Data / Research funding / Charcot-Marie-Tooth Disease
Charcot-Marie-Tooth Disease: 64 NIH awards ($56.1M) to 36 organizations
64 NIH awards ($56.1M) in the NIH spending category Charcot-Marie-Tooth Disease, to 36 organizations, read 2026-11-03. NIH fiscal years 2021 to 2025.
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Awards
64 awards in the window.
| Award | Agency | Institute or division | Fiscal year | Amount in window | Start | End | Principal investigator | Source |
|---|---|---|---|---|---|---|---|---|
| STRUCTURAL VARIATION IN NEUROLOGICAL DISEASE | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $4,141,654 | December 15, 2017 | November 30, 2026 | LUPSKI, JAMES R. | reporter.nih.gov |
| Accelerate Clinical Trials in CMT (ACTCMT) Study | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2023 | $3,658,507 | May 1, 2019 | February 28, 2026 | HERRMANN, DAVID N | reporter.nih.gov |
| Exploring the Functions of tRNA Synthetases in the Nucleus and their Relationship to CMT | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $2,285,535 | April 1, 2020 | March 31, 2025 | YANG, XIANG-LEI | reporter.nih.gov |
| Link extracellular function of tRNA synthetase with pathological mechanism of disease | NIH | National Institute of General Medical Sciences | 2021 to 2025 | $2,260,000 | June 1, 2021 | August 31, 2026 | YANG, XIANG-LEI | reporter.nih.gov |
| Control of calcium flux and mitochondrial fission by the Charcot Marie Tooth disease protein Mfn2. | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $2,243,240 | January 1, 2021 | December 31, 2025 | VAN DER BLIEK, ALEXANDER M | reporter.nih.gov |
| The Genetics of the Neuromuscular Junction: Mechanisms and Disease Models | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $2,053,330 | August 1, 2025 | May 31, 2027 | BURGESS, ROBERT W. | reporter.nih.gov |
| Mitofusin agonists to prevent Charcot-Marie-Tooth disease 2A | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $1,960,976 | September 30, 2019 | August 31, 2024 | DORN, GERALD W. | reporter.nih.gov |
| Mitofusin Agonists to Treat Neurodegenerative Disease | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2023 | $1,954,883 | May 15, 2022 | April 30, 2025 | HAUGER, DEBORAH ANN | reporter.nih.gov |
| Genomic Studies in Charcot-Marie-Tooth Disease | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2023 | $1,886,243 | September 15, 2019 | July 31, 2025 | ZUCHNER, STEPHAN | reporter.nih.gov |
| Allele-specific inactivation for dominant negative NEFL Mutations | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2025 | $1,855,975 | August 15, 2021 | June 30, 2027 | JUDGE, LUKE M | reporter.nih.gov |
| Folding, Misfolding, and Function of PMP22 | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2025 | $1,650,616 | April 1, 2016 | January 31, 2028 | SANDERS, CHARLES R | reporter.nih.gov |
| JAX-Gladstone, SCGE Disease Models Studies Supplement | NIH | National Institute of Environmental Health Sciences | 2021 to 2022 | $1,641,672 | September 25, 2018 | June 30, 2023 | CONKLIN, BRUCE R | reporter.nih.gov |
| Impact of Schwann Cell Pathology on Axon Structure and Function | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2025 | $1,574,423 | December 1, 2022 | November 30, 2027 | SALZER, JAMES | reporter.nih.gov |
| Laminin Receptors and Signals in Schwann Cells | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $1,546,694 | July 1, 2003 | January 31, 2025 | SIM, FRASER JAMES | reporter.nih.gov |
| Functional Analysis of O-GlcNAc using Synthetic Protein Chemistry | NIH | National Institute of General Medical Sciences | 2021 to 2024 | $1,442,331 | August 1, 2015 | July 31, 2025 | PRATT, MATTHEW ROBERT | reporter.nih.gov |
| Generalizing genome editing for rare disease-causing variants | NIH | Office of the Director, National Institutes of Health | 2025 | $1,416,375 | September 18, 2025 | August 31, 2028 | NEWBY, GREGORY A. | reporter.nih.gov |
