Data / Nonprofits / North Carolina / Durham
Nonprofits in Durham, NC: 2,189 registered with the IRS
2,189 nonprofits are registered with the IRS in Durham, NC, 1,988 of them 501(c)(3) charities; the 676 that report revenue took in $20.72 billion. The largest by revenue: Duke University Health System Inc ($6.17 billion), Duke University ($4.75 billion), Gothic Corporation ($3.18 billion). Most common causes: education (285), religion-related (283), human services (196).
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The 500 largest by revenue
| Organization | Category | Type | Since | Revenue | Assets | Filing |
|---|---|---|---|---|---|---|
| Duke University Health System Inc | Health care | 501(c)(3) | 1998 | $6.17 billion | $8.97 billion | 2025-06 |
| Duke University | Education | 501(c)(3) | 1939 | $4.75 billion | $22.13 billion | 2025-06 |
| Gothic Corporation | Education | 501(c)(3) | 1993 | $3.18 billion | $8.96 billion | 2025-06 |
| Duke Health Integrated Practice Inc | 501(c)(3) | 2021 | $1.33 billion | $251.4 million | 2025-06 | |
| Gothic HSP Corporation | Health care | 501(c)(3) | 2010 | $974.8 million | $2.75 billion | 2025-06 |
| Family Health International | International, foreign affairs and national security | 501(c)(3) | 1974 | $539.6 million | $348.2 million | 2025-09 |
| L C Ind Inc | Human services | 501(c)(3) | 1960 | $408.1 million | $267.9 million | 2025-06 |
| Ncinnovation Inc | Education | 501(c)(3) | 2020 | $272.1 million | $534.3 million | 2025-06 |
| Duke University Affiliated Physicans Inc | Health care | 501(c)(3) | 1996 | $252.4 million | $88.1 million | 2025-06 |
| American Institute of Certified Public Accountants | 501(c)(6) | 1953 | $227.8 million | $239.8 million | 2024-12 | |
| Association of International Certified Professional Accountants | Community improvement and capacity building | 501(c)(6) | 2019 | $214.2 million | $81.9 million | 2024-12 |
| Self Help Ventures Fund | Community improvement and capacity building | 501(c)(3) | 1984 | $189.2 million | $3.45 billion | 2024-12 |
| The United Methodist Retirement Homes Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2011 | $113.2 million | $490.8 million | 2025-09 |
| Self Help Credit Union | 501(c)(14) | 1969 | $102.2 million | $1.98 billion | 2024-12 | |
| State Chartered Credit Unions in North Carolina | 501(c)(14) | 1969 | $82.5 million | $1.05 billion | 2024-12 | |
| Self-Help Services Corp | 501(c)(3) | 1994 | $80.4 million | $10.7 million | 2024-12 | |
| Associated Health Services Inc | Health care | 501(c)(3) | 1997 | $76 million | $31.6 million | 2025-06 |
| Latino Community Development Center | Human services | 501(c)(3) | 2002 | $65.3 million | $62 million | 2024-12 |
| Goodwill Industries of Eastern North Carolina Inc | Employment | 501(c)(3) | 1964 | $53.6 million | $132 million | 2025-12 |
| Srcco Inc | Community improvement and capacity building | 501(c)(6) | 2002 | $53.5 million | $44.1 million | 2024-12 |
| Durham Academy Inc | Education | 501(c)(3) | 1961 | $47.6 million | $124.2 million | 2025-06 |
| Triangle Community Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1984 | $42.5 million | $335.8 million | 2025-06 |
| Just Trust for Education | Crime and legal-related | 501(c)(3) | 2023 | $41.4 million | $66.9 million | 2024-12 |
| North Carolina Learns Inc | Education | 501(c)(3) | 2016 | $38.1 million | $17.8 million | 2025-06 |
| Lincoln Community Health Center Incorporated | Health care | 501(c)(3) | 1973 | $37 million | $21.7 million | 2025-06 |
| Duke Health Lake Norman Regional Medical Center Inc | Health care | 501(c)(3) | 2025 | $34.6 million | $313.6 million | 2025-06 |
| Forest at Duke Inc | Human services | 501(c)(3) | 1989 | $34.5 million | $243.9 million | 2025-09 |
| Duke Corporate Education | Education | 501(c)(3) | 2007 | $33.7 million | $37.3 million | 2025-06 |
| Dumac Inc | Education | 501(c)(3) | 2011 | $31.8 million | $33.3 million | 2025-06 |
| Southern Vision Alliance | Public and societal benefit | 501(c)(3) | 2013 | $28.4 million | $12.7 million | 2024-12 |
| Triangle Land Conservancy Inc | Environment | 501(c)(3) | 1983 | $26.1 million | $219.4 million | 2025-06 |
| Duke Integrated Network Inc | Health care | 501(c)(3) | 2015 | $25.5 million | $1.7 million | 2025-06 |
| Durham Technical Community College Foundation Inc | Education | 501(c)(3) | 1984 | $25.1 million | $37.5 million | 2025-06 |
| Trinity School of Durham and Chapel Hill Inc | Education | 501(c)(3) | 1996 | $24.9 million | $35.6 million | 2025-06 |
| Triangle Residential Options for Substance Abusers Inc | 501(c)(3) | 1994 | $22.5 million | $54.6 million | 2025-06 | |
| North Carolina Central University Foundation Inc | Education | 501(c)(3) | 1974 | $22.3 million | $63.7 million | 2025-06 |
| North Carolina Biotechnology Center | Science and technology | 501(c)(3) | 1985 | $21 million | $42.2 million | 2025-06 |
| Healthy Start Education Inc | Education | 501(c)(3) | 1999 | $20.6 million | $44.1 million | 2025-06 |
| Voyager Academy Inc | Education | 501(c)(3) | 2007 | $20 million | $16.7 million | 2025-06 |
| Rescue Missions Ministries Inc | 501(c)(3) | 1982 | $19.4 million | $17.9 million | 2025-12 | |
| Reinvestment Partners | Community improvement and capacity building | 501(c)(3) | 1998 | $18.7 million | $27.6 million | 2024-12 |
| Carolina Friends School | 501(c)(3) | 1965 | $17.6 million | $46.5 million | 2025-06 | |
