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Data / Research funding / Cocaine

Cocaine: 427 NIH awards ($581.8M) to 160 organizations

427 NIH awards ($581.8M) in the NIH spending category Cocaine, to 160 organizations, read 2026-11-04. NIH fiscal years 2021 to 2025.

SpecStream is the live web data engine for teams and agents. It reads the NIH and NSF award files each time the agencies update them, and this page is that reading, joined to the open federal funding opportunities on Grants.gov. Ask for the awards you track by topic, organization or state and new awards arrive in your sheet, CRM, Slack or agent as the agencies publish them.

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Awards

427 awards in the window.

AwardAgencyInstitute or divisionFiscal yearAmount in windowStartEndPrincipal investigatorSource
NIDA Clinical Trials Network: Big South/West Node (CTN-0132 and CTN-0139)NIHNational Institute on Drug Abuse2021 to 2025$43,417,361March 1, 2025February 28, 2032TRIVEDI, MADHUKAR H.reporter.nih.gov
The Florida Node Alliance of the National Drug Abuse Clinical Trials Network (CTN-121)NIHNational Institute on Drug Abuse2021 to 2025$26,301,696March 1, 2025February 29, 2028SZAPOCZNIK, JOSEreporter.nih.gov
Single cell transcriptomic and epigenomic changes during chronic HIV infection and cocaine self-administrationNIHNational Institute on Drug Abuse2022 to 2025$14,516,969June 1, 2022March 31, 2027ZENG, HONGKUIreporter.nih.gov
Single Cell Transcriptomic and Epigenomic Dissection of Opioid and Cocaine Responses in HIVNIHNational Institute on Drug Abuse2021 to 2025$12,564,620September 1, 2021June 30, 2027KELLIS, MANOLISreporter.nih.gov
Development of PPL-138, a Novel Mixed NOP/Mu Partial Agonist for Treatment of CocaineUse DisorderNIHNational Institute on Drug Abuse2022 to 2024$8,683,509September 30, 2022July 31, 2025TOLL, LAWRENCE Rreporter.nih.gov
Development of a Long-acting Enzyme Therapy for Treatment of Cocaine AbuseNIHNational Institute on Drug Abuse2021 to 2022$8,242,506August 15, 2020April 30, 2026ZHAN, CHANG-GUOreporter.nih.gov
Single cell determinants of brain in the context of viral persistence in SIV/cART/cocaine non-human primatesNIHNational Institute on Drug Abuse2023 to 2025$7,434,979June 1, 2023February 29, 2028RANA, TARIQ Mreporter.nih.gov
Cohort Studies of HIV/AIDS and Substance Use in MiamiNIHNational Institute on Drug Abuse2025$7,372,834September 30, 2025June 30, 2030BAUM, MARIANNA Kreporter.nih.gov
Development of sigma receptor/DAT dual-targeting compounds to treat stimulant use disorderNIHNational Institute on Drug Abuse2023 to 2024$6,903,733August 15, 2023July 31, 2026REICH, JEFFREYreporter.nih.gov
PDE7 Inhibitor for the Treatment of Cocaine Use DisorderNIHNational Institute on Drug Abuse2023 to 2025$6,689,019April 15, 2023March 31, 2027GAITANARIS, GEORGEreporter.nih.gov
Single Cell Transcriptomics of the Cocaine Use Disorder in the Context of HIVNIHNational Institute on Drug Abuse2022 to 2025$6,266,450June 15, 2022March 31, 2027CHENG, CHRISTINEreporter.nih.gov
Effects of HIV, Cocaine, and Prolonged ART Use on Subclinical Cardiovascular DiseaseNIHNational Institute on Drug Abuse2021 to 2024$5,744,264June 1, 2016April 30, 2025LAI, SHENGHANreporter.nih.gov
TMP-301, A Negative Allosteric Modulator of type 5 metabotropic glutamate receptors (mGluR5), for Treatment of Cocaine Use DisorderNIHNational Institute on Drug Abuse2022 to 2023$5,310,920September 1, 2022August 31, 2025MEYERS, CHARLES DANIELreporter.nih.gov
Development of TNX-1300 (Double Mutant Cocaine Esterase) for the Treatment of Life-Threatening Cocaine IntoxicationNIHNational Institute on Drug Abuse2022 to 2025$5,181,674August 1, 2022November 30, 2025SULLIVAN, GREGORY Mreporter.nih.gov
Discovery of Addiction-Related Genes with Advanced Mouse ResourcesNIHNational Institute on Drug Abuse2021 to 2025$4,405,786April 1, 2015May 31, 2027CHESLER, ELISSA Jreporter.nih.gov
Single nuclei transcriptome profiling in addiction circuitry of the HIV+ brainNIHNational Institute on Drug Abuse2021 to 2025$4,310,228April 1, 2021February 28, 2027AKBARIAN, SCHAHRAMreporter.nih.gov
Identification of Genetic Variants that Contribute to Compulsive Cocaine Intakein RatsNIHNational Institute on Drug Abuse2021 to 2025$3,976,898April 1, 2017June 30, 2027GEORGE, OLIVIERreporter.nih.gov
Early Life Stress, Chronic Drug Use and Neuroplasticity in Nonhuman Primate Models of Cocaine Abuse: Relevance to Treatment StrategiesNIHNational Institute on Drug Abuse2021 to 2025$3,974,079April 1, 2021January 31, 2027SANCHEZ, MAR Mreporter.nih.gov
The Comparative Effectiveness and Safety of Pharmacotherapies for the Treatment of Opioid Use Disorder in PregnancyNIHNational Institute on Drug Abuse2021 to 2025$3,680,536April 1, 2020May 31, 2029HUYBRECHTS, KRISTA Freporter.nih.gov
Understanding neuronal subtype-specific function of NAc in cocaine addictionNIHNational Institute on Drug Abuse2021 to 2025$3,661,419April 1, 2021February 28, 2026ZHANG, YIreporter.nih.gov
Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C UCB J PET StudyNIHNational Institute on Drug Abuse2021 to 2025$3,657,020July 1, 2021April 30, 2027ANGARITA, GUSTAVO ADOLFOreporter.nih.gov
Small molecule modulators of ΔFosBNIHNational Institute on Drug Abuse2021 to 2025$3,586,553July 1, 2016March 31, 2027RUDENKO, GABRIELLEreporter.nih.gov
PTPRD Phosphatase inhibitors for stimulant use disordersNIHNational Institute on Drug Abuse2022 to 2024$3,540,141July 1, 2022June 30, 2025UHL, GEORGE RICHARDreporter.nih.gov
Allosteric Modulators of Dopamine Transporter as Therapeutic Agents for NeuroAIDSNIHNational Institute on Drug Abuse2021 to 2024$3,446,099July 1, 2020April 30, 2026AUGELLI-SZAFRAN, CORINNE ELIZABETHreporter.nih.gov
Epigenetic mechanisms of sustained transcription across cocaine abstinenceNIHNational Institute on Drug Abuse2021 to 2025$3,351,544July 1, 2021May 31, 2026HELLER, ELIZABETH Areporter.nih.gov
Drug development of clavulanic acid, a GLT-1 activator: proof of concept for cocaine use disorderNIHNational Institute on Drug Abuse2022 to 2023$3,340,215May 15, 2020December 31, 2024MORRISON, MARY F.reporter.nih.gov
Genetics of novelty seeking and propensity for drug abuse in outbred ratsNIHNational Institute on Drug Abuse2021 to 2025$3,193,903September 1, 2023June 30, 2028AKIL, HUDAreporter.nih.gov
Cocaine use, viral suppression and precursors of stroke in HIV infectionNIHNational Institute on Drug Abuse2021 to 2024$3,185,105June 1, 2020April 30, 2026RILEY, ELISE D.reporter.nih.gov
Contingency management plus deep transcranial magnetic stimulation for the treatment of cocaine use disorderNIHNational Institute on Drug Abuse2025$3,119,619September 15, 2025June 30, 2029SCHMITZ, JOY MARIEreporter.nih.gov
PET Imaging of neurochemical transmission in cocaine use disordersNIHNational Institute on Drug Abuse2021 to 2025$3,096,100September 30, 2009June 30, 2027NARENDRAN, RAJESHreporter.nih.gov
Mechanisms Mediating Cocaine Abuse in Socially Housed Female and Male MonkeysNIHNational Institute on Drug Abuse2021 to 2025$3,072,958September 1, 2001May 31, 2029NADER, MICHAEL Areporter.nih.gov
cART, neuroHIV, cocaine abuse and the mPFC neuron/astrocyte dysfunctionNIHNational Institute on Drug Abuse2022 to 2025$3,070,264September 15, 2022August 31, 2027HU, XIU-TIreporter.nih.gov
Treating Polysubstance Use in Methadone Maintenance: Application of Novel Digital TechnologyNIHNational Institute on Drug Abuse2022 to 2025$3,027,776September 30, 2022July 31, 2027ALEXANDER, KARENreporter.nih.gov
Atherosclerosis in cocaine addiction: imaging risk with PET/MRNIHNational Institute on Drug Abuse2022 to 2025$3,015,410June 1, 2022March 31, 2027ALIA-KLEIN, NELLYreporter.nih.gov
AIM(2)ing at the inflammasome: Impact of MAVS signaling in cocaine-and HIV-1 induced neuroinflammationNIHNational Institute on Drug Abuse2021 to 2025$3,004,104March 15, 2021February 28, 2027CISNEROS, IRMAreporter.nih.gov
Molecular Studies of Cocaine Action in BrainNIHNational Institute on Drug Abuse2021 to 2025$2,971,622August 1, 1991January 31, 2026NESTLER, ERIC J.reporter.nih.gov
Role of GRIN2 in ART and SUD associated neurological deficits.NIHNational Institute on Drug Abuse2022 to 2025$2,965,829September 15, 2022August 31, 2027DASH, CHANDRAVANUreporter.nih.gov
The Development and Evaluation of Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders (EDITOR)NIHNational Institute on Drug Abuse2022 to 2024$2,923,597July 1, 2023June 30, 2025NWAOKOBIA, CHARLES CHIEDUreporter.nih.gov
D1 and D2 Dopaminoceptive Ensembles in Limbic Brain Regions in Drug AddictionNIHNational Institute on Drug Abuse2021 to 2025$2,909,999September 1, 2000April 30, 2030NESTLER, ERIC J.reporter.nih.gov
Reelin Signaling and Function in Cocaine ResponseNIHNational Institute on Drug Abuse2021 to 2025$2,847,900July 1, 2021April 30, 2027DAY, JEREMY Jreporter.nih.gov
An Experimental Medicine Approach for the Mechanistic Understanding of Cocaine Use Disorder: Reinforcer PathologyNIHNational Institute on Drug Abuse2022 to 2025$2,821,784July 15, 2022April 30, 2027LACONTE, STEPHEN Mreporter.nih.gov
In Vivo Characterization of 5-HT7 Modulators in Rat Models of Cocaine Use DisorderNIHNational Institute on Drug Abuse2022 to 2024$2,820,000June 1, 2022May 31, 2026PIPPIN, DOUGLAS ANTHONYreporter.nih.gov
Drug abuse and HIV-associated pulmonary vascular injuryNIHNational Heart, Lung, and Blood Institute2021 to 2024$2,784,947February 1, 2021December 31, 2025DHILLON, NAVNEET KAURreporter.nih.gov
Gene Network Identification and Integration (GNetii) Approach to Understanding the Biology Underlying HIV and Drug Abuse.NIHNational Institute on Drug Abuse2021 to 2024$2,762,265August 1, 2020May 31, 2026JOHNSON, ERIC OTTOreporter.nih.gov
Sex differences in the neural correlates underlying impairments in response inhibition and salience attribution in cocaine addictionNIHNational Institute on Drug Abuse2021 to 2024$2,749,037April 1, 2020February 28, 2025GOLDSTEIN, RITA Zreporter.nih.gov
Altered Midbrain GABAergic Circuitry Drives Greater Cocaine Self-administrationNIHNational Institute on Drug Abuse2021 to 2025$2,670,057May 15, 2021February 28, 2026DANI, JOHN A.reporter.nih.gov
Epigenetic mechanisms in the medial habenula governing drug-seeking behaviorNIHNational Institute on Drug Abuse2021 to 2024$2,638,720July 15, 2020April 30, 2026WOOD, MARCELO ANDRESreporter.nih.gov
Cocaine-induced mitochondrial mechanisms and molecular mediators in reward circuitryNIHNational Institute on Drug Abuse2021 to 2025$2,612,514September 15, 2014June 30, 2027LOBO, MARY KAYreporter.nih.gov
Role of Gadd45b in Cocaine-driven Epigenetic and Behavioral DynamicsNIHNational Institute on Drug Abuse2022 to 2025$2,581,972May 1, 2022March 31, 2027DAY, JEREMY Jreporter.nih.gov
Laboratories for Early Clinical Evaluation of Pharmacotherapies for Substance Use DisordersNIHNational Institute on Drug Abuse2021 to 2024$2,568,075May 1, 2020January 31, 2026MOELLER, FREDERICK GERARDreporter.nih.gov
A Clinical Laboratory with Integrated Neuroscience (CLIN) for Early Evaluation of Medications for Substance Use DisordersNIHNational Institute on Drug Abuse2021 to 2024$2,557,655May 1, 2020January 31, 2026KAMPMAN, KYLE MATTHEWreporter.nih.gov
Kappa Opioid Receptors and Phospho-Dopamine Transporters Drive Cocaine RewardNIHNational Institute on Drug Abuse2022 to 2025$2,532,199September 15, 2022June 30, 2027RAMAMOORTHY, SAMMANDAreporter.nih.gov
Genetics of Cocaine Sensitivity in DrosophilaNIHNational Institute on Drug Abuse2021 to 2025$2,469,830September 15, 2017April 30, 2027MACKAY, TRUDY F.reporter.nih.gov
Parvalbumin interneurons regulate nucleus accumbens synapses and behaviorNIHNational Institute on Drug Abuse2021 to 2025$2,435,138September 1, 2016May 31, 2026GRUETER, BRAD ALANreporter.nih.gov
MEDICATION DISCOVERY USING RAT MODELS OF RELAPSE. PERIOD OF PERFORMANCE: 7/10/2019-7/9/2024. N01DA-19-8949NIHNational Institute on Drug Abuse2022 to 2023$2,430,107July 10, 2019July 9, 2024SHELTON, KEITHreporter.nih.gov
Mechanisms of dopaminergic dysfunction in substance use disorderNIHNational Institute on Drug Abuse2021 to 2025$2,425,095September 30, 2021July 31, 2026CALIPARI, ERINreporter.nih.gov