| Novel SMARD1 Mouse Models: Characterization and Evaluation of Potential Therapeutic Targets | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $1,380,377 | February 1, 2020 | January 31, 2026 | LORSON, CHRISTIAN L. | reporter.nih.gov |
| The Role of ESCRTs in Regulating Nervous System Function | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2024 | $1,306,650 | December 1, 2019 | November 30, 2025 | WILSON, SCOTT MICHAEL | reporter.nih.gov |
| Translational control of stress response signaling | NIH | National Institute of General Medical Sciences | 2023 to 2025 | $1,286,370 | September 22, 2023 | August 31, 2028 | RYOO, HYUNG D | reporter.nih.gov |
| Understanding the role of patient-derived Ighmbp2 mutations in neurodegeneration and pre-rRNA processing | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $1,181,939 | January 1, 2024 | December 31, 2028 | LORSON, CHRISTIAN L. | reporter.nih.gov |
| Comprehensive gene and DNA variant curation for neuromuscular diseases | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2023 | $1,079,672 | June 15, 2021 | May 31, 2025 | ZUCHNER, STEPHAN | reporter.nih.gov |
| Role of a Fatty Acid Chaperone in Schwann Cell Myelination | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $1,019,124 | February 1, 2024 | January 31, 2029 | BELIN, SOPHIE | reporter.nih.gov |
| Develop pan-specific antibody against mutant glycyl-tRNA synthetase for treating CMT2D | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2023 | $887,500 | January 1, 2021 | March 31, 2024 | YANG, XIANG-LEI | reporter.nih.gov |
| tRNA Gene Replacement Therapy for tRNA-Synthetase Related Charcot-Marie-Tooth Disorder | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $841,280 | July 1, 2024 | March 31, 2027 | BURGESS, ROBERT W. | reporter.nih.gov |
| Pathogenesis in Segmental Demyelination | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2025 | $804,961 | June 1, 2023 | May 31, 2028 | HU, BO | reporter.nih.gov |
| Small Molecule Tools for Modulating Membrane Rafts | NIH | National Institute of General Medical Sciences | 2021 to 2022 | $764,342 | September 1, 2020 | August 31, 2024 | KENWORTHY, ANNE K | reporter.nih.gov |
| A Novel Pharmacologic Approach to Treat CMT1X | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $751,688 | September 15, 2020 | August 31, 2024 | DOBROWSKY, RICK T | reporter.nih.gov |
| Structural Biology of Connexin Membrane Channels | NIH | National Institute of General Medical Sciences | 2022 to 2023 | $705,371 | July 1, 2020 | June 30, 2025 | YEAGER, MARK JAY | reporter.nih.gov |
| Structural Biology of Connexin Membrane Channels | NIH | National Institute of General Medical Sciences | 2021 to 2022 | $693,855 | July 1, 2020 | October 31, 2022 | YEAGER, MARK JAY | reporter.nih.gov |
| Molecular mechanisms underlying mitochondria-lysosome membrane contact sites in neuronal function and neurodegeneration | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2023 | $633,556 | September 30, 2018 | November 30, 2023 | WONG, YVETTE | reporter.nih.gov |
| Charcot-Marie-Tooth Disease Type 2E: Mechanism and therapy | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $499,452 | May 15, 2025 | April 30, 2030 | BROWN, ANTHONY | reporter.nih.gov |
| Function and Regulation of PMP22 in CMT1A and HNPP | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2023 | $481,950 | September 21, 2021 | March 31, 2024 | MOSS, KATHRYN RENAE | reporter.nih.gov |
| Dissecting the Integrated Stress Response in tRNA Synthetase-Associated Neuropathies | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2024 | $481,875 | March 1, 2023 | February 28, 2025 | BURGESS, ROBERT W. | reporter.nih.gov |
| Function and Regulation of PMP22 in CMT1A and HNPP | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $469,902 | September 21, 2021 | March 31, 2027 | MOSS, KATHRYN RENAE | reporter.nih.gov |
| The impact of ITPR3 mutations on immunity | NIH | National Institute of Allergy and Infectious Diseases | 2024 to 2025 | $451,000 | June 21, 2024 | April 30, 2027 | VAN OERS, NICOLAI STANISLAS CYRILLE | reporter.nih.gov |