| Families and Communities Rising Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1993 | $17.6 million | $12.9 million | 2025-06 |
| The Family Health International Foundation | International, foreign affairs and national security | 501(c)(3) | 1991 | $17.4 million | $200.9 million | 2024-12 |
| Duke School | 501(c)(3) | 1984 | $16.6 million | $33.1 million | 2025-06 | |
| North Carolina Museum of Life & Science | Arts, culture and humanities | 501(c)(3) | 1958 | $16.1 million | $26.3 million | 2025-06 |
| Excelsior Classical Academy - A Challenge Foundation Academy | Education | 501(c)(3) | 2015 | $14 million | $37.6 million | 2025-06 |
| Institute for Medical Research Inc | 501(c)(3) | 1989 | $13.8 million | $11.1 million | 2025-09 | |
| Durhams Partnership for Children | Education | 501(c)(3) | 1994 | $13.7 million | $488,525 | 2025-06 |
| Book Harvest | Education | 501(c)(3) | 2011 | $13.5 million | $13.1 million | 2025-12 |
| Chordoma Foundation | Medical research | 501(c)(3) | 2007 | $13.4 million | $18 million | 2025-12 |
| Research Triangle Foundation of North Carolina | 501(c)(4) | 1972 | $13.4 million | $206.1 million | 2025-09 | |
| Divers Alert Network | Recreation and sports | 501(c)(3) | 1990 | $13.4 million | $49.2 million | 2024-12 |
| American Society of Echocardiography Incorporated | 501(c)(6) | 1977 | $12 million | $14.1 million | 2025-12 | |
| B & D Integrated Health Services | Mental health and crisis intervention | 501(c)(3) | 2004 | $11.9 million | $4.6 million | 2024-12 |
| Ronald McDonald House Charities of the Triangle | 501(c)(3) | 1979 | $11.2 million | $30.1 million | 2025-12 | |
| North Carolina School of Science & Mathematics Foundation | 501(c)(3) | 1979 | $11.2 million | $42 million | 2025-06 | |
| Rtca Inc | Education | 501(c)(3) | 2018 | $11.1 million | $2.7 million | 2025-06 |
| New Durham Corporation | Community improvement and capacity building | 501(c)(3) | 1987 | $11.1 million | $242.3 million | 2025-06 |
| Maureen Joy Charter School | Education | 501(c)(3) | 1997 | $11 million | $9.1 million | 2025-06 |
| L C Industries Foundation | Human services | 501(c)(3) | 2013 | $10.8 million | $81.4 million | 2025-06 |
| The Center for Child and Family Health Inc | Crime and legal-related | 501(c)(3) | 1981 | $10.2 million | $5.3 million | 2025-06 |
| Stop Soldier Suicide | Mental health and crisis intervention | 501(c)(3) | 2011 | $10 million | $3.4 million | 2025-03 |
| Durham-Chapel Hill Jewish Federation | 501(c)(3) | 2002 | $10 million | $27.2 million | 2025-09 | |
| MDC Inc | 501(c)(3) | 1968 | $9.9 million | $14.6 million | 2025-06 | |
| Organization for Tropical Studies Inc | International, foreign affairs and national security | 501(c)(3) | 1999 | $9.7 million | $18.6 million | 2025-06 |
| Center for Responsible Lending | Crime and legal-related | 501(c)(3) | 2002 | $9.7 million | $11.5 million | 2024-12 |
| National Humanities Center | Arts, culture and humanities | 501(c)(3) | 1977 | $9.6 million | $96.8 million | 2025-06 |
| Code the Dream Inc | Education | 501(c)(3) | 2009 | $9.5 million | $8.2 million | 2024-12 |
| Hope Valley Country Club Inc | 501(c)(7) | 1944 | $9.5 million | $11.3 million | 2024-12 | |
| Hill Center Inc | Education | 501(c)(3) | 1998 | $9.3 million | $34.3 million | 2025-06 |
| Durham Exchange Club Industries Inc | Employment | 501(c)(3) | 1967 | $9.2 million | $31.9 million | 2025-06 |
| Central Park School for Children | Education | 501(c)(3) | 2002 | $9.1 million | $9.4 million | 2025-06 |
| Voyager Foundation Inc | Education | 501(c)(3) | 2013 | $8.9 million | $49.2 million | 2025-06 |
| Habitat for Humanity of Durham Inc | 501(c)(3) | 1988 | $8.5 million | $23.7 million | 2024-06 | |
| International Zinc Association | 501(c)(6) | 1991 | $8.4 million | $5.8 million | 2024-12 | |
| Triangle Day School Inc | 501(c)(3) | 1993 | $7.8 million | $14.9 million | 2025-06 | |
| Center for Community Self-Help | Employment | 501(c)(3) | 1981 | $7.6 million | $57.3 million | 2024-12 |
| Duke Affiliations Network Inc | Health care | 501(c)(3) | 2018 | $7.3 million | $24.2 million | 2025-06 |
| Rescue Legacy Fund Inc | Religion-related | 501(c)(3) | 2010 | $7.3 million | $45.2 million | 2025-12 |
| Contemporary Science Center | 501(c)(3) | 2002 | $7.2 million | $12.4 million | 2025-06 | |
| Corporation for Effective Schooling | Education | 501(c)(3) | 1998 | $7.2 million | $19.6 million | 2025-06 |
| Old Chatham Golf Club | Recreation and sports | 501(c)(7) | 2000 | $7.1 million | $24.9 million | 2024-12 |
| El Futuro | Mental health and crisis intervention | 501(c)(3) | 2005 | $7 million | $5.3 million | 2025-06 |
| Carolina Theatre of Durham Inc | Arts, culture and humanities | 501(c)(3) | 1996 | $7 million | $8.5 million | 2025-06 |
| Institute for the Development of Young Leaders | Mutual and membership benefit | 501(c)(3) | 2014 | $6.6 million | $6.8 million | 2025-06 |
| Communities in Schools of North Carolina Inc | Human services | 501(c)(3) | 1991 | $6.5 million | $7.3 million | 2025-06 |
| National Institute of Minority Economic Development | 501(c)(3) | 1988 | $6.5 million | $19.1 million | 2024-12 | |
| Reaching All Minds Academy Inc | Education | 501(c)(3) | 2016 | $6.4 million | $2.7 million | 2025-06 |
| Self-Help Community Development Corp | Community improvement and capacity building | 501(c)(3) | 1996 | $6 million | $106.1 million | 2024-12 |