Neighborhood conditions, neural circuits, and substance use behaviors across the early life course.NIHNational Institute on Drug Abuse2025$2,314,254September 30, 2025June 30, 2029BARR, PETER BRENDANreporter.nih.gov
Impact of prescription stimulants on the drug overdose epidemicNIHNational Institute on Drug Abuse2023 to 2025$2,253,245May 1, 2023March 31, 2028DE NADAI, ALESSANDRO STEVENSreporter.nih.gov
Autophagic regulation of cocaine abuseNIHNational Institute on Drug Abuse2022 to 2025$2,222,317August 15, 2022May 31, 2027HE, CONGCONGreporter.nih.gov
Glial-mediated synaptic remodeling in drug addictionNIHNational Institute on Drug Abuse2022 to 2025$2,202,322June 1, 2016April 30, 2027DONG, YANreporter.nih.gov
Circadian Rhythms and Cocaine Use DisorderNIHNational Institute on Drug Abuse2021 to 2025$2,173,145August 1, 2021May 31, 2026FERRIS, MARK Jreporter.nih.gov
Investigate Host Gene Isoforms Contributing to HIV Persistence in Cocaine UsersNIHNational Institute on Drug Abuse2023 to 2025$2,161,166September 30, 2023July 31, 2028ZHU, JIANreporter.nih.gov
Cocaine, Parvalbumin, and Perineuronal NetsNIHNational Institute on Drug Abuse2023 to 2025$2,155,184April 1, 2023January 31, 2028SORG, BARBARA Areporter.nih.gov
5-HT2 Receptor Allosterism in Cocaine Use DisorderNIHNational Institute on Drug Abuse2022 to 2025$2,154,204August 1, 2015April 30, 2027ZHOU, JIAreporter.nih.gov
Cocaine-induced adaptation in NMDA receptorsNIHNational Institute on Drug Abuse2021 to 2025$2,139,400December 1, 2022November 30, 2027DONG, YANreporter.nih.gov
Comorbidities and other consequences at the intersection of the HIV and substance use epidemicsNIHNational Institute on Drug Abuse2023 to 2025$2,110,949September 1, 2023June 30, 2028CRANE, HEIDI M.reporter.nih.gov
Inflammasome activation in an SIV-ART model of chronic drug abuseNIHNational Institute on Drug Abuse2021 to 2023$2,104,458September 30, 2019July 31, 2025VEENHUIS, REBECCA TERILLIreporter.nih.gov
Individual Differences & Cocaine Effects on Impulsive Choice in RatNIHNational Institute on Drug Abuse2022 to 2025$2,102,499July 1, 2016March 31, 2027TAYLOR, JANE Rreporter.nih.gov
Immune mechanisms that shape the blood brain barrier in people living with HIV and cocaine use disorderNIHNational Institute on Drug Abuse2024 to 2025$2,096,862June 1, 2024March 31, 2029VEENHUIS, REBECCA TERILLIreporter.nih.gov
Benzodiazepine Choice and Polydrug UseNIHNational Institute on Drug Abuse2022 to 2025$2,074,200April 1, 2022January 31, 2027HUSKINSON, SALLY Lreporter.nih.gov
New psychoactive substance exposure among NYC nightclub and festival attendeesNIHNational Institute on Drug Abuse2023 to 2025$2,051,804August 15, 2023May 31, 2027PALAMAR, JOSEPH Jreporter.nih.gov
Dopaminergic and Glutamatergic Mechanisms of Cocaine Addiction: Sex DifferencesNIHNational Institute on Drug Abuse2022 to 2025$2,046,903April 1, 2008May 31, 2027LYNCH, WENDY JEANreporter.nih.gov
Targeting gut brain-signaling to reduce cocaine seeking behaviorsNIHNational Institute on Drug Abuse2023 to 2025$2,040,985September 1, 2023June 30, 2028KIRALY, DREWreporter.nih.gov
Retinoic acid, homeostatic plasticity and cocaine cravingNIHNational Institute on Drug Abuse2021 to 2024$2,026,004March 15, 2020December 31, 2025WOLF, MARINA ELIZABETHreporter.nih.gov
Neural mechanisms regulating cocaine consumptionNIHNational Institute on Drug Abuse2021 to 2024$2,000,599July 15, 2020April 30, 2026PHILLIPS, PAUL E. M.reporter.nih.gov
Mitochondrial signaling dynamics in cocaine use disorderNIHNational Institute on Drug Abuse2023 to 2025$1,977,342August 15, 2023June 30, 2028ABRAHAM, ANTONY DANIELreporter.nih.gov
Stimulant and Polysubstance use, Inflammation and Sex Effects on Myocardial Disease in HIV (SPISE)NIHNational Institute on Drug Abuse2025$1,969,877July 15, 2025March 31, 2030TIEN, PHYLLIS Creporter.nih.gov
Novel Addiction Neurocircuits in Cocaine TakingNIHNational Institute on Drug Abuse2022 to 2025$1,955,360April 1, 2022January 31, 2027HOMMEL, JONATHAN DEANreporter.nih.gov
Examining predictors of substance use and treatment adequacy among formerly incarcerated opiod and cocaine usersNIHNational Institute on Drug Abuse2022 to 2024$1,937,137August 1, 2022June 30, 2027ROWELL-CUNSOLO, TAWANDRA LASHONEreporter.nih.gov
Regulation of striatal microcircuits by endogenous opioids as a novel mechanism underlying cocaine seekingNIHNational Institute on Drug Abuse2022 to 2025$1,936,984August 1, 2022May 31, 2027DOBBS, LAUREN Kreporter.nih.gov
Cocaine: effects on single neuronsNIHNational Institute on Drug Abuse2021 to 2025$1,925,000July 1, 1987July 31, 2027WILLIAMS, JOHN Treporter.nih.gov
SARS-CoV-2 signaling and interactions with stimulant drugs of abuse via Sigma-1R: Impact on the BBBNIHNational Institute on Drug Abuse2022 to 2025$1,914,927July 1, 2022April 30, 2027UNTERWALD, ELLEN Mreporter.nih.gov
Molecular mechanisms underlying HIV & Cocaine-mediated microglial activation: Targeting NLRP3 inflammasomeNIHNational Institute on Drug Abuse2021 to 2023$1,904,596September 30, 2019July 31, 2025BUCH, SHILPA J.reporter.nih.gov
Pioglitazone as an adjunct to CBT for cocaine relapse preventionNIHNational Institute on Drug Abuse2021 to 2023$1,864,756July 1, 2020May 31, 2025SCHMITZ, JOY MARIEreporter.nih.gov
Glutamergic Mechanisms in Opioid and Cocaine Co-UseNIHNational Institute on Drug Abuse2022 to 2024$1,854,763September 30, 2020August 31, 2025GIPSON-REICHARDT, CASSANDRA Dreporter.nih.gov
Incubated drug-craving and neurochemical interactionsNIHNational Institute on Drug Abuse2021 to 2025$1,780,211April 15, 2021December 31, 2025SZUMLINSKI, KAREN KATHLEENreporter.nih.gov
Neural systems mediating the extinction and inhibition of cocaine seekingNIHNational Institute on Drug Abuse2021 to 2024$1,771,684July 15, 2020April 30, 2026LALUMIERE, RYAN Treporter.nih.gov
Mechanisms underlying the influence of stress on drug-seeking behaviorNIHNational Institute on Drug Abuse2023 to 2025$1,764,926July 1, 2023April 30, 2028MANTSCH, JOHN Rreporter.nih.gov
Calcium-related neurotoxicity of cocaineNIHNational Institute on Drug Abuse2021 to 2025$1,729,326February 15, 2012January 31, 2027DU, CONGWUreporter.nih.gov
Molecular mechanisms: Dysregulation of monoamine transporters by HIV-1 Tat and cocaineNIHNational Institute on Drug Abuse2021 to 2024$1,726,798July 1, 2013April 30, 2025ZHU, JUNreporter.nih.gov
Hippocampal mechanisms of cocaine-memory reconsolidationNIHNational Institute on Drug Abuse2023 to 2025$1,719,615June 1, 2023March 30, 2028FUCHS LOKENSGARD, RITA Areporter.nih.gov
PACAP-Dependent Coordination of Glutamate Signaling between Neurons and AstrocytesNIHNational Institute on Drug Abuse2021 to 2025$1,708,450August 15, 2020April 30, 2027BAKER, DAVID Areporter.nih.gov
Nitrergic interneurons and cue-induced cocaine seekingNIHNational Institute on Drug Abuse2021 to 2025$1,697,532August 1, 2021May 31, 2027SCOFIELD, MICHAEL DAVIDreporter.nih.gov
Genetic and hormonal contributions to sex differences in vulnerability to drug useNIHNational Institute on Drug Abuse2021 to 2024$1,691,545March 1, 2020December 31, 2025LYNCH, WENDY JEANreporter.nih.gov
Nature and Predictors of Impaired Harm Avoidance in Polysubstance AbuseNIHNational Institute on Drug Abuse2021 to 2023$1,690,491July 1, 2018June 30, 2026OTTO, MICHAEL W.reporter.nih.gov
Diurnal rhythms in the nucleus accumbens: Mechanisms and role in substance use disordersNIHNational Institute on Drug Abuse2021 to 2024$1,678,144July 1, 2015March 31, 2026MCCLUNG, COLLEEN Areporter.nih.gov
Host and viral genomic determinants of HIV latent reservoir size and characteristics in individuals with substance use disordersNIHNational Institute on Drug Abuse2022 to 2023$1,677,906August 15, 2018May 31, 2024SILICIANO, ROBERT Freporter.nih.gov
Cognitive Reappraisal for Mitigating Incubation of Cocaine Cue-ReactivityNIHNational Institute on Drug Abuse2024 to 2025$1,675,624September 30, 2023August 31, 2028PARVAZ, MUHAMMAD ADEELreporter.nih.gov
Assessing central muscarinic acetylcholine type-1 receptors in cocaine use disorder with 11C-LSN3172176.NIHNational Institute on Drug Abuse2024 to 2025$1,664,691April 15, 2022June 30, 2027ANGARITA, GUSTAVO ADOLFOreporter.nih.gov
Non-beta-lactam GLT-1 activators: characterization in preclinical models of opioid and cocaine addictionNIHNational Institute on Drug Abuse2021 to 2024$1,661,677September 30, 2020June 30, 2025RAWLS, SCOTT M.reporter.nih.gov
Circuitry and function of ventral striatum subregionsNIHNational Institute on Drug Abuse2021 to 2024$1,660,649April 1, 2020January 31, 2026WESSON, DANIEL Wreporter.nih.gov
Memory Destabilization and Cocaine-Cue Induced Reinstatement in RatNIHNational Institute on Drug Abuse2021 to 2025$1,653,750July 1, 2021April 30, 2027TAYLOR, JANE Rreporter.nih.gov
L-Type Calcium Channel Mechanisms Mediating Comorbid Substance Use and Mood DisordersNIHNational Institute on Drug Abuse2021 to 2024$1,645,542September 30, 2020July 31, 2025ADDY, NII Areporter.nih.gov
Development of selective cannabinoid receptor 2 agonists for treatment of addictionNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,621,997April 19, 2022April 30, 2027SHAMLOO, MEHRDADreporter.nih.gov
Epigenetic regulation of Cdk5 in cognition and emotionNIHNational Institute of Mental Health2023 to 2025$1,621,522January 1, 2023October 31, 2027HELLER, ELIZABETH Areporter.nih.gov
Transdermal Rotigotine as Adjunct to Behavioral Therapy for Cocaine Use DisorderNIHNational Institute on Drug Abuse2022$1,597,923September 30, 2022September 29, 2025BJORK, JAMES Mreporter.nih.gov
Transgenerational Inheritance of a Cocaine Resistance PhenotypeNIHNational Institute on Drug Abuse2023 to 2025$1,594,735April 1, 2012January 31, 2027PIERCE, ROBERT CHRISTOPHERreporter.nih.gov
Cholinergic interneuron D2 receptor function in impulsive behavior: implications for addictionNIHNational Institute on Drug Abuse2022 to 2025$1,571,833July 1, 2022May 31, 2027GALLO, EDUARDO FRANCISCOreporter.nih.gov
Supporting Treatment Adherence for Resilience and Thriving (START): A mHealth intervention to improve ART adherence for HIV-positive stimulant-using menNIHNational Institute on Drug Abuse2021 to 2022$1,555,079September 30, 2019July 31, 2024CARRICO, ADAM WAYNEreporter.nih.gov
Vagus nerve stimulation modulates synaptic plasticity in the rat prefrontal cortex during the extinction of drug-seekingNIHNational Institute on Drug Abuse2022 to 2025$1,554,112April 1, 2022January 31, 2027KROENER, SVENreporter.nih.gov
Genetic Control of Addiction by Host and MicrobiomeNIHNational Institute on Drug Abuse2021 to 2022$1,533,193September 30, 2018July 31, 2024BUBIER, JASON Areporter.nih.gov
Domain- and protein-selective BET mechanisms in cocaine-seeking behaviorsNIHNational Institute on Drug Abuse2023 to 2025$1,521,368August 1, 2023May 31, 2028SARTOR, GREGORY CHARLESreporter.nih.gov
Effects of intrinsic and drug-induced neuromodulation on functional brain imagingNIHNational Institute on Drug Abuse2021 to 2024$1,517,943August 1, 2020May 31, 2025DEVOR, ANNAreporter.nih.gov
Role of the NLRP3 Inflammasome in Mediating Microglial Activation and Development of Neuropsychiatric Symptoms Induced by HIV, Antiretrovirals and CocaineNIHNational Institute on Drug Abuse2021 to 2023$1,515,246August 15, 2021June 30, 2024GUO, MINGLEIreporter.nih.gov
Restoration and Further Assessment of the Actor-Critic Circuit and Connected Areas After Cocaine Self-AdministrationNIHNational Institute on Drug Abuse2021 to 2025$1,495,707July 1, 2011February 29, 2028ROESCH, MATTHEW Rreporter.nih.gov
A novel opioid receptor antagonist for treating abuse and overdoseNIHNational Institute on Drug Abuse2021 to 2023$1,477,314April 1, 2019February 28, 2025FRANCE, CHARLES Preporter.nih.gov
Glutamate and Craving for CocaineNIHNational Institute on Drug Abuse2021 to 2024$1,472,920February 10, 2000March 31, 2025KALIVAS, PETER Wreporter.nih.gov
Examining Mechanisms Underlying Drug-Associated Memory Erasure by Zeta-Inhibitory PeptideNIHNational Institute on Drug Abuse2021 to 2023$1,470,367April 15, 2019January 31, 2025BRIAND, LISA Areporter.nih.gov
Systems genetics of premorbid and cocaine use traits in a rat reduced complexity crossNIHNational Institute on Drug Abuse2022 to 2023$1,444,164May 1, 2022December 31, 2023KANTAK, KATHLEEN M.reporter.nih.gov
Bath Salts: abuse-related and toxic effectsNIHNational Institute on Drug Abuse2021 to 2024$1,439,490April 1, 2015March 31, 2026COLLINS, GREGORY THOMASreporter.nih.gov
