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Data / Research funding / Charcot-Marie-Tooth Disease

Charcot-Marie-Tooth Disease: 64 NIH awards ($56.1M) to 36 organizations

64 NIH awards ($56.1M) in the NIH spending category Charcot-Marie-Tooth Disease, to 36 organizations, read 2026-11-03. NIH fiscal years 2021 to 2025.

SpecStream is the live web data engine for teams and agents. It reads the NIH and NSF award files each time the agencies update them, and this page is that reading, joined to the open federal funding opportunities on Grants.gov. Ask for the awards you track by topic, organization or state and new awards arrive in your sheet, CRM, Slack or agent as the agencies publish them.

Topic
NIH spending category

Awards

64 awards in the window.

AwardAgencyInstitute or divisionFiscal yearAmount in windowStartEndPrincipal investigatorSource
STRUCTURAL VARIATION IN NEUROLOGICAL DISEASENIHNational Institute of Neurological Disorders and Stroke2021 to 2025$4,141,654December 15, 2017November 30, 2026LUPSKI, JAMES R.reporter.nih.gov
Accelerate Clinical Trials in CMT (ACTCMT) StudyNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$3,658,507May 1, 2019February 28, 2026HERRMANN, DAVID Nreporter.nih.gov
Exploring the Functions of tRNA Synthetases in the Nucleus and their Relationship to CMTNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$2,285,535April 1, 2020March 31, 2025YANG, XIANG-LEIreporter.nih.gov
Link extracellular function of tRNA synthetase with pathological mechanism of diseaseNIHNational Institute of General Medical Sciences2021 to 2025$2,260,000June 1, 2021August 31, 2026YANG, XIANG-LEIreporter.nih.gov
Control of calcium flux and mitochondrial fission by the Charcot Marie Tooth disease protein Mfn2.NIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,243,240January 1, 2021December 31, 2025VAN DER BLIEK, ALEXANDER Mreporter.nih.gov
The Genetics of the Neuromuscular Junction: Mechanisms and Disease ModelsNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$2,053,330August 1, 2025May 31, 2027BURGESS, ROBERT W.reporter.nih.gov
Mitofusin agonists to prevent Charcot-Marie-Tooth disease 2ANIHNational Institute of Neurological Disorders and Stroke2021 to 2022$1,960,976September 30, 2019August 31, 2024DORN, GERALD W.reporter.nih.gov
Mitofusin Agonists to Treat Neurodegenerative DiseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2023$1,954,883May 15, 2022April 30, 2025HAUGER, DEBORAH ANNreporter.nih.gov
Genomic Studies in Charcot-Marie-Tooth DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,886,243September 15, 2019July 31, 2025ZUCHNER, STEPHANreporter.nih.gov
Allele-specific inactivation for dominant negative NEFL MutationsNIHNational Institute of Neurological Disorders and Stroke2021 to 2025$1,855,975August 15, 2021June 30, 2027JUDGE, LUKE Mreporter.nih.gov
Folding, Misfolding, and Function of PMP22NIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,650,616April 1, 2016January 31, 2028SANDERS, CHARLES Rreporter.nih.gov
JAX-Gladstone, SCGE Disease Models Studies SupplementNIHNational Institute of Environmental Health Sciences2021 to 2022$1,641,672September 25, 2018June 30, 2023CONKLIN, BRUCE Rreporter.nih.gov
Impact of Schwann Cell Pathology on Axon Structure and FunctionNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$1,574,423December 1, 2022November 30, 2027SALZER, JAMESreporter.nih.gov
Laminin Receptors and Signals in Schwann CellsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,546,694July 1, 2003January 31, 2025SIM, FRASER JAMESreporter.nih.gov
Functional Analysis of O-GlcNAc using Synthetic Protein ChemistryNIHNational Institute of General Medical Sciences2021 to 2024$1,442,331August 1, 2015July 31, 2025PRATT, MATTHEW ROBERTreporter.nih.gov
Generalizing genome editing for rare disease-causing variantsNIHOffice of the Director, National Institutes of Health2025$1,416,375September 18, 2025August 31, 2028NEWBY, GREGORY A.reporter.nih.gov
Novel SMARD1 Mouse Models: Characterization and Evaluation of Potential Therapeutic TargetsNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,380,377February 1, 2020January 31, 2026LORSON, CHRISTIAN L.reporter.nih.gov
The Role of ESCRTs in Regulating Nervous System FunctionNIHNational Institute of Neurological Disorders and Stroke2021 to 2024$1,306,650December 1, 2019November 30, 2025WILSON, SCOTT MICHAELreporter.nih.gov
Translational control of stress response signalingNIHNational Institute of General Medical Sciences2023 to 2025$1,286,370September 22, 2023August 31, 2028RYOO, HYUNG Dreporter.nih.gov
