ALS: 203 NIH awards ($158M) to 96 organizations

Name: NIH and NSF awards on ALS
Creator: SpecStream
License: https://creativecommons.org/licenses/by/4.0/

203 NIH awards ($158M) in the NIH spending category ALS, to 96 organizations, read 2026-11-03. NIH fiscal years 2021 to 2025.

SpecStream is the live web data engine for teams and agents. It reads the NIH and NSF award files each time the agencies update them, and this page is that reading, joined to the open federal funding opportunities on Grants.gov. Ask for the awards you track by topic, organization or state and new awards arrive in your sheet, CRM, Slack or agent as the agencies publish them.

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Awards

203 awards in the window.

Award	Agency	Institute or division	Fiscal year	Amount in window	Start	End	Principal investigator	Source
An Expanded Access Protocol of Intravenous Trehalose Injection 90 mg/mL Treatment of Patients with Amyotrophic Lateral Sclerosis	NIH	National Institute of Neurological Disorders and Stroke	2022	$18,136,504	September 28, 2022	August 31, 2025	PAGANONI, SABRINA	reporter.nih.gov
Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe)	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2025	$6,609,782	September 30, 2014	August 31, 2030	BENATAR, MICHAEL	reporter.nih.gov
In vivo modelling and therapy development for stathmin-2 loss in TDP-43 proteinopathies	NIH	National Institute of Neurological Disorders and Stroke	2021	$2,507,311	August 1, 2021	July 31, 2024	LAGIER-TOURENNE, CLOTILDE	reporter.nih.gov
Disruption of Nucleocytoplasmic Transport in FUS-related Neurodegenerative Diseases	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2023	$2,460,641	May 15, 2019	September 30, 2024	BOSCO, DARYL ANGELA	reporter.nih.gov
Development of a Microphysiological Organ-on-Chip System to Model Amyotrophic	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2022	$2,385,538	September 15, 2017	February 28, 2024	SVENDSEN, CLIVE NIELS	reporter.nih.gov
C9orf72 frontotemporal dementia (FTD) and amyotrophic lateral sclerosis(ALS): using patient cells and CRISPR to reveal therapeutic approaches	NIH	National Institute on Aging	2021 to 2022	$2,365,559	May 1, 2021	April 30, 2024	CONKLIN, BRUCE R	reporter.nih.gov
Synaptopathy and Pathogenesis in Frontotemporal Dementia: Role of CYLD	NIH	National Institute on Aging	2023	$2,364,013	June 1, 2023	May 31, 2026	YAO, WEI-DONG	reporter.nih.gov
C9orf72-mediated features, transcriptomic signatures, and translational studies for frontotemporal dementia and related disorders	NIH	National Institute of Neurological Disorders and Stroke	2022	$2,351,241	June 15, 2022	May 31, 2025	VAN BLITTERSWIJK, MARKA	reporter.nih.gov
Full human gene-replacement mouse models of ADRDs	NIH	National Institute of Neurological Disorders and Stroke	2021	$2,280,898	September 18, 2019	August 31, 2025	KOOB, MICHAEL D	reporter.nih.gov
Development of a Synthetic, Cell-Permeable Peptide for the Inhibition of CDK5-p25 Hyperactivity in Amyotrophic Lateral Sclerosis	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2022	$2,210,678	September 22, 2021	August 31, 2024	WERNER, JOHN KENT	reporter.nih.gov
Mechanistic studies and therapeutics for ALS/FTD linked to UBQLN2 mutations	NIH	National Institute of Neurological Disorders and Stroke	2022	$2,200,770	January 15, 2017	January 31, 2025	MONTEIRO, MERVYN J	reporter.nih.gov
Novel patient-derived 3D platform for detecting TDP-43 proteinopathy and associated biomarkers for ALS/FTD	NIH	National Institute of Neurological Disorders and Stroke	2022 to 2023	$2,175,360	February 15, 2022	January 31, 2025	GHAFFARI, LAYLA	reporter.nih.gov
Molecular effects of metformin, PKR and TBI on C9orf72 ALS/FTD	NIH	National Institute of Neurological Disorders and Stroke	2022	$2,152,606	August 1, 2016	August 31, 2025	RANUM, LAURA P.W	reporter.nih.gov
Understanding Frontotemporal Dementia Using Drosophila and iPSC Models	NIH	National Institute of Neurological Disorders and Stroke	2022	$2,086,468	April 15, 2017	March 31, 2025	GAO, FEN-BIAO	reporter.nih.gov
Resolving the Role of Neuronal STING in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia	NIH	National Institute of Neurological Disorders and Stroke	2023	$2,085,362	January 5, 2023	December 31, 2025	WAINGER, BRIAN JASON	reporter.nih.gov
S-Nitrosylation-Dependent Pathological Spread of Abnormal Proteins in Frontotemporal Dementia and Lewy Body Dementia	NIH	National Institute of Neurological Disorders and Stroke	2021	$2,081,944	August 1, 2021	July 31, 2024	NAKAMURA, TOMOHIRO	reporter.nih.gov
SWITCH trial: Early feasibility study of Stentrode BCI for augmentative communication	NIH	National Institute of Neurological Disorders and Stroke	2021	$2,056,909	August 15, 2021	July 31, 2022	WEBER, DOUGLAS J	reporter.nih.gov
Subcellular mechanisms of subtype-specific neuron vulnerability in ALS and FTD: dysregulation of synapse-localized RNA, protein, and translation in mouse models and human cortico-spinal assembloids	NIH	National Institute on Aging	2023	$2,001,864	September 1, 2023	August 31, 2026	MACKLIS, JEFFREY D	reporter.nih.gov
Mitofusin Agonists to Treat Neurodegenerative Disease	NIH	National Institute of Neurological Disorders and Stroke	2022 to 2023	$1,954,883	May 15, 2022	April 30, 2025	HAUGER, DEBORAH ANN	reporter.nih.gov
Multi-Center ALS Biomarker Validation Study (CReATe Biomarkers)	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2023	$1,935,846	May 15, 2018	March 31, 2025	BENATAR, MICHAEL	reporter.nih.gov
Novel repeat associated non-AUG (RAN) proteins in sALS, sFTD and SBMA: shared pathological features and unifying therapeutic opportunities	NIH	National Institute of Neurological Disorders and Stroke	2022	$1,930,065	July 1, 2022	June 30, 2025	RANUM, LAURA P.W	reporter.nih.gov
Brain aging and Alzheimer's related dementias: convergence onto retrotransposons and endogenous retroviruses	NIH	National Institute on Aging	2022	$1,797,870	May 1, 2022	April 30, 2025	DUBNAU, JOSHUA T	reporter.nih.gov
Study on PFN1 Pathobiology Using Rat Models	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2023	$1,774,266	April 15, 2019	March 31, 2026	XIA, XUGANG	reporter.nih.gov
Preserving Mitochondrial Function for Alleviating ALS Progression	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2023	$1,716,766	June 15, 2019	March 31, 2026	ZHOU, JINGSONG	reporter.nih.gov
Deep Pathological Phenotyping in Frontotemporal Dementia and Motor Neuron Disease.	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2022	$1,708,426	July 1, 2018	June 30, 2025	SEELEY, WILLIAM W	reporter.nih.gov
Motoneuron mortality in neurodegenerative diseases induced by homeostatic dysregulation of excitability	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2023	$1,658,443	August 15, 2019	May 31, 2025	HECKMAN, CHARLES	reporter.nih.gov
Comprehensive Harmonization and Analysis of Case/Control Whole Genome Sequencing Data from the ALS/FTD Compute Project	NIH	National Institute of Neurological Disorders and Stroke	2023	$1,630,264	February 1, 2023	July 31, 2025	LANDERS, JOHN E	reporter.nih.gov