Dissecting the role of ventral pallidal circuitry in cocaine seeking after the withdrawalNIHNational Institute on Drug Abuse2021 to 2024$1,425,586July 15, 2020April 30, 2025LIM, BYUNGKOOKreporter.nih.gov
Neural Mechanisms of Individual Differences in Cocaine AvoidanceNIHNational Institute on Drug Abuse2023 to 2025$1,404,531August 1, 2021May 31, 2026JHOU, THOMAS Creporter.nih.gov
Impacts of drug abuse-mediated inflammatory perturbations on affinity maturation of anti-CD4 autoantibodies and poor immune reconstitution from ART in HIVNIHNational Institute on Drug Abuse2024 to 2025$1,402,812September 30, 2024May 31, 2029JIANG, WEIreporter.nih.gov
Modulating ventral striatal activity and connectivity with transcranial focused ultrasound as a putative novel intervention for cocaine use disorderNIHNational Institute on Drug Abuse2024 to 2025$1,395,182June 15, 2024May 31, 2027PHILLIPS, MARY LOUISEreporter.nih.gov
Selective Targeting of Nicotinic Acetylcholine Receptor Subtypes for Cocaine Use DisorderNIHNational Institute on Drug Abuse2024 to 2025$1,393,000March 1, 2024December 31, 2028RILEY, ANDREWreporter.nih.gov
Estrogen regulation of the prefrontal cortex and drug seekingNIHNational Institute on Drug Abuse2021 to 2024$1,390,995July 1, 2020April 30, 2026MANTSCH, JOHN R.reporter.nih.gov
Using Omics to Understand the Effects of Drug Abuse on HIV Latent ReservoirNIHNational Institute on Drug Abuse2021 to 2022$1,377,622August 15, 2018May 31, 2025JOHNSON, ERIC OTTOreporter.nih.gov
Sleep Disturbances During Cocaine Abstinence, Dopamine Adaptations, and Motivation for CocaineNIHNational Institute on Drug Abuse2023 to 2025$1,375,686May 1, 2023February 29, 2028ESPAÑA, RODRIGO A.reporter.nih.gov
Animal Models of AddictionNIHNational Institute on Drug Abuse2021 to 2023$1,368,000December 1, 2018November 30, 2024FERRARIO, CARRIEreporter.nih.gov
Pathway-specific Intervention in Prelimbic Cortical Circuitry Decreases Cocaine-seekingNIHNational Institute on Drug Abuse2021 to 2024$1,357,969September 30, 2020July 31, 2025MCGINTY, JACQUELINE F.reporter.nih.gov
Regulating dopamine transport through allosteric modulation - Functional and Behavioral StudiesNIHNational Institute on Drug Abuse2024 to 2025$1,337,160September 15, 2024May 31, 2029MORTENSEN, OLE VALENTEreporter.nih.gov
Dissecting the shared genetic mechanisms driving fentanyl addiction, cocaine addiction, and incentive sensitization using the Collaborative Cross mouse panelNIHNational Institute on Drug Abuse2024 to 2025$1,331,986June 1, 2024March 31, 2029DICKSON, PRICE EVANSreporter.nih.gov
CELL - AND CIRCUIT - SPECIFIC EXPLORATION OF HIV NEUROGENOMICS IN CONTEXT OF OPIATE AND COCAINE ABUSENIHNational Institute on Drug Abuse2023 to 2024$1,327,322June 1, 2019March 31, 2026AKBARIAN, SCHAHRAMreporter.nih.gov
Systems genetics of premorbid and cocaine use traits in a rat reduced complexity crossNIHNational Institute on Drug Abuse2024 to 2025$1,325,341March 7, 2024February 28, 2028BRYANT, CAMRON Dreporter.nih.gov
Involvement of Cortical Excitatory Projections in Cocaine AddictionNIHNational Institute on Drug Abuse2024 to 2025$1,324,728September 30, 2024May 31, 2029MA, YAO-YINGreporter.nih.gov
Microglial modulation of neurocircuits in HIV/cocaine comorbidityNIHNational Institute on Drug Abuse2023 to 2024$1,323,376June 1, 2023March 31, 2025BOOZE, ROSEMARIE Mreporter.nih.gov
A cutaneous gene therapy for cocaine abuse and alcohol co-abuseNIHNational Institute on Drug Abuse2021 to 2023$1,312,200September 30, 2019July 31, 2025XU, MINGreporter.nih.gov
Ventral pallidum molecular mediators in cocaine addictionNIHNational Institute on Drug Abuse2021 to 2023$1,302,852February 1, 2019November 30, 2024LOBO, MARY KAYreporter.nih.gov
Opioid and Psychostimulant Taking: Testing the Impact of Behavioral Economic ContextsNIHNational Institute on Drug Abuse2022 to 2025$1,280,955September 15, 2022July 31, 2027KEARNS, DAVID Nreporter.nih.gov
Influence of 5-HT1b Activation on the Abuse Related Effects of CocaineNIHNational Institute on Drug Abuse2021 to 2022$1,280,534August 1, 2021July 31, 2025STOOPS, WILLIAM WALTONreporter.nih.gov
HIV and cocaine use leads to loss of astrocyte neurotrophic support and impaired lipid homeostasis in the brainNIHNational Institute of Neurological Disorders and Stroke2022 to 2023$1,272,487September 20, 2022August 31, 2026LANGFORD, DIANNE TERESAreporter.nih.gov
Antecedents and Consequences of Cocaine Taking: Impact of OxytocinNIHNational Institute on Drug Abuse2021 to 2022$1,241,165September 1, 2017May 31, 2024EVANS, SUZETTE Mreporter.nih.gov
Human dopamine transporter gene: variation and transcriptional regulationNIHNational Institute on Drug Abuse2021 to 2024$1,230,000September 1, 2007July 31, 2025LIN, ZHICHENG CARLreporter.nih.gov
Genomic Analysis of Avoidance Learning in AddictionNIHNational Institute on Drug Abuse2021 to 2022$1,223,491April 15, 2018June 4, 2023JHOU, THOMAS Creporter.nih.gov
A translational determination of the mechanisms of maladaptive choice in cocaine use disorderNIHNational Institute on Drug Abuse2021 to 2022$1,222,073July 1, 2018April 30, 2024LILE, JOSHUA ANTHONYreporter.nih.gov
Estradiol signaling pathways mediating sex differences in striatal synaptic plasticityNIHNational Institute on Drug Abuse2024 to 2025$1,218,955February 1, 2024January 31, 2028BLACKWELL, KIM Lreporter.nih.gov
Diagnostic and prognostic biomarkers for subtypes of addiction-related circuit dysfunctionNIHNational Institute on Drug Abuse2021 to 2022$1,207,946August 1, 2019May 31, 2024LISTON, CONOR Mreporter.nih.gov
Low-intensity focused ultrasound for cocaine use disorder: High resolution targeting of the human insulaNIHNational Institute on Drug Abuse2022 to 2023$1,197,126August 1, 2022January 31, 2025AIT-DAOUD, NASSIMAreporter.nih.gov
The role of central GLP-1 receptors in animal models of cocaine addictionNIHNational Institute on Drug Abuse2021 to 2023$1,188,835March 1, 2015May 31, 2025SCHMIDT, HEATH Dreporter.nih.gov
Dissecting the Abuse Liability of Cathinone and Amphetamine StimulantsNIHNational Institute on Drug Abuse2023 to 2025$1,185,000September 30, 2016July 31, 2028TAFFE, MICHAEL A.reporter.nih.gov
Dissection of Addiction Relevant Signal Integration by Cyfip2 through Precise Genome EngineeringNIHNational Institute on Drug Abuse2021 to 2024$1,178,521July 15, 2020June 30, 2025KUMAR, VIVEKreporter.nih.gov
A2: Striosomal models of drug use and costNIHNational Institute on Drug Abuse2024 to 2025$1,173,870September 15, 2024May 31, 2029FRIEDMAN, ALEXANDERreporter.nih.gov
Mechanistic studies of alcohol-sleep interactionsNIHNational Institute on Alcohol Abuse and Alcoholism2021 to 2023$1,173,750September 17, 2019August 31, 2025TORREGROSSA, MARY Mreporter.nih.gov
Neuronal exosomes in cocaine abuse and treatment response in socially housed monkeysNIHNational Institute on Drug Abuse2021 to 2023$1,162,500July 1, 2019April 30, 2025DEEP, GAGANreporter.nih.gov
Molecular determinants of ensemble recruitment by drugs of abuseNIHNational Institute on Drug Abuse2025$1,159,396July 1, 2025March 31, 2030CALIPARI, ERINreporter.nih.gov
Novel 5-HT2A/mGluR5 Antagonist for Opioid Use DisorderNIHNational Institute on Drug Abuse2025$1,153,945September 15, 2025August 31, 2027MOELLER, FREDERICK GERARDreporter.nih.gov
Identifying patterns of human polysubstance use to guidedevelopment of rodent modelsNIHNational Institute on Drug Abuse2021 to 2022$1,138,416September 30, 2018June 30, 2024KNACKSTEDT, LORI Areporter.nih.gov
Establishing a link between habits and punishment resistanceNIHNational Institute on Drug Abuse2021 to 2023$1,106,838February 15, 2019December 31, 2025SMITH, RACHEL Jreporter.nih.gov
Zona Incerta Contributions to Reward and Cocaine AddictionNIHNational Institute on Drug Abuse2021 to 2023$1,097,250September 15, 2019June 30, 2025LIU, QING-SONGreporter.nih.gov
Functional consequences of cocaine self-administration on astrocytesNIHNational Institute on Drug Abuse2023 to 2025$1,086,725May 1, 2023February 29, 2028REISSNER, KATHRYN JOANNAreporter.nih.gov
Multimodal profiling of microglia during HIV infection and substance use disorderNIHNational Institute on Drug Abuse2023 to 2024$1,076,164September 30, 2023August 31, 2025JORDAN-SCIUTTO, KELLY Lreporter.nih.gov
Developing a sleep EEG-based biomarker for drug relapse propensityNIHNational Institute on Drug Abuse2024 to 2025$1,075,270April 15, 2024January 31, 2029HUANG, YANHUA Hreporter.nih.gov
ROLE OF OREXIN IN COCAINE DEMAND AND ADDICTIONNIHNational Institute on Drug Abuse2023 to 2024$1,067,550August 1, 1992November 30, 2025ASTON-JONES, GARY S.reporter.nih.gov
Long-acting aldicarb hydrolase as a medical countermeasure for aldicarb poisoningNIHNational Institute of Neurological Disorders and Stroke2023 to 2024$1,065,924September 1, 2023August 31, 2025ZHENG, FANGreporter.nih.gov
Investigating the mechanistic contribution of Cav1.2 channels in extinction of cocaine-associated memoriesNIHNational Institute on Drug Abuse2022 to 2023$1,063,494April 1, 2022October 31, 2023RAJADHYAKSHA, ANJALI Mreporter.nih.gov
Mechanistic studies of cAMP effectors in cocaine addictionNIHNational Institute on Drug Abuse2021 to 2023$1,062,600April 15, 2014May 31, 2025LIU, QING-SONGreporter.nih.gov
Sleep regulates drug relapse and addictionNIHNational Institute on Drug Abuse2021 to 2023$1,056,375April 1, 2019January 31, 2025HUANG, YANHUA Hreporter.nih.gov
Encoding dopamine signals in the mesolimbic systemNIHNational Institute on Drug Abuse2021 to 2023$1,049,625August 1, 2013February 28, 2025FORD, CHRISTOPHER PETERreporter.nih.gov
ROLE OF OREXIN IN COCAINE DEMAND AND ADDICTIONNIHNational Institute on Drug Abuse2021 to 2022$1,048,129August 1, 1992November 30, 2022ASTON-JONES, GARY S.reporter.nih.gov
Pharmacology of Stimulant ChoiceNIHNational Institute on Drug Abuse2023 to 2025$1,047,939April 15, 2023February 29, 2028BANKS, MATTHEW Lreporter.nih.gov
Extensive drug histories result in compulsive appetite: functional identification of punishment-reactive neural network re-organization in the rostromedial tegmental nucleusNIHNational Institute on Drug Abuse2022 to 2023$1,042,506September 1, 2022April 26, 2024SUTO, NOBUYOSHIreporter.nih.gov
Reprogramming KZFP function to understand drug-specific transcription and behaviorNIHNational Institute on Drug Abuse2024 to 2025$1,040,268May 1, 2024February 28, 2029HAMILTON, PETER JAMESreporter.nih.gov
Investigating the mechanistic contribution of Cav1.2 channels in extinction of cocaine-associated memoriesNIHNational Institute on Drug Abuse2024 to 2025$1,031,426July 1, 2020January 31, 2027RAJADHYAKSHA, ANJALI Mreporter.nih.gov
Neural Mechanisms of Individual Differences in Cocaine AvoidanceNIHNational Institute on Drug Abuse2021 to 2022$1,031,082August 1, 2021May 31, 2023JHOU, THOMAS Creporter.nih.gov
Characterization of cortical neuronal subtypes in cocaine self-administrationNIHNational Institute on Drug Abuse2021 to 2022$1,029,911August 15, 2019May 31, 2023FERGUSON, SUSAN MARIEreporter.nih.gov
Serotonin receptors that potentiate addiction-related behavioral and molecular effects induced by methylphenidate plus SSRI exposureNIHNational Institute on Drug Abuse2021 to 2023$1,013,596April 1, 2019January 31, 2024STEINER, HEINZreporter.nih.gov
Transgenerational Inheritance of a Cocaine Resistance PhenotypeNIHNational Institute on Drug Abuse2021 to 2022$1,009,002April 1, 2012January 31, 2023PIERCE, ROBERT CHRISTOPHERreporter.nih.gov
The Genetic and Epigenetic Interplay of Cocaine Addiction: A Cell-Type, Circuitry, and Functional DissectionNIHNational Institute on Drug Abuse2024 to 2025$984,000August 1, 2024June 30, 2029ZHANG, ZHUZHUreporter.nih.gov
Cyclic Peptides to Treat Cocaine Use DisorderNIHNational Institute of Neurological Disorders and Stroke2024$981,998May 15, 2023April 30, 2026ALDRICH, JANE Vreporter.nih.gov
Differential Roles of Prefrontal Cortical Interneurons in Drug Seeking after WithdrawalNIHNational Institute on Drug Abuse2024 to 2025$972,206July 1, 2024April 30, 2029LIM, BYUNGKOOKreporter.nih.gov
Hypocretinergic control of cocaine abuseNIHNational Institute on Drug Abuse2021 to 2022$964,962September 30, 2018June 30, 2023HORVATH, TAMAS Lreporter.nih.gov
