementia | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $647,454 | April 1, 1989 | August 31, 2022 | CLEVELAND, DON W | reporter.nih.gov |
| Proteostasis, Neuroinflammation and Neurodegeneration in Frontotemporal Dementia | NIH | National Institute on Aging | 2025 | $630,496 | June 1, 2025 | March 31, 2030 | FINKBEINER, STEVEN M | reporter.nih.gov |
| Immunotherapy Targeting Tau Aggregate Polymorphs | NIH | National Institute on Aging | 2025 | $614,629 | June 1, 2022 | May 31, 2027 | KAYED, RAKEZ | reporter.nih.gov |
| Language in Primary Progressive Aphasia | NIH | National Institute on Deafness and Other Communication Disorders | 2021 | $606,614 | May 1, 2007 | April 30, 2022 | MESULAM, MAREK-MARSEL M | reporter.nih.gov |
| Oligodendroglial Dysfunction in C9orf72 ALS and FTD | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $597,360 | August 1, 2017 | April 30, 2022 | ROTHSTEIN, JEFFREY D | reporter.nih.gov |
| Proteomics for fluid biomarker discovery in frontotemporal dementia | NIH | National Institute on Aging | 2021 to 2023 | $597,294 | April 1, 2019 | March 31, 2024 | ROJAS-MARTINEZ, JULIO CESAR | reporter.nih.gov |
| Deubiquitinase USP19 in TDP-43 pathogenesis. | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $595,610 | May 1, 2022 | April 30, 2027 | KANG, DAVID E | reporter.nih.gov |
| Structure and Genesis of tau Aggregates | NIH | National Institute on Aging | 2025 | $595,096 | June 1, 2017 | August 31, 2027 | KURET, JEFF | reporter.nih.gov |
| Tau accumulation in the pedunculopontine tegmentum as an early node in Progressive Supranuclear Palsy pathogenesis | NIH | National Institute of Neurological Disorders and Stroke | 2024 | $594,588 | August 1, 2021 | July 31, 2025 | CLARK, STEWART DONALDSON | reporter.nih.gov |
| Structure and Function of Tau | NIH | National Institute on Aging | 2024 | $588,747 | September 15, 2020 | August 31, 2025 | ELIEZER, DAVID | reporter.nih.gov |
| The role of m6A RNA methylation in C9ORF72-ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $582,989 | July 15, 2022 | April 30, 2027 | SUN, SHUYING | reporter.nih.gov |
| Targeting Tau Proteoforms in Frontotemporal Dementia | NIH | National Institute of Neurological Disorders and Stroke | 2024 | $575,398 | August 1, 2021 | July 31, 2025 | KARCH, CELESTE MARIE | reporter.nih.gov |
| New Targets in C9orf72 FTD: Exploring Histone H3 S10 Phosphorylation | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2023 | $575,365 | June 1, 2023 | March 31, 2025 | TORRENTE, MARIANA PLAZAS | reporter.nih.gov |
| Multimodal Imaging in Frontotemporal Degeneration | NIH | National Institute on Aging | 2021 to 2023 | $574,659 | September 1, 2013 | January 31, 2024 | ROSEN, HOWARD J | reporter.nih.gov |
| PET PROBES FOR IMAGING THE VESICULAR ACETYLCHOLINE TRANSPORTER | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $574,625 | June 15, 2011 | May 31, 2025 | TU, ZHUDE | reporter.nih.gov |
| Probing the Role of Chaperone-TPR Complexes in Tau Proteostasis | NIH | National Institute on Aging | 2024 | $568,644 | September 1, 2020 | August 31, 2025 | GESTWICKI, JASON E | reporter.nih.gov |
| Brain aging and Alzheimer's related dementias: convergence onto retrotransposons and endogenous retroviruses | NIH | National Institute on Aging | 2025 | $567,909 | May 1, 2022 | April 30, 2027 | DUBNAU, JOSHUA T | reporter.nih.gov |
| Development and validation of a high throughput screening assay for identification of tau aggregation inhibitors in Alzheimer's disease | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $566,145 | July 1, 2024 | December 31, 2025 | SOTO, CLAUDIO | reporter.nih.gov |
| Dynamic Brain Imaging of Speech in Primary Progressive Aphasia | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $562,274 | September 15, 2017 | June 30, 2023 | NAGARAJAN, SRIKANTAN S. | reporter.nih.gov |
| Activation of the niacin receptor HCAR2 to mitigate tau pathology | NIH | National Institute on Aging | 2025 | $560,636 | May 15, 2025 | February 28, 2030 | MOUTINHO, MIGUEL | reporter.nih.gov |
| Convergence of tauopathy and Huntington's disease through selective autophagy | NIH | National Institute on Aging | 2021 | $558,425 | September 30, 2017 | May 31, 2022 | ZHENG, HUI | reporter.nih.gov |
| Novel pathways in C9ORF72-associated ALS and dementia | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2023 | $557,171 | August 15, 2019 | May 31, 2024 | MORDES, DANIEL ADAM | reporter.nih.gov |
| Deciphering the role of ER stress in ALS pathogenesis caused by UBQLN2 mutations | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $547,956 | September 28, 2017 | June 30, 2023 | MONTEIRO, MERVYN J | reporter.nih.gov |
| Optimizing Clinical Trial Endpoints in Frontotemporal Dementia | NIH | National Institute on Aging | 2021 to 2023 | $547,668 | August 1, 2019 | April 30, 2024 | STAFFARONI, ADAM MARK | reporter.nih.gov |
| The pathogenic relationship between neuronal activity and C9orf72-linked neurodegeneration | NIH | National Institute of Neurological Disorders and Stroke | 2024 | $536,869 | September 15, 2020 | August 31, 2025 | HAEUSLER, AARON RAYMOND | reporter.nih.gov |
| PIKFYVE antagonism as a therapy for C9ORF72-ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $533,459 | May 1, 2018 | May 31, 2023 | ALWORTH, SAMUEL V | reporter.nih.gov |
| A Phenotype-Optimized Zebrafish Model of Progressive Supranuclear Palsy | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2024 | $530,516 | January 15, 2022 | December 31, 2025 | SCHOPPIK, DAVID | reporter.nih.gov |