Harnessing tongue exercise to enhance neuroplasticity and preserve upper airway function in a novel model of hypoglossal motor neuron degeneration	NIH	National Heart, Lung, and Blood Institute	2021 to 2023	$1,601,630	July 1, 2020	June 30, 2025	NICHOLS, NICOLE L.	reporter.nih.gov
Determining stathmin-2 function and potential as a therapeutic target in ALS/FTD	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2022	$1,595,758	April 1, 2020	March 31, 2025	CLEVELAND, DON W	reporter.nih.gov
Homeostatic Reset as a New Therapeutic Paradigm for Slow Progression Diseases	NIH	National Institute of General Medical Sciences	2021 to 2023	$1,556,531	September 15, 2021	December 31, 2023	LU, QUN	reporter.nih.gov
RNA Processing Machines in Biology and Disease	NIH	National Institute of General Medical Sciences	2021 to 2023	$1,500,462	April 1, 2017	August 31, 2023	MOAZED, DANESH	reporter.nih.gov
Defining trajectories of dynamic biomarkers for C9ORF72 repeat expansion carriers	NIH	National Institute on Aging	2021 to 2022	$1,365,380	August 15, 2018	April 30, 2026	LEE, SUZEE EURIE	reporter.nih.gov
Mitochondrial inner membrane architecture in skeletal muscle pathophysiology	NIH	National Institute of Arthritis and Musculoskeletal and Skin Diseases	2021 to 2023	$1,335,581	July 17, 2019	June 30, 2024	LU, BINGWEI	reporter.nih.gov
The Role of the Smcr8-Wdr41-C9orf72 (SWC) Complex in the Maintenance of Intestinal Homeostasis	NIH	National Institute of Diabetes and Digestive and Kidney Diseases	2021 to 2023	$1,312,569	June 1, 2020	February 28, 2025	TURER, EMRE EROL	reporter.nih.gov
Mechanisms of FUS Toxicity in Animal and Cellular Models of ALS/FTD.	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2022	$1,296,000	June 15, 2019	February 29, 2024	SHNEIDER, NEIL ALAN	reporter.nih.gov
Pre-Symptomatic Familial ALS (Pre-fALS) Study - Prelude to a Treatment Trial	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2022	$1,272,742	September 15, 2018	August 31, 2024	BENATAR, MICHAEL	reporter.nih.gov
TDP-43 Proteinopathy in ALS-FTD: Mechanism, Target Validation and Biomarker	NIH	National Institute of Neurological Disorders and Stroke	2023	$1,245,777	February 1, 2016	February 28, 2026	WONG, PHILIP C	reporter.nih.gov
Gene Therapy Targeting of CNTFRalpha and CLC in Muscle to Treat ALS	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2023	$1,217,751	September 15, 2019	June 30, 2026	MACLENNAN, ALEXANDER JOHN	reporter.nih.gov
Whole genome sequencing consortium on Frontotemporal dementia with underlying TDP-43 pathology	NIH	National Institute of Neurological Disorders and Stroke	2021	$1,213,868	September 25, 2017	August 31, 2024	RADEMAKERS, ROSA	reporter.nih.gov
The functions of the zinc finger protein ZPR1 in R-loop metabolism and neurodegeneration.	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2023	$1,203,169	January 1, 2021	January 2, 2023	GANGWANI, LAXMAN DASS	reporter.nih.gov
Developing RNA Oligonucleotides to Mitigate Abberant FUS Phase Transition in FTD/ALS	NIH	National Institute of Neurological Disorders and Stroke	2021	$1,170,000	April 1, 2021	March 31, 2024	GUO, LIN	reporter.nih.gov
Cellular and Molecular Mechanisms of FUS-related ALS/FTD	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2023	$1,161,739	April 15, 2013	January 31, 2025	PANDEY, UDAI B	reporter.nih.gov
Regulated energy metabolism in ALS/FTD	NIH	National Institute of Neurological Disorders and Stroke	2022	$1,157,896	May 1, 2022	April 30, 2025	WHARTON, KRISTI A	reporter.nih.gov
Impeding transcription of expanded microsatellite repeats using deactivated Cas9	NIH	National Institute on Aging	2021 to 2023	$1,133,433	February 15, 2019	December 31, 2023	WANG, ERIC T	reporter.nih.gov
Dysregulation of p97/VCP disease mutants in IBM and FTLD-U	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2022	$1,088,809	July 1, 2018	April 30, 2024	CHOU, TSUI-FEN	reporter.nih.gov
Bayesian methods for cortical surface neuroimaging data	NIH	National Institute of Biomedical Imaging and Bioengineering	2021 to 2022	$1,072,419	February 1, 2019	September 30, 2024	MEJIA, AMANDA	reporter.nih.gov
Examining neuronal resilience in a mouse model of sporadic ALS	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2023	$1,056,564	April 1, 2019	March 31, 2025	LEE, VIRGINIA M	reporter.nih.gov
Spinal circuitry for ventilatory control and compensation	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2023	$1,043,439	May 1, 2019	April 30, 2024	CRONE, STEVEN ALLEN	reporter.nih.gov
Mechanisms of Axon Pathology in ALS	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2022	$1,040,776	September 1, 2018	May 31, 2024	PRZEDBORSKI, SERGE E	reporter.nih.gov
Contribution of astrocytes to mutant FUS-linked Amyotrophic Lateral Sclerosis	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2023	$1,023,750	May 15, 2019	April 30, 2025	PASINELLI, PIERA	reporter.nih.gov
Non-Invasive Tracking of Genome-Corrected iPS cells in ALS	NIH	National Institute of Biomedical Imaging and Bioengineering	2021 to 2022	$950,463	September 1, 2019	July 31, 2025	BULTE, JEFF W.	reporter.nih.gov
Optimization of CRISPR genome editor and its delivery strategy for C9orf72 frontotemporal dementia	NIH	National Institute of Neurological Disorders and Stroke	2023	$869,959	August 18, 2023	July 31, 2025	CLELLAND, CLAIRE	reporter.nih.gov
Relaxivity Contrast Imaging as Biomarker of Muscle Degeneration in ALS	NIH	National Institute of Neurological Disorders and Stroke	2022	$809,219	December 1, 2021	July 31, 2022	QUARLES, CHRISTOPHER CHAD	reporter.nih.gov
A microphysiologic multicellular organ-on-chip to inform clinical trials in FTD/ALS	NIH	National Center for Advancing Translational Sciences	2021	$800,773	July 1, 2020	May 31, 2022	SVENDSEN, CLIVE NIELS	reporter.nih.gov
Electrical impedance myography in an animal model	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2022	$766,280	August 1, 2007	July 31, 2024	RUTKOVE, SEWARD B.	reporter.nih.gov
Deconstructing and challenging TDP-43 proteinopathies: from FTLD/ALS to Alzheimer's disease	NIH	National Institute on Aging	2021 to 2022	$762,500	August 15, 2018	April 30, 2024	RINCON-LIMAS, DIEGO E	reporter.nih.gov
Development of a novel therapeutic strategy for treatment of SOD1-linked ALS by CRISPR/Cas9-mediated SOD1 promoter editing	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2022	$750,825	July 1, 2020	June 30, 2024	DENG, HAN-XIANG	reporter.nih.gov
Exploring Mechanisms of Pathogenicity in C9ORF72 Frontotemporal Dementia and Amyotrophic Lateral Sclerosis	NIH	National Institute on Aging	2021 to 2023	$746,997	July 1, 2021	March 31, 2024	BURBERRY, AARON	reporter.nih.gov
Determining How Defective Nucleo-Cytoplasmic Trafficking Leads To Neurodegeneration In C9orf72-Related ALS And FTD	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2022	$746,849	March 1, 2018	February 28, 2025	KISKINIS, EVANGELOS	reporter.nih.gov