Regulation of monoamine neurons by delta glutamate receptorsNIHNational Institute on Drug Abuse2024 to 2025$961,242April 1, 2024January 31, 2029GANTZ, STEPHANIE C.reporter.nih.gov
Epitranscriptomic Regulation of Synaptic Responses to Drugs of AbuseNIHNational Institute on Drug Abuse2021 to 2022$954,795July 15, 2018June 30, 2024MEYER, KATHRYN Dreporter.nih.gov
Cyclic Peptides to Treat Cocaine Use DisorderNIHNational Institute of Neurological Disorders and Stroke2023$945,491May 15, 2023April 30, 2024ALDRICH, JANE Vreporter.nih.gov
Deep Analysis of Transcriptome to Understand the Genetics of Substance Use Disorders in RatsNIHNational Institute on Drug Abuse2025$944,888July 1, 2025March 31, 2030MOHAMMADI, PEJMANreporter.nih.gov
Mentoring patient-oriented research on the health consequences of polydrug useNIHNational Institute on Drug Abuse2021 to 2025$941,480July 1, 2015June 30, 2027RILEY, ELISE D.reporter.nih.gov
Extensive drug histories result in compulsive appetite: functional identification of punishment-reactive neural network re-organization in the rostromedial tegmental nucleusNIHNational Institute on Drug Abuse2024 to 2025$939,600July 15, 2024June 30, 2027SUTO, NOBUYOSHIreporter.nih.gov
Cocaine Abstinence or Reduced Use May Retard Alterations in Brain Structure and Function, and Associated Cognitive Changes among African American Cocaine Users with HIVNIHNational Institute on Drug Abuse2024$939,459May 1, 2024February 28, 2029LAI, SHENGHANreporter.nih.gov
Characterization of cocaine induced signaling pathways that enhances HIV transcriptionNIHNational Institute on Drug Abuse2021 to 2023$916,120September 1, 2017April 30, 2026TYAGI, MUDITreporter.nih.gov
Examination of epigenetic spatial architecture in the CNS as a method to understand cocaine relapse in ecoHIV infected miceNIHNational Institute on Drug Abuse2024 to 2025$908,940September 30, 2024November 30, 2026KLASE, ZACHARY ALANreporter.nih.gov
Cannabinoid inhibition of CNS inflammasome activation via modulation of the gut-brain axisNIHNational Institute on Drug Abuse2025$898,025April 15, 2025February 28, 2030BYRAREDDY, SIDDAPPA Nreporter.nih.gov
Chemokine CXCL12/CXCR4 system and synthetic cathinonesNIHNational Institute on Drug Abuse2021 to 2022$894,344July 1, 2018April 30, 2024RAWLS, SCOTT M.reporter.nih.gov
High-throughput identification and characterization of conserved regulators of drug-induced plasticity using single-neuron resolution atlases of the complete Caenorhabditis elegans nervous systemNIHNational Institute on Drug Abuse2024 to 2025$891,000September 30, 2024July 31, 2029SUN, HAOSHENGreporter.nih.gov
Elucidating Ih Biophysical Epigenetic Modifications in VTA Dopaminergic Neurons after Contingent and Non-Contingent Cocaine AdministrationNIHNational Institute of General Medical Sciences2022 to 2025$884,337July 15, 2022June 30, 2027JIMENEZ-RIVERA, CARLOS Areporter.nih.gov
Retinoic acid signaling: a novel factor for addiction-related behaviorNIHNational Institute on Drug Abuse2021 to 2022$864,126September 15, 2018June 30, 2024GREEN, THOMAS ARTHURreporter.nih.gov
Assessing central muscarinic acetylcholine type-1 receptors in cocaine use disorder with 11C-LSN3172176.NIHNational Institute on Drug Abuse2022 to 2023$837,270April 15, 2022June 30, 2024WORHUNSKY, PATRICK Dreporter.nih.gov
Cognitively-enhanced tDCS of the dorsolateral prefrontal cortex to reduce craving in cocaine addictionNIHNational Institute on Drug Abuse2025$833,825May 1, 2025February 28, 2030GOLDSTEIN, RITA Zreporter.nih.gov
Role of prelimbic cortical endocannabinoid signaling in enhanced cocaine-seeking behavior following combined repeated stress and cocaine use in ratsNIHNational Institute on Drug Abuse2024 to 2025$832,475March 1, 2024January 31, 2029MCREYNOLDS, JAYME ROSEreporter.nih.gov
Expanding the Scope and Usability of Fast Voltammetric MeasurementsNIHNational Institute on Drug Abuse2024 to 2025$832,134September 15, 2024July 31, 2029SOMBERS, LESLIE Areporter.nih.gov
The Sex-specific Roles and Neural Processing Correlates of Future Outcome Estimation in the Drug Addiction ProcessNIHNational Institute on Drug Abuse2021 to 2022$822,627July 1, 2018April 30, 2024JAMES, GEORGE ANDREWreporter.nih.gov
B1 noradrenergic blockade in early withdrawal to reduce cocaine induced behavioral flexibility deficitNIHNational Institute on Drug Abuse2021 to 2022$818,813March 1, 2020February 29, 2024WEST, ELIZABETH Areporter.nih.gov
Short-term Outcome of Stimulant Use Disorder Treatment TrialsNIHNational Institute on Drug Abuse2022 to 2023$818,750August 1, 2022January 31, 2024MOJTABAI, RAMINreporter.nih.gov
Basolateral amygdala dopamine in addiction-related learning strategiesNIHNational Institute on Drug Abuse2024 to 2025$818,513September 15, 2024May 31, 2029SAUNDERS, BENJAMIN THOMASreporter.nih.gov
Cognitive Reappraisal for Mitigating Incubation of Cocaine Cue-ReactivityNIHNational Institute on Drug Abuse2023$815,875September 30, 2023August 31, 2028PARVAZ, MUHAMMAD ADEELreporter.nih.gov
Computational Methods for Identification of Genetic Factors Affecting the Response to Drug AbuseNIHNational Institute on Drug Abuse2021 to 2022$807,872September 1, 2017June 30, 2023PELTZ, GARY Areporter.nih.gov
Genetic substrates of cue-reactivity and cocaine motivationNIHNational Institute on Drug Abuse2025$802,735August 1, 2025April 30, 2030MEYER, PAUL Jreporter.nih.gov
Discovery of GPR52 ligand probes for cocaine use disorderNIHNational Institute on Drug Abuse2025$795,090September 1, 2025May 31, 2030ALLEN, JOHN Areporter.nih.gov
Reversing Cocaine-induced Impairments in the NAc with Controllable StressorsNIHNational Institute on Drug Abuse2021 to 2022$782,589September 30, 2018August 31, 2024SADDORIS, MICHAELreporter.nih.gov
Novel anti-cocaine D1 partial agonistsNIHNational Institute on Drug Abuse2021 to 2022$780,000May 1, 2019April 30, 2024HARDING, WAYNE WESLEYreporter.nih.gov
Analyzing Sequential, Multiple Assignment, Randomized Trials in the Presence of Partial ComplianceNIHNational Institute on Drug Abuse2021 to 2022$769,466September 30, 2019August 31, 2024ERTEFAIE, ASHKANreporter.nih.gov
Addiction liability, poor attentional control, and cholinergic deficiencyNIHNational Institute on Drug Abuse2021 to 2022$768,539September 15, 2018June 30, 2023SARTER, MARTIN Freporter.nih.gov
THE ROLE OF RYANODINE RECEPTORS IN DRUG SEEKINGNIHNational Institute on Drug Abuse2021 to 2022$767,162July 15, 2018May 31, 2024RIEGEL, ARTHUR Creporter.nih.gov
Cocaine Addition and the Need-State HypothesisNIHNational Institute on Drug Abuse2025$762,063May 1, 2025February 28, 2030GRIGSON, PATRICIA SUEreporter.nih.gov
NOP receptors as targets for novel pharmacotherapies for cocaine use disorder in nonhuman primate modelsNIHNational Institute on Drug Abuse2025$758,218September 1, 2025May 31, 2030CZOTY, PAUL W.reporter.nih.gov
Role of the NLRP3 Inflammasome in Mediating Microglial Activation and Development of Neuropsychiatric Symptoms Induced by HIV, Antiretrovirals and CocaineNIHNational Institute on Drug Abuse2024 to 2025$751,970August 15, 2021June 30, 2027GUO, MINGLEIreporter.nih.gov
Cucurbituril Type Receptors as Sequestration Agents for Drugs of AbuseNIHNational Institute of General Medical Sciences2021 to 2022$747,910April 15, 2019January 31, 2024ISAACS, LYLE Dreporter.nih.gov
Role of Class IIa HDAC Target Genes in Opioid and Cocaine AddictionNIHNational Institute on Drug Abuse2021 to 2022$747,500July 1, 2013May 31, 2024COWAN, CHRISTOPHER Wreporter.nih.gov
Sex Differences in AddictionNIHNational Institute on Drug Abuse2022 to 2024$747,000March 1, 2019February 28, 2026KOHTZ, AMYreporter.nih.gov
Effects of exercise on dopaminergic mechanisms of cocaine relapseNIHNational Institute on Drug Abuse2022 to 2024$746,997August 1, 2019February 28, 2026ZLEBNIK, NATALIEreporter.nih.gov
Circuit Mechanisms for Conditioned Stress Regulation of AddictionNIHNational Institute on Drug Abuse2022 to 2024$746,997July 15, 2019June 30, 2026GARCIA KELLER, CONSTANZAreporter.nih.gov
Orexin (hypocretin) signaling in ventral tegmental area as a common mediator of sleep disturbances and drug demand in cocaine abstinenceNIHNational Institute on Drug Abuse2024 to 2025$745,734July 15, 2024May 31, 2029ASTON-JONES, GARY S.reporter.nih.gov
Neural circuitry of distress toleranceNIHNational Institute on Drug Abuse2021 to 2023$745,315March 1, 2019February 28, 2025MOSCHAK, TRAVIS Mreporter.nih.gov
Role of Nucleus Accumbens D2-expressing Neurons in Punished Cocaine SeekingNIHNational Institute on Drug Abuse2021 to 2023$744,648April 1, 2019April 30, 2025VENTO, PETER J.reporter.nih.gov
Multimodal profiling of microglia during HIV infection and substance use disorderNIHNational Institute on Drug Abuse2025$744,484September 30, 2023August 31, 2028JORDAN-SCIUTTO, KELLY Lreporter.nih.gov
Hypocretin/Orexin Regulation of Dopamine Signaling and Cocaine ReinforcementNIHNational Institute on Drug Abuse2021 to 2022$742,144January 1, 2013May 31, 2025ESPAÑA, RODRIGO A.reporter.nih.gov
Unpredictable availability as a determinant of drug-related outcomesNIHNational Institute on Drug Abuse2021 to 2022$736,250April 1, 2018March 31, 2025HUSKINSON, SALLYreporter.nih.gov
Augmenting cognitive-behavioral therapy with rTMS of the medial prefrontal and anterior cingulate cortices for the treatment of cocaine use disorderNIHNational Institute on Drug Abuse2023$728,927May 15, 2023April 30, 2027MARTINEZ, DIANA Mreporter.nih.gov
Molecular mechanisms: Dysregulation of monoamine transporters by HIV-1Tat and cocaineNIHNational Institute on Drug Abuse2025$728,575May 15, 2025April 30, 2029ZHU, JUNreporter.nih.gov
Intervention to Reduce Internalized Stigma (IRIS) among People Living with HIV who use SubstancesNIHNational Institute on Drug Abuse2022 to 2024$724,401September 1, 2022July 31, 2026FLETCHER, JESSE BRADFORDreporter.nih.gov
Mechanisms underlying dysregulated neuroimmune signaling and neuronal dysfunction in HIV (+) individuals with cART and cocaineNIHNational Institute on Drug Abuse2021 to 2022$724,376September 30, 2018July 31, 2025BUCH, SHILPA J.reporter.nih.gov
Repurposing Semaglutide for the Treatment of Cocaine Use Disorder: a Pilot Mechanistic StudyNIHNational Institute on Drug Abuse2025$702,965June 15, 2025February 28, 2029YAMMINE, LUBAreporter.nih.gov
Effect of Mindfulness Training on Opioid Use and Anxiety During Primary Care Buprenorphine TreatmentNIHNational Center for Complementary & Integrative Health2022$700,000July 1, 2022August 31, 2024SCHUMAN OLIVIER, ZEV DAVIDreporter.nih.gov
Relevance and plasticity of inhibitory metabotropic signaling in reward circuitsNIHNational Institute on Drug Abuse2021 to 2022$688,500August 1, 2013February 28, 2023WICKMAN, KEVIN Dreporter.nih.gov
Combined mGluR5 PET and fMRI imaging of Sex Differences during Cocaine WithdrawalNIHNational Institute on Drug Abuse2022$685,732June 1, 2017March 31, 2025MCCAUL, MARY Ereporter.nih.gov
Social Influences on Drug-Seeking BehaviorNIHNational Institute on Drug Abuse2021 to 2022$685,534April 1, 2012July 31, 2025SMITH, MARK Areporter.nih.gov
Neuron subtype specific role of DNA methylcytosine dioxygenase TET1 in cocaine addictionNIHNational Institute on Drug Abuse2021 to 2022$681,815September 15, 2018June 30, 2024FENG, JIANreporter.nih.gov
Development of selective cannabinoid receptor 2 agonists for treatment of addictionNIHNational Institute of Neurological Disorders and Stroke2022$661,980April 19, 2022March 31, 2023SHAMLOO, MEHRDADreporter.nih.gov
Estradiol signaling pathways mediating sex differences in striatal synaptic plasticityNIHNational Institute on Drug Abuse2023$652,413April 15, 2023August 11, 2023BLACKWELL, KIM Lreporter.nih.gov
The Influence of Gonadal Hormones on Opioid UseNIHNational Institute on Drug Abuse2021 to 2022$651,443September 30, 2018July 31, 2024SMITH, MARK Areporter.nih.gov
The role of GPER-1 and addictionNIHNational Institute on Drug Abuse2021 to 2022$649,193September 30, 2020July 31, 2024BECKER, JILL B.reporter.nih.gov
Long-acting aldicarb hydrolase as a medical countermeasure for aldicarb poisoningNIHNational Institute of Neurological Disorders and Stroke2025$643,949September 1, 2023August 31, 2028ZHENG, FANGreporter.nih.gov
Psilocybin-Assisted Treatment of Cocaine Use DisorderNIHNational Institute on Drug Abuse2025$643,019July 15, 2025June 30, 2027ARIAS, ALBERT JOSEPHreporter.nih.gov