Understanding the role of patient-derived Ighmbp2 mutations in neurodegeneration and pre-rRNA processingNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,181,939January 1, 2024December 31, 2028LORSON, CHRISTIAN L.reporter.nih.gov
Comprehensive gene and DNA variant curation for neuromuscular diseasesNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$1,079,672June 15, 2021May 31, 2025ZUCHNER, STEPHANreporter.nih.gov
Role of a Fatty Acid Chaperone in Schwann Cell MyelinationNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$1,019,124February 1, 2024January 31, 2029BELIN, SOPHIEreporter.nih.gov
Develop pan-specific antibody against mutant glycyl-tRNA synthetase for treating CMT2DNIHNational Institute of Neurological Disorders and Stroke2022 to 2023$887,500January 1, 2021March 31, 2024YANG, XIANG-LEIreporter.nih.gov
tRNA Gene Replacement Therapy for tRNA-Synthetase Related Charcot-Marie-Tooth DisorderNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$841,280July 1, 2024March 31, 2027BURGESS, ROBERT W.reporter.nih.gov
Pathogenesis in Segmental DemyelinationNIHNational Institute of Neurological Disorders and Stroke2023 to 2025$804,961June 1, 2023May 31, 2028HU, BOreporter.nih.gov
Small Molecule Tools for Modulating Membrane RaftsNIHNational Institute of General Medical Sciences2021 to 2022$764,342September 1, 2020August 31, 2024KENWORTHY, ANNE Kreporter.nih.gov
A Novel Pharmacologic Approach to Treat CMT1XNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$751,688September 15, 2020August 31, 2024DOBROWSKY, RICK Treporter.nih.gov
Structural Biology of Connexin Membrane ChannelsNIHNational Institute of General Medical Sciences2022 to 2023$705,371July 1, 2020June 30, 2025YEAGER, MARK JAYreporter.nih.gov
Structural Biology of Connexin Membrane ChannelsNIHNational Institute of General Medical Sciences2021 to 2022$693,855July 1, 2020October 31, 2022YEAGER, MARK JAYreporter.nih.gov
Molecular mechanisms underlying mitochondria-lysosome membrane contact sites in neuronal function and neurodegenerationNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$633,556September 30, 2018November 30, 2023WONG, YVETTEreporter.nih.gov
Charcot-Marie-Tooth Disease Type 2E: Mechanism and therapyNIHNational Institute of Neurological Disorders and Stroke2025$499,452May 15, 2025April 30, 2030BROWN, ANTHONYreporter.nih.gov
Function and Regulation of PMP22 in CMT1A and HNPPNIHNational Institute of Neurological Disorders and Stroke2021 to 2023$481,950September 21, 2021March 31, 2024MOSS, KATHRYN RENAEreporter.nih.gov
Dissecting the Integrated Stress Response in tRNA Synthetase-Associated NeuropathiesNIHNational Institute of Neurological Disorders and Stroke2023 to 2024$481,875March 1, 2023February 28, 2025BURGESS, ROBERT W.reporter.nih.gov
Function and Regulation of PMP22 in CMT1A and HNPPNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$469,902September 21, 2021March 31, 2027MOSS, KATHRYN RENAEreporter.nih.gov
The impact of ITPR3 mutations on immunityNIHNational Institute of Allergy and Infectious Diseases2024 to 2025$451,000June 21, 2024April 30, 2027VAN OERS, NICOLAI STANISLAS CYRILLEreporter.nih.gov
Characterizing Tissue Specific Regulation of Mutant Lamin Protein DegradationNIHNational Institute on Aging2021$442,936July 1, 2016August 30, 2025HAMMOND, THOMAS MICHAELreporter.nih.gov
Targeting the PMP22 Protein to Develop Leads Against Charcot-Marie-Tooth DiseaseNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$435,441January 20, 2021December 31, 2022SANDERS, CHARLES Rreporter.nih.gov
Restoring neurofilaments to axons in a mouse model of CMT2ENIHNational Institute of Neurological Disorders and Stroke2021$433,125September 15, 2021February 29, 2024BROWN, ANTHONYreporter.nih.gov
Develop pan-specific antibody against mutant glycyl-tRNA synthetase for treating CMT2DNIHNational Institute of Neurological Disorders and Stroke2021$431,350January 1, 2021December 31, 2021YANG, XIANG-LEIreporter.nih.gov
Exploring a new arm of the integrated stress response and its connection to neurodegenerationNIHNational Institute of Neurological Disorders and Stroke2021$410,563July 1, 2021December 31, 2022YANG, XIANG-LEIreporter.nih.gov
Creation of a Schwann Cell Gene Regulatory NetworkNIHNational Institute of Neurological Disorders and Stroke2022 to 2023$400,985March 1, 2022February 28, 2025SVAREN, JOHN Preporter.nih.gov
Pathogenesis in Segmental DemyelinationNIHNational Institute of Neurological Disorders and Stroke2022$385,000July 15, 2022July 17, 2022HU, BOreporter.nih.gov
Assessment of Chemotherapy-Induced Peripheral Neuropathy Susceptibility Using Patient-derived iPSC TechnologyNIHNational Cancer Institute2021$363,713September 18, 2017August 31, 2022STAFF, NATHAN Preporter.nih.gov