| Characterizing Tissue Specific Regulation of Mutant Lamin Protein Degradation | NIH | National Institute on Aging | 2021 | $442,936 | July 1, 2016 | August 30, 2025 | HAMMOND, THOMAS MICHAEL | reporter.nih.gov |
| Targeting the PMP22 Protein to Develop Leads Against Charcot-Marie-Tooth Disease | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $435,441 | January 20, 2021 | December 31, 2022 | SANDERS, CHARLES R | reporter.nih.gov |
| Restoring neurofilaments to axons in a mouse model of CMT2E | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $433,125 | September 15, 2021 | February 29, 2024 | BROWN, ANTHONY | reporter.nih.gov |
| Develop pan-specific antibody against mutant glycyl-tRNA synthetase for treating CMT2D | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $431,350 | January 1, 2021 | December 31, 2021 | YANG, XIANG-LEI | reporter.nih.gov |
| Exploring a new arm of the integrated stress response and its connection to neurodegeneration | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $410,563 | July 1, 2021 | December 31, 2022 | YANG, XIANG-LEI | reporter.nih.gov |
| Creation of a Schwann Cell Gene Regulatory Network | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2023 | $400,985 | March 1, 2022 | February 28, 2025 | SVAREN, JOHN P | reporter.nih.gov |
| Pathogenesis in Segmental Demyelination | NIH | National Institute of Neurological Disorders and Stroke | 2022 | $385,000 | July 15, 2022 | July 17, 2022 | HU, BO | reporter.nih.gov |
| Assessment of Chemotherapy-Induced Peripheral Neuropathy Susceptibility Using Patient-derived iPSC Technology | NIH | National Cancer Institute | 2021 | $363,713 | September 18, 2017 | August 31, 2022 | STAFF, NATHAN P | reporter.nih.gov |
| TISSUE ENGINEERED HUMAN NEUROMUSCULAR JUNCTIONS FOR MODELING AXONAL NEUROPATHY | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $356,426 | November 15, 2016 | October 31, 2023 | KIM, DEOK-HO | reporter.nih.gov |
| Fibroblast-derived Engineered Extracellular Vesicle (FieEV) Technology for Targeted Delivery of RNA Therapeutics to treat CMT1A Diseases | NIH | National Center for Advancing Translational Sciences | 2025 | $350,000 | August 15, 2025 | August 14, 2026 | DUARTE SANMIGUEL, SILVIA M. | reporter.nih.gov |
| MRI Biomarkers of Disease Progression in Inherited Neuropathies | NIH | National Center for Advancing Translational Sciences | 2021 to 2022 | $286,885 | April 1, 2021 | July 11, 2022 | LI, JUN | reporter.nih.gov |
| Development of novel ASO-based therapeutics for CMT1A | NIH | National Institute of Neurological Disorders and Stroke | 2022 | $256,580 | June 1, 2022 | May 31, 2023 | OCONNOR, STEVE | reporter.nih.gov |
| Understanding the Role of the Integrated Stress Response in tRNA Synthetase-associated Charcot-Marie-Tooth Disease | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2024 | $244,402 | August 1, 2023 | July 31, 2025 | HINES, TIMOTHY | reporter.nih.gov |
| Pathogenesis of TRPV4-related peripheral neuropathy | NIH | National Institute of Neurological Disorders and Stroke | 2021 to 2022 | $244,178 | September 15, 2018 | June 30, 2023 | MCCRAY, BRETT ANDREW | reporter.nih.gov |
| Longitudinal Changes in Gait and Ankle Function in Youth with Charcot-Marie-Tooth Disease | NIH | National Institute of Neurological Disorders and Stroke | 2023 | $186,250 | September 21, 2023 | August 31, 2025 | WREN, TISHYA A L | reporter.nih.gov |
| Testing SARM1 as a Therapeutic Target in Multiple Forms of Charcot-Marie-Tooth Disease | NIH | National Institute of Neurological Disorders and Stroke | 2022 | $173,100 | August 1, 2022 | July 31, 2024 | BURGESS, ROBERT W. | reporter.nih.gov |
| Exploring the Pathophysiology of CMT1G | NIH | National Institute of Neurological Disorders and Stroke | 2024 to 2025 | $163,500 | March 1, 2024 | February 28, 2027 | BELIN, SOPHIE | reporter.nih.gov |