HIV and Cocaine Use Leads to Loss of Astrocyte Neurotrophic Support and Impaired Lipid Homeostasis in the BrainNIHNational Institute of Neurological Disorders and Stroke2025$627,502September 20, 2022May 31, 2027LANGFORD, DIANNE TERESAreporter.nih.gov
Targeting Immune Inflammation in Cocaine Use Disorder: A Human Laboratory Study with PentoxifyllineNIHNational Institute on Drug Abuse2025$620,383July 1, 2025February 29, 2028STOOPS, WILLIAM WALTONreporter.nih.gov
Norepinephrine modulates medial prefrontal cortex neural ensembles that control cocaine seeking behaviorNIHNational Institute on Drug Abuse2022 to 2025$586,321December 12, 2022May 31, 2027GHEIDI, ALIreporter.nih.gov
Cell-Types Specific Neuroadaptations in the Nucleus Accumbens Shell Associated with Individual Differences in Cocaine-SeekingNIHNational Institute on Drug Abuse2021 to 2023$580,446September 30, 2021September 2, 2023CARRERO, JEFFREY PARRILLAreporter.nih.gov
Chromatin regulation of neuronal activity-induced enhancer priming and epigenetic memoryNIHNational Institute of Neurological Disorders and Stroke2025$578,632March 1, 2025December 31, 2029WU, JIANGreporter.nih.gov
Understanding the role of paraventricular neurotensin neurons in valence processingNIHNational Institute on Drug Abuse2024 to 2025$577,653February 1, 2022January 31, 2027LI, HAOreporter.nih.gov
Cardiovascular, Immune and Psychosocial Benefits of Reduced Cocaine UseNIHNational Institute on Drug Abuse2022$574,367September 1, 2017November 30, 2024STOOPS, WILLIAM WALTONreporter.nih.gov
TASK ORDER 01 COCAINE INTERACTION SAFETY STUDIES IN RATS. TOXICOLOGICAL EVALUATIONS OF POTENTIAL MEDICATIONS IDIQ. ORDERING PERIOD: 09/12/2023 - 09/11/2024. NIDA REF. NO. N01DA-23-8939NIHNational Institute on Drug Abuse2023$571,190September 12, 2023September 11, 2024AROLFO , MARIAreporter.nih.gov
HIV and Cocaine Drive Bone-Marrow Blood (BMB) Barrier Dysfunction and Altered Hematopoietic Stem Cell (HSC) Differentiation Leading to Cardiovascular DiseaseNIHNational Institute on Drug Abuse2022$570,030April 1, 2022October 26, 2023ANDREWS, ALLISON MICHELLEreporter.nih.gov
Nucleus accumbens neuronal ensembles in drugs and natural rewards seeking.NIHNational Institute on Drug Abuse2021 to 2023$564,842December 1, 2020August 16, 2023BATCHELDER, ABIGAILreporter.nih.gov
HIV and cocaine mediated lipid dysregulation in microglia: Immunometabolism mechanisms underlying NeuroHIVNIHNational Institute on Drug Abuse2025$563,742July 15, 2025May 31, 2030GUO, MINGLEIreporter.nih.gov
The role of neuronal ensemble Rac1 activity in cocaine seeking behaviorNIHNational Institute on Drug Abuse2024$563,694July 15, 2024April 30, 2025WARREN, BRANDON Lreporter.nih.gov
MRI data fusion to investigate effects of drug abuse on HIV neurological complicationsNIHNational Institute on Drug Abuse2021 to 2022$556,750March 15, 2018June 30, 2023MEADE, CHRISTINA Sreporter.nih.gov
Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use DisorderNIHNational Institute on Drug Abuse2023 to 2025$547,813July 1, 2023June 30, 2028WEBBER, HEATHER Ereporter.nih.gov
The role of neuroactive steroids in stress, drug craving and drug use in cocaine use disordersNIHNational Institute on Drug Abuse2021 to 2023$547,788February 1, 2019January 31, 2025MILIVOJEVIC, VERICAreporter.nih.gov
Unhealthy alcohol use, other drug use, and mental health disorders: comorbidity burden in people with HIV, gaps in treatment, and impact on the HIV care continuumNIHNational Institute on Alcohol Abuse and Alcoholism2021 to 2023$535,104September 25, 2019August 31, 2025LESKO, CATHERINEreporter.nih.gov
Defining the role of cortical circuit dynamics in learning and addictionNIHNational Institute on Drug Abuse2021 to 2022$514,599March 1, 2020February 28, 2023SICILIANO, CODYreporter.nih.gov
Characterization of cortical neuronal subtypes in cocaine self-administrationNIHNational Institute on Drug Abuse2023$509,066June 1, 2023May 31, 2025FERGUSON, SUSAN MARIEreporter.nih.gov
Cocaine-motivated behaviors: development of novel viral-based strategies to target orexinergic input to the infralimbic cortex.NIHNational Institute on Drug Abuse2022 to 2023$501,228August 1, 2022July 31, 2025MARTIN-FARDON, REMIreporter.nih.gov
Orexin/hypocretin as a common mediator of stress and reward behavior in cocaine addictionNIHNational Institute on Drug Abuse2021 to 2022$498,000March 1, 2019April 30, 2023JAMES, MORGAN H.reporter.nih.gov
A novel role for the medial amygdala in the modulation of sex differences in cocaine rewardNIHNational Institute on Drug Abuse2021 to 2022$497,999May 1, 2018June 30, 2024WALKER, DEENA M.reporter.nih.gov
Intersecting genetic risk for extreme cocaine self-administration with dopamine neurotransmissionNIHNational Institute on Drug Abuse2024 to 2025$497,999January 1, 2024December 31, 2026BAGLEY, JARED Rreporter.nih.gov
Discovery and Characterization of Genetic Mechanisms Driving Stress-induced Addiction VulnerabilityNIHNational Institute on Drug Abuse2021 to 2022$497,966July 1, 2020June 30, 2024DICKSON, PRICE EVANSreporter.nih.gov
Information encoding by spatiotemporal patterns of dopamine releaseNIHNational Institute on Drug Abuse2024 to 2025$497,791April 1, 2024March 31, 2027COSTA, KAUE MACHADOreporter.nih.gov
Prevention of Methamphetamine Use among Postpartum Women (PROMPT)NIHNational Institute on Drug Abuse2021 to 2022$496,125June 1, 2022May 31, 2024SMID, MARCELAreporter.nih.gov
Molecular interplay of HIV Tat, cocaine, and cART in microglial pyroptosis: Role of NLRP3 inflammasomeNIHNational Institute on Drug Abuse2025$490,172April 15, 2025January 31, 2030BUCH, SHILPA Jreporter.nih.gov
Using CRISPR tools to uncover the role of CREB-gene regulation in drug abuseNIHNational Institute on Drug Abuse2021 to 2022$490,120May 1, 2020April 30, 2023HAMILTON, PETER JAMESreporter.nih.gov
Summer Undergraduate Research Program in Neuroscience of AddictionNIHNational Institute on Drug Abuse2022 to 2025$489,258July 1, 2012March 31, 2028LAVIN, ANTONIETAreporter.nih.gov
Action of psychostimulant drugs on neuronal intrinsic excitability and drug-seeking behaviorNIHNational Institute on Drug Abuse2021 to 2022$486,000April 1, 2018January 31, 2024KOURRICH, SAIDreporter.nih.gov
Dysregulation of midbrain GABAergic circuitry contributes to the motivational properties of cocaineNIHNational Institute on Drug Abuse2021 to 2023$477,903June 15, 2019April 30, 2024OSTROUMOV, ALEXEYreporter.nih.gov
Investigating the Impact of Nicotine and Alcohol Co-Use on the Abuse Potential of Cocaine In Monkey ModelsNIHNational Institute on Drug Abuse2025$474,347August 15, 2025April 30, 2030NADER, MICHAEL Areporter.nih.gov
Control of drug-reward behavior and relapse vulnerability via a specialized serotonergic-septohippocampal circuitNIHNational Institute on Drug Abuse2024 to 2025$466,125July 15, 2024September 30, 2026DYMECKI, SUSAN M.reporter.nih.gov
Targeting neural, behavioral and pharmacological mechanisms of drug memories in cocaine addictionNIHNational Institute on Drug Abuse2022 to 2023$464,750September 30, 2022August 31, 2024GOLDSTEIN, RITA Zreporter.nih.gov
Elucidating phenotype and etiology of substance use disorders via integrative analysis of multi-dimensional datasetsNIHNational Institute on Drug Abuse2023$462,378August 1, 2023July 31, 2026SUN, JIANGWENreporter.nih.gov
A 11C-UCB-J PET Study of Synaptic Density in Binge Eating Disorder (BED)NIHNational Institute of Mental Health2023 to 2024$460,625May 2, 2023April 30, 2026POTENZA, MARC Nreporter.nih.gov
Mesolimbic Nociceptin Signaling and Cocaine Reward SuppressionNIHNational Institute on Drug Abuse2024 to 2025$460,625June 15, 2024May 31, 2026MELIKIAN, HALEY Ereporter.nih.gov
Development of NLRP3 inhibitors for HIV-associated neuroinflammation in cocaine use.NIHNational Institute on Drug Abuse2024 to 2025$459,995August 1, 2024July 31, 2027KULKARNI, AMOL ANANTreporter.nih.gov
Targeting Phospholipase C and Dendritic Spines to Reduce Cocaine and Heroin MotivationNIHNational Institute on Drug Abuse2021 to 2023$455,575April 1, 2019August 16, 2023ANDERSON, ETHAN MICHAELreporter.nih.gov
A Human Laboratory Study of Exenatide for Reducing the Reinforcing Effects of CocaineNIHNational Institute on Drug Abuse2023 to 2024$453,530May 15, 2023April 30, 2026VERRICO, CHRISTOPHER Dreporter.nih.gov
Role of Patrolling Monocytes in Cerebral Vascular Repair during HIV/Substance AbuseNIHNational Institute on Drug Abuse2021 to 2023$449,697February 1, 2019January 31, 2024ANDREWS, ALLISON MICHELLEreporter.nih.gov
Ultra-fast high-resolution imaging of whole mouse brain for the study of drug addictionNIHNational Institute on Drug Abuse2021 to 2022$447,931March 1, 2021February 28, 2025FREYBERG, ZACHARYreporter.nih.gov
Chromatin regulation of BDNF in cocaine cravingNIHNational Institute on Drug Abuse2024 to 2025$443,893July 15, 2024June 30, 2026WEST, ANNE ELIZABETHreporter.nih.gov
GPR6: A Circuit-Level Druggable Target in Cocaine Use DisorderNIHNational Institute on Drug Abuse2025$440,000July 15, 2025June 30, 2027CUNNINGHAM, KATHRYN A.reporter.nih.gov
Enhancing Addiction Severity Prediction by Modulating GABAergic Activity in the Central Amygdala of RATTACA RatsNIHNational Institute on Drug Abuse2025$438,750July 15, 2025June 30, 2027KALLUPI, MARSIDAreporter.nih.gov
Dissecting and modulating cell type and circuit-specific epigenetic mechanisms of cocaine addictionNIHNational Institute on Drug Abuse2025$436,050September 30, 2025May 31, 2030VELMESHEV, DMITRYreporter.nih.gov
Contribution of BLA-mPFC pathway to risky choice and compulsive cocaine seekingNIHNational Institute on Drug Abuse2021 to 2023$432,012June 1, 2019June 30, 2026YATES, JUSTIN RYANreporter.nih.gov
Neural mechanisms preventing postpartum relapse to cocaine seeking in new mothersNIHNational Institute on Drug Abuse2022 to 2023$429,417May 1, 2022April 30, 2025PEREIRA ARBOLEYA, MARIANAreporter.nih.gov
The glucocorticoid receptor as a mechanism of top-down control of cue-motivated behaviorNIHNational Institute on Drug Abuse2021 to 2022$429,000March 1, 2021February 28, 2025FLAGEL, SHELLY BETHreporter.nih.gov
Early cannabis use and later opioid use disorder - the role of adverse childhood experiences, genetic liability and comorbid stimulant useNIHNational Institute on Drug Abuse2024 to 2025$427,625August 1, 2024July 31, 2027AGRAWAL, ARPANAreporter.nih.gov
Targeting adenosine monophosphate activated protein kinase (AMPK) to reduce cocaine relapseNIHNational Institute on Drug Abuse2022 to 2023$426,250April 1, 2022March 31, 2024SPENCER, SADE MONIQUEreporter.nih.gov
Macrocyclic Arenes as Sequestrants for Drugs of AbuseNIHNational Institute on Drug Abuse2024 to 2025$425,976June 15, 2024May 31, 2027ISAACS, LYLE Dreporter.nih.gov
Midbrain astrocyte energy metabolism regulating drug-evoked dopamine release and behaviorNIHNational Institute on Drug Abuse2021 to 2022$425,908May 1, 2021April 30, 2024WANAT, MATTHEW J.reporter.nih.gov
Cue Incubation in Substance Use Disorders: Validation and Assessment of MechanismsNIHNational Institute on Drug Abuse2021 to 2022$424,875May 1, 2021April 30, 2026BERNAT, EDWARD M.reporter.nih.gov
The Role of Endothelial Injury and Myeloid Cell Migration in the Activation of Inflammasomes in HIV infection and Cocaine ExposureNIHNational Institute on Drug Abuse2024 to 2025$424,875September 30, 2024August 31, 2027NEKHAI, SERGEIreporter.nih.gov
Cocaine self-administration and cholesterol metabolismNIHNational Institute on Drug Abuse2022 to 2023$422,192August 1, 2022July 31, 2025CHEN, RONGreporter.nih.gov
Preclinical Trial: Targeting the Neuropeptide S Receptor to Curb Opioid Taking and SeekingNIHNational Institute on Drug Abuse2024$419,876September 15, 2024August 31, 2026CLARK, STEWART DONALDSONreporter.nih.gov
Reward Homeostasis, Accumbens AMPA Receptor Trafficking and Drug AbuseNIHNational Institute on Drug Abuse2021 to 2022$419,513July 15, 2021June 30, 2024CARR, KENNETH Dreporter.nih.gov
Selective real-time activation of ERK1/2 signaling in dopamine neuronsNIHNational Institute on Drug Abuse2022 to 2023$416,625September 30, 2022August 31, 2025MORTENSEN, OLE VALENTEreporter.nih.gov
HIV and estrogen effects on hypothalamic regulation of cocaine-related behaviorNIHNational Institute on Drug Abuse2024 to 2025$416,625August 1, 2024July 31, 2026BARKER, JACQUELINE Mreporter.nih.gov