| Kipp North Carolina Public Schools Inc | Education | 501(c)(3) | 2022 | $6 million | $4.8 million | 2025-06 |
| Southern Coalition for Socialjustice | Crime and legal-related | 501(c)(3) | 2007 | $5.9 million | $19.5 million | 2024-12 |
| Jacaranda Health | Health care | 501(c)(3) | 2013 | $5.7 million | $13.9 million | 2024-12 |
| Montessori Community School Inc | Education | 501(c)(3) | 1981 | $5.7 million | $6.3 million | 2025-06 |
| National MPS Society Inc | 501(c)(3) | 1986 | $5.6 million | $6.6 million | 2025-12 | |
| Family Connects International | Health care | 501(c)(3) | 2022 | $5.5 million | $3.4 million | 2025-06 |
| Croasdaile Country Club Inc | 501(c)(7) | 1995 | $5.5 million | $14.5 million | 2025-12 | |
| Preserving Home Inc | Housing and shelter | 501(c)(3) | 1996 | $5 million | $3.2 million | 2025-12 |
| Cristo Rey Research Triangle High School Inc | Education | 501(c)(3) | 2022 | $4.9 million | $9.9 million | 2025-06 |
| Development Ventures Incorporated | 501(c)(3) | 1986 | $4.9 million | $24 million | 2024-12 | |
| Sigma Xi the Scientific Research Honor Society Inc | 501(c)(3) | 1943 | $4.9 million | $19.5 million | 2025-06 | |
| Student U | Education | 501(c)(3) | 2010 | $4.8 million | $9.5 million | 2024-12 |
| Urban Ministries of Durham Inc | 501(c)(3) | 1983 | $4.7 million | $3.2 million | 2025-06 | |
| Alpha Management Community Services Inc | Human services | 501(c)(3) | 2002 | $4.6 million | $2.8 million | 2025-12 |
| North Carolina Community School Coalition Inc | Education | 501(c)(3) | 2023 | $4.6 million | $4.9 million | 2025-12 |
| American Civil Liberties Union of North Carolina Legl Foundation Inc | 501(c)(3) | 1971 | $4.6 million | $8.6 million | 2025-03 | |
| Durham Community Land Trustees Inc | Housing and shelter | 501(c)(3) | 1979 | $4.6 million | $30.9 million | 2025-06 |
| The Center for Black Health and Equity | Mental health and crisis intervention | 501(c)(3) | 2021 | $4.5 million | $6.3 million | 2025-12 |
| Temps To the Rescue Inc | Employment | 501(c)(3) | 2001 | $4.4 million | $770,095 | 2024-12 |
| The North Carolina Coalition Against Domestic Violence Incorpor | 501(c)(3) | 1986 | $4.4 million | $1.9 million | 2024-12 | |
| Montessori School of Durham | Education | 501(c)(3) | 1979 | $4.3 million | $5.9 million | 2025-05 |
| Village of Wisdom Inc | Youth development | 501(c)(3) | 2015 | $4.1 million | $4.5 million | 2025-12 |
| Duke Allmo Services Inc | Education | 501(c)(3) | 2016 | $4.1 million | $2.7 million | 2025-06 |
| Duke Global Inc | Education | 501(c)(3) | 2009 | $4.1 million | $2.2 million | 2025-06 |
| International Montessori School Inc | Education | 501(c)(3) | 2005 | $4 million | $9.1 million | 2025-06 |
| Kramden Institute Inc | Human services | 501(c)(3) | 2004 | $3.8 million | $4.6 million | 2025-12 |
| Duke University Philanthropies Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2005 | $3.8 million | $13.1 million | 2025-06 |
| Housing for New Hope Inc | Housing and shelter | 501(c)(3) | 1994 | $3.8 million | $12.1 million | 2025-08 |
| American Dance Festival Inc | Arts, culture and humanities | 501(c)(3) | 1976 | $3.8 million | $18.1 million | 2025-09 |
| International Lead Association Inc | Community improvement and capacity building | 501(c)(6) | 2020 | $3.8 million | $1.9 million | 2025-12 |
| Rewriting the Code Inc | Education | 501(c)(3) | 2017 | $3.7 million | $7 million | 2025-12 |
| Blueprint North Carolina | Education | 501(c)(3) | 2010 | $3.7 million | $3.9 million | 2025-12 |
| Male Contraception Initiative | Civil rights, social action and advocacy | 501(c)(3) | 2014 | $3.7 million | $4.1 million | 2024-12 |
| Duke Juldec Services Inc | Education | 501(c)(3) | 2016 | $3.7 million | $866,838 | 2025-06 |
| Farmer Foodshare Inc | Food, agriculture and nutrition | 501(c)(3) | 2011 | $3.6 million | $1.3 million | 2025-09 |
| El Centro Hispano Inc | Community improvement and capacity building | 501(c)(3) | 1998 | $3.5 million | $1.8 million | 2025-06 |
| Emily Krzyzewski Center Inc | Recreation and sports | 501(c)(3) | 2003 | $3.4 million | $19.3 million | 2025-06 |
| First Environments Parents Organization | Human services | 501(c)(3) | 1987 | $3.3 million | $1.3 million | 2024-12 |
| Institute Capital Inc | Community improvement and capacity building | 501(c)(3) | 2000 | $3.3 million | $41.3 million | 2024-12 |
| Global Scholars Academy Gsa | Education | 501(c)(3) | 2014 | $3.2 million | $954,309 | 2025-06 |
| Durham County Community Living Programs Inc | 501(c)(3) | 1980 | $3.2 million | $2.5 million | 2025-06 | |
| Hollow Rock Racquet and Swim Club Inc | 501(c)(7) | 1985 | $3.1 million | $4.4 million | 2025-09 | |
| Durham Arts Council Inc | Arts, culture and humanities | 501(c)(3) | 1957 | $3.1 million | $1 million | 2025-06 |
| Duke Janjun Services Inc | Education | 501(c)(3) | 2016 | $3 million | $3 million | 2025-06 |
| Center for Death Penalty Litigation | Crime and legal-related | 501(c)(3) | 1995 | $3 million | $4.1 million | 2025-06 |
| Kay Yow Cancer Foundation Inc | Education | 501(c)(3) | 2010 | $2.8 million | $6.7 million | 2025-08 |
| The Scrap Exchange Inc | Environment | 501(c)(3) | 1991 | $2.8 million | $6.9 million | 2024-12 |
| Carolina Federation | Civil rights, social action and advocacy | 501(c)(4) | 2019 | $2.8 million | $3.5 million | 2025-06 |
| Watts College of Nursing Inc | Education | 501(c)(3) | 2019 | $2.7 million | $19,927 | 2025-06 |