| Novel imaging genetic biomarkers for sporadic frontotemporal dementia through machine learning | NIH | National Institute on Aging | 2021 to 2025 | $527,986 | March 15, 2021 | February 28, 2026 | BROCE-DIAZ, IRIS J | reporter.nih.gov |
| Studying roles of CASP8 SVA GGGAGA repeat expansions in Alzheimer's disease | NIH | National Institute on Aging | 2025 | $507,371 | June 1, 2025 | March 31, 2030 | NGUYEN, LIEN | reporter.nih.gov |
| Neural mechanisms of social attachment disruption in frontotemporal dementia | NIH | National Institute on Aging | 2023 to 2025 | $507,060 | June 1, 2023 | May 31, 2028 | BERENDZEN, KRISTEN | reporter.nih.gov |
| Novel artificial intelligence-based approaches to understand the pathological and genetic drivers of primary tauopathies | NIH | National Institute on Aging | 2022 to 2025 | $503,448 | September 15, 2022 | May 31, 2026 | FARRELL, KURT WILLIAM | reporter.nih.gov |
| Astrocyte regulation of cortical neurodegeneration in C9orf72 FTD/ALS | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $502,724 | September 29, 2021 | March 19, 2024 | SATTLER, RITA | reporter.nih.gov |
| High-throughput optimization of gene editing systems for treating Amyotrophic lateral sclerosis | NIH | National Institute on Aging | 2024 to 2025 | $500,000 | September 20, 2024 | May 31, 2027 | HUGHES, NICHOLAS | reporter.nih.gov |
| Mature brain organoid platform for therapeutic screening for ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2023 | $499,999 | August 1, 2023 | July 31, 2025 | GHAFFARI, LAYLA | reporter.nih.gov |
| PET Imaging to Evaluate a Novel Chemokine Antagonist to Protect Synapses in ADRD | NIH | National Institute on Aging | 2023 to 2024 | $499,906 | September 30, 2023 | June 30, 2025 | RUFF, MICHAEL R | reporter.nih.gov |
| A Phenotype-Optimized Zebrafish Model of Progressive Supranuclear Palsy | NIH | National Institute of Neurological Disorders and Stroke | 2022 | $497,436 | January 15, 2022 | December 31, 2022 | SCHOPPIK, DAVID | reporter.nih.gov |
| Mutant Tubulins Confer Resistance to Pathological Tau | NIH | National Institute on Aging | 2024 to 2025 | $493,021 | July 1, 2024 | June 30, 2027 | BENBOW, SARAH JEAN ZIMMERMAN | reporter.nih.gov |
| TMS in Primary Progressive Aphasia: Modulation of Brain Networks and Language | NIH | National Institute on Deafness and Other Communication Disorders | 2021 to 2023 | $490,050 | February 1, 2019 | April 30, 2024 | TOUROUTOGLOU, ALEXANDRA | reporter.nih.gov |
| Formation and function of pathologic stress granules containing RNA-Binding Protein SFPQ in tauopathy | NIH | National Institute on Aging | 2023 to 2024 | $489,500 | January 15, 2023 | December 31, 2024 | SEGAL, ROSALIND A. | reporter.nih.gov |
| Digital monitoring of autonomic activity to detect empathy loss in behavioral variant frontotemporal dementia | NIH | National Institute on Aging | 2023 to 2025 | $488,628 | August 1, 2023 | July 31, 2028 | RHODES, EMMA | reporter.nih.gov |
| Investigating a novel vascular pathway that regulates neuronal survival | NIH | National Institute on Aging | 2025 | $480,710 | September 5, 2025 | May 31, 2030 | SOCKANATHAN, SHANTHINI | reporter.nih.gov |
| Cell-type-specific contributions to cortical dysfunction in frontotemporal dementia | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $476,795 | July 1, 2021 | November 30, 2022 | COWELL, RITA MARIE | reporter.nih.gov |
| Implicating the major G-quadruplex helicase, DHX36, as a novel pathogenic modifier of C9ORF72 frontal temporal dementia | NIH | National Institute on Aging | 2024 | $475,516 | May 1, 2020 | July 31, 2027 | SMALDINO, PHILIP J | reporter.nih.gov |
| Super-Resolved Multimodal Imaging Biomarkers for Frontotemporal Dementia | NIH | National Institute on Aging | 2024 to 2025 | $473,852 | June 15, 2024 | March 31, 2026 | DUTTA, JOYITA | reporter.nih.gov |
| Dissecting the role of Tau-induced changes of SUMO and succinylCoA conjugation in mitochondrial-nuclear anterograde and retrograde signaling in FTD | NIH | National Institute on Aging | 2025 | $472,073 | September 1, 2025 | May 31, 2030 | QUINZII, CATARINA M. | reporter.nih.gov |
| Humanized MAPT knockin mouse models for frontotemporal dementia | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $468,992 | August 1, 2021 | November 17, 2023 | KANG, JONGKYUN | reporter.nih.gov |
| Mechanisms of disruption of axon transport of autophagic vesicles and lysosomes in C9orf72 ALS | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2024 | $465,774 | July 1, 2020 | June 30, 2026 | BERTH, SARAH HATCH | reporter.nih.gov |
| Digital Spatial Profiling of Hippocampal Subregions in Alzheimer’s Disease, Primary Age-Related Tauopathy, and Chronic Traumatic Encephalopathy | NIH | National Institute on Aging | 2022 | $464,750 | August 15, 2022 | July 31, 2024 | RICHARDSON, TIMOTHY ERIC | reporter.nih.gov |
| Differentiating chronic sleep disruption from intermittent hypoxia in OSA on tau pathology and spread | NIH | National Institute on Aging | 2025 | $464,750 | September 5, 2025 | August 31, 2027 | KAM, KOREY | reporter.nih.gov |
| Exploring the Pathogenicity of CYLD Variants in FTD | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $463,750 | September 29, 2021 | March 31, 2025 | YAO, WEI-DONG | reporter.nih.gov |
| Lysosomal Regulation and Functions for TBK1 in Neurodegenerative Diseases | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $461,197 | June 9, 2025 | May 31, 2027 | FERGUSON, SHAWN | reporter.nih.gov |