An optogenetic approach to establish the interplay between stress granules and TDP-43 proteinopathy in ALS/FTD	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2022	$744,882	March 15, 2018	February 28, 2023	DONNELLY, CHRISTOPHER JAMES	reporter.nih.gov
Early development of small molecule neuroprotectants.	NIH	National Institute of Neurological Disorders and Stroke	2021	$733,123	August 15, 2018	April 1, 2022	LASMEZAS, CORINNE IDA	reporter.nih.gov
A virtual vocal tract for speech output using non-invasive brain-computer interface	NIH	National Institute on Deafness and Other Communication Disorders	2021 to 2022	$728,085	July 16, 2018	June 30, 2025	BRUMBERG, JONATHAN S	reporter.nih.gov
Molecular mechanism of dipeptide repeat protein production from hexanucleotide repeats in C9ORF72-related ALS and FTD	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2022	$716,406	July 1, 2018	March 31, 2024	SUN, SHUYING	reporter.nih.gov
Molecular mechanisms that match lysosome function to cellular demand	NIH	National Institute of General Medical Sciences	2021 to 2022	$686,750	September 1, 2013	January 31, 2024	FERGUSON, SHAWN	reporter.nih.gov
CYLD in Synapse Pruning and Pathogenesis of FTD	NIH	National Institute of Neurological Disorders and Stroke	2021	$682,211	August 1, 2021	July 31, 2023	YAO, WEI-DONG	reporter.nih.gov
Rad and amyotrophic lateral sclerosis (ALS)	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2022	$675,938	May 15, 2018	April 30, 2024	HERNANDEZ-OCHOA, ERICK OMAR	reporter.nih.gov
Disease mechanism in ALS and frontotemporal dementia	NIH	National Institute of Neurological Disorders and Stroke	2021	$647,454	April 1, 1989	August 31, 2022	CLEVELAND, DON W	reporter.nih.gov
Molecular Genetic Characterization of SCA8	NIH	National Institute of Neurological Disorders and Stroke	2021	$636,489	June 16, 2000	July 31, 2023	RANUM, LAURA P.W	reporter.nih.gov
Brain-Computer Interface Implant for Severe Communication Disability	NIH	National Institute on Deafness and Other Communication Disorders	2021	$606,866	September 1, 2018	January 31, 2024	RAMSEY, NICOLAS FRANCISCUS	reporter.nih.gov
Oligodendroglial Dysfunction in C9orf72 ALS and FTD	NIH	National Institute of Neurological Disorders and Stroke	2021	$597,360	August 1, 2017	April 30, 2022	ROTHSTEIN, JEFFREY D	reporter.nih.gov
New Targets in C9orf72 FTD: Exploring Histone H3 S10 Phosphorylation	NIH	National Institute of Neurological Disorders and Stroke	2022 to 2023	$575,365	June 1, 2023	March 31, 2025	TORRENTE, MARIANA PLAZAS	reporter.nih.gov
Closed-Loop Stimulus Optimization to Increase Communication Efficiency in Brain-Computer Interfaces	NIH	National Institute on Deafness and Other Communication Disorders	2021 to 2022	$569,360	January 1, 2020	December 31, 2023	MAINSAH, BOYLA	reporter.nih.gov
Novel pathways in C9ORF72-associated ALS and dementia	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2023	$557,171	August 15, 2019	May 31, 2024	MORDES, DANIEL ADAM	reporter.nih.gov
Deciphering the role of ER stress in ALS pathogenesis caused by UBQLN2 mutations	NIH	National Institute of Neurological Disorders and Stroke	2021	$547,956	September 28, 2017	June 30, 2023	MONTEIRO, MERVYN J	reporter.nih.gov
Modulation of astrocyte-mediated neurotoxicity by NR1D1 in ALS models	NIH	National Institute of Neurological Disorders and Stroke	2023	$537,818	April 15, 2023	March 31, 2025	PEHAR, MARIANA ATINA	reporter.nih.gov
PIKFYVE antagonism as a therapy for C9ORF72-ALS/FTD	NIH	National Institute of Neurological Disorders and Stroke	2021	$533,459	May 1, 2018	May 31, 2023	ALWORTH, SAMUEL V	reporter.nih.gov
MiR-218 regulatory networks in adult mice and its relationship to ALS	NIH	National Institute of Neurological Disorders and Stroke	2021	$529,100	May 15, 2021	October 31, 2022	PFAFF, SAMUEL L.	reporter.nih.gov
Using mitochondrial Ca2+ uptake as a therapeutic target for ALS	NIH	National Institute of Neurological Disorders and Stroke	2021	$511,505	August 1, 2021	July 31, 2023	WEI-LAPIERRE, LAN	reporter.nih.gov
Compromised LDH activity causes motor deficits and hastens ALS progression	NIH	National Institute on Aging	2022	$503,248	July 1, 1996	April 30, 2023	MILBRANDT, JEFFREY D	reporter.nih.gov
Astrocyte regulation of cortical neurodegeneration in C9orf72 FTD/ALS	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2022	$502,724	September 29, 2021	March 19, 2024	SATTLER, RITA	reporter.nih.gov
Mature brain organoid platform for therapeutic screening for ALS/FTD	NIH	National Institute of Neurological Disorders and Stroke	2023	$499,999	August 1, 2023	July 31, 2025	GHAFFARI, LAYLA	reporter.nih.gov
The impact of dysarthria on communicative participation in people with ALS	NIH	National Institute on Deafness and Other Communication Disorders	2021	$498,575	April 1, 2021	March 31, 2025	CONNAGHAN, KATHRYN PATRICIA	reporter.nih.gov
Comparative genomic approaches to improve iPSC-derived motor neuron models of ALS	NIH	National Institute on Aging	2021 to 2022	$498,000	September 1, 2017	May 31, 2023	HO, RITCHIE	reporter.nih.gov
Landis Outstanding Mentor Award Supplement	NIH	National Institute of Neurological Disorders and Stroke	2021	$495,768	September 1, 2021	March 31, 2023	PLOWMAN, EMILY KATE	reporter.nih.gov
Exploring the modulation of synaptic/extrasynaptic NMDAR balance as a novel therapeutic strategy in Alzheimer's disease and other neurodegenerations	NIH	National Institute on Aging	2021	$491,840	August 1, 2020	October 1, 2021	SANZ-CLEMENTE, ANTONIO	reporter.nih.gov
CHABMAP (Cyanobacterial Harmful Algal Bloom Mapping and Analyses Platform) technology automates the quantification of toxic CyanoHABs exposure epochs for any waterbody.	NIH	National Institute of Environmental Health Sciences	2021	$486,219	January 15, 2016	May 31, 2023	CHEN, HAIXIN	reporter.nih.gov
Exploring Akkermansia Genomic and Functional Diversity in Neurologic Diseases	NIH	National Institute of Neurological Disorders and Stroke	2022	$472,026	May 15, 2022	October 30, 2024	COX, LAURA MICHELLE	reporter.nih.gov
Phenotyping Corticospinal Axon Degeneration in Preclinical ALS Models.	NIH	National Institute of Neurological Disorders and Stroke	2023	$466,125	June 1, 2023	May 31, 2025	SCHMIDT, ERIC F	reporter.nih.gov
Novel Targets that Modulate Multiple Adult Models of ALS in Drosophila	NIH	National Institute of Neurological Disorders and Stroke	2021	$464,750	July 1, 2021	December 31, 2022	VAN VACTOR, DAVID L.	reporter.nih.gov
Exploring the Pathogenicity of CYLD Variants in FTD	NIH	National Institute of Neurological Disorders and Stroke	2021	$463,750	September 29, 2021	March 31, 2025	YAO, WEI-DONG	reporter.nih.gov
Analysis of pathogenic mosaic mutations in human Amyotrophic Lateral Sclerosis nervous system	NIH	National Institute of Neurological Disorders and Stroke	2022	$460,625	September 10, 2022	February 28, 2025	LODATO, MICHAEL ANTHONY	reporter.nih.gov
Development of a novel fluorescent tracer for detection of retinal TDP43 in ALS and FTD	NIH	National Institute on Aging	2022	$458,527	August 15, 2022	July 31, 2024	SARRAF, STELLA	reporter.nih.gov