| Animal Protection Society of Durham | Animal-related | 501(c)(3) | 1971 | $2.7 million | $2.1 million | 2025-06 |
| Made in Durham | Education | 501(c)(3) | 2015 | $2.7 million | $1.1 million | 2025-06 |
| The Just Trust for Action | Crime and legal-related | 501(c)(4) | 2023 | $2.7 million | $57 million | 2024-12 |
| International Union of Pure and Applied Chemistry | Science and technology | 501(c)(3) | 1953 | $2.6 million | $7.5 million | 2024-12 |
| American Civil Liberties Union | 501(c)(4) | 1970 | $2.5 million | $9.1 million | 2025-03 | |
| Carolina Abortion Fund | Health care | 501(c)(3) | 2022 | $2.5 million | $7.7 million | 2025-06 |
| Local Start Dental Inc | Health care | 501(c)(3) | 2019 | $2.5 million | $2.7 million | 2025-12 |
| North Carolina Association of Black Lawyer Land Loss Prevention Projec | 501(c)(3) | 1984 | $2.5 million | $5.7 million | 2024-12 | |
| First in Families of North Carolina | Human services | 501(c)(3) | 2003 | $2.5 million | $1.4 million | 2025-06 |
| Downtown Durham Inc | 501(c)(6) | 1995 | $2.4 million | $1.5 million | 2025-06 | |
| Durham Center for Senior Life | 501(c)(3) | 1954 | $2.4 million | $1.6 million | 2025-06 | |
| Epsilon Beta of Chi Omega Foundation | 501(c)(7) | 1956 | $2.3 million | $7.7 million | 2025-06 | |
| TBC Foundation | Religion-related | 501(c)(3) | 2024 | $2.3 million | $2.2 million | 2025-12 |
| Carolina Federation Fund | Human services | 501(c)(3) | 2020 | $2.3 million | $2.5 million | 2025-06 |
| Justicematters Inc | Crime and legal-related | 501(c)(3) | 2011 | $2.3 million | $709,356 | 2025-09 |
| International Union of Operating Engineers Local 465 Afl-Cio | 501(c)(5) | 1970 | $2.3 million | $4 million | 2025-06 | |
| East Coast Greenway Alliance Inc | Environment | 501(c)(3) | 1997 | $2.2 million | $2.7 million | 2025-12 |
| North Carolina Amateur Sports | Recreation and sports | 501(c)(3) | 1983 | $2.1 million | $3.4 million | 2024-12 |
| Triangle Research Libraries Network | Education | 501(c)(3) | 2020 | $2.1 million | $537,680 | 2025-06 |
| Glioblastoma Foundation Inc | Medical research | 501(c)(3) | 2016 | $2.1 million | $3.7 million | 2024-12 |
| Hayti Reborn - Justice Movement | Human services | 501(c)(3) | 2023 | $2 million | $758,228 | 2025-06 |
| International Brotherhood of Electrical Workers | 501(c)(5) | 1940 | $2 million | $2.4 million | 2025-12 | |
| Embodiment Institute Incorporated | Education | 501(c)(3) | 2023 | $2 million | $5.5 million | 2024-12 |
| North Carolina Housing Coalition Inc | 501(c)(3) | 1988 | $2 million | $976,865 | 2025-12 | |
| Durham Public Schools Foundation | Education | 501(c)(3) | 2017 | $1.9 million | $2.2 million | 2025-06 |
| First Flight Venture Center Inc | Community improvement and capacity building | 501(c)(3) | 1993 | $1.9 million | $12.5 million | 2025-12 |
| Sheriff Accountability Action | Community improvement and capacity building | 501(c)(4) | 2019 | $1.9 million | $952,957 | 2025-06 |
| The Chamber Orchestra of the Triangle Inc | 501(c)(3) | 1988 | $1.9 million | $3.8 million | 2025-06 | |
| Families Moving Forward | 501(c)(3) | 1989 | $1.9 million | $3.7 million | 2025-12 | |
| Durham Childrens Initiative | Youth development | 501(c)(3) | 2009 | $1.9 million | $2.2 million | 2025-06 |
| Schoolhouse of Wonder | Environment | 501(c)(3) | 1991 | $1.8 million | $302,331 | 2025-12 |
| Meals On Wheels of Durham Inc | Food, agriculture and nutrition | 501(c)(3) | 1991 | $1.8 million | $2.3 million | 2025-06 |
| Durham Crisis Response Center | 501(c)(3) | 1983 | $1.8 million | $1.7 million | 2025-06 | |
| Scalawag | Education | 501(c)(3) | 2014 | $1.8 million | $583,955 | 2024-12 |
| Lebanon Volunteer Fire Department Inc | 501(c)(4) | 1971 | $1.8 million | $1.4 million | 2025-06 | |
| NC Warn Incorporated | Environment | 501(c)(3) | 1991 | $1.8 million | $2.2 million | 2025-12 |
| Caring House Inc | Health care | 501(c)(3) | 1992 | $1.8 million | $18.7 million | 2026-06 |
| Association for the Preservation of the Eno River Valley Inc | Environment | 501(c)(3) | 1976 | $1.7 million | $8 million | 2025-12 |
| Forward Cities Inc | Community improvement and capacity building | 501(c)(3) | 2006 | $1.7 million | $583,572 | 2024-12 |
| Durham Nativity School Inc | Education | 501(c)(3) | 2002 | $1.7 million | $11 million | 2025-06 |
| Boys & Girls Clubs of Durham and Orange Counties | 501(c)(3) | 1942 | $1.7 million | $1.2 million | 2025-12 | |
| Intercollegiate Mens Lacrosse Coaches Association | Recreation and sports | 501(c)(3) | 2021 | $1.6 million | $1 million | 2025-06 |
| Communities in Partnership | Community improvement and capacity building | 501(c)(3) | 2016 | $1.6 million | $3.1 million | 2025-12 |
| Samaritan Health Center Inc | Health care | 501(c)(3) | 2009 | $1.6 million | $988,876 | 2025-12 |
| American Institute of Certified Public Accountants Foundation | 501(c)(3) | 1980 | $1.6 million | $8.7 million | 2024-12 | |
| Durham Asset Management Company Incorporated | Health care | 501(c)(3) | 1994 | $1.6 million | $9,120 | 2025-06 |
| Durham Library Foundation | Education | 501(c)(3) | 2001 | $1.6 million | $8 million | 2025-06 |
| Forest History Society Inc | Environment | 501(c)(3) | 1956 | $1.6 million | $15.5 million | 2025-06 |
| Greater Durham Chamber of Commerce | 501(c)(6) | 1939 | $1.6 million | $1.2 million | 2024-12 | |
| Utility Broadband Alliance Inc | Mutual and membership benefit | 501(c)(6) | 2022 | $1.6 million | $2 million | 2024-12 |