| Progranulin Prosaposin and Lipid Biology in FTD | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $460,785 | April 1, 2022 | May 31, 2027 | KAO, AIMEE | reporter.nih.gov |
| Role of Sarm1 in TBI-accentuated C9orf72 Frontotemporal Dementia | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2024 | $460,625 | February 1, 2023 | April 30, 2025 | HENNINGER, NILS | reporter.nih.gov |
| Cryo-EM Analysis of Ribosomal Defects in C9ORF72-Associated Frontotemporal Dementia and ALS | NIH | National Institute on Aging | 2023 to 2024 | $460,625 | August 15, 2023 | May 31, 2025 | GAO, FEN-BIAO | reporter.nih.gov |
| Upregulation of progranulin in a human iPSC-derived neurovascular model of GRN-associated Frontotemporal Dementia | NIH | National Institute on Aging | 2023 | $460,625 | September 30, 2023 | September 29, 2025 | ALMEIDA, SANDRA | reporter.nih.gov |
| Mechanistic Investigation of Innate Immunity in a Drosophila Model of Frontotemporal Dementia | NIH | National Institute on Aging | 2024 | $460,625 | April 15, 2024 | March 31, 2026 | GAO, FEN-BIAO | reporter.nih.gov |
| Development of Mutant Specific Antisense Oligonucleotides for TARDBP and KIF5A as a Therapeutic for ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2024 | $460,625 | June 1, 2024 | May 31, 2026 | LANDERS, JOHN E | reporter.nih.gov |
| Investigating the Roles of the Deubiquitylation Pathway in TDP-43 Pathology in ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $460,625 | June 7, 2025 | May 31, 2027 | GAO, FEN-BIAO | reporter.nih.gov |
| Discovering targeted modulator of microglial activity as a candidate treatment for FTD and related dementias. | NIH | National Institute of Neurological Disorders and Stroke | 2024 | $459,525 | July 2, 2024 | March 31, 2025 | JACKO, MARTIN | reporter.nih.gov |
| Cortical hyperexcitability in FTD and ALS: Exploring physiological biomarkers | NIH | National Institute on Aging | 2024 | $459,250 | June 1, 2024 | May 31, 2026 | DICKERSON, BRADFORD C | reporter.nih.gov |
| Characterizing autonomic impairments in Frontotemporal Dementia | NIH | National Institute on Aging | 2024 to 2025 | $459,250 | September 1, 2024 | August 31, 2026 | ELDAIEF, MARK CHRISTIAN | reporter.nih.gov |
| Development of a novel fluorescent tracer for detection of retinal TDP43 in ALS and FTD | NIH | National Institute on Aging | 2022 | $458,527 | August 15, 2022 | July 31, 2024 | SARRAF, STELLA | reporter.nih.gov |
| A new biomarker for frontotemporal lobar degeneration with TDP-43 proteinopathy and Alzheimer's disease | NIH | National Institute on Aging | 2023 to 2024 | $454,336 | January 1, 2023 | December 31, 2025 | MAO, QINWEN | reporter.nih.gov |
| Rigid Preoccupations in Right Temporal Degeneration: Phenomenology and Neural Mechanisms | NIH | National Institute on Aging | 2025 | $451,000 | January 1, 2025 | December 31, 2026 | RANKIN, KATHERINE P | reporter.nih.gov |
| Dysregulation of inhibitory synapse by poly-GR in C9ORF72-ALS/FTD | NIH | National Institute on Aging | 2021 | $450,313 | May 1, 2021 | April 30, 2024 | SUN, SHUYING | reporter.nih.gov |
| Investigating the role of progranulin in TDP-43 proteinopathy | NIH | National Institute on Aging | 2022 | $449,419 | July 15, 2022 | June 30, 2025 | HU, FENGHUA | reporter.nih.gov |
| A novel diagnostic assay for parkinsonian tauopathies | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $446,991 | August 7, 2025 | July 31, 2027 | BITAN, GAL | reporter.nih.gov |
| Influence of thalamic IL-33 signaling in aging-associated exacerbation of cognitive impairment after brain injury via microglial dysfunction and tau pathology | NIH | National Institute on Aging | 2025 | $445,757 | September 15, 2022 | June 30, 2027 | KANO, SHINICHI | reporter.nih.gov |
| The tRNA pool in C9-ALS/FTD | NIH | National Institute on Aging | 2023 to 2024 | $444,696 | April 1, 2023 | March 31, 2026 | HOU, YA-MING | reporter.nih.gov |
| Can diagnostic biomarkers for parkinsonian syndromes be measured in postmortem blood samples? | NIH | National Institute of Neurological Disorders and Stroke | 2023 | $444,459 | February 1, 2023 | January 31, 2026 | BITAN, GAL | reporter.nih.gov |
| Use of machine learning to quantify cognitive function in AD, FTD, and DLB | NIH | National Institute on Aging | 2021 to 2022 | $443,109 | August 1, 2021 | November 30, 2023 | DICKERSON, BRADFORD C | reporter.nih.gov |
| Synthetic replicas of TDP-43 filaments associated with frontotemporal dementia | NIH | National Institute on Aging | 2025 | $442,750 | May 15, 2025 | April 30, 2027 | SUREWICZ, WITOLD K | reporter.nih.gov |
| Computational psycholinguistic analysis of speech samples in PPA and AD and FTD | NIH | National Institute on Deafness and Other Communication Disorders | 2022 to 2023 | $442,690 | February 4, 2022 | July 31, 2024 | DICKERSON, BRADFORD C | reporter.nih.gov |
| Functional consequences of the interactions between tau protein and opioids | NIH | National Institute on Drug Abuse | 2024 to 2025 | $441,176 | September 15, 2024 | August 31, 2026 | ATWOOD, BRADY | reporter.nih.gov |
| Digital detection of handwriting impairments in patients with atypical Alzheimer’s disease and frontotemporal dementia | NIH | National Institute on Aging | 2025 | $441,100 | July 1, 2025 | June 30, 2027 | MEADE, GABRIELA | reporter.nih.gov |
| Does Vision Loss Affect Tauopathy in the Brain | NIH | National Institute on Aging | 2023 to 2024 | $440,000 | April 15, 2023 | March 31, 2026 | ZHANG, WENBO | reporter.nih.gov |