Investigating the impact of p97 mutation in Amyotrophic Lateral Sclerosis	NIH	National Institute of Neurological Disorders and Stroke	2022 to 2023	$453,750	April 1, 2022	March 31, 2025	RAMAN, MALAVIKA	reporter.nih.gov
Dysregulation of inhibitory synapse by poly-GR in C9ORF72-ALS/FTD	NIH	National Institute on Aging	2021	$450,313	May 1, 2021	April 30, 2024	SUN, SHUYING	reporter.nih.gov
Axonal pathogenesis of human iPSC-derived motor neurons	NIH	National Institute of Neurological Disorders and Stroke	2022	$450,313	September 19, 2022	August 31, 2024	FARAH, MOHAMED H	reporter.nih.gov
Mechanisms of RNA binding proteins rescuing FUS induced toxicity in yeast	NIH	National Institute of Neurological Disorders and Stroke	2021	$450,000	April 1, 2021	March 31, 2026	JU, SHULIN	reporter.nih.gov
Evaluation of Alzheimers disease experimental small molecule therapeutics in the models of Amyotrophic lateral sclerosis	NIH	National Institute on Aging	2021	$449,984	June 1, 2021	May 31, 2024	RAVULA, SATHEESH B	reporter.nih.gov
Investigating the role of progranulin in TDP-43 proteinopathy	NIH	National Institute on Aging	2022	$449,419	July 15, 2022	June 30, 2025	HU, FENGHUA	reporter.nih.gov
Using motor neuron specific miRNA to understand and develop novel therapeutics for motor neuron disease	NIH	National Institute of Neurological Disorders and Stroke	2021	$448,083	April 15, 2012	March 31, 2022	MILLER, TIMOTHY M.	reporter.nih.gov
A new human iPSC model of ALS: natural modifiers protecting FUS mutation carriers from the disease	NIH	National Institute of Neurological Disorders and Stroke	2021	$443,750	July 1, 2021	December 31, 2023	GUO, ZIYUAN	reporter.nih.gov
Functional Biomarkers for ALS	NIH	National Center for Advancing Translational Sciences	2022 to 2023	$441,561	April 1, 2022	March 31, 2025	WILKINS, HEATHER M.	reporter.nih.gov
Profiles of Common and Unique aspects of Upper Motor Neuron degeneration in HSP and ALS	NIH	National Institute of Neurological Disorders and Stroke	2022	$440,000	September 1, 2022	August 31, 2024	OZDINLER, PEMBE HANDE	reporter.nih.gov
Identification of conserved ALS-FTD suppressor genes	NIH	National Institute of Neurological Disorders and Stroke	2021	$437,532	April 1, 2021	March 31, 2024	HART, ANNE CHURCH	reporter.nih.gov
THE ROLE OF HYDROGEN GAS IN HEALTH AND DISEASE	NIH	National Institute on Aging	2021	$437,142	February 15, 2021	January 31, 2025	RADYUK, SVETLANA NIKOLAEVNA	reporter.nih.gov
High-throughput Screen for Discovery of Ciliary Neurotrophic Factor (CNTF) Receptor Agonists for the Treatment of Amyotrophic Lateral Sclerosis (ALS)	NIH	National Institute of Neurological Disorders and Stroke	2021	$434,563	May 1, 2020	October 31, 2022	ROSSOLL, WILFRIED	reporter.nih.gov
Glycogen promotes protein aggregation in ALS and FTD	NIH	National Institute of Neurological Disorders and Stroke	2022	$430,375	April 15, 2022	March 31, 2025	ZHANG, YONGJIE	reporter.nih.gov
NUP50 as a modifier and risk factor for TDP-43 pathology in FTD/ALS	NIH	National Institute on Aging	2023	$430,267	September 30, 2023	September 29, 2025	ROSSOLL, WILFRIED	reporter.nih.gov
A role for extracellular vesicles in neuroinflammation associated to frontotemporal dementia	NIH	National Institute of Neurological Disorders and Stroke	2022	$429,000	May 15, 2022	October 31, 2024	TROTTI, DAVIDE	reporter.nih.gov
Targeted neuromodulation strategies to delay hypoglossal motoneuron death and preserve tongue strength, function, and structure in a mouse model of ALS	NIH	National Institute of Neurological Disorders and Stroke	2022	$426,985	June 1, 2022	June 30, 2025	LEVER, TERESA E	reporter.nih.gov
Cell Senescence and Death in Neurodegenerative Diseases	NIH	National Institute of Neurological Disorders and Stroke	2021	$426,250	September 29, 2021	January 1, 2025	MILLIGAN, CAROL	reporter.nih.gov
Remotely supervised transcranial direct current stimulation for slowing disease progression in amyotrophic lateral sclerosis (ALS)	NIH	Eunice Kennedy Shriver National Institute of Child Health & Human Development	2021 to 2022	$424,243	August 1, 2021	July 31, 2024	MADHAVAN, SANGEETHA	reporter.nih.gov
Molecular Phenotyping of Cortical Cell Types in ALS Related Neurodegeneration	NIH	National Institute of Neurological Disorders and Stroke	2022	$423,750	May 1, 2016	May 31, 2023	SCHMIDT, ERIC F	reporter.nih.gov
Nanoparticle-Based Drug Delivery Targeting the Respiratory Neural Network	NIH	National Institute of Neurological Disorders and Stroke	2021	$423,540	August 1, 2021	July 31, 2024	SEVEN, YASIN B	reporter.nih.gov
Investigation on Ataxin2 and Matrin3 in neurodegenerative disease	NIH	National Institute of Neurological Disorders and Stroke	2023	$422,125	April 1, 2023	March 31, 2025	SCOLES, DANIEL R	reporter.nih.gov
Pathway discovery for ubiquilin-associated ALS/Dementia	NIH	National Institute on Aging	2021	$421,841	March 1, 2021	February 29, 2024	KIM, SANG HWA	reporter.nih.gov
ELAVL3 in ALS/FTD	NIH	National Institute of Neurological Disorders and Stroke	2021	$417,259	April 1, 2021	September 30, 2023	RAVITS, JOHN	reporter.nih.gov
Examining cross-species suppression of neurodegeneration by loss of a conserved RNA binding protein in models of ALS and FTD	NIH	National Institute of Neurological Disorders and Stroke	2021	$416,481	April 1, 2021	June 30, 2023	HART, ANNE CHURCH	reporter.nih.gov
Generating Personalized Synthetic Speech for Progressive Dysarthria Using Severity-Appropriate Adaptation Strategies for Neural Text-to-Speech and Voice Conversion	NIH	National Institute on Deafness and Other Communication Disorders	2022 to 2023	$416,143	July 1, 2022	June 30, 2025	ZHAO, YUNXIN	reporter.nih.gov
FAIM Proteostasis in ALS	NIH	National Institute of Neurological Disorders and Stroke	2022	$415,250	July 1, 2022	June 30, 2025	ROTHSTEIN, THOMAS L	reporter.nih.gov
Exploring chaperone code control of TDP-43 function in ALS	NIH	National Institute of Neurological Disorders and Stroke	2023	$413,826	June 15, 2023	May 31, 2026	TRUMAN, ANDREW WILLIAM	reporter.nih.gov
Axonal TDP-43 Dysregulation in ALS and Dementia	NIH	National Institute of Neurological Disorders and Stroke	2023	$407,758	June 1, 2023	May 31, 2025	DONNELLY, CHRISTOPHER JAMES	reporter.nih.gov
On-demand neuronal condensate interactomes using new optogenomics tools	NIH	National Institute on Drug Abuse	2022 to 2023	$405,000	September 1, 2022	August 31, 2024	BRANGWYNNE, CLIFFORD P	reporter.nih.gov
Mechanisms underlying DNA double strand break response in Alzheimer?s disease and frontal temporal dementia	NIH	National Institute of Neurological Disorders and Stroke	2021	$401,374	September 15, 2017	June 30, 2023	TSAI, LI-HUEI	reporter.nih.gov
Mechanisms of disruption of axon transport of autophagic vesicles and lysosomes in C9orf72 ALS	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2023	$398,521	July 1, 2020	August 7, 2023	BERTH, SARAH HATCH	reporter.nih.gov
Mitochondrial dynamics for the maintenance of neuromuscular junctions during aging and in ALS	NIH	National Institute of Neurological Disorders and Stroke	2021	$396,330	February 1, 2017	January 31, 2023	WANG, XINGLONG	reporter.nih.gov