| Mechanisms of Neurodegeneration in CMT4B3: a Complex Pediatric Neurodevelopmental Disorder | NIH | Eunice Kennedy Shriver National Institute of Child Health & Human Development | 2023 to 2025 | $161,206 | August 1, 2023 | July 31, 2027 | JACOBS, ELIZABETH HALEY | reporter.nih.gov |
| Structure of GDAP1 bound to a product of lipid peroxidation | NIH | National Institute of Neurological Disorders and Stroke | 2023 to 2024 | $144,326 | March 1, 2023 | February 28, 2026 | VANDEMARK, ANDREW PAUL | reporter.nih.gov |
| Production and evaluation CMT2 mouse models of ATP1A1 loss-of-function-mutation using Cre-LoxP technology | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $136,941 | April 1, 2021 | January 31, 2022 | ARTIGAS, PABLO | reporter.nih.gov |
| Actin-mediated regulation of organelle dynamics in Charcot-Marie-Tooth disease | NIH | National Institute of General Medical Sciences | 2021 to 2022 | $136,192 | January 1, 2021 | December 31, 2022 | SCHIAVON, CARA RAE | reporter.nih.gov |
| Exploring the Role of OSM-9 in Odor Aversive Learning and Long-term Memory | NIH | National Institute on Deafness and Other Communication Disorders | 2021 to 2023 | $126,637 | September 1, 2021 | August 31, 2024 | SAIFUDDIN, MASHEL FATEMA | reporter.nih.gov |
| Effects of Aging on Neuronal Lysosomal Damage Responses Driven by CMT2B-linked Rab7 | NIH | National Institute on Aging | 2023 to 2025 | $102,738 | April 1, 2023 | June 2, 2025 | MULLIGAN, RYAN J | reporter.nih.gov |
| MITOFUSIN AGONISTS TO TREAT NEURODEGENERATIVE DISEASE | NIH | National Institute of Neurological Disorders and Stroke | 2021 | $78,500 | March 15, 2021 | July 31, 2021 | DORN, GERALD W. | reporter.nih.gov |
| Investigating axonal length-dependent pathology in a human stem cell-based model of Charcot-Marie-Tooth disease (type 2D) | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $77,752 | September 1, 2025 | August 31, 2028 | MCCLOSKEY, MOLLY CATHERINE | reporter.nih.gov |
| Investigating the pathomechanisms underlying Charcot-Marie-Tooth Disease | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2023 | $70,446 | July 1, 2022 | June 30, 2024 | JONES, JULIA ALEXIS | reporter.nih.gov |
| YAP/TAZ in Schwann Cells as Potential Therapeutic Targets in CMT1A and HNPP. | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2023 | $65,619 | August 1, 2022 | July 31, 2024 | MOORE, SETH MICHAEL | reporter.nih.gov |
| Investigating the Role of the Helicase, IGHMBP2, and the RIG-I-Like Receptor Pathway in Spinal Muscular Atrophy with Respiratory Distress Type 1 and Neuromuscular Development (SMARD1) | NIH | National Institute of Neurological Disorders and Stroke | 2022 to 2023 | $62,446 | August 1, 2022 | July 31, 2024 | HOLBROOK, SARAH | reporter.nih.gov |
| Investigating the Contribution of Motor Neuronal Mitochondria to Charcot Marie Tooth Type 2D (CMT2D) | NIH | National Institute of Neurological Disorders and Stroke | 2025 | $45,726 | August 1, 2025 | July 31, 2027 | FUNKE, JONATHAN | reporter.nih.gov |
Organizations
Funding by fiscal year
| Fiscal year | NIH awards | NIH amount | NSF awards | NSF amount |
|---|---|---|---|---|
| 2025 | 22 | $9,296,804 | 0 | $0 |
| 2024 | 24 | $9,030,950 | 0 | $0 |
| 2023 | 32 | $11,842,879 | 0 | $0 |
| 2022 | 34 | $12,577,858 | 0 | $0 |
| 2021 | 33 | $13,317,790 | 0 | $0 |
Open federal funding opportunities
From Grants.gov: notices that funded awards in this table, and open notices on the same agency and assistance listing.
Updated November 3, 2026. Read from NIH RePORTER ExPORTER and NSF Award Search. Published by NIH and NSF as U.S. government data. NIH awards are fiscal years 2021 to 2025 (NIH files published to 2026-07-09); NSF awards are fiscal years 2022 to 2026 (NSF files published to 2026-11-02). NIH amounts are the total cost of each fiscal year in the window; NSF amounts are the funds obligated in the window. Organizations are matched on the UEI. Open opportunities come from Grants.gov and match on agency and assistance listing number, and on the notice number NIH prints on an award. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.