| Establishing iPSC-based models to investigate the mechanistic interaction between neurotrauma and ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $438,606 | August 1, 2025 | July 31, 2027 | KISKINIS, EVANGELOS | reporter.nih.gov |
| Identification of conserved ALS-FTD suppressor genes | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $437,532 | April 1, 2021 | March 31, 2024 | HART, ANNE CHURCH | reporter.nih.gov |
| Dysregulated Ribosomal Protein Synthesis in Amyloid and Tau Mouse Models | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $435,875 | April 15, 2021 | September 30, 2023 | KLANN, ERIC | reporter.nih.gov |
| Protein homeostasis in a frontotemporal dementia iPSC model | NIH | National Institute on Aging | 2022 | $434,890 | August 1, 2022 | July 31, 2025 | CHU, CHARLEEN T | reporter.nih.gov |
| The Role of Chromogranin A in Tauopathy | NIH | National Institute on Aging | 2021 | $434,375 | May 1, 2021 | April 30, 2024 | GHOSH, GOURISANKAR | reporter.nih.gov |
| Functional evaluation of genes adjacent to risk-modulating SNPs in the pathogenesis of PSP | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $434,125 | July 1, 2021 | December 31, 2023 | BURTON, EDWARD ALAN | reporter.nih.gov |
| Investigating the cause of cerebral blood flow reductions in a mouse model of frontotemporal dementia | NIH | National Institute on Aging | 2022 to 2023 | $433,787 | August 1, 2022 | July 31, 2025 | BRACKO, OLIVER | reporter.nih.gov |
| Development of a brain penetrating single-chain antibody selectively targeting three repeat tau protein as a new treatment for frontotemporal dementia | NIH | National Institute of Neurological Disorders and Stroke | 2022 | $433,405 | August 1, 2022 | July 31, 2025 | SAITO, ERIN | reporter.nih.gov |
| Imaging Ligands for Alpha-Synuclein Fibril Accumulation in Multiple System Atrophy | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2023 | $433,125 | March 1, 2022 | February 28, 2026 | KOTZBAUER, PAUL T | reporter.nih.gov |
| Cross validation of gene expression changes in C9orf72 FTD using Drosophila and human model systems | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $432,802 | June 1, 2025 | May 31, 2027 | ZARNESCU, DANIELA C | reporter.nih.gov |
| Tau Oligomeric Complex 1 Antibody as a Novel Immuno-Gene Therapy for Tauopathy. | NIH | National Institute on Aging | 2024 | $431,750 | September 30, 2024 | August 31, 2026 | KANAAN, NICHOLAS M | reporter.nih.gov |
| The role of mitochondrial deficits in tauopathy-linked autophagy defects | NIH | National Institute on Aging | 2025 | $431,750 | June 1, 2025 | May 31, 2027 | CAI, QIAN | reporter.nih.gov |
| Glycogen promotes protein aggregation in ALS and FTD | NIH | National Institute of Neurological Disorders and Stroke | 2022 | $430,375 | April 15, 2022 | March 31, 2025 | ZHANG, YONGJIE | reporter.nih.gov |
| A novel non-transgenic fly model for tauopathies | NIH | National Institute on Aging | 2023 to 2024 | $430,375 | April 15, 2023 | January 31, 2026 | KUO, MIN-HAO | reporter.nih.gov |
| NUP50 as a modifier and risk factor for TDP-43 pathology in FTD/ALS | NIH | National Institute on Aging | 2023 | $430,267 | September 30, 2023 | September 29, 2025 | ROSSOLL, WILFRIED | reporter.nih.gov |
| Improving Prediction of Prognosis in Frontotemporal Dementia Using Epigenetic and Genetic Markers of Biological Aging and Disease | NIH | National Institute on Aging | 2021 | $429,000 | June 1, 2021 | May 31, 2024 | OPHOFF, ROEL A | reporter.nih.gov |
| A role for extracellular vesicles in neuroinflammation associated to frontotemporal dementia | NIH | National Institute of Neurological Disorders and Stroke | 2022 | $429,000 | May 15, 2022 | October 31, 2024 | TROTTI, DAVIDE | reporter.nih.gov |
| Molecular pathways linking frontotemporal dementia and circadian dysfunction | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $429,000 | March 7, 2024 | August 31, 2026 | KOH, KYUNGHEE | reporter.nih.gov |
| Delineating the role of Matrin-3 in driving aberrant liquid-liquid phase separation that underpins ALS/FTD | NIH | National Institute on Aging | 2023 to 2024 | $428,876 | January 1, 2023 | December 31, 2025 | JACKREL, MEREDITH E. | reporter.nih.gov |
| Integrated micro-to-macro network models of disease spread in frontotemporal dementia | NIH | National Institute on Aging | 2025 | $427,919 | August 15, 2025 | July 31, 2027 | CHEN, MIN | reporter.nih.gov |
| Peptide Nucleic Acid (PNA) Oligomers for Targeted Disruption of Biomolecular Condensates in ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $427,762 | September 9, 2024 | August 31, 2027 | ARMITAGE, BRUCE A. | reporter.nih.gov |
| Hyperphosphorylated tau aggregation-based Alzheimer’s disease early drug discovery | NIH | National Institute on Aging | 2021 | $427,676 | April 1, 2019 | January 31, 2024 | KUO, MIN-HAO | reporter.nih.gov |
| Fluid biomarkers in primary tauopathies | NIH | National Institute on Aging | 2023 to 2024 | $427,625 | August 1, 2023 | April 30, 2026 | SATO, CHIHIRO | reporter.nih.gov |
| A humanized mouse model for UBQLN2-associated ALS-dementia | NIH | National Institute on Aging | 2023 | $427,625 | September 1, 2023 | August 31, 2025 | TIBBETTS, RANDAL SCOT | reporter.nih.gov |
| Directly Converted Neurons as a Novel Cellular Model for ALS and FTD | NIH | National Institute of Neurological Disorders and Stroke | 2024 | $427,625 | July 15, 2024 | June 30, 2026 | MILLER, TIMOTHY M. | reporter.nih.gov |