Imaging neural, astrocytic and vascular synchronization to assess cocaine's effects on mPFCNIHNational Institute on Drug Abuse2023 to 2024$416,248June 1, 2023May 31, 2025PAN, YINGTIANreporter.nih.gov
The role of negative reinforcement in drug abuseNIHNational Institute on Drug Abuse2021 to 2022$413,126March 1, 2021February 29, 2024BANKS, MATTHEW Lreporter.nih.gov
Discovery of genetic and genomic mechanisms driving the relationship between social reward and cocaine addictionNIHNational Institute on Drug Abuse2022 to 2023$407,000August 1, 2022July 31, 2025DICKSON, PRICE EVANSreporter.nih.gov
Regulation of cocaine use by astrocyte voltage-gated channelsNIHNational Institute on Drug Abuse2024 to 2025$405,746April 1, 2024March 31, 2027ORTINSKI, PAVEL IVANOVICHreporter.nih.gov
Advancing Nr4a1 as a novel target in cocaine use disorder.NIHNational Institute on Drug Abuse2025$405,230January 15, 2025December 31, 2026HELLER, ELIZABETH Areporter.nih.gov
Novel cellular markers of drug-mediated calcium signaling in astrocytesNIHNational Institute on Drug Abuse2021 to 2022$405,199March 15, 2021February 29, 2024REISSNER, KATHRYN JOANNAreporter.nih.gov
Short-term Outcome of Stimulant Use Disorder Treatment TrialsNIHNational Institute on Drug Abuse2024$403,206July 1, 2024June 30, 2026MOJTABAI, RAMINreporter.nih.gov
Sex Difference in Cocaine-Induced Impulsivity: Contribution of the Mesocorticolimbic Dopamine System and EstradiolNIHNational Institute on Drug Abuse2025$400,836July 15, 2025June 30, 2028PAINE, TRACIE ANNreporter.nih.gov
Targeting Immunometabolism: a novel role for itaconate in the treatment of HIV-associated neurocognitive disorder and cocaine use disorderNIHNational Institute on Drug Abuse2023 to 2024$400,798May 1, 2023April 30, 2026SHTUTMAN, MICHAELreporter.nih.gov
Advancing FGF13-Nav1.6 modulators to normalize Nucleus Accumbens activity for Cocaine Use DisorderNIHNational Institute on Drug Abuse2025$400,000May 15, 2025April 30, 2027LIJFFIJT, MARIJNreporter.nih.gov
Cell-Types Specific Neuroadaptations in the Nucleus Accumbens Shell Associated with Individual Differences in Cocaine-SeekingNIHNational Institute on Drug Abuse2024 to 2025$393,868September 30, 2021January 31, 2027CARRERO, JEFFREY PARRILLAreporter.nih.gov
Cholinergic mechanisms of cocaine reinforcement probed with nicotinic receptor gene editingNIHNational Institute on Drug Abuse2022 to 2023$387,500September 15, 2022August 31, 2024DRENAN, RYAN MICHAELreporter.nih.gov
Cholinergic mechanisms of cocaine reinforcement probed with nicotinic receptor gene editingNIHNational Institute on Drug Abuse2025$380,460September 15, 2022November 30, 2027DRENAN, RYAN MICHAELreporter.nih.gov
Drd3 transcript variants and cocaine self-administrationNIHNational Institute on Drug Abuse2024 to 2025$378,869September 1, 2024August 31, 2026CHEN, RONGreporter.nih.gov
Oxytocin Induces Retrograde Metaplasticity to Attenuate CocainePreference BehaviorNIHNational Institute on Drug Abuse2023 to 2024$371,023September 30, 2023August 31, 2025LEONG, KAH CHUNGreporter.nih.gov
Nucleus accumbens cholinergic interneurons and cue-induced cocaine cravingNIHNational Institute on Drug Abuse2023 to 2024$370,694July 1, 2023January 31, 2026KAWA, ALEXANDER BORGreporter.nih.gov
Investigating microbiota of the gut-brain axis and the impact of cocaineNIHNational Institute of General Medical Sciences2023 to 2025$370,212September 1, 2023July 31, 2027JAVAN, GULNAZreporter.nih.gov
Using novel data sources across genetic, biological, and social domains to refine genome-wide investigations of substance use disordersNIHNational Institute on Drug Abuse2024 to 2025$362,080August 1, 2024July 31, 2029DEAK, JOSEPH D.reporter.nih.gov
Role of Dopamine Neuron-Specific Gene Enhancers in Cocaine RelapseNIHNational Institute on Drug Abuse2021 to 2022$359,310February 15, 2019July 31, 2023TUESTA, LUIS MIGUELreporter.nih.gov
Immune profiling of antibodies and B cells that recognize HIV and substances in people who use substances and live with HIV (PWUSH)NIHNational Institute on Drug Abuse2025$356,630September 1, 2025August 31, 2027WU, XUELINGreporter.nih.gov
Determining how neurotensin mediates valence processing and compulsive cocaine seekingNIHNational Institute on Drug Abuse2022 to 2023$345,168February 1, 2022January 31, 2024LI, HAOreporter.nih.gov
Advancing mGlu1 positive allosteric modulators as therapeutics to facilitate abstinence in cocaine use disorderNIHNational Institute on Drug Abuse2022$325,386September 30, 2022September 29, 2025WOLF, MARINA ELIZABETHreporter.nih.gov
Investigation of a Novel PDE4B Inhibitor for Stimulant Use DisorderNIHNational Institute on Drug Abuse2024$320,000May 1, 2024April 30, 2026VARADHACHARY, ATULreporter.nih.gov
Developing a novel treatment of cocaine use disorder using an IND dual inhibitor of Cav3 channel and soluble epoxide hydrolaseNIHNational Institute on Drug Abuse2023$319,547September 15, 2023September 14, 2025XIE, XINMIN SIMONreporter.nih.gov
AI-assisted behavioral profiling of an invertebrate model to identify new psychedelic therapeutics for stimulant use disordersNIHNational Institute on Drug Abuse2022$318,373April 1, 2022September 30, 2023PATEL, DHAVAL SUBHASreporter.nih.gov
Development of the AI-driven model for anti-SUD drug development based on neuronal plasticityNIHNational Institute on Drug Abuse2022$312,310April 1, 2022September 30, 2023VARSHNEY, JYOTIKAreporter.nih.gov
HIV effects on astrocytic regulation of stress-induced cocaine reinstatementNIHNational Institute on Drug Abuse2024 to 2025$303,000June 15, 2024May 31, 2026GIACOMETTI, LAURA Lreporter.nih.gov
Investigate B cell perturbations and immune reconstitution failure in response to antiretroviral therapy in HIV-infected cocaine usersNIHNational Institute on Drug Abuse2022 to 2023$302,000August 15, 2022July 31, 2025JIANG, WEIreporter.nih.gov
Developing a novel epigenetic regulator as a treatment for cocaine use disorderNIHNational Institute on Drug Abuse2024$295,325June 1, 2024May 31, 2025KIM, THOMASreporter.nih.gov
Mechanisms of mGlu1 regulation of cortical inhibition and cognitive function: Implications in adolescent cocaine exposureNIHNational Institute on Drug Abuse2024 to 2025$288,470April 1, 2024March 31, 2026LUESSEN, DEBORAH JOYCEreporter.nih.gov
Decoding the dynamic representation of reward predictions across mesocorticostriatal circuits during learningNIHNational Institute on Drug Abuse2022$283,500May 1, 2020April 30, 2025NIV, YAELreporter.nih.gov
Ventral Pallidum Circuits in Motivation, Risky Decision Making, and Opioid AddictionNIHNational Institute on Drug Abuse2022 to 2024$274,286September 30, 2020August 31, 2025FARRELL, MITCHELLreporter.nih.gov
Investigating the long-term effects of prenatal circadian rhythm disruption on substance use-related disordersNIHNational Institute on Drug Abuse2022 to 2023$273,684February 15, 2022January 31, 2025DEPOY, LAUREN MARIEreporter.nih.gov
Neural activity-based candidate gene identification to link eating disorders and drug addictionNIHNational Institute on Drug Abuse2023$271,500July 1, 2023June 30, 2024SUTO, NOBUYOSHIreporter.nih.gov
Mentalizing deficits in cocaine addiction, associations with immune dysregulation and childhood maltreatmentNIHNational Institute on Drug Abuse2021 to 2022$260,140March 15, 2018February 28, 2023BACHI, KERENreporter.nih.gov
Investigation of how sex steroids and nicotinic acetylcholine receptors promote cocaine self-administrationNIHNational Institute on Drug Abuse2023 to 2025$252,158December 1, 2020January 31, 2027SNEDDON, ELIZABETHreporter.nih.gov
Orexin/hypocretin as a common mediator of stress and reward behavior in cocaine addictionNIHNational Institute on Drug Abuse2023$249,000March 1, 2019April 30, 2025JAMES, MORGAN H.reporter.nih.gov
Investigating the long-term effects of prenatal circadian rhythm disruption on substance use-related disordersNIHNational Institute on Drug Abuse2025$248,996February 15, 2022January 31, 2028DEPOY, LAUREN MARIEreporter.nih.gov
Engineering chemoproteomic tools for identifying molecular mechanisms of substance use disordersNIHNational Institute on Drug Abuse2025$246,000March 15, 2024February 28, 2027KIM, CHRISTINAreporter.nih.gov
Rapid protein translation in nucleus accumbens neurons in response to a cocaine-associated cueNIHNational Institute on Drug Abuse2025$234,000April 15, 2025March 31, 2027WOLF, MARINA ELIZABETHreporter.nih.gov
Contributions of KCNQ2/3 channels to medium spiny neuron excitability and cocaine rewardNIHNational Institute on Drug Abuse2023 to 2025$225,897May 1, 2023April 30, 2026JORGENSEN, EMILYreporter.nih.gov
Validation of a rat model of co-morbid cocaine and alcohol useNIHNational Institute on Drug Abuse2025$225,000September 1, 2025July 31, 2027GILPIN, NICHOLAS WARRENreporter.nih.gov
Integrating preclinical models to develop converging mechanistic data in co-occuring HIV and substance useNIHNational Institute on Drug Abuse2022$222,260July 1, 2020June 30, 2024BARKER, JACQUELINE Mreporter.nih.gov
Affective States and Large-scale Network ActivityNIHNational Institute on Drug Abuse2025$206,955June 15, 2025May 31, 2027DOUTON, JOAQUIN Ereporter.nih.gov
Single Cell Encoding of Cocaine Seeking Behavior in the Nucleus AccumbensNIHNational Institute on Drug Abuse2021 to 2024$202,476July 1, 2020April 30, 2025CHALHOUB, REDAreporter.nih.gov
Neural activity-based candidate gene identification to link eating disorders and drug addictionNIHNational Institute on Drug Abuse2024$201,750July 1, 2024June 30, 2025SUTO, NOBUYOSHIreporter.nih.gov
Engineering chemoproteomic tools for identifying molecular mechanisms of substance use disordersNIHNational Institute on Drug Abuse2024$189,579March 15, 2024January 15, 2025KIM, CHRISTINAreporter.nih.gov
Role of parasubthalamic astrocytic dysfunction in alcohol use disorderNIHNational Institute on Alcohol Abuse and Alcoholism2024 to 2025$181,753February 1, 2023January 31, 2028WHITE, ALLISONreporter.nih.gov
Investigation of the Molecular Mechanisms Underlying Astrocytic CREB's Regulation of Cocaine Drug-SeekingNIHNational Institute on Drug Abuse2025$180,646December 15, 2024November 30, 2029HOLT, LEANNEreporter.nih.gov
From synapse to function: cocaine-induced cell-type- and circuit-specific accumbal proteome changesNIHNational Institute on Drug Abuse2025$180,606April 1, 2025March 31, 2030YIM, YUN YOUNGreporter.nih.gov
Accumbal integration of brain wide glutamatergic inputs and their dysregulation by cocaine self-administrationNIHNational Institute on Drug Abuse2022 to 2025$175,861June 1, 2022May 31, 2026GABRIEL, STEPHANIE ANN CAJIGASreporter.nih.gov
Corticolimbic circuit and neuroimmune mechanisms of comorbid HIV and cocaine useNIHNational Institute on Drug Abuse2024 to 2025$161,324July 1, 2024June 30, 2026NAMBA, MARK Dreporter.nih.gov
Repurposing Metformin as a Treatment for Cocaine Use DisorderNIHNational Institute on Drug Abuse2023 to 2025$159,738September 27, 2023September 26, 2027HERNANDEZ, EDITHreporter.nih.gov
Age and sex-differences in reward responding after punishmentNIHNational Institute on Drug Abuse2025$159,625July 1, 2025June 30, 2027MARINELLI, MICHELA (MICKY)reporter.nih.gov
Rhythms in Cholinergic Interneuron Activity Mediate Drug-Taking BehaviorsNIHNational Institute on Drug Abuse2024 to 2025$152,324September 1, 2024August 31, 2026STOWE, TAYLOR ASHLEYreporter.nih.gov
Estrogen receptor regulation of cocaine effects on dopamine terminalsNIHNational Institute on Drug Abuse2022 to 2025$149,266September 1, 2022June 30, 2026ERICKSON, KIRSTY R.reporter.nih.gov
Enabling Discovery-Based Brain Metabolomics with Ultra-High Resolution Liquid Chromatography and Machine LearningNIHNational Institute on Drug Abuse2024 to 2025$148,460July 1, 2024June 30, 2027CAIN, CAITLINreporter.nih.gov
Cocaine effects on spatial patterns of striatal dopamine releaseNIHNational Institute on Drug Abuse2024 to 2025$148,112June 1, 2024May 31, 2027REILEY, HANNAHreporter.nih.gov
Astrocyte-mediated regulation of cocaine-generated synapses during cocaine seekingNIHNational Institute on Drug Abuse2023 to 2025$146,206September 1, 2023August 31, 2026ZINSMAIER, ALEXANDERreporter.nih.gov
5-HT7 receptor modulation of cocaine effectsNIHNational Institute on Drug Abuse2022 to 2023$144,503August 1, 2022July 31, 2025OLIVE, M. FOSTERreporter.nih.gov