| Encore Connects | Public and societal benefit | 501(c)(3) | 2025 | $1.6 million | $1.6 million | 2024-12 |
| Friends of Bonobos | Animal-related | 501(c)(3) | 2004 | $1.5 million | $449,271 | 2024-12 |
| Cristo Rey Research Triangle Corporate Work Study Program Inc | Employment | 501(c)(3) | 2022 | $1.5 million | $1.6 million | 2025-06 |
| Association of International Education Administrators | 501(c)(6) | 1987 | $1.5 million | $3 million | 2025-06 | |
| NC Budget & Tax Center | Civil rights, social action and advocacy | 501(c)(3) | 2022 | $1.5 million | $1.7 million | 2024-12 |
| Redwood Volunteer Fire Department Inc | 501(c)(4) | 1981 | $1.5 million | $3.1 million | 2025-06 | |
| Carolinas Clean Energy Business Association | Community improvement and capacity building | 501(c)(6) | 2018 | $1.5 million | $297,498 | 2024-12 |
| Exchange Clubs Child Abuse Prevention Center in Durham Inc | Crime and legal-related | 501(c)(3) | 2026 | $1.5 million | $525,743 | 2024-06 |
| Reality Ministries Inc | Youth development | 501(c)(3) | 2008 | $1.5 million | $3 million | 2025-06 |
| Central Park School for Children Foundation | Education | 501(c)(3) | 2006 | $1.4 million | $12.2 million | 2025-06 |
| The North Carolina Homes for the Aging Foundation Inc | 501(c)(3) | 1985 | $1.4 million | $4 million | 2024-12 | |
| Mira Education | Education | 501(c)(3) | 2002 | $1.4 million | $1.8 million | 2025-06 |
| Spirithouse South Inc | Human services | 501(c)(3) | 2022 | $1.3 million | $2.6 million | 2025-12 |
| Emancipate NC Inc | Crime and legal-related | 501(c)(3) | 1977 | $1.3 million | $1.6 million | 2025-12 |
| Independent Animal Rescue Inc | Animal-related | 501(c)(3) | 1996 | $1.3 million | $3.1 million | 2025-06 |
| Zoweh Inc | Religion-related | 501(c)(3) | 2006 | $1.3 million | $349,653 | 2025-12 |
| Senior Pharmassist Inc | Health care | 501(c)(3) | 1998 | $1.3 million | $3.2 million | 2025-06 |
| All My Children Family Resource Center | Human services | 501(c)(3) | 2021 | $1.3 million | $2.6 million | 2024-12 |
| Kathrine R Everett Charitable Testamentary Trust | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1997 | $1.2 million | $14.4 million | 2024-11 |
| Croatan Institute | Environment | 501(c)(3) | 2014 | $1.2 million | $1.6 million | 2024-12 |
| St Josephs Historic Foundation Inc | 501(c)(3) | 1977 | $1.2 million | $3 million | 2025-06 | |
| Leadingage North Carolina | Human services | 501(c)(6) | 1981 | $1.2 million | $1.1 million | 2024-12 |
| American Sexual Health Association | Health care | 501(c)(3) | 1991 | $1.2 million | $1 million | 2025-06 |
| North Carolina Association of Pharmacists | Community improvement and capacity building | 501(c)(6) | 2001 | $1.1 million | $1 million | 2024-12 |
| Automation Standards Complianceinstitute | Community improvement and capacity building | 501(c)(6) | 2008 | $1.1 million | $1.3 million | 2024-12 |
| Wildflower Cottage for Children Inc | 501(c)(3) | 2016 | $1.1 million | $2 million | 2025-07 | |
| Project Access of Durham County | Health care | 501(c)(3) | 2008 | $1.1 million | $679,075 | 2025-06 |
| Duke Student Publishing Company Inc | Education | 501(c)(3) | 1995 | $1.1 million | $4.2 million | 2025-06 |
| North Carolina Hospital Engineers Assoc | Mutual and membership benefit | 501(c)(6) | 2024 | $1.1 million | $1.1 million | 2025-09 |
| North Carolina Center On Actual Innocence | Civil rights, social action and advocacy | 501(c)(3) | 2000 | $1.1 million | $2.8 million | 2025-12 |
| North Carolina Climate Justice Collective | Environment | 501(c)(3) | 2022 | $1.1 million | $885,332 | 2025-12 |
| First Presbyterian Church of Durham Day School Incorporated | 501(c)(3) | 1972 | $1 million | $622,019 | 2025-08 | |
| The Center for Inquiry Based Learning Inc | Youth development | 501(c)(3) | 2006 | $1 million | $3.8 million | 2025-06 |
| Udi-Community Development Corporation | 501(c)(3) | 1974 | $1 million | $8.9 million | 2024-12 | |
| Action Institute NC | 501(c)(3) | 1975 | $1 million | $71,693 | 2024-12 | |
| Threshold Inc | 501(c)(3) | 1985 | $1 million | $1.8 million | 2025-06 | |
| Friends of Conservation Carpathia in the United States - FCC Us Inc | Environment | 501(c)(3) | 2024 | $999,635 | $55,043 | 2025-12 |
| North Carolina Academy of Physician Associates Inc | 501(c)(6) | 1987 | $997,742 | $3.9 million | 2024-12 | |
| Home Builders Association of Durham and Orange Counties | 501(c)(6) | 1964 | $977,326 | $610,743 | 2025-12 | |
| Ellerbee Creek | Environment | 501(c)(3) | 1999 | $966,779 | $5.7 million | 2023-09 |
| Emanuel Food Pantry | Food, agriculture and nutrition | 501(c)(3) | 2023 | $963,838 | $872,428 | 2025-12 |
| New Nearly New Inc | Human services | 501(c)(3) | 2021 | $956,935 | $122,717 | 2025-12 |
| International Society of Barristers Inc | 501(c)(6) | 1976 | $955,970 | $584,099 | 2025-12 | |
| Formerly Incarcerated College Graduates Network | Community improvement and capacity building | 501(c)(3) | 2018 | $945,900 | $510,909 | 2025-06 |
| Bridge II Sports | Recreation and sports | 501(c)(3) | 2007 | $929,698 | $647,081 | 2024-12 |
| Innovations in Healthcare Inc | Education | 501(c)(3) | 2013 | $884,855 | $679,607 | 2025-06 |
| Pauli Murray Center for History and Social Justice | Arts, culture and humanities | 501(c)(3) | 2013 | $883,130 | $1.9 million | 2024-12 |
| The Ruth K Broad Biomedical Research Foundation Inc | 501(c)(3) | 1989 | $879,876 | $18.5 million | 2025-06 | |