TISSUE ENGINEERED HUMAN NEUROMUSCULAR JUNCTIONS FOR MODELING AXONAL NEUROPATHYNIHNational Institute of Neurological Disorders and Stroke2021$356,426November 15, 2016October 31, 2023KIM, DEOK-HOreporter.nih.gov
Fibroblast-derived Engineered Extracellular Vesicle (FieEV) Technology for Targeted Delivery of RNA Therapeutics to treat CMT1A DiseasesNIHNational Center for Advancing Translational Sciences2025$350,000August 15, 2025August 14, 2026DUARTE SANMIGUEL, SILVIA M.reporter.nih.gov
MRI Biomarkers of Disease Progression in Inherited NeuropathiesNIHNational Center for Advancing Translational Sciences2021 to 2022$286,885April 1, 2021July 11, 2022LI, JUNreporter.nih.gov
Development of novel ASO-based therapeutics for CMT1ANIHNational Institute of Neurological Disorders and Stroke2022$256,580June 1, 2022May 31, 2023OCONNOR, STEVEreporter.nih.gov
Understanding the Role of the Integrated Stress Response in tRNA Synthetase-associated Charcot-Marie-Tooth DiseaseNIHNational Institute of Neurological Disorders and Stroke2023 to 2024$244,402August 1, 2023July 31, 2025HINES, TIMOTHYreporter.nih.gov
Pathogenesis of TRPV4-related peripheral neuropathyNIHNational Institute of Neurological Disorders and Stroke2021 to 2022$244,178September 15, 2018June 30, 2023MCCRAY, BRETT ANDREWreporter.nih.gov
Longitudinal Changes in Gait and Ankle Function in Youth with Charcot-Marie-Tooth DiseaseNIHNational Institute of Neurological Disorders and Stroke2023$186,250September 21, 2023August 31, 2025WREN, TISHYA A Lreporter.nih.gov
Testing SARM1 as a Therapeutic Target in Multiple Forms of Charcot-Marie-Tooth DiseaseNIHNational Institute of Neurological Disorders and Stroke2022$173,100August 1, 2022July 31, 2024BURGESS, ROBERT W.reporter.nih.gov
Exploring the Pathophysiology of CMT1GNIHNational Institute of Neurological Disorders and Stroke2024 to 2025$163,500March 1, 2024February 28, 2027BELIN, SOPHIEreporter.nih.gov
Mechanisms of Neurodegeneration in CMT4B3: a Complex Pediatric Neurodevelopmental DisorderNIHEunice Kennedy Shriver National Institute of Child Health & Human Development2023 to 2025$161,206August 1, 2023July 31, 2027JACOBS, ELIZABETH HALEYreporter.nih.gov
Structure of GDAP1 bound to a product of lipid peroxidationNIHNational Institute of Neurological Disorders and Stroke2023 to 2024$144,326March 1, 2023February 28, 2026VANDEMARK, ANDREW PAULreporter.nih.gov
Production and evaluation CMT2 mouse models of ATP1A1 loss-of-function-mutation using Cre-LoxP technologyNIHNational Institute of Neurological Disorders and Stroke2021$136,941April 1, 2021January 31, 2022ARTIGAS, PABLOreporter.nih.gov
Actin-mediated regulation of organelle dynamics in Charcot-Marie-Tooth diseaseNIHNational Institute of General Medical Sciences2021 to 2022$136,192January 1, 2021December 31, 2022SCHIAVON, CARA RAEreporter.nih.gov
Exploring the Role of OSM-9 in Odor Aversive Learning and Long-term MemoryNIHNational Institute on Deafness and Other Communication Disorders2021 to 2023$126,637September 1, 2021August 31, 2024SAIFUDDIN, MASHEL FATEMAreporter.nih.gov
Effects of Aging on Neuronal Lysosomal Damage Responses Driven by CMT2B-linked Rab7NIHNational Institute on Aging2023 to 2025$102,738April 1, 2023June 2, 2025MULLIGAN, RYAN Jreporter.nih.gov
MITOFUSIN AGONISTS TO TREAT NEURODEGENERATIVE DISEASENIHNational Institute of Neurological Disorders and Stroke2021$78,500March 15, 2021July 31, 2021DORN, GERALD W.reporter.nih.gov
Investigating axonal length-dependent pathology in a human stem cell-based model of Charcot-Marie-Tooth disease (type 2D)NIHNational Institute of Neurological Disorders and Stroke2025$77,752September 1, 2025August 31, 2028MCCLOSKEY, MOLLY CATHERINEreporter.nih.gov
Investigating the pathomechanisms underlying Charcot-Marie-Tooth DiseaseNIHNational Institute of Neurological Disorders and Stroke2022 to 2023$70,446July 1, 2022June 30, 2024JONES, JULIA ALEXISreporter.nih.gov
YAP/TAZ in Schwann Cells as Potential Therapeutic Targets in CMT1A and HNPP.NIHNational Institute of Neurological Disorders and Stroke2022 to 2023$65,619August 1, 2022July 31, 2024MOORE, SETH MICHAELreporter.nih.gov
Investigating the Role of the Helicase, IGHMBP2, and the RIG-I-Like Receptor Pathway in Spinal Muscular Atrophy with Respiratory Distress Type 1 and Neuromuscular Development (SMARD1)NIHNational Institute of Neurological Disorders and Stroke2022 to 2023$62,446August 1, 2022July 31, 2024HOLBROOK, SARAHreporter.nih.gov
Investigating the Contribution of Motor Neuronal Mitochondria to Charcot Marie Tooth Type 2D (CMT2D)NIHNational Institute of Neurological Disorders and Stroke2025$45,726August 1, 2025July 31, 2027FUNKE, JONATHANreporter.nih.gov