Relapse to drug-seeking behavior is regulated by medial habenula NR4A2 in male and female miceNIHNational Institute on Drug Abuse2022 to 2023$143,574March 1, 2022February 29, 2024CHILDS, JESSICA ERINreporter.nih.gov
Synaptogyrin-3 promotes behavioral resilience and protects against cocaine-induced dopaminergic adaptationsNIHNational Institute on Drug Abuse2021 to 2023$140,482February 16, 2021April 30, 2025PECK, EMILY GRACEreporter.nih.gov
Investigating the ventral pallidum-ventral tegmental area circuit in cocaine relapseNIHNational Institute on Drug Abuse2022 to 2024$140,303March 8, 2022March 22, 2024CAMPBELL, RIANNEreporter.nih.gov
Intersecting genetic risk for extreme cocaine self-administration with dopamine neurotransmissionNIHNational Institute on Drug Abuse2023$140,144January 1, 2023December 31, 2023BAGLEY, JARED Rreporter.nih.gov
Circuit mechanisms underlying inflexible habitual behaviors following chronic cocaine useNIHNational Institute on Drug Abuse2025$136,929April 1, 2025March 31, 2027CHEVEE, MAXIME F.reporter.nih.gov
Defining sex differences in GABA regulation of dopamine release in cocaine use disorderNIHNational Institute on Drug Abuse2022 to 2025$134,187September 1, 2022August 31, 2026CHRISTENSEN, BROOKE A.reporter.nih.gov
Developing an Ex Vivo Model of the Mesolimbic Pathway for Studying Addiction PhenotypesNIHNational Institute on Drug Abuse2021 to 2023$126,352April 15, 2021April 14, 2024RUDIBAUGH, THOMASreporter.nih.gov
Resting State fMRI Functional and Effective Connectivity in Opioid and Cocaine Use DisordersNIHNational Institute on Drug Abuse2022 to 2024$123,065June 10, 2022June 9, 2025WOISARD, KYLEreporter.nih.gov
FGF13 Control of Hippocampal Excitability in Cocaine Contextual MemoryNIHNational Institute on Drug Abuse2022 to 2024$122,013April 1, 2022July 28, 2024LIN, SUSANreporter.nih.gov
Cocaine-Mediated Modulation of Dopamine Transmission and Its Effects on Peripheral ImmunityNIHNational Institute on Drug Abuse2025$118,962July 1, 2025June 30, 2027GOPINATH, ADITHYA Kreporter.nih.gov
Kappa Opioid Receptor Availability, Social Rank, and Cocaine Self-Administration in Female and Male MonkeysNIHNational Institute on Drug Abuse2022 to 2024$117,170February 1, 2022March 29, 2024JOHNSON, BERNARD Nreporter.nih.gov
Reversing Cocaine-induced Neurobehavioral Deficits using a Combination Drug ApproachNIHNational Institute on Drug Abuse2021 to 2023$116,987January 15, 2019March 14, 2023ESTAVE, PAIGE MARIEreporter.nih.gov
The influence of peroxisome proliferator-activated receptor gamma coactivator - 1 alpha (PGC-1a) on the nucleus accumbens during cocaine-self-administrationNIHNational Institute on Drug Abuse2021 to 2022$114,062September 2, 2021May 1, 2023CALARCO, CALI ANNreporter.nih.gov
Defining the cell-type specific role of histone acetyltransferase KAT2a in nucleus accumbens D1 medium spiny neurons as a driver of cocaine use disorderNIHNational Institute on Drug Abuse2023 to 2025$111,489August 1, 2023July 31, 2027EMERSON, SOREN Dreporter.nih.gov
Concurrent chronic stress and cocaine self-administration: Understanding effects on mPFC microglia and drug choice behaviorNIHNational Institute on Drug Abuse2024 to 2025$108,512July 1, 2024April 30, 2028NOWAK, DAVID Breporter.nih.gov
FMRP in the striatum: mechanisms of early drug rewardNIHNational Institute on Drug Abuse2021 to 2022$105,669April 1, 2021March 31, 2023HUEBSCHMAN, JESSICAreporter.nih.gov
Involvement of Gq Signaling in the Mobilization of 2-Arachidonoylglycerol by Corticosterone in the Prefrontal CortexNIHNational Institute on Drug Abuse2024 to 2025$98,512April 1, 2024March 31, 2027LASKOWSKI, LAUREN Jreporter.nih.gov
Opioidergic mechanisms underlying cocaine conditioned reinforcementNIHNational Institute on Drug Abuse2021 to 2023$97,312August 1, 2021December 10, 2023RYSZTAK, LAUREN GRACEreporter.nih.gov
Systems Genetics of Cocaine Preference in DrosophilaNIHNational Institute on Drug Abuse2023 to 2024$96,668September 8, 2023September 7, 2025HATFIELD, JEFFREY Sreporter.nih.gov
Diurnal Variation in Acetylcholine Modulation of Dopamine Dynamics Following Chronic Cocaine IntakeNIHNational Institute on Drug Abuse2023 to 2024$96,668March 15, 2023March 14, 2025IACINO, MELODY COURTNEY-LYNNreporter.nih.gov
Characterizing BLA dopaminergic and glutamatergic mechanisms of dynamic drug seekingNIHNational Institute on Drug Abuse2024 to 2025$95,260February 12, 2024February 11, 2027BRICKNER, MEGAN Areporter.nih.gov
Extended amygdala mGlu8 receptor signaling in stress-reward interactionsNIHNational Institute on Drug Abuse2021 to 2023$94,759July 1, 2021June 30, 2024NABIT, BRETTONreporter.nih.gov
Differential Nicotinic Acetylcholine Receptor Modulation of Striatal Dopamine Release as a Mechanism Underlying Individual Differences in Drug Acquisition RatesNIHNational Institute on Drug Abuse2022 to 2023$94,446January 2, 2022January 1, 2024LEACH, AMY CLAIREreporter.nih.gov
Identifying the Distinct Intracellular Pathways That Mediate Dopamine-Driven BehaviorsNIHNational Institute on Drug Abuse2021 to 2022$92,788September 1, 2021August 31, 2023RAUFFENBART, CAROLINEreporter.nih.gov
Recruitment of striatal enkephalin by cocaine as a substrate for striatopallidal circuit adaptations and cocaine seekingNIHNational Institute on Drug Abuse2024 to 2025$92,106June 1, 2024May 31, 2027MATSUMURA, KANAKOreporter.nih.gov
Endocannabinoid regulation of the corticoaccumbens pathway and stress-enhanced cocaine-seeking behaviorNIHNational Institute on Drug Abuse2023 to 2024$91,456August 9, 2023August 8, 2026GAULDEN, ANDREWreporter.nih.gov
Role of Reelin protein in the cellular and behavioral response to drugs of abuseNIHNational Institute on Drug Abuse2024 to 2025$90,850April 1, 2024March 31, 2027BRIDA, KASEY LYNNreporter.nih.gov
Investigating the role of locus coeruleus in conditioned cocaine-stimulus control of attentionNIHNational Institute on Drug Abuse2021 to 2022$90,721July 1, 2019June 30, 2023PRESKER, MARK ANTONreporter.nih.gov
The effect of ethanol self-administration on cocaine reinforcement in male and female monkeysNIHNational Institute on Drug Abuse2024 to 2025$86,188April 1, 2024November 29, 2025ROUGH, MIA ISABELreporter.nih.gov
The design, synthesis, and evaluation of natural product-inspired small molecules targeting the 5-HT2C receptor as novel therapeutics for opioid use disorderNIHNational Institute on Drug Abuse2021 to 2022$83,776April 1, 2020March 31, 2023ORR, MEGHAN JOreporter.nih.gov
Defining the role of glucocorticoid-related dendritic spine plasticity in cocaine-induced habitsNIHNational Institute on Drug Abuse2021 to 2022$80,919June 9, 2020December 31, 2022SEQUEIRA, MICHELLE KATHRYNreporter.nih.gov
Mechanisms of nicotinic acetylcholine receptor modulation of cocaine rewardNIHNational Institute on Drug Abuse2022 to 2023$80,437July 1, 2022August 15, 2023MOEN, JANNA Kreporter.nih.gov
Dopaminergic regulation of aversion-motivated behaviorsNIHNational Institute on Drug Abuse2023 to 2025$78,699August 28, 2023January 9, 2026GRAFELMAN, ELAINEreporter.nih.gov
Impact of cocaine-associated cues and contexts on adolescent relapseNIHNational Institute on Drug Abuse2025$78,500May 1, 2025April 30, 2027JOHNSON, ALEXANDER W.reporter.nih.gov
Investigating cytoskeletal dynamics in astrocyte structure and cocaine seeking behaviorNIHNational Institute on Drug Abuse2022 to 2023$78,176September 1, 2022August 31, 2024FRANKLIN, JANAYreporter.nih.gov
Specificity and stability of cocaine ensemblesNIHNational Institute on Drug Abuse2025$77,612June 24, 2025June 23, 2027BARTH, BRADLEY BRIGHAMreporter.nih.gov
Exploring striatal circuits underlying behavioral flexibility during punishment of cocaine seekingNIHNational Institute of Neurological Disorders and Stroke2022 to 2023$77,523September 15, 2022September 14, 2024CRUZ, ADELIS MARIEreporter.nih.gov
Defining Disruptions to Dopaminergic Control of Striatal Activity after Chronic Cocaine UseNIHNational Institute on Drug Abuse2024$77,284July 1, 2024June 30, 2025LEONARD, MICHAEL Z.reporter.nih.gov
Interaction of HIV-1 Nef and glutamate homeostasis in the nucleus accumbens during cocaine addictionNIHNational Institute on Drug Abuse2022 to 2023$76,160September 1, 2022August 31, 2024PLA TENORIO, JESSALYN GABRIELLEreporter.nih.gov
The role of nucleus accumbens dopamine in incubation of cocaine cravingNIHNational Institute on Drug Abuse2023 to 2024$74,771March 8, 2023June 28, 2024WEBER, SOPHIA JIAHNreporter.nih.gov
Dissecting the role of amygdalo-striatal circuits in the regulation of stress and cocaine comorbidity in ratsNIHNational Institute on Drug Abuse2021 to 2022$73,256July 1, 2021June 30, 2023MORALES-SILVA, ROBERTO Jreporter.nih.gov
Cell Subtype Transcriptional Role of Nab2 in Cocaine Self AdministrationNIHNational Institute on Drug Abuse2021 to 2022$69,756August 30, 2021May 17, 2023CHOI, ERIC Yreporter.nih.gov
The Role of Estradiol on Central Dopamine Signaling and its Associations with Cocaine Preference and ExerciseNIHNational Institute on Drug Abuse2022 to 2023$68,340August 5, 2022August 4, 2024SHAY, DUSTIreporter.nih.gov
Designing synthetic transcription factors to study drug-specific transcription and behaviorsNIHNational Institute on Drug Abuse2023 to 2024$66,095June 25, 2023November 29, 2024PICONE, JOSEPH ANTHONYreporter.nih.gov
Competing basolateral amygdala inputs to the infralimbic and prelimbic cortices in cocaine-seeking behaviorNIHNational Institute on Drug Abuse2024 to 2025$64,595February 8, 2024November 2, 2025ZIMBELMAN, ALEXA RYANreporter.nih.gov
Defining the neural ensembles of cocaine addictionNIHNational Institute on Drug Abuse2021 to 2022$62,224June 1, 2020May 31, 2023THIBEAULT, KIMBERLY Creporter.nih.gov
Claustrum serotonin and spike-timing plasticity associated with cognitive deficits after cocaineNIHNational Institute on Drug Abuse2023 to 2025$58,453November 1, 2023March 31, 2025ANDERSON, TANNERreporter.nih.gov
Polysubstance use and mental health outcomes after substance abuse treatment among community-based men of color who have sex with men in Los Angeles living with and without HIVNIHNational Institute on Drug Abuse2023$52,499September 30, 2023August 31, 2024KOERBER, JULIA JANreporter.nih.gov
The effect of opioids, stimulants, and the simultaneous use of both on the hepatitis C virus (HCV) cascade of care in rural communities in the United StatesNIHNational Institute on Drug Abuse2022 to 2023$51,995May 3, 2022May 7, 2023ESTADT, ANGELA Treporter.nih.gov
Mechanisms of Nucleus Accumbens Cell-Type Specific Deep Brain Stimulation in Cocaine ReinstatementNIHNational Institute on Drug Abuse2023$49,182January 8, 2022September 7, 2023RICH, MATTHEW Treporter.nih.gov
Investigation of Novel Drug Targets for Stimulant Use DisorderNIHNational Institute of Neurological Disorders and Stroke2023$48,694February 1, 2023December 8, 2023WHITE, ALLISONreporter.nih.gov
Elucidating the Mechanisms and Relevance of Cocaine-Induced Plasticity of Inhibitory G Protein Signaling in the Prelimbic CortexNIHNational Institute on Drug Abuse2025$47,042June 1, 2025May 31, 2028WELTER, ALEX LARSENreporter.nih.gov
Epigenetic Mechanisms Underlying Drug-seeking Behavior: Role of HDAC3 in Regulating Gene Expression within the MHb Cholinergic Population for Cocaine-induced Relapse-like BehaviorNIHNational Institute on Drug Abuse2024$44,850April 1, 2024March 31, 2025ALIZO VERA, VANESSAreporter.nih.gov
The role of NPAS4 in drug addictionNIHNational Institute on Drug Abuse2022$44,208July 1, 2021June 30, 2022HUGHES, BRANDON W.reporter.nih.gov
The role of dopamine in OFC-DMS plasticity in punishment-resistant reward-seeking behaviorNIHNational Institute on Drug Abuse2024$44,187June 1, 2024May 31, 2025MWENDA, NKATHA KARIMIreporter.nih.gov
Muscarinic Receptor Mediation of Cocaine-Dependent Reward Signals: Impact of Pharmacological ModulationNIHNational Institute on Drug Abuse2025$44,160August 25, 2025August 24, 2028GEISLER, ELIZABETH STELLAreporter.nih.gov
Molecular and Functional Characterization of Transcriptionally Defined Subpopulations of VTA Dopamine NeuronsNIHNational Institute on Drug Abuse2025$43,420May 1, 2025October 31, 2027FITZGERALD, NATALIE DALTONreporter.nih.gov