Spatiotemporal analysis of TDP-43 toxicity and endolysosomal turnover mechanisms	NIH	National Institute of Neurological Disorders and Stroke	2022	$393,027	July 1, 2022	June 30, 2024	BUCHAN, JOHN ROSS	reporter.nih.gov
Human-iPSC derived neuromuscular junctions as a model for neuromuscular diseases.	NIH	National Institute of Neurological Disorders and Stroke	2023	$390,007	September 8, 2023	July 31, 2025	MIRANDA, HELEN C	reporter.nih.gov
Supplement -- The pathogenic relationship between neuronal activity and C9orf72-linked neurodegeneration	NIH	National Institute of Neurological Disorders and Stroke	2021	$390,000	July 1, 2021	June 30, 2022	HAEUSLER, AARON RAYMOND	reporter.nih.gov
The Convergence of Titin and Elongator in Amyotrophic Lateral Sclerosis	NIH	National Institute of Neurological Disorders and Stroke	2022	$385,521	September 1, 2015	August 31, 2025	GEORGE, LYNN D	reporter.nih.gov
Targeting STAU1 for TDP-43 proteinopathies	NIH	National Institute of Neurological Disorders and Stroke	2022	$383,748	August 1, 2022	July 31, 2024	SCOLES, DANIEL R	reporter.nih.gov
Using human IPS cells to study fate, function and neurodegenerative disease	NIH	National Institute of Neurological Disorders and Stroke	2021	$378,225	April 1, 2012	June 30, 2024	IACOVITTI, LORRAINE	reporter.nih.gov
CircRNAs and CNS Gene Transfer	NIH	National Institute of Neurological Disorders and Stroke	2021	$375,678	September 1, 2018	April 30, 2022	ASOKAN, ARAVIND	reporter.nih.gov
Multi-path DCS as a novel non-invasive treatment for amyotrophic lateral sclerosis	NIH	National Institute of Neurological Disorders and Stroke	2021	$371,628	September 23, 2021	August 31, 2023	AHMED, ZAGHLOUL	reporter.nih.gov
An in vivo approach to understanding mutant PFN1 toxicity on motor neurons	NIH	National Institute of Neurological Disorders and Stroke	2021	$366,406	July 1, 2017	April 30, 2022	XU, ZUOSHANG	reporter.nih.gov
Role of serotonergic-activation of heat shock transcription factor in the regulation of age-related protein misfolding and toxicity in mammalian systems	NIH	National Institute on Aging	2021 to 2022	$363,731	September 5, 2021	June 30, 2023	PRAHLAD, VEENA	reporter.nih.gov
Mechanisms of A-I RNA editing-mediated nuclear export of TDP-43	NIH	National Institute of Neurological Disorders and Stroke	2022	$345,566	September 22, 2022	August 31, 2025	SATTLER, RITA	reporter.nih.gov
NGF and RAGE-p75NTR signaling in models of amyotrophic lateral sclerosis	NIH	National Institute of Neurological Disorders and Stroke	2021	$327,031	March 15, 2017	December 31, 2023	PEHAR, MARIANA ATINA	reporter.nih.gov
Investigating mechanisms of pathogenesis in TBK1-associated amyotrophic lateral sclerosis	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2022	$326,160	July 1, 2018	June 30, 2024	LY, CINDY V	reporter.nih.gov
Delineating the functional impact of recurrent repeat expansions in ALS using integrative multiomic analysis	NIH	Office of the Director, National Institutes of Health	2023	$323,817	September 20, 2023	September 19, 2025	GURSOY, GAMZE	reporter.nih.gov
Targeted immunotherapy for amyotrophic lateral sclerosis and frontotemporal dementia	NIH	National Institute of Neurological Disorders and Stroke	2023	$299,989	September 1, 2023	February 28, 2025	LARRICK, JAMES W	reporter.nih.gov
In vivo characterization of the molecular drivers of biomolecular condensate formation in TDP-43 neuropathology	NIH	National Institute on Drug Abuse	2022 to 2023	$292,122	September 15, 2022	August 31, 2024	MORSCH, MARCO	reporter.nih.gov
Microglial regulation of neuronal activity in TDP-43 neurodegeneration	NIH	National Institute on Aging	2023	$256,234	May 15, 2023	March 26, 2024	WU, LONG-JUN	reporter.nih.gov
A Novel TDP-43-Targeting Circular RNA to Treat Amyotrophic Lateral Sclerosis (ALS)	NIH	National Institute of Neurological Disorders and Stroke	2022	$256,158	September 8, 2022	August 31, 2024	LITKE, JACOB	reporter.nih.gov
Investigating the role of traumatic injury in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD)	NIH	National Institute on Aging	2022 to 2023	$254,067	September 15, 2022	August 31, 2025	ANDERSON, ERIC NATHANIEL	reporter.nih.gov
Precision Base Editing for the Treatment of Motor Neuron Diseases	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2022	$252,990	August 1, 2021	June 30, 2023	ARBAB, MANDANA	reporter.nih.gov
Elucidating the role of RNA oxidation on amyotrophic lateral sclerosis onset and progression	NIH	National Institute of Neurological Disorders and Stroke	2022 to 2023	$249,006	December 1, 2021	November 30, 2023	CHAIM, ISAAC ALEXANDER	reporter.nih.gov
Determining the molecular organization of TDP-43 in liquid spherical annuli and establishing a designer gene therapeutic strategy to degrade TDP-43 aggregates	NIH	National Institute of Neurological Disorders and Stroke	2022	$249,000	June 21, 2022	March 31, 2023	YU, HAIYANG	reporter.nih.gov
Protein therapeutics inspired by importins	NIH	National Institute of Neurological Disorders and Stroke	2022	$215,341	August 15, 2022	July 31, 2024	CINGOLANI, GINO	reporter.nih.gov
Mechanisms of Neurodegeneration in KIF5A ALS/FTD	NIH	National Institute of Neurological Disorders and Stroke	2023	$208,170	August 1, 2023	July 31, 2024	BRENT, JONATHAN ROBERT	reporter.nih.gov
Impact of Geospatial Factors and Environmental Pollutants on Amyotrophic Lateral Sclerosis in the State of Michigan	NIH	National Institute of Environmental Health Sciences	2021	$202,076	June 1, 2017	May 31, 2022	GOUTMAN, STEPHEN	reporter.nih.gov
FG-nucleoporins and nuclear transport disruption in C9ORF72-ALS/FTD	NIH	National Institute of Neurological Disorders and Stroke	2021	$199,800	September 1, 2017	August 31, 2022	HAYES, LINDSEY RENAE	reporter.nih.gov
A comparative inter-neuronal and inter-species platform to understand neuronal differential sensitivity to neurodegeneration	NIH	National Institute on Aging	2021	$198,125	May 1, 2020	April 30, 2022	MAZZONI, ESTEBAN ORLANDO	reporter.nih.gov
Tools for regulated expression control of miR-218	NIH	National Institute of Neurological Disorders and Stroke	2021	$192,400	May 15, 2021	November 30, 2022	PFAFF, SAMUEL L.	reporter.nih.gov
Prolonging Functional Speech in Persons with Amyotrophic Lateral Sclerosis: A Real-Time Virtual Vocal Tract	NIH	National Institute on Deafness and Other Communication Disorders	2021	$189,937	July 10, 2017	June 30, 2024	GREEN, JORDAN R	reporter.nih.gov
Unraveling the mechanisms of motor neuron degeneration if Spinocerebellar Ataxia, type 1	NIH	National Institute of Neurological Disorders and Stroke	2021	$189,431	August 1, 2017	July 31, 2022	ORENGO, JAMES P	reporter.nih.gov
Using functional readouts from engineering models of innervated skeletal muscle to assess the efficacy of CRISPR-based c9orf72 ALS gene therapies	NIH	National Center for Advancing Translational Sciences	2022 to 2023	$176,500	July 1, 2022	June 30, 2024	SMITH, ALEC SIMON TULLOCH	reporter.nih.gov