| The LGBTQ Center of Durham Inc | Human services | 501(c)(3) | 2012 | $866,882 | $19,832 | 2024-12 |
| El Sistema USA | Human services | 501(c)(3) | 2014 | $862,655 | $475,150 | 2025-06 |
| Maame Mobilizing African American Mothers Through Empowerment Inc | Health care | 501(c)(3) | 2024 | $817,584 | $187,870 | 2025-06 |
| Saint Stephens Episcopal Church Foundation | 501(c)(3) | 1976 | $813,886 | $2.8 million | 2025-12 | |
| Empowered Parents in Community | 501(c)(3) | 2020 | $811,822 | $746,293 | 2025-12 | |
| L I F E Skills Foundation | Youth development | 501(c)(3) | 2006 | $806,132 | $778,141 | 2025-06 |
| Piedmont Wildlife Center | Animal-related | 501(c)(3) | 2003 | $797,764 | $739,895 | 2025-06 |
| The Hope Project Live Love Serve Inc | Human services | 501(c)(3) | 2010 | $794,439 | $623,542 | 2025-06 |
| Discerning Deacons | Religion-related | 501(c)(3) | 2024 | $786,238 | $466,426 | 2025-12 |
| Aicpa Benevolent Fund Inc | 501(c)(3) | 1937 | $775,689 | $14 million | 2024-12 | |
| Equity Before Birth | Human services | 501(c)(3) | 2020 | $760,917 | $749,407 | 2025-12 |
| Durham Jazz Workshop | Arts, culture and humanities | 501(c)(3) | 2012 | $756,747 | $264,859 | 2025-12 |
| Upstream Policy Institute Inc | Environment | 501(c)(3) | 2004 | $754,660 | $1.4 million | 2025-06 |
| Student Action With Farmworkers | Education | 501(c)(3) | 1992 | $742,918 | $939,202 | 2025-08 |
| Communities in Schools of the Rocky Mount Region Inc | 501(c)(3) | 1988 | $726,402 | $98,360 | 2025-06 | |
| The Triangle Nonprofit & Volunteer Leadership Center | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1997 | $717,616 | $296,171 | 2025-06 |
| National Lymphedema Network Inc | 501(c)(3) | 1990 | $715,907 | $257,332 | 2025-12 | |
| Iranian Cultural Society of North Carolina Inc | 501(c)(3) | 1989 | $712,302 | $2.9 million | 2025-12 | |
| Open Table Ministry | Food, agriculture and nutrition | 501(c)(3) | 2010 | $706,086 | $803,779 | 2025-12 |
| Environmental Federation of North Carolina Inc | Environment | 501(c)(3) | 1992 | $703,042 | $556,707 | 2025-06 |
| Friends of Amal-Tikva | International, foreign affairs and national security | 501(c)(3) | 2022 | $698,418 | $11,387 | 2025-12 |
| Center for Christianity and Scholarship | Religion-related | 501(c)(3) | 2013 | $692,040 | $1.4 million | 2025-06 |
| Durham Regional Association of Realtors Inc | 501(c)(6) | 1978 | $679,517 | $2.2 million | 2025-12 | |
| Beyond Fences Inc | Animal-related | 501(c)(3) | 2009 | $678,666 | $1.3 million | 2025-12 |
| Leadership Edge Inc | Human services | 501(c)(3) | 1994 | $667,714 | $305,371 | 2025-06 |
| Global Genomic Medicine Collaborative | Health care | 501(c)(3) | 2018 | $666,860 | $285,845 | 2024-12 |
| Pro-Choice NC Foundation | Human services | 501(c)(3) | 2005 | $664,753 | $540,425 | 2025-06 |
| Pregnancy Support Services | Civil rights, social action and advocacy | 501(c)(3) | 1983 | $664,274 | $684,143 | 2025-12 |
| Grand Chapter Order of Eastern Star | 501(c)(8) | 1941 | $660,409 | $3.1 million | 2024-12 | |
| West End Community Foundation Inc | Education | 501(c)(3) | 1995 | $658,024 | $4 million | 2024-12 |
| The R A M Organization | Education | 501(c)(3) | 2006 | $637,747 | $456,523 | 2024-12 |
| Ase Education and Research Foundation Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2003 | $635,298 | $3.3 million | 2025-12 |
| Ninth Street Kin | Human services | 501(c)(3) | 1986 | $631,148 | $532,931 | 2025-09 |
| Equality North Carolina Foundation | 501(c)(3) | 1980 | $630,281 | $902,013 | 2024-12 | |
| Kidznotes | Arts, culture and humanities | 501(c)(3) | 2009 | $625,090 | $185,217 | 2025-06 |
| Institute Community Development Initiative Inc | Human services | 501(c)(3) | 2024 | $618,258 | $618,258 | 2024-12 |
| Stepup Durham | Human services | 501(c)(3) | 2017 | $613,579 | $171,793 | 2025-06 |
| Straight Talk Support Group Transitional House Resource Center | Crime and legal-related | 501(c)(3) | 2016 | $611,385 | $20,394 | 2023-12 |
| Durham Literacy Center Inc | Education | 501(c)(3) | 1986 | $608,466 | $794,632 | 2025-06 |
| North Carolina Alliance for Health | Health care | 501(c)(3) | 2017 | $606,310 | $815,231 | 2025-12 |
| Duke Memorial Week Day School Inc | Education | 501(c)(3) | 1972 | $603,790 | $527,374 | 2025-07 |
| Insight Colearning Center | Education | 501(c)(3) | 2019 | $599,391 | $95,275 | 2025-06 |
| Piedmont Conservation Council | Environment | 501(c)(3) | 1988 | $590,121 | $309,221 | 2025-06 |
| International Indigenous Community Development | International, foreign affairs and national security | 501(c)(3) | 2010 | $587,209 | $1.1 million | 2024-06 |
| Swingpals Inc | Youth development | 501(c)(3) | 2012 | $584,730 | $641,849 | 2025-08 |
| Me Fine Foundation | Health care | 501(c)(3) | 2005 | $570,957 | $491,212 | 2025-12 |
| Muslim Power Building Project | Education | 501(c)(3) | 2024 | $556,011 | $437,388 | 2024-12 |
| Carolina Aquatic Team | Recreation and sports | 501(c)(3) | 2003 | $554,563 | $178,074 | 2025-07 |
| Modernist Archive Inc | Arts, culture and humanities | 501(c)(3) | 2009 | $553,259 | $500,077 | 2025-12 |
| Walltown Childrens Theatre | Youth development | 501(c)(3) | 2002 | $549,312 | $383,398 | 2025-12 |
| Islamic Ahlul Bayt Association of the Triangle | Religion-related | 501(c)(3) | 1999 | $548,095 | $3.5 million | 2025-12 |