| Innovation in monitoring tau-induced dysregulation of the autophagy lysosomal pathway | NIH | National Institute on Aging | 2024 | $426,250 | June 1, 2024 | May 31, 2026 | SACHS, JONATHAN N | reporter.nih.gov |
| Tau-PI3Kalpha Complex in Regulation of PI3K/Akt-dependent Neuronal Function and Survival | NIH | National Institute on Aging | 2022 to 2023 | $424,295 | September 30, 2022 | May 31, 2024 | ANDERSON, RICHARD A. | reporter.nih.gov |
| CRISPR gene therapies targeting tau in Alzheimer's disease and tauopathies | NIH | National Institute on Aging | 2023 | $424,095 | September 1, 2023 | August 31, 2025 | COHEN, TODD JONATHAN | reporter.nih.gov |
| Therapeutic Value of BNC-1 in Addressing Tau Pathology in TBI | NIH | National Institute on Aging | 2024 | $423,500 | September 15, 2024 | August 31, 2026 | BACHSTETTER, ADAM D | reporter.nih.gov |
| Regulation of paraspeckles by STAU1 in neurodegenerative disease | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2024 | $423,344 | April 1, 2023 | March 31, 2025 | SCOLES, DANIEL R | reporter.nih.gov |
| Deciphering the tau phosphorylation code | NIH | National Institute on Aging | 2021 to 2022 | $422,840 | January 15, 2021 | December 31, 2023 | PAK, DANIEL T | reporter.nih.gov |
| Pathway discovery for ubiquilin-associated ALS/Dementia | NIH | National Institute on Aging | 2021 | $421,841 | March 1, 2021 | February 29, 2024 | KIM, SANG HWA | reporter.nih.gov |
| Defining the Mechanisms by Which Mutations in DNAJC7 Increase Susceptibility to ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2024 | $420,310 | January 18, 2023 | December 31, 2024 | KISKINIS, EVANGELOS | reporter.nih.gov |
| Probing Biomolecular Condensates in Live Cells using Microsecond-scale Single Molecule Rotational Diffusion Microscopy (µs-SiMRoD) | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $419,375 | September 18, 2024 | August 31, 2026 | MUSSER, SIEGFRIED M | reporter.nih.gov |
| ELAVL3 in ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $417,259 | April 1, 2021 | September 30, 2023 | RAVITS, JOHN | reporter.nih.gov |
| Examining cross-species suppression of neurodegeneration by loss of a conserved RNA binding protein in models of ALS and FTD | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $416,481 | April 1, 2021 | June 30, 2023 | HART, ANNE CHURCH | reporter.nih.gov |
| Mechanisms of Neurodegeneration in KIF5A ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $416,340 | August 1, 2023 | July 31, 2028 | BRENT, JONATHAN ROBERT | reporter.nih.gov |
| Hyperphosphorylated tau and the molecular mechanisms of tauopathy | NIH | National Institute on Aging | 2025 | $412,095 | June 1, 2022 | May 31, 2027 | KUO, MIN-HAO | reporter.nih.gov |
| Lifespan extension, Somatotropic signaling and Tauopathy | NIH | National Institute on Aging | 2023 to 2024 | $408,375 | May 15, 2023 | February 28, 2026 | SUN, LIOU | reporter.nih.gov |
| Catestatin regulation of tauopathy and its therapeutic potentials | NIH | National Institute on Aging | 2025 | $405,625 | September 15, 2025 | August 31, 2027 | MAHATA, SUSHIL K | reporter.nih.gov |
| A novel approach to restore functional TDP43 for the treatment of FTD and ALS | NIH | National Institute on Aging | 2025 | $404,058 | May 1, 2025 | April 30, 2027 | SACHS, JONATHAN N | reporter.nih.gov |
| Small molecule inhibitors of hyperphosphorylated tau aggregation and cytotoxicity for the development of Alzheimer’s therapeutics | NIH | National Institute on Aging | 2021 to 2022 | $402,226 | September 15, 2021 | May 31, 2024 | FORTIN, JESSICA | reporter.nih.gov |
| Mechanisms underlying DNA double strand break response in Alzheimer?s disease and frontal temporal dementia | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $401,374 | September 15, 2017 | June 30, 2023 | TSAI, LI-HUEI | reporter.nih.gov |
| High-Throughput In Vitro Analyses of Trauma-Induced Tauopathy | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2025 | $399,750 | April 1, 2023 | March 31, 2026 | ALFORD, PATRICK W | reporter.nih.gov |
| Mechanisms of disruption of axon transport of autophagic vesicles and lysosomes in C9orf72 ALS | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2023 | $398,521 | July 1, 2020 | August 7, 2023 | BERTH, SARAH HATCH | reporter.nih.gov |
| The contribution of p16-expressing cells to tauopathy | NIH | National Institute on Aging | 2021 | $397,500 | July 15, 2017 | March 31, 2023 | BAKER, DARREN | reporter.nih.gov |
| Serotonin Modulation of Neural Circuitry in bvFTD: Understanding the Neurobiology of Mood and Cognitive Symptoms | NIH | National Institute on Aging | 2024 to 2025 | $396,259 | August 15, 2024 | May 31, 2029 | MORROW, CHRISTOPHER B. | reporter.nih.gov |
| Spatiotemporal analysis of TDP-43 toxicity and endolysosomal turnover mechanisms | NIH | National Institute of Neurological Disorders and Stroke | 2022 | $393,027 | July 1, 2022 | June 30, 2024 | BUCHAN, JOHN ROSS | reporter.nih.gov |
| Cell-based RNA degradation assay for C9ALS/FTD drug discovery | NIH | National Institute on Aging | 2024 | $392,116 | December 1, 2023 | November 30, 2025 | O'HANLON, RYAN | reporter.nih.gov |
| Supplement -- The pathogenic relationship between neuronal activity and C9orf72-linked neurodegeneration | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $390,000 | July 1, 2021 | June 30, 2022 | HAEUSLER, AARON RAYMOND | reporter.nih.gov |
| Connecting nuclear functions of Tau with pathology in Alzheimer's disease and other Tauopathies | NIH | National Institute on Aging | 2024 | $390,000 | September 15, 2020 | August 31, 2026 | KRETZSCHMAR, DORIS | reporter.nih.gov |