Development of TDP-43 nuclear targeting aptamers for ALS/FTD	NIH	National Institute of Neurological Disorders and Stroke	2022 to 2023	$163,750	February 1, 2022	January 31, 2024	HAYES, LINDSEY RENAE	reporter.nih.gov
Generation of tools for visualizing understudied KvS potassium channel proteins	NIH	National Center for Advancing Translational Sciences	2022	$158,875	July 18, 2022	July 17, 2024	SACK, JON THOMAS	reporter.nih.gov
Linking TBI secondary injuries to FTLD- and ALS-like neurodegeneration	NIH	National Institute of Neurological Disorders and Stroke	2021	$157,000	August 15, 2021	July 31, 2024	STABENFELDT, SARAH E	reporter.nih.gov
Presynaptic degeneration in ALS mouse neuromuscular junctions and a targeted therapeutic approach	NIH	National Institute of Neurological Disorders and Stroke	2022	$154,870	September 19, 2022	August 31, 2024	BADAWI, YOMNA	reporter.nih.gov
Translation dysregulation in neurodegeneration	NIH	National Institute of Neurological Disorders and Stroke	2022	$144,936	September 1, 2015	June 30, 2022	ZARNESCU, DANIELA C	reporter.nih.gov
Mechanisms of nuclear pore complex homeostasis and injury in ALS/FTD and related neurodegenerative diseases	NIH	National Institute of Neurological Disorders and Stroke	2021	$130,140	July 15, 2021	July 14, 2022	COYNE, ALYSSA	reporter.nih.gov
Defining the molecular drivers and modulators of MATR3 proteinopathy implicated in amyotrophic lateral sclerosis and frontotemporal dementia	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2023	$128,302	February 1, 2021	October 31, 2023	SPRUNGER, MACY L	reporter.nih.gov
Nucleation and Dissolution Mechanism Underlying ALS/FTLD-linked FUS Condensates	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2023	$127,890	August 1, 2021	June 16, 2024	DJAJA, NATHALIE ASHLEY	reporter.nih.gov
Determining the molecular organization of TDP-43 in liquid spherical annuli and establishing a designer gene therapeutic strategy to degrade TDP-43 aggregates	NIH	National Institute of Neurological Disorders and Stroke	2021	$124,794	January 1, 2020	December 31, 2021	YU, HAIYANG	reporter.nih.gov
Engineering improved delivery and immune profiles of Cas9 orthologues for gene therapy	NIH	National Institute of General Medical Sciences	2021 to 2022	$124,304	August 1, 2021	May 31, 2023	STAHL, ELIZABETH	reporter.nih.gov
Brainwide Computations Underlying Future Action Plans	NIH	National Institute of Neurological Disorders and Stroke	2021	$123,174	May 15, 2020	April 30, 2023	MACHADO, TIMOTHY ALOYSIUS	reporter.nih.gov
Deciphering the role of Ataxin-2 in amyotrophic lateral sclerosis	NIH	National Institute of Neurological Disorders and Stroke	2021	$102,843	April 1, 2022	April 2, 2022	RODRIGUEZ, CAITLIN MARIE	reporter.nih.gov
Mechanisms of autophagic dysfunction in progranulin-related neurodegeneration	NIH	National Institute on Aging	2021 to 2022	$102,788	December 1, 2018	November 30, 2022	FERNANDOPULLE, MICHAEL	reporter.nih.gov
Development of immunotherapy targeting pathological TDP-43 in ALS and FTLD	NIH	National Institute of Neurological Disorders and Stroke	2021	$101,101	June 15, 2020	November 30, 2022	POLYMENIDOU, MAGDALINI	reporter.nih.gov
Tissue-specific modulation of Apolipoprotein E in neurodegeneration	NIH	National Institute on Aging	2021 to 2022	$96,138	September 10, 2019	September 9, 2023	FERGUSON, CHANTAL	reporter.nih.gov
The Role of RNA in Defining FUS Specificity and Activity in Phase Separation and Splicing	NIH	National Institute of General Medical Sciences	2021 to 2022	$91,131	July 1, 2021	November 4, 2022	GANSER, LAURA R.	reporter.nih.gov
Synergistic Interaction of FTD Genes in Neuroinflammation and Neurodegeneration	NIH	National Institute of Neurological Disorders and Stroke	2022 to 2023	$88,925	January 12, 2022	December 31, 2023	JAHAN, NAZNIN	reporter.nih.gov
A Chemical Footprinting Approach towards Poly-ADP-Ribosylation-regulated Biomolecular Condensation	NIH	National Institute of Neurological Disorders and Stroke	2022	$88,659	December 1, 2021	April 30, 2022	YU, YONGHAO	reporter.nih.gov
Functional role of Sec20, a BH3 and Secretory (Sec) domain protein, in neurons and its relevance to a motor neuron disease in Drosophila	NIH	National Institute of Neurological Disorders and Stroke	2023	$81,705	April 15, 2023	February 29, 2024	BHAT, KRISHNA MOORTHI	reporter.nih.gov
A new conditional TDPΔNLS knock-in mouse model generated using CRISPR/Cas9 technology to study the linkage of TDP-43 pathology to motor and cognitive defects in ALS, FTD and ADRD	NIH	National Institute on Aging	2021	$80,750	April 15, 2020	February 28, 2023	HEGDE, MURALIDHAR L	reporter.nih.gov
MITOFUSIN AGONISTS TO TREAT NEURODEGENERATIVE DISEASE	NIH	National Institute of Neurological Disorders and Stroke	2021	$78,500	March 15, 2021	July 31, 2021	DORN, GERALD W.	reporter.nih.gov
Identifying and understanding the role of repeat RNAs and RAN proteins in Alzheimer's disease	NIH	National Institute on Aging	2021	$76,719	September 15, 2020	June 30, 2023	NGUYEN, LIEN	reporter.nih.gov
A Comprehensive Protocol for Tissue of Origin Prediction in Circulating Cell-Free DNA	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2022	$76,422	April 1, 2021	March 31, 2023	CAGGIANO, CHRISTA	reporter.nih.gov
Impact of Rad-mediated inhibition of Cav1.1 on muscle composition and contractile function	NIH	National Institute on Aging	2021	$75,900	August 1, 2020	March 27, 2022	BANNISTER, ROGER ALAN	reporter.nih.gov
Elucidating mechanisms of ATXN2 interaction with TDP-43 in human motor neuron models of Amyotrophic Lateral Sclerosis	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2022	$74,066	June 1, 2021	August 31, 2023	GILL, STANLEY PERNELL	reporter.nih.gov
Defining the molecular connections between hyperexcitability and neurodegeneration in ALS	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2022	$68,767	July 1, 2020	May 31, 2022	HELD, AARON HARRY	reporter.nih.gov
Mechanistic dissection of novel regulators of TDP-43 aggregation identified in a genome-wide CRISPR-Cas9 knockout screen	NIH	National Institute of Neurological Disorders and Stroke	2021 to 2022	$67,642	June 1, 2020	May 30, 2023	SWEENEY, KATELYN	reporter.nih.gov
Programming Human Chaperone Systems Against Neurodegenerative Disease	NIH	National Institute of Neurological Disorders and Stroke	2021	$67,462	September 30, 2019	September 29, 2022	BARBIERI, EDWARD MATTHEW	reporter.nih.gov
Investigation of the innate and adaptive immune responses to TDP-43 aggregates in Amyotrophic Lateral Sclerosis	NIH	National Institute of Neurological Disorders and Stroke	2022 to 2023	$61,951	January 1, 2022	May 31, 2023	EVANGELISTA, BAGGIO ANGELO	reporter.nih.gov
Curation of the Seattle ALS Patient	NIH	National Institute of Neurological Disorders and Stroke	2022	$56,638	August 1, 2022	June 30, 2023	SEGERSTROM, SUZANNE C.	reporter.nih.gov
Therapeutic targeting of ATXN2 for sporadic amyotrophic lateral sclerosis (ALS)	NIH	National Institute on Aging	2022	$51,752	September 16, 2019	April 30, 2022	TAYLOR, AMY ELIZABETH	reporter.nih.gov