| Human Kindness Foundation | Crime and legal-related | 501(c)(3) | 1987 | $546,916 | $2.5 million | 2025-12 |
| Carolina Sexual Wellness Center PLLC | Mental health and crisis intervention | 501(c)(3) | 2017 | $534,795 | $55,601 | 2024-12 |
| Claymakers Arts Community Inc | Recreation and sports | 501(c)(3) | 2013 | $532,789 | $639,405 | 2025-12 |
| Ardmore Ahimsa Initiative Inc | Animal-related | 501(c)(3) | 2019 | $529,855 | $0 | 2024-12 |
| Girls On the Run of the Triangle Inc | Recreation and sports | 501(c)(3) | 2001 | $528,210 | $585,685 | 2025-06 |
| Durham County Farm Bureau Inc | 501(c)(5) | 1959 | $526,540 | $3.1 million | 2025-12 | |
| Triangle Universities Center for Advanced Studies Inc | 501(c)(3) | 1976 | $516,767 | $4.8 million | 2025-06 | |
| Echo System | Employment | 501(c)(3) | 2015 | $511,805 | $165,220 | 2025-12 |
| Carolina Common Enterprise | Community improvement and capacity building | 501(c)(3) | 2013 | $507,100 | $877,285 | 2024-12 |
| Information Systems Security Association | 501(c)(6) | 1985 | $504,655 | $101,389 | 2024-12 | |
| Bridgehaven Counseling Associates | Mental health and crisis intervention | 501(c)(3) | 2014 | $504,022 | $50,407 | 2025-12 |
| You Can Vote | Civil rights, social action and advocacy | 501(c)(3) | 2019 | $502,218 | $751,377 | 2025-12 |
| Spoleto Study Abroad | International, foreign affairs and national security | 501(c)(3) | 1998 | $495,715 | $2.1 million | 2025-06 |
| Durham Sports Commission | Recreation and sports | 501(c)(3) | 2018 | $491,316 | $409,362 | 2025-06 |
| Semper Fit Incorporated | Mental health and crisis intervention | 501(c)(3) | 2010 | $487,985 | $113,233 | 2025-12 |
| Wildtrack Inc | Animal-related | 501(c)(3) | 2011 | $487,316 | $517,593 | 2025-12 |
| Curanopy Inc | 501(c)(3) | 2021 | $484,125 | $569,645 | 2024-12 | |
| North Carolina for the People | Civil rights, social action and advocacy | 501(c)(3) | 2023 | $481,336 | $290,661 | 2024-12 |
| Johnson Service Corps | Religion-related | 501(c)(3) | 2005 | $479,805 | $288,730 | 2025-07 |
| International Association for Near Death Studies Inc | Environment | 501(c)(3) | 2014 | $470,449 | $466,131 | 2024-12 |
| Just A Clean House Inc | Crime and legal-related | 501(c)(3) | 2008 | $468,744 | $56,738 | 2025-12 |
| Toxic Free North Carolina Inc | 501(c)(3) | 1977 | $463,637 | $826,241 | 2025-12 | |
| Durhamcares Inc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2009 | $462,005 | $640,060 | 2025-12 |
| Little League Baseball Inc | 501(c)(3) | 1967 | $452,017 | $355,359 | 2025-09 | |
| Triangle Curling Club of North Carolina | Recreation and sports | 501(c)(3) | 2009 | $448,283 | $1.9 million | 2025-06 |
| Rare Cancer Research Foundation | Medical research | 501(c)(3) | 2014 | $446,172 | $1.4 million | 2025-12 |
| Edgemont Elms Housing Inc | Housing and shelter | 501(c)(3) | 2007 | $445,758 | $1.2 million | 2025-12 |
| Crest Street Community Elderly Housing Corporation | 501(c)(4) | 1984 | $445,556 | $950,215 | 2025-12 | |
| Carolina Wren Press Inc | Arts, culture and humanities | 501(c)(3) | 1979 | $444,824 | $375,492 | 2025-06 |
| Museum of Durham History Inc | Arts, culture and humanities | 501(c)(3) | 2009 | $440,067 | $183,052 | 2025-06 |
| Forward Justice Action Network | Human services | 501(c)(4) | 2020 | $439,971 | $2 million | 2024-12 |
| Communities in Schools of Cumberland County | Education | 501(c)(3) | 1997 | $437,520 | $130,351 | 2025-06 |
| Liberty Arts Inc | Arts, culture and humanities | 501(c)(3) | 2001 | $430,274 | $117,618 | 2025-12 |
| Movement of Youth Incorporated | Youth development | 501(c)(3) | 2009 | $419,697 | $58,497 | 2023-12 |
| Uhuru Child | International, foreign affairs and national security | 501(c)(3) | 2010 | $419,330 | $102,605 | 2024-12 |
| Peace and Hope International | International, foreign affairs and national security | 501(c)(3) | 2003 | $415,412 | $202,560 | 2025-12 |
| Ab Community | Community improvement and capacity building | 501(c)(3) | 2022 | $415,290 | $35,597 | 2024-12 |
| Durham Association of Educators | Community improvement and capacity building | 501(c)(6) | 2019 | $413,928 | $254,640 | 2025-06 |
| The Junior League of Durham and Orange Counties Inc | Community improvement and capacity building | 501(c)(3) | 1945 | $412,038 | $455,390 | 2025-05 |
| Blind Spot Animal Sanctuary Inc | Animal-related | 501(c)(3) | 2017 | $408,989 | $531,106 | 2025-12 |
| Croasdaile Village Residents Association | Human services | 501(c)(3) | 2001 | $402,198 | $187,421 | 2025-09 |
| The Beautiful Project Inc | 501(c)(3) | 2020 | $395,843 | $0 | 2023-12 | |
| Purpose Learning Lab the Premier Drop-In Studio | Youth development | 501(c)(3) | 2020 | $394,492 | $142,358 | 2024-12 |
| Bike Durham | Recreation and sports | 501(c)(3) | 2014 | $392,025 | $409,592 | 2025-03 |
| Community Health Coalition | Health care | 501(c)(3) | 2002 | $389,374 | $484,750 | 2025-12 |
| Cassilhaus Foster Arts | 501(c)(3) | 2025 | $388,418 | $381,671 | 2025-12 | |
| North Carolina Tar Heels Ice Hockey Booster Club | Education | 501(c)(3) | 2018 | $385,116 | $154,504 | 2025-05 |
| Resource Center for Women and Ministry in the South Inc | Religion-related | 501(c)(3) | 1977 | $384,650 | $279,724 | 2025-12 |
| Jubilee Home | Human services | 501(c)(3) | 2013 | $384,440 | $424,773 | 2024-12 |
| Larche North Carolina | Mental health and crisis intervention | 501(c)(3) | 2016 | $380,306 | $845,934 | 2025-06 |