Organizations

OrganizationPlaceNIH awardsNIH amountNSF awardsNSF amount
Scripps Research Institute, theLa Jolla, CA6$6.3 million0$0
Baylor College of MedicineHouston, TX1$4.1 million0$0
Mitochondria in Motion, Inc.Saint Louis, MO3$4 million0$0
Jackson LaboratoryBar Harbor, ME6$3.9 million0$0
University of RochesterRochester, NY1$3.7 million0$0
University of Miami School of MedicineCoral Gables, FL3$3.1 million0$0
University of Missouri-ColumbiaColumbia, MO3$3 million0$0
New York University School of MedicineNew York, NY2$2.9 million0$0
Johns Hopkins UniversityBaltimore, MD4$2.5 million0$0
University of California Los AngelesLos Angeles, CA1$2.2 million0$0
Vanderbilt UniversityNashville, TN2$2.1 million0$0
University of California, San FranciscoSan Francisco, CA2$2 million0$0
J. David Gladstone InstitutesSan Francisco, CA1$1.6 million0$0
SUNY at BuffaloAmherst, NY2$1.6 million0$0
University of VirginiaCharlottesville, VA3$1.6 million0$0
University of Southern CaliforniaLos Angeles, CA1$1.4 million0$0
University of Alabama at BirminghamBirmingham, AL1$1.3 million0$0
Albany Medical CollegeAlbany, NY2$1.2 million0$0
Ohio State UniversityColumbus, OH2$932,5770$0
Methodist Hospital Research InstituteHouston, TX1$804,9610$0
University of Kansas Center for Research IncLawrence, KS1$751,6880$0
University of MiamiCoral Gables, FL1$705,3710$0
Wayne State UniversityDetroit, MI2$671,8850$0
Northwestern University at ChicagoChicago, IL1$633,5560$0
Ut Southwestern Medical CenterDallas, TX1$451,0000$0
Board of Trustees of Illinois State UniversityNormal, IL1$442,9360$0
University of Wisconsin-MadisonMadison, WI1$400,9850$0
Mayo Clinic RochesterRochester, MN1$363,7130$0
Neucore Bio, Inc.Columbus, OH1$350,0000$0
Shift Pharmaceuticals Holdings, Inc.Columbia, MO1$256,5800$0
Children's Hospital of Los AngelesLos Angeles, CA1$186,2500$0
University of Pittsburgh at PittsburghPittsburgh, PA1$144,3260$0
Texas Tech University Health Scis CenterLubbock, TX1$136,9410$0
Salk Institute for Biological StudiesLa Jolla, CA1$136,1920$0
University of WashingtonSeattle, WA1$77,7520$0
Tufts University BostonBoston, MA1$45,7260$0

Funding by fiscal year

Fiscal yearNIH awardsNIH amountNSF awardsNSF amount
202522$9,296,8040$0
202424$9,030,9500$0
202332$11,842,8790$0
202234$12,577,8580$0
202133$13,317,7900$0

Open federal funding opportunities

From Grants.gov: notices that funded awards in this table, and open notices on the same agency and assistance listing.