Exploring the validity of articulatory impairment phenotypes in speech motor disorders	NIH	National Institute on Deafness and Other Communication Disorders	2021 to 2022	$49,507	January 20, 2021	August 2, 2022	ROWE, HANNAH PRESCOTT	reporter.nih.gov
SPOP modifies neurodegenerative proteinopathy in Alzheimer’s Disease.	NIH	National Institute on Aging	2023	$47,694	September 16, 2023	September 15, 2024	ECK, RANDALL	reporter.nih.gov
Effectiveness of Expiratory Muscle Strength Training for Improving Communication in ALS	NIH	National Institute on Deafness and Other Communication Disorders	2022	$46,752	January 1, 2021	October 14, 2022	KIEFER, BRIANNA ROSE	reporter.nih.gov
A Novel Genome-Wide Screen to Identify and Characterize Regulators of ALS Disease Modifier Gene Ataxin-2	NIH	National Institute of Neurological Disorders and Stroke	2022	$46,752	January 3, 2022	January 2, 2023	KIM, GARAM	reporter.nih.gov
Elucidating the molecular mechanism underlying ALS/FTD-linked FUS mutations with single-molecule resolution	NIH	National Institute of Neurological Disorders and Stroke	2021	$46,036	May 1, 2020	April 30, 2022	RHINE, KEVIN	reporter.nih.gov
Engineering KapB2 to Disaggregate Disease-Linked Proteins	NIH	National Institute of Neurological Disorders and Stroke	2021	$46,036	September 1, 2019	August 31, 2022	FARE, CHARLOTTE MIRIAM	reporter.nih.gov
Metabolic perturbations as a modifier of repeat-associated non-AUG translation in C9orf72-linked ALS/FTD	NIH	National Institute of Neurological Disorders and Stroke	2021	$46,036	September 17, 2020	September 16, 2022	NELSON, ANDREW	reporter.nih.gov
Cellular reprogramming to promote longevity, resilience, and repair in motor unit degeneration	NIH	National Institute on Aging	2022	$42,683	December 1, 2022	May 14, 2023	RICH, KELLY	reporter.nih.gov
Novel pathways in C9ORF72-associated ALS and dementia	NIH	National Institute of Neurological Disorders and Stroke	2021	$39,721	August 15, 2019	June 30, 2021	MORDES, DANIEL ADAM	reporter.nih.gov
Kapβ2 recognition of cargos involved in neurodegenerative/neurodevelopmental diseases	NIH	National Institute of Neurological Disorders and Stroke	2021	$39,636	September 29, 2020	September 28, 2022	GONZALEZ-CASTRO, ABNER	reporter.nih.gov
Investigating the mechanism of UPF1-mediated rescue of TDP-43-based models of ALS and FTD	NIH	National Institute of Neurological Disorders and Stroke	2021	$38,495	January 1, 2020	December 31, 2021	GOMEZ, NICOLAS BENJAMIN	reporter.nih.gov
Development of a chemogenetically controlled RNA aggregation system and its application in elucidating the role of RNA foci in repeat expansion disease	NIH	National Institute of Neurological Disorders and Stroke	2022	$37,968	July 1, 2022	February 28, 2023	UNTI, MILDRED JOHANNA	reporter.nih.gov
Clear speech in ALS: Effects of feedback from a novel ASR practice paradigm and practice dosage	NIH	National Institute on Deafness and Other Communication Disorders	2021	$33,743	September 1, 2020	August 31, 2022	GUTZ, SARAH	reporter.nih.gov
Solving the Phase Problem of TDP-43 and ALS-Associated Variants	NIH	National Institute of General Medical Sciences	2021	$33,253	August 1, 2020	July 31, 2023	BRYAN, NIKAELA WHITNEY	reporter.nih.gov
Optical Tomography and Decoding for Communication via Brain-Computer Interface	NIH	National Institute of Neurological Disorders and Stroke	2021	$29,520	January 1, 2020	December 31, 2021	MARKOW, ZACHARY E	reporter.nih.gov
Investigating ETF1 at the Interface of Translation Repression and Nonsense-Mediated Decay in C9-ALS/FTD Neurotoxicity	NIH	National Institute of Neurological Disorders and Stroke	2021	$26,659	April 1, 2020	June 30, 2021	DALEY, ELIZABETH	reporter.nih.gov

Organizations

Organization	Place	NIH awards	NIH amount	NSF amount
Massachusetts General Hospital	Boston, MA	5	$22.8 million	$0
University of Miami School of Medicine	Coral Gables, FL	3	$9.8 million	$0
University of Florida	Gainesville, FL	9	$8.1 million	$0
Univ of Massachusetts Med SCH Worcester	Worcester, MA	6	$7.1 million	$0
Johns Hopkins University	Baltimore, MD	13	$5.6 million	$0
Mayo Clinic Jacksonville	Jacksonville, FL	5	$4.9 million	$0
University of California, San Francisco	San Francisco, CA	5	$4.6 million	$0
Northwestern University at Chicago	Chicago, IL	8	$4.4 million	$0
Cedars-Sinai Medical Center	Los Angeles, CA	3	$3.7 million	$0
Thomas Jefferson University	Philadelphia, PA	7	$3.7 million	$0
Upstate Medical University	Syracuse, NY	3	$3.5 million	$0
University of Maryland Baltimore	Baltimore, MD	4	$3.5 million	$0
University of Pittsburgh at Pittsburgh	Pittsburgh, PA	5	$2.7 million	$0
Synapticure, Inc.	Kenilworth, IL	2	$2.7 million	$0
Columbia University Health Sciences	New York, NY	3	$2.7 million	$0
University of Missouri-Columbia	Columbia, MO	3	$2.4 million	$0
Ludwig Institute for Cancer Res LTD	La Jolla, CA	3	$2.4 million	$0
J. David Gladstone Institutes	San Francisco, CA	1	$2.4 million	$0
University of Minnesota	Minneapolis, MN	1	$2.3 million	$0
Cogentis Therapeutics, Inc.	Baltimore, MD	1	$2.2 million	$0
Scripps Research Institute, the	La Jolla, CA	1	$2.1 million	$0
Harvard Medical School	Boston, MA	4	$2.1 million	$0
Carnegie Mellon University	Pittsburgh, PA	1	$2.1 million	$0
Mitochondria in Motion, Inc.	Saint Louis, MO	2	$2 million	$0
Brown University	Providence, RI	3	$2 million	$0
Harvard University	Cambridge, MA	1	$2 million	$0
SUNY at Stony Brook	Stony Brook, NY	1	$1.8 million	$0
Florida International University	Miami, FL	1	$1.8 million	$0
University of Texas at Arlington	Arlington, TX	1	$1.7 million	$0
Ut Southwestern Medical Center	Dallas, TX	4	$1.7 million	$0
ST. Joseph's Hospital and Medical Center	Phoenix, AZ	3	$1.7 million	$0
Stanford University	Stanford, CA	4	$1.6 million	$0
East Carolina University	Greenville, NC	1	$1.6 million	$0
Cincinnati Childrens Hosp Med CTR	Cincinnati, OH	2	$1.5 million	$0
Washington University	Saint Louis, MO	5	$1.4 million	$0
University of Wisconsin-Madison	Madison, WI	3	$1.3 million	$0
University of Pennsylvania	Philadelphia, PA	5	$1.3 million	$0
University of Cincinnati	Cincinnati, OH	1	$1.2 million	$0
Texas Tech University Health Sciences Center at El Paso	El Paso, TX	1	$1.2 million	$0
Case Western Reserve University	Cleveland, OH	2	$1.1 million	$0
California Institute of Technology	Pasadena, CA	1	$1.1 million	$0
Indiana University	Bloomington, IN	1	$1.1 million	$0
Duke University	Durham, NC	2	$945,038	$0
Rockefeller University	New York, NY	2	$889,875	$0
University of Utah	Salt Lake City, UT	2	$805,873	$0
Beth Israel Deaconess Medical Center	Boston, MA	1	$766,280	$0
MGH Institute of Health Professions	Charlestown, MA	3	$738,019	$0
Scripps Florida	Jupiter, FL	1	$733,123	$0
University of Kansas Center for Research Inc	Lawrence, KS	1	$728,085	$0
Salk Institute for Biological Studies	La Jolla, CA	2	$721,500	$0
University of California, San Diego	La Jolla, CA	3	$718,017	$0
Yale University	New Haven, CT	1	$686,750	$0
University Medical Center Utrecht	Utrecht	1	$606,866	$0
CUNY Brooklyn College	New York, NY	1	$575,365	$0
University of Arizona	Tucson, AZ	2	$537,963	$0
Acurastem, Inc.	Pasadena, CA	1	$533,459	$0
Applied Geosolutions, LLC	Durham, NH	1	$486,219	$0