| The role of PHR signaling in tauopathy-related neurodegeneration | NIH | National Institute of Neurological Disorders and Stroke | 2024 | $389,851 | September 17, 2024 | August 31, 2027 | BORGEN, MELISSA | reporter.nih.gov |
| Genetic analysis of UBQLN2-associated neurodegeneration in frontotemporal dementia | NIH | National Institute on Aging | 2024 | $386,449 | September 15, 2020 | August 31, 2025 | TIBBETTS, RANDAL SCOT | reporter.nih.gov |
| MRI Signatures of Neuromelanin and Iron Pathology in Parkinsonism | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $385,128 | September 30, 2018 | August 31, 2024 | HUDDLESTON, DANIEL | reporter.nih.gov |
| Multi-modal magnetic resonance imaging in progressive supranuclear palsy (PSP) | NIH | National Institute on Aging | 2021 to 2022 | $383,027 | September 15, 2018 | May 31, 2024 | PANTELYAT, ALEXANDER Y. | reporter.nih.gov |
| Neuropathology in tauopathies stem from depolarization-induced alterations in the planar distribution of phosphoinositides | NIH | National Institute on Aging | 2025 | $382,528 | September 1, 2020 | March 31, 2027 | VENKATACHALAM, KARTIK | reporter.nih.gov |
| Histopathologic interrogation of laminar microcircuits underlying cognition in frontotemporal dementia | NIH | National Institute on Aging | 2023 to 2025 | $381,915 | May 1, 2023 | January 31, 2028 | OHM, DANIEL TIMOTHY | reporter.nih.gov |
| Molecular drivers of tauopathies in stem cell models from diverse human populations | NIH | National Institute on Aging | 2023 to 2025 | $380,943 | August 1, 2023 | April 30, 2028 | MINAYA, MIGUEL | reporter.nih.gov |
| Alterations in somatodendritic bioenergetics in Drosophila models of tauopathy | NIH | National Institute on Aging | 2025 | $378,910 | May 15, 2021 | April 30, 2027 | VENKATACHALAM, KARTIK | reporter.nih.gov |
| CircRNAs and CNS Gene Transfer | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $375,678 | September 1, 2018 | April 30, 2022 | ASOKAN, ARAVIND | reporter.nih.gov |
| The translational potential of next-generation sporadic mouse and human models of ALS/FTD | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $374,349 | December 24, 2024 | November 30, 2026 | COHEN, TODD JONATHAN | reporter.nih.gov |
| Novel role of β-arrestins in Tauopathy | NIH | National Institute on Aging | 2021 | $373,750 | May 15, 2019 | June 30, 2021 | WOO, JUNGA "ALEXA" | reporter.nih.gov |
| Chinese Language Assessment in Primary Progressive Aphasia | NIH | National Institute on Aging | 2021 to 2022 | $360,089 | July 1, 2021 | March 31, 2024 | GORNO TEMPINI, MARIA LUISA | reporter.nih.gov |
| Bacterial triggers of neural inflammation. | NIH | National Institute on Aging | 2023 to 2024 | $322,000 | December 15, 2022 | November 30, 2024 | BURBERRY, AARON | reporter.nih.gov |
| TMEM106B and Mitochondrial Dysfunction in FTLD and Other Dementia | NIH | National Institute on Aging | 2025 | $310,083 | September 1, 2025 | August 31, 2027 | GAO, JU | reporter.nih.gov |
| Assessment of the therapeutic potential of the anticancer agent Silmitasertib in the treatment of memory loss in Frontotemporal dementia | NIH | National Institute on Aging | 2024 | $310,000 | April 15, 2024 | March 31, 2026 | GOMEZ-PASTOR, ROCIO | reporter.nih.gov |
| Development of a novel gene therapy for the treatment of tauopathy | NIH | National Institute on Aging | 2022 | $308,000 | July 15, 2022 | June 30, 2025 | KHAN, MOHAMMAD MOSHAHID | reporter.nih.gov |
| Striatal Contribution to the Motor Symptoms and Aphasia in GRN-FTD | NIH | National Institute on Aging | 2024 | $305,000 | September 1, 2024 | August 31, 2026 | LI, YUQING | reporter.nih.gov |
| Targeted immunotherapy for amyotrophic lateral sclerosis and frontotemporal dementia | NIH | National Institute of Neurological Disorders and Stroke | 2023 | $299,989 | September 1, 2023 | February 28, 2025 | LARRICK, JAMES W | reporter.nih.gov |
| Assessment of Deep Learning Classification Methods for Parkinsonism | NIH | National Institute of Neurological Disorders and Stroke | 2023 | $272,736 | June 15, 2023 | May 31, 2024 | BARMPOUTIS, ANGELOS | reporter.nih.gov |
| Digital biomarkers in narrative and conversational speech in Frontotemporal Dementia | NIH | National Institute on Aging | 2021 to 2022 | $258,978 | September 30, 2021 | August 31, 2024 | NEVLER, NAOMI | reporter.nih.gov |
| Patient-tailored network prediction of neurodegenerative disease progression | NIH | National Institute on Aging | 2021 to 2022 | $258,434 | July 1, 2017 | May 31, 2023 | BROWN, JESSE AARON | reporter.nih.gov |
| Neurogenetic contributions to the spread of tau pathology in sporadic early-onset Alzheimer's disease | NIH | National Institute on Aging | 2024 to 2025 | $258,150 | December 1, 2023 | November 30, 2028 | KATSUMI, YUTA | reporter.nih.gov |
| Investigating the role of traumatic injury in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) | NIH | National Institute on Aging | 2022 to 2023 | $254,067 | September 15, 2022 | August 31, 2025 | ANDERSON, ERIC NATHANIEL | reporter.nih.gov |
| Investigating Dysfunction of Neuroimmune-Related Processes in Models of ALS/FTD TDP-43 | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $251,250 | April 1, 2025 | March 31, 2027 | BOSCO, DARYL ANGELA | reporter.nih.gov |
| Synaptic mechanisms of tau-mediated pathogenesis in human iPSC-derived neurons | NIH | National Institute on Aging | 2021 to 2022 | $249,678 | April 15, 2018 | February 28, 2023 | TRACY, TARA | reporter.nih.gov |