Open opportunityNumberAgencyListingClosesAward ceilingWhy it matches
Functional Target Validation for Alzheimer's Disease-Related DementiasRFA-NS-26-034NIH93.853November 6, 2026Not listedSame assistance listing 93.853 as 47 awards here
Clinical Trials and Ancillary Studies Conducted within NIH-Funded Clinical Trial Research Networks (UG3/UH3 - Clinical Trial Required)PAR-27-007NIH93.853November 10, 2026Not listedSame assistance listing 93.853 as 47 awards here
Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)RFA-NS-26-001NIH93.853November 10, 2026Not listedSame assistance listing 93.853 as 47 awards here
Genomic and Biologic Therapies for ADRD (U01 Clinical Trial Optional)RFA-NS-26-030NIH93.853November 10, 2026Not listedSame assistance listing 93.853 as 47 awards here
Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant (R21 Clinical Trial Optional)PAR-25-369NIH93.853November 18, 2026Not listedSame assistance listing 93.853 as 47 awards here
Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)PAR-25-371NIH93.853November 18, 2026Not listedSame assistance listing 93.853 as 47 awards here
NIH StrokeNet Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention (UG3/UH3 Clinical Trial Optional)PAR-25-052NIH93.853November 19, 2026Not listedSame assistance listing 93.853 as 47 awards here
HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)RFA-AT-25-003NIH93.853November 23, 2026$375,000Same assistance listing 93.853 as 47 awards here
Maximizing the Scientific Value of Data Generated by the Environmental Influences on Child Health Outcomes (ECHO) Program: Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32)RFA-OD-27-008NIH93.853December 2, 2026Not listedSame assistance listing 93.853 as 47 awards here
Emerging Global Leader Award (K43 Independent Clinical Trial Required)PAR-24-295NIH93.853December 3, 2026Not listedSame assistance listing 93.853 as 47 awards here
Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed)PAR-24-296NIH93.853December 3, 2026Not listedSame assistance listing 93.853 as 47 awards here
NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)RFA-OD-24-011NIH93.853December 4, 2026Not listedSame assistance listing 93.853 as 47 awards here
Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required)PAR-24-214NIH93.853January 7, 2027$375,000Same assistance listing 93.853 as 47 awards here
HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)RFA-NS-25-023NIH93.853January 15, 2027$350,000Same assistance listing 93.853 as 47 awards here
HEAL Initiative: Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required)RFA-DA-28-011NIH93.853January 26, 2027Not listedSame assistance listing 93.853 as 47 awards here
HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR) - Building Engagement, Assistance, Capacity, Outreach, and Networks (BEACON) Center (U2C Clinical Trial Not Allowed)RFA-DA-28-012NIH93.853January 26, 2027Not listedSame assistance listing 93.853 as 47 awards here
Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program (UC2- Clinical Trial Not Allowed)PAR-24-268NIH93.853January 27, 2027$500,000Same assistance listing 93.853 as 47 awards here
Translational Neural Devices (R61/R33 - Clinical Trial Optional)PAR-25-053NIH93.853January 28, 2027Not listedSame assistance listing 93.853 as 47 awards here
BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS (R18 - Clinical Trial Not Allowed)RFA-NS-24-031NIH93.853January 28, 2027$750,000Same assistance listing 93.853 as 47 awards here
BRAIN Initiative: Clinical Studies to Advance Next-Generation Devices for Recording and Modulation in the Human Central Nervous SystemRFA-NS-28-006NIH93.853January 28, 2027Not listedSame assistance listing 93.853 as 47 awards here

Updated November 3, 2026. Read from NIH RePORTER ExPORTER and NSF Award Search. Published by NIH and NSF as U.S. government data. NIH awards are fiscal years 2021 to 2025 (NIH files published to 2026-07-09); NSF awards are fiscal years 2022 to 2026 (NSF files published to 2026-11-02). NIH amounts are the total cost of each fiscal year in the window; NSF amounts are the funds obligated in the window. Organizations are matched on the UEI. Open opportunities come from Grants.gov and match on agency and assistance listing number, and on the notice number NIH prints on an award. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.