Brigham and Women's Hospital	Boston, MA	1	$472,026	$0
Amydis Diagnostics, Inc.	La Jolla, CA	1	$458,527	$0
Tufts University Boston	Boston, MA	1	$453,750	$0
Wright State University	Dayton, OH	1	$450,000	$0
Epigen Biosciences, Inc.	San Diego, CA	1	$449,984	$0
Cornell University	Ithaca, NY	1	$449,419	$0
University of Kansas Medical Center	Kansas City, KS	1	$441,561	$0
Southern Methodist University	Dallas, TX	1	$437,142	$0
Wake Forest University Health Sciences	Winston-Salem, NC	1	$426,250	$0
University of Illinois at Chicago	Chicago, IL	1	$424,243	$0
Western Michigan Univ School of Medicine	Kalamazoo, MI	1	$415,250	$0
University of North Carolina at Charlotte	Charlotte, NC	1	$413,826	$0
Princeton University	Princeton, NJ	1	$405,000	$0
Massachusetts Institute of Technology	Cambridge, MA	1	$401,374	$0
University of Nebraska Medical Center	Omaha, NE	1	$396,330	$0
Montana State University -Billings	Billings, MT	1	$385,521	$0
Pathmaker Neurosystems, Inc.	Boston, MA	1	$371,628	$0
University of Iowa	Iowa City, IA	1	$363,731	$0
Panorama Research, Inc.	Sunnyvale, CA	1	$299,989	$0
Macquarie University	North Ryde	1	$292,122	$0
Mayo Clinic Rochester	Rochester, MN	1	$256,234	$0
Chimerna Therapeutics Inc.	New York, NY	1	$256,158	$0
Broad Institute, Inc.	Cambridge, MA	1	$252,990	$0
University of Michigan at Ann Arbor	Ann Arbor, MI	2	$240,571	$0
University of Washington	Seattle, WA	2	$224,194	$0
New York University	New York, NY	1	$198,125	$0
Baylor College of Medicine	Houston, TX	1	$189,431	$0
University of California at Davis	Davis, CA	1	$158,875	$0
Arizona State University	Scottsdale, AZ	1	$157,000	$0
University of California-Berkeley	Berkeley, CA	1	$124,304	$0
University of Zurich	Zurich	1	$101,101	$0
University of South Florida	Tampa, FL	1	$81,705	$0
Methodist Hospital Research Institute	Houston, TX	1	$80,750	$0
University of California Los Angeles	Los Angeles, CA	1	$76,422	$0
Univ of North Carolina Chapel Hill	Chapel Hill, NC	1	$61,951	$0
University of Kentucky	Lexington, KY	1	$56,638	$0
Purdue University	West Lafayette, IN	1	$46,752	$0
Ohio State University	Columbus, OH	1	$42,683	$0
Weill Medical Coll of Cornell Univ	New York, NY	1	$37,968	$0

Funding by fiscal year

Fiscal year	NIH awards	NIH amount	NSF amount
2025	1	$1,804,011	$0
2023	57	$27,646,558	$0
2022	112	$68,606,356	$0
2021	131	$59,925,738	$0

Open federal funding opportunities

From Grants.gov: notices that funded awards in this table, and open notices on the same agency and assistance listing.

Open opportunity	Number	Agency	Listing	Closes	Award ceiling	Why it matches
Functional Target Validation for Alzheimer's Disease-Related Dementias	RFA-NS-26-034	NIH	93.853	November 6, 2026	Not listed	Same assistance listing 93.853 as 142 awards here
Clinical Trials and Ancillary Studies Conducted within NIH-Funded Clinical Trial Research Networks (UG3/UH3 - Clinical Trial Required)	PAR-27-007	NIH	93.853	November 10, 2026	Not listed	Same assistance listing 93.853 as 142 awards here
Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)	RFA-NS-26-001	NIH	93.853	November 10, 2026	Not listed	Same assistance listing 93.853 as 142 awards here
Genomic and Biologic Therapies for ADRD (U01 Clinical Trial Optional)	RFA-NS-26-030	NIH	93.853	November 10, 2026	Not listed	Same assistance listing 93.853 as 142 awards here
Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant (R21 Clinical Trial Optional)	PAR-25-369	NIH	93.853	November 18, 2026	Not listed	Same assistance listing 93.853 as 142 awards here
Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)	PAR-25-371	NIH	93.853	November 18, 2026	Not listed	Same assistance listing 93.853 as 142 awards here
NIH StrokeNet Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention (UG3/UH3 Clinical Trial Optional)	PAR-25-052	NIH	93.853	November 19, 2026	Not listed	Same assistance listing 93.853 as 142 awards here
HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)	RFA-AT-25-003	NIH	93.853	November 23, 2026	$375,000	Same assistance listing 93.853 as 142 awards here
Maximizing the Scientific Value of Data Generated by the Environmental Influences on Child Health Outcomes (ECHO) Program: Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32)	RFA-OD-27-008	NIH	93.853	December 2, 2026	Not listed	Same assistance listing 93.853 as 142 awards here
Emerging Global Leader Award (K43 Independent Clinical Trial Required)	PAR-24-295	NIH	93.853	December 3, 2026	Not listed	Same assistance listing 93.853 as 142 awards here
Emerging Global Leader Award (K43 Independent Clinical Trial Not Allowed)	PAR-24-296	NIH	93.853	December 3, 2026	Not listed	Same assistance listing 93.853 as 142 awards here
NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed)	RFA-OD-24-011	NIH	93.853	December 4, 2026	Not listed	Same assistance listing 93.853 as 142 awards here
Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required)	PAR-24-214	NIH	93.853	January 7, 2027	$375,000	Same assistance listing 93.853 as 142 awards here
HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)	RFA-NS-25-023	NIH	93.853	January 15, 2027	$350,000	Same assistance listing 93.853 as 142 awards here
HEAL Initiative: Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required)	RFA-DA-28-011	NIH	93.853	January 26, 2027	Not listed	Same assistance listing 93.853 as 142 awards here
HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR) - Building Engagement, Assistance, Capacity, Outreach, and Networks (BEACON) Center (U2C Clinical Trial Not Allowed)	RFA-DA-28-012	NIH	93.853	January 26, 2027	Not listed	Same assistance listing 93.853 as 142 awards here
Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program (UC2- Clinical Trial Not Allowed)	PAR-24-268	NIH	93.853	January 27, 2027	$500,000	Same assistance listing 93.853 as 142 awards here
Translational Neural Devices (R61/R33 - Clinical Trial Optional)	PAR-25-053	NIH	93.853	January 28, 2027	Not listed	Same assistance listing 93.853 as 142 awards here
BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS (R18 - Clinical Trial Not Allowed)	RFA-NS-24-031	NIH	93.853	January 28, 2027	$750,000	Same assistance listing 93.853 as 142 awards here
BRAIN Initiative: Clinical Studies to Advance Next-Generation Devices for Recording and Modulation in the Human Central Nervous System	RFA-NS-28-006	NIH	93.853	January 28, 2027	Not listed	Same assistance listing 93.853 as 142 awards here

Updated November 3, 2026. Read from NIH RePORTER ExPORTER and NSF Award Search. Published by NIH and NSF as U.S. government data. NIH awards are fiscal years 2021 to 2025 (NIH files published to 2026-07-09); NSF awards are fiscal years 2022 to 2026 (NSF files published to 2026-11-02). NIH amounts are the total cost of each fiscal year in the window; NSF amounts are the funds obligated in the window. Organizations are matched on the UEI. Open opportunities come from Grants.gov and match on agency and assistance listing number, and on the notice number NIH prints on an award. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.