| Abnormal Late Endosomal Trafficking in Frontotemporal Dementia due to Progranulin Mutation | NIH | National Institute on Aging | 2021 | $249,000 | September 1, 2019 | May 31, 2023 | ARRANT, ANDREW EMMETT | reporter.nih.gov |
| Patching Amyloid Surface onto Soluble Protein | NIH | National Institute on Aging | 2025 | $244,022 | September 1, 2024 | August 31, 2028 | YANG, HYUNJUN | reporter.nih.gov |
| Neural circuits underlying motor impairments in a rodent model of progressive supranuclear palsy | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2023 | $240,342 | July 1, 2018 | June 30, 2024 | CREED, ROSE BERTHE | reporter.nih.gov |
| Tau Kinetics in the human CNS in vivo and in vitro | NIH | National Institute on Aging | 2021 to 2022 | $238,652 | June 1, 2019 | February 28, 2025 | SATO, CHIHIRO | reporter.nih.gov |
| Elucidating the Mechanisms that Underlie Tau Aggregation and Neurotoxicity | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $238,410 | August 1, 2025 | July 31, 2030 | KAUFMAN, SARAH KATHRYN | reporter.nih.gov |
| Analysis of C9ORF72-associated poly (GR) interactions on BAF chromatin remodeling complex structure and function | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $236,668 | December 15, 2024 | November 30, 2029 | LOPEZ GONZALEZ, RODRIGO | reporter.nih.gov |
| Investigating the regulation of lipid homeostasis and lysosomal function in neurodegenerative disease by prosaposin and progranulin in C. elegans | NIH | National Institute on Aging | 2023 to 2025 | $233,428 | September 1, 2023 | August 31, 2026 | HODUL, MOLLY | reporter.nih.gov |
| The role of astrocytes in the pathogenesis of sporadic tauopathy | NIH | National Institute on Aging | 2022 to 2025 | $232,470 | December 5, 2022 | December 4, 2025 | WHITNEY, KRISTEN | reporter.nih.gov |
| Understanding the relationship between cortical hyperexcitability and the progression of FTD/ALS pathology and behavioral deficits in mice | NIH | National Institute on Aging | 2024 to 2025 | $224,140 | September 1, 2024 | August 31, 2026 | ALGAMAL, MOUSTAFA | reporter.nih.gov |
Organizations
| Organization | Place | NIH awards | NIH amount | NSF awards | NSF amount |
|---|---|---|---|---|---|
| University of California, San Francisco | San Francisco, CA | 57 | $131.9 million | 0 | $0 |
| University of Pennsylvania | Philadelphia, PA | 34 | $79.1 million | 0 | $0 |
| Mayo Clinic Rochester | Rochester, MN | 12 | $70.7 million | 0 | $0 |
| Mayo Clinic Jacksonville | Jacksonville, FL | 16 | $42.5 million | 0 | $0 |
| Johns Hopkins University | Baltimore, MD | 32 | $40.5 million | 0 | $0 |
| Northwestern University at Chicago | Chicago, IL | 22 | $31.1 million | 0 | $0 |
| Columbia University Health Sciences | New York, NY | 14 | $26 million | 0 | $0 |
| Univ of Massachusetts Med SCH Worcester | Worcester, MA | 15 | $23.5 million | 0 | $0 |
| Massachusetts General Hospital | Boston, MA | 18 | $22.2 million | 0 | $0 |
| University of Florida | Gainesville, FL | 14 | $20.5 million | 0 | $0 |
| Case Western Reserve University | Cleveland, OH | 14 | $17.9 million | 0 | $0 |
| University of Pittsburgh at Pittsburgh | Pittsburgh, PA | 9 | $17.4 million | 0 | $0 |
| Stanford University | Stanford, CA | 4 | $14.8 million | 0 | $0 |
| Icahn School of Medicine at Mount Sinai | New York, NY | 7 | $14.8 million | 0 | $0 |
| Washington University | Saint Louis, MO | 16 | $14.8 million | 0 | $0 |
| University of California, San Diego | La Jolla, CA | 8 | $13.9 million | 0 | $0 |
| Yale University | New Haven, CT | 8 | $12.9 million | 0 | $0 |
| Indiana University Indianapolis | Indianapolis, IN | 10 | $12.1 million | 0 | $0 |
| University of Miami School of Medicine | Coral Gables, FL | 1 | $11.3 million | 0 | $0 |
| University of Texas Med BR Galveston | Galveston, TX | 5 | $10.9 million | 0 | $0 |
| University of Alabama at Birmingham | Birmingham, AL | 10 | $10.3 million | 0 | $0 |
| Ut Southwestern Medical Center | Dallas, TX | 7 | $10.2 million | 0 | $0 |
| New York University School of Medicine | New York, NY | 6 | $10.1 million | 0 | $0 |
| University of California Los Angeles | Los Angeles, CA | 9 | $9.8 million | 0 | $0 |
| Seattle Inst for Biomedical/clinical Res | Seattle, WA | 6 | $9.7 million | 0 | $0 |
| University of Texas at Austin | Austin, TX | 6 | $9.1 million | 0 | $0 |
| University of Michigan at Ann Arbor | Ann Arbor, MI | 9 | $8.8 million | 0 | $0 |
| Acurastem, Inc. | Pasadena, CA | 4 | $8.7 million | 0 | $0 |
| University of Chicago | Chicago, IL | 2 | $7.9 million | 0 | $0 |
| Emory University | Atlanta, GA | 8 | $7.9 million | 0 | $0 |
| Biosensics, LLC | Newton, MA | 2 | $7.7 million | 0 | $0 |
| J. David Gladstone Institutes | San Francisco, CA | 5 | $7.5 million | 0 | $0 |
| University of Minnesota | Minneapolis, MN | 7 | $7.3 million | 0 | $0 |
| University of Illinois at Chicago | Chicago, IL | 3 | $7.3 million | 0 | $0 |
| Brown University | Providence, RI | 5 | $6.6 million | 0 | $0 |
| Thomas Jefferson University | Philadelphia, PA | 10 | $5.8 million | 0 | $0 |
| Cornell University | Ithaca, NY | 3 | $5.4 million | 0 | $0 |
| Weill Medical Coll of Cornell Univ | New York, NY | 5 | $5.4 million | 0 | $0 |
| Pennsylvania State Univ Hershey Med CTR | Hershey, PA | 3 | $5.1 million | 0 | $0 |
| University of Wisconsin-Madison | Madison, WI | 7 | $5 million | 0 | $0 |
| Regenerative Research Foundation | Albany, NY | 3 | $5 million | 0 | $0 |