Role of PL CaMKII in incubated cocaine-cravingNIHNational Institute of Neurological Disorders and Stroke2024$43,017September 13, 2024August 31, 2025HUERTA SANCHEZ, LAURAreporter.nih.gov
DREADD Manipulations of Drug ChoiceNIHNational Institute on Drug Abuse2023$41,535July 1, 2023May 24, 2024ROBINSON, HANNAHreporter.nih.gov
Structural and functional responses of nucleus accumbens microglia following long-access cocaine self-administrationNIHNational Institute on Drug Abuse2024$40,441August 1, 2024July 31, 2025BELLINGER, TANIA JAZMINEreporter.nih.gov
Norepinephrine modulates medial prefrontal cortex neural ensembles that control cocaine seeking behaviorNIHNational Institute on Drug Abuse2022$40,364June 15, 2022September 30, 2022GHEIDI, ALIreporter.nih.gov
Influence of fear conditioning prior to cocaine self-administration on cocaine seeking in adult rats: assessing the role of the frontostriatal circuits in trauma and cocaine use co-occurrenceNIHNational Institute on Drug Abuse2024$39,552July 1, 2024June 30, 2025PEREZ, YOBET Areporter.nih.gov
The Role of Prelimbic Corticotrophin Releasing Factor Type 1 Receptor and L-Type Calcium Channels in Stress-induced RelapseNIHNational Institute on Drug Abuse2025$37,522April 1, 2025June 30, 2028UCHENDU, STACY NDIDIreporter.nih.gov
Defining the effects of cocaine delivery speed on the encoding of drug-cue associationsNIHNational Institute on Drug Abuse2025$34,980September 1, 2025August 31, 2030CLARITY, THOMASreporter.nih.gov
Investigating the Role of Gilz, an X-linked Gene, in Regulating Cocaine-Induced Cellular Activity and Cocaine-Associated MemoryNIHNational Institute on Drug Abuse2024$26,034April 1, 2024July 31, 2024ROUNDS, JACOBreporter.nih.gov
Impact of Cocaine History on Pharmacotherapy EffectivenessNIHNational Institute on Drug Abuse2023$19,379August 25, 2023January 1, 2024MARCUS, MADISON Mreporter.nih.gov

Organizations

OrganizationPlaceNIH awardsNIH amountNSF awardsNSF amount
Ut Southwestern Medical CenterDallas, TX2$44 million0$0
University of Miami School of MedicineCoral Gables, FL3$28.2 million0$0
University of California, San DiegoLa Jolla, CA8$22 million0$0
Icahn School of Medicine at Mount SinaiNew York, NY14$21.8 million0$0
University of KentuckyLexington, KY10$16 million0$0
University of Maryland BaltimoreBaltimore, MD9$15.9 million0$0
University of Pittsburgh at PittsburghPittsburgh, PA12$14.8 million0$0
Allen InstituteSeattle, WA1$14.5 million0$0
Virginia Commonwealth UniversityRichmond, VA15$14.2 million0$0
Yale UniversityNew Haven, CT11$13.9 million0$0
University of PennsylvaniaPhiladelphia, PA7$13.2 million0$0
University of Texas Med BR GalvestonGalveston, TX7$12.8 million0$0
Temple Univ of the CommonwealthPhiladelphia, PA9$12.6 million0$0
Broad Institute, Inc.Cambridge, MA1$12.6 million0$0
Wake Forest University Health SciencesWinston-Salem, NC16$11.9 million0$0
Medical University of South CarolinaCharleston, SC13$11 million0$0
Phoenix Pharmalabs, Inc.Woodscross, UT1$8.7 million0$0
Johns Hopkins UniversityBaltimore, MD6$7.9 million0$0
Florida International UniversityMiami, FL1$7.4 million0$0
University of Alabama at BirminghamBirmingham, AL7$7.2 million0$0
Jackson LaboratoryBar Harbor, ME3$7.1 million0$0
Sparian Biosciences, Inc.New York City, NY1$6.9 million0$0
Omeros CorporationSeattle, WA1$6.7 million0$0
University of Michigan at Ann ArborAnn Arbor, MI7$6.7 million0$0
Medical College of WisconsinMilwaukee, WI7$6.3 million0$0
University of FloridaGainesville, FL7$6.2 million0$0
University of Texas HLTH Sci CTR HoustonHouston, TX4$6.2 million0$0
Research Triangle InstituteResearch Triangle Park, NC3$6.1 million0$0
Drexel UniversityPhiladelphia, PA9$5.9 million0$0
Vanderbilt UniversityNashville, TN15$5.6 million0$0
Tempero Bio, Inc.Oakland, CA1$5.3 million0$0
Tonix Pharmaceuticals, Inc.Chatham, NJ1$5.2 million0$0
Oregon Health & Science UniversityPortland, OR6$5.1 million0$0
University of VirginiaCharlottesville, VA3$4.9 million0$0
University of WashingtonSeattle, WA3$4.6 million0$0
University of South Carolina at ColumbiaColumbia, SC4$4.2 million0$0
University of California, San FranciscoSan Francisco, CA2$4.1 million0$0
Emory UniversityAtlanta, GA2$4.1 million0$0
University of Nebraska Medical CenterOmaha, NE4$4 million0$0
University of IowaIowa City, IA4$4 million0$0
Friends Research Institute, Inc.Baltimore, MD2$3.8 million0$0
Rutgers Biomedical and Health SciencesNewark, NJ5$3.7 million0$0
Brigham and Women's HospitalBoston, MA1$3.7 million0$0
Boston Children's HospitalBoston, MA1$3.7 million0$0
University of Mississippi Med CTRJackson, MS3$3.6 million0$0
Mclean HospitalBelmont, MA2$3.5 million0$0
Southern Research InstituteBirmingham, AL1$3.4 million0$0
Trustees of Boston UniversityBoston, MA2$3.2 million0$0
University of Maryland, College ParkCollege Park, MD4$3.1 million0$0
Stanford UniversityStanford, CA3$3.1 million0$0
Rush University Medical CenterChicago, IL1$3.1 million0$0
Meharry Medical CollegeNashville, TN1$3 million0$0
Evon Medics, LLCElkridge, MD1$2.9 million0$0
University of Texas HLTH Science CenterSan Antonio, TX2$2.9 million0$0
University of California-IrvineIrvine, CA4$2.9 million0$0
Northwestern University at ChicagoChicago, IL3$2.8 million0$0
Virginia Polytechnic Institute and State UniversityBlacksburg, VA1$2.8 million0$0
Praeventix, LLCExton, PA1$2.8 million0$0
University of Kansas Medical CenterKansas City, KS1$2.8 million0$0
Rbhs-Robert Wood Johnson Medical SchoolPiscataway, NJ4$2.6 million0$0
Clemson UniversityClemson, SC2$2.6 million0$0
New York University School of MedicineNew York, NY2$2.5 million0$0
Vanderbilt University Medical CenterNashville, TN1$2.4 million0$0
Weill Medical Coll of Cornell UnivNew York, NY3$2.4 million0$0
Duke UniversityDurham, NC4$2.4 million0$0
University of Texas at El PasoEl Paso, TX3$2.4 million0$0
SUNY Downstate Medical CenterBrooklyn, NY1$2.3 million0$0
University of ChicagoChicago, IL2$2.3 million0$0
Marshall University Research CorporationHuntington, WV3$2.2 million0$0
University of MinnesotaMinneapolis, MN6$2.2 million0$0
Ohio State UniversityColumbus, OH2$2.2 million0$0
University of Texas at AustinAustin, TX3$2.2 million0$0
Legacy Emanuel Hospital and Health CenterPortland, OR1$2.2 million0$0
SUNY at Stony BrookStony Brook, NY2$2.1 million0$0
Scripps Research Institute, theLa Jolla, CA4$2 million0$0
Seattle Children's HospitalSeattle, WA2$2 million0$0
New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INCNew York, NY2$2 million0$0
Northern California Institute/res/eduSan Francisco, CA1$2 million0$0
University of Wisconsin-MadisonMadison, WI1$1.9 million0$0
University of California-Santa BarbaraSanta Barbara, CA2$1.8 million0$0
Univ of North Carolina Chapel HillChapel Hill, NC5$1.8 million0$0
Marquette UniversityMilwaukee, WI2$1.8 million0$0
Old Dominion UniversityNorfolk, VA3$1.8 million0$0
Washington State UniversityPullman, WA1$1.7 million0$0
Fordham UniversityBronx, NY1$1.6 million0$0
University of Texas at DallasRichardson, TX1$1.6 million0$0
University of ConnecticutStorrs, CT1$1.5 million0$0
Eastern Virginia Medical SchoolNorfolk, VA1$1.5 million0$0
Rowan University School/osteopathic MedStratford, NJ2$1.4 million0$0
Boston University Medical CampusBoston, MA1$1.4 million0$0
University of Illinois at ChicagoChicago, IL1$1.4 million0$0
Davidson CollegeDavidson, NC2$1.3 million0$0
Northeastern UniversityBoston, MA1$1.3 million0$0
Indiana University IndianapolisIndianapolis, IN1$1.3 million0$0
American UniversityWashington, DC1$1.3 million0$0
SUNY at BuffaloAmherst, NY2$1.2 million0$0
Texas A&M UniversityCollege Station, TX2$1.2 million0$0
Mayo Clinic RochesterRochester, MN2$1.1 million0$0
University of Colorado DenverAurora, CO1$1 million0$0
Rosalind Franklin Univ of Medicine & SciNorth Chicago, IL1$1 million0$0

Funding by fiscal year

Fiscal yearNIH awardsNIH amountNSF awardsNSF amount
2025195$124,788,6970$0
2024217$121,331,7370$0
2023227$127,939,0830$0
2022242$125,084,8960$0
2021158$82,608,7360$0

Open federal funding opportunities

From Grants.gov: notices that funded awards in this table, and open notices on the same agency and assistance listing.

Open opportunityNumberAgencyListingClosesAward ceilingWhy it matches
NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed)PA-24-194NIHMay 7, 2027Not listedNotice number printed on 3 awards here
Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed)PA-24-176NIHMay 7, 2027Not listedNotice number printed on 1 award here
High Priority HIV and Substance Use Research (RM1 Clinical Trial Optional)RFA-DA-25-060NIHMarch 5, 2027$1.5 millionNotice number printed on 1 award here
Change of Recipient Organization (Type 7 Parent Clinical Trial Optional)PA-24-254NIHJuly 12, 2027Not listedNotice number printed on 1 award here
NIDA Mentored Clinical Scientist Development Program Award in Substance Use and Substance Use Disorder Research (K12 Clinical Trial Optional)PAR-24-089NIH93.279November 13, 2026$750,000Same assistance listing 93.279 as 403 awards here
Ethical, Legal and Social Implications (ELSI) Small Research Grant (R03 Clinical Trial Optional)PAR-25-370NIH93.279November 16, 2026$50,000Same assistance listing 93.279 as 403 awards here
Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant (R21 Clinical Trial Optional)PAR-25-369NIH93.279November 18, 2026Not listedSame assistance listing 93.279 as 403 awards here
Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)PAR-25-371NIH93.279November 18, 2026Not listedSame assistance listing 93.279 as 403 awards here
Competing Revisions to Existing NIH Single Project Research Grants and Cooperative Agreements (Clinical Trial Optional)PA-23-317NIH93.279November 24, 2026Not listedSame assistance listing 93.279 as 403 awards here
Emerging Global Leader Award (K43 Independent Clinical Trial Required)PAR-24-295NIH93.279December 3, 2026Not listedSame assistance listing 93.279 as 403 awards here
Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed)PAR-24-296NIH93.279December 3, 2026Not listedSame assistance listing 93.279 as 403 awards here
NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)RFA-OD-24-011NIH93.279December 4, 2026Not listedSame assistance listing 93.279 as 403 awards here
Small Business Transition Grant for New Entrepreneurs (Parent R43/R44 Clinical Trial Optional)PAR-27-039NIH93.279January 5, 2027Not listedSame assistance listing 93.279 as 403 awards here
Small Business Transition Grant for New Entrepreneurs (Parent R41/R42 Clinical Trial Optional)PAR-27-040NIH93.279January 5, 2027Not listedSame assistance listing 93.279 as 403 awards here
Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required)PAR-24-214NIH93.279January 7, 2027$375,000Same assistance listing 93.279 as 403 awards here
Intervention Research to Improve Native American Health (R34 Clinical Trial Optional)PAR-25-378NIH93.279January 7, 2027Not listedSame assistance listing 93.279 as 403 awards here
Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)PAR-25-379NIH93.279January 7, 2027Not listedSame assistance listing 93.279 as 403 awards here
HEAL Initiative: Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required)RFA-DA-28-011NIH93.279January 26, 2027Not listedSame assistance listing 93.279 as 403 awards here
HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR) - Building Engagement, Assistance, Capacity, Outreach, and Networks (BEACON) Center (U2C Clinical Trial Not Allowed)RFA-DA-28-012NIH93.279January 26, 2027Not listedSame assistance listing 93.279 as 403 awards here
Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program (UC2- Clinical Trial Not Allowed)PAR-24-268NIH93.279January 27, 2027$500,000Same assistance listing 93.279 as 403 awards here

Updated November 4, 2026. Read from NIH RePORTER ExPORTER and NSF Award Search. Published by NIH and NSF as U.S. government data. NIH awards are fiscal years 2021 to 2025 (NIH files published to 2026-07-09); NSF awards are fiscal years 2022 to 2026 (NSF files published to 2026-11-04). NIH amounts are the total cost of each fiscal year in the window; NSF amounts are the funds obligated in the window. Organizations are matched on the UEI. Open opportunities come from Grants.gov and match on agency and assistance listing number, and on the notice number NIH prints on an award. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.