| Temple Univ of the Commonwealth | Philadelphia, PA | 2 | $4.9 million | 0 | $0 |
| University of California-Irvine | Irvine, CA | 3 | $4.9 million | 0 | $0 |
| Upstate Medical University | Syracuse, NY | 5 | $4.8 million | 0 | $0 |
| ST. Joseph's Hospital and Medical Center | Phoenix, AZ | 3 | $4.8 million | 0 | $0 |
| Brigham and Women's Hospital | Boston, MA | 2 | $4.1 million | 0 | $0 |
| Massachusetts Institute of Technology | Cambridge, MA | 2 | $4.1 million | 0 | $0 |
| SUNY at Stony Brook | Stony Brook, NY | 3 | $4 million | 0 | $0 |
| Columbia University | New York, NY | 1 | $4 million | 0 | $0 |
| University of Maryland Baltimore | Baltimore, MD | 3 | $4 million | 0 | $0 |
| Synapticure, Inc. | Kenilworth, IL | 3 | $3.9 million | 0 | $0 |
| Enclear Therapies, Inc. | Newburyport, MA | 1 | $3.6 million | 0 | $0 |
| Scripps Research Institute, the | La Jolla, CA | 2 | $3.5 million | 0 | $0 |
| University of California-Santa Barbara | Santa Barbara, CA | 1 | $3.3 million | 0 | $0 |
| Baylor College of Medicine | Houston, TX | 4 | $3.2 million | 0 | $0 |
| New York Genome Center | New York, NY | 1 | $3.1 million | 0 | $0 |
| Cedars-Sinai Medical Center | Los Angeles, CA | 2 | $3 million | 0 | $0 |
| University of Arizona | Tucson, AZ | 4 | $3 million | 0 | $0 |
| University of Southern California | Los Angeles, CA | 2 | $2.8 million | 0 | $0 |
| Saint Louis University | Saint Louis, MO | 3 | $2.7 million | 0 | $0 |
| Boston University Medical Campus | Boston, MA | 2 | $2.6 million | 0 | $0 |
| Michigan State University | East Lansing, MI | 4 | $2.6 million | 0 | $0 |
| Oregon Health & Science University | Portland, OR | 4 | $2.6 million | 0 | $0 |
| Rutgers University New Brunswick | New Brunswick, NJ | 2 | $2.6 million | 0 | $0 |
| Univ of North Carolina Chapel Hill | Chapel Hill, NC | 5 | $2.5 million | 0 | $0 |
| Vanderbilt University Medical Center | Nashville, TN | 2 | $2.5 million | 0 | $0 |
| Lifesensors, Inc. | Malvern, PA | 1 | $2.5 million | 0 | $0 |
| University of Texas HLTH Sci CTR Houston | Houston, TX | 4 | $2.5 million | 0 | $0 |
| University of Notre Dame | Notre Dame, IN | 1 | $2.5 million | 0 | $0 |
| SUNY at Buffalo | Amherst, NY | 3 | $2.4 million | 0 | $0 |
| University of Utah | Salt Lake City, UT | 3 | $2.4 million | 0 | $0 |
| Wright State University | Dayton, OH | 1 | $2.3 million | 0 | $0 |
| Ludwig Institute for Cancer Res LTD | La Jolla, CA | 2 | $2.2 million | 0 | $0 |
| Ohio State University | Columbus, OH | 3 | $2.2 million | 0 | $0 |
| Northeastern University | Boston, MA | 1 | $2.1 million | 0 | $0 |
| University of Colorado at Boulder | Boulder, CO | 3 | $2 million | 0 | $0 |
| Harvard University | Cambridge, MA | 1 | $2 million | 0 | $0 |
| University of Virginia | Charlottesville, VA | 3 | $2 million | 0 | $0 |
| Automated Imaging Diagnostics, LLC | Gainesville, FL | 2 | $1.9 million | 0 | $0 |
| University of Rhode Island | Kingston, RI | 1 | $1.9 million | 0 | $0 |
| University of Illinois at Urbana-Champaign | Urbana, IL | 1 | $1.9 million | 0 | $0 |
| Salk Institute for Biological Studies | La Jolla, CA | 1 | $1.9 million | 0 | $0 |
| Amydis Diagnostics, Inc. | La Jolla, CA | 2 | $1.8 million | 0 | $0 |
| University of South Alabama | Mobile, AL | 2 | $1.5 million | 0 | $0 |
| Palo Alto Veterans Instit for Research | Palo Alto, CA | 1 | $1.4 million | 0 | $0 |
| George Washington University | Washington, DC | 1 | $1.2 million | 0 | $0 |
| Research Foundation CUNY - Advanced Science Research Center | New York, NY | 1 | $1.2 million | 0 | $0 |
| California Institute of Technology | Pasadena, CA | 1 | $1.1 million | 0 | $0 |
| Flanders Interuniv Inst Biotechnology | Gent | 1 | $1.1 million | 0 | $0 |
| Purdue University | West Lafayette, IN | 2 | $1.1 million | 0 | $0 |
| University of Cincinnati | Cincinnati, OH | 1 | $1.1 million | 0 | $0 |
| Harvard Medical School | Boston, MA | 2 | $948,104 | 0 | $0 |
| Texas Woman's University | Denton, TX | 1 | $934,383 | 0 | $0 |
| Methodist Hospital Research Institute | Houston, TX | 2 | $871,664 | 0 | $0 |
| University College London | London | 1 | $799,700 | 0 | $0 |
| University of Wyoming | Laramie, WY | 1 | $736,565 | 0 | $0 |
| Cayman Chemical Company, Inc. | Ann Arbor, MI | 1 | $734,479 | 0 | $0 |
| University of Nebraska Medical Center | Omaha, NE | 1 | $722,719 | 0 | $0 |
| Virtici, LLC | Seattle, WA | 1 | $700,000 | 0 | $0 |
| Myriel, Inc. | Saint Paul, MN | 1 | $699,984 | 0 | $0 |
Funding by fiscal year
| Fiscal year | NIH awards | NIH amount | NSF awards | NSF amount |
|---|---|---|---|---|
| 2025 | 281 | $268,735,856 | 0 | $0 |
| 2024 | 285 | $189,315,504 | 0 | $0 |
| 2023 | 257 | $175,086,589 | 0 | $0 |
| 2022 | 240 | $160,521,056 | 0 | $0 |
| 2021 | 220 | $149,280,483 | 0 | $0 |
Open federal funding opportunities
From Grants.gov: notices that funded awards in this table, and open notices on the same agency and assistance listing.
Updated November 3, 2026. Read from NIH RePORTER ExPORTER and NSF Award Search. Published by NIH and NSF as U.S. government data. NIH awards are fiscal years 2021 to 2025 (NIH files published to 2026-07-09); NSF awards are fiscal years 2022 to 2026 (NSF files published to 2026-11-02). NIH amounts are the total cost of each fiscal year in the window; NSF amounts are the funds obligated in the window. Organizations are matched on the UEI. Open opportunities come from Grants.gov and match on agency and assistance listing number, and on the notice number NIH prints on an award. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.