| Latino Educational Achievement Partnership | Education | 501(c)(3) | 2014 | $379,365 | $101,275 | 2025-06 |
| Rhine Research Center Inc | Social science | 501(c)(3) | 2010 | $376,421 | $474,106 | 2025-12 |
| Hope Animal Rescue | Animal-related | 501(c)(3) | 2013 | $376,228 | $218,882 | 2025-12 |
| Northstar Church of the Arts Inc | Religion-related | 501(c)(3) | 2019 | $370,801 | $291,132 | 2025-12 |
| Naral Pro-Choice North Carolina | Health care | 501(c)(4) | 2004 | $367,245 | $79,776 | 2025-06 |
| Congregation at Duke University Chapel Inc | 501(c)(3) | 1987 | $366,966 | $336,409 | 2025-06 | |
| Five Oaks Recreational Association Inc | 501(c)(7) | 1983 | $360,989 | $534,460 | 2024-03 | |
| Center for European Church Planting | Religion-related | 501(c)(3) | 2005 | $357,055 | $105,904 | 2025-05 |
| National Association of Blacks in Criminal Justice Inc | Social science | 501(c)(3) | 2000 | $353,684 | $234,618 | 2025-12 |
| North Carolina Central University Alumni Association | Education | 501(c)(3) | 1972 | $351,890 | $1.5 million | 2025-06 |
| Urban Community Agri-Nomics | Food, agriculture and nutrition | 501(c)(3) | 2016 | $350,086 | $1.2 million | 2025-12 |
| Working To Extend Anti-Racist Education | Education | 501(c)(3) | 2018 | $344,424 | $36,025 | 2025-06 |
| Markaz Tawheed Wa Sunnah | Religion-related | 501(c)(3) | 2021 | $341,396 | $1.3 million | 2024-12 |
| Jammers Volleyball Club Inc | Recreation and sports | 501(c)(3) | 2008 | $336,028 | $73,272 | 2025-08 |
| Global Healthcare Innovation Alliance Accelerator | Health care | 501(c)(3) | 2017 | $332,568 | $170,168 | 2024-12 |
| Family Preschool | Education | 501(c)(3) | 1972 | $329,585 | $266,090 | 2025-06 |
| Breastfeeding Family Friendly Communities | Health care | 501(c)(3) | 2020 | $326,598 | $114,408 | 2025-12 |
| Candor NC | Diseases, disorders and medical disciplines | 501(c)(3) | 2010 | $326,411 | $69,619 | 2025-12 |
| Freedom United | Human services | 501(c)(3) | 2014 | $326,163 | $245,586 | 2025-12 |
| Restorative Transitions Inc | Crime and legal-related | 501(c)(3) | 2022 | $324,838 | $19,594 | 2025-12 |
| One Wake | Community improvement and capacity building | 501(c)(3) | 2020 | $321,058 | $354,893 | 2025-12 |
| North Carolina Employee Ownership Center | Employment | 501(c)(3) | 2020 | $320,891 | $274,676 | 2025-12 |
| Durham C A N-Congregations Associations and Neighborhoods | Community improvement and capacity building | 501(c)(3) | 1999 | $320,868 | $370,373 | 2025-12 |
| Hawks Nation Athletic Club Inc | Recreation and sports | 501(c)(3) | 2021 | $320,306 | $263,353 | 2025-06 |
| Equality NC | Civil rights, social action and advocacy | 501(c)(4) | 2004 | $320,180 | $262,778 | 2024-12 |
| Duke Homestead Education and History Corporation | 501(c)(3) | 1972 | $320,070 | $367,585 | 2026-06 | |
| Udist Josephs Inc | Housing and shelter | 501(c)(3) | 2001 | $318,641 | $1.3 million | 2025-09 |
| H E A R T S Helping Each Adolescent Reach Their Spark | 501(c)(3) | 2016 | $318,440 | $131,902 | 2025-06 | |
| Unitarian Universalist Justice Ministry of North Carolina | Religion-related | 501(c)(3) | 2017 | $317,311 | $210,142 | 2024-12 |
| Pinnacle Community Developmentcorporation | Community improvement and capacity building | 501(c)(3) | 2007 | $316,365 | $150,572 | 2025-12 |
| North Carolina Trapshooters Hall of Fame Inc | Arts, culture and humanities | 501(c)(3) | 1995 | $315,055 | $512,212 | 2025-12 |
| Porch-Durham | Food, agriculture and nutrition | 501(c)(3) | 2012 | $313,848 | $243,808 | 2025-12 |
| Durham Firemens Supplemental Retirement System | Mutual and membership benefit | 501(c)(3) | 1953 | $313,714 | $487,183 | 2025-06 |
| Eno Valley Swim & Racquet Club | 501(c)(7) | 1994 | $312,738 | $147,742 | 2024-12 | |
| Carolina Jews for Justice | Religion-related | 501(c)(3) | 2014 | $309,948 | $253,661 | 2025-12 |
| Jordan High School Athletic Booster Club Inc | Recreation and sports | 501(c)(3) | 1994 | $290,943 | $188,159 | 2025-06 |
| Orthopedic Foot Club | Education | 501(c)(3) | 2005 | $290,856 | $322,595 | 2024-12 |
| Society for Translational Oncology Inc | Medical research | 501(c)(3) | 2009 | $289,410 | $1.3 million | 2025-12 |
| TDV Ministries | Religion-related | 501(c)(3) | 2023 | $287,944 | $146 | 2025-12 |
| Spread the Fire U S Inc | Religion-related | 501(c)(3) | 2006 | $281,670 | $921,105 | 2025-12 |
| Mallarme Chamber Players Inc | Arts, culture and humanities | 501(c)(3) | 1987 | $280,917 | $250,339 | 2025-06 |
| Institute for Southern Studies Inc | Social science | 501(c)(3) | 1970 | $277,758 | $1.4 million | 2024-12 |
| Montessori Farm School | Education | 501(c)(3) | 2008 | $277,708 | $70,302 | 2025-07 |
| Durham Symphony Incorporated | Arts, culture and humanities | 501(c)(3) | 1977 | $276,381 | $364,978 | 2025-06 |
| Emergency Chaplains Inc | Public safety, disaster preparedness and relief | 501(c)(3) | 2008 | $274,523 | $396,498 | 2024-12 |
| Parkwood Association | 501(c)(4) | 1992 | $272,464 | $508,460 | 2025-12 | |
| Standup-Speakout-Nc | Human services | 501(c)(3) | 2015 | $271,003 | $251,048 | 2024-12 |
| Mali Health Organizing Project Inc | Community improvement and capacity building | 501(c)(3) | 2007 | $263,453 | $166,741 | 2024-12 |
| FPC Ministries | Religion-related | 501(c)(3) | 2017 | $260,011 | $715,418 | 2024-12 |
| Audacity Labs | Education | 501(c)(3) | 2020 | $258,935 | $58,478 | 2023-12 |
| Choral Society of Durham Inc | Arts, culture and humanities | 501(c)(3) | 1958 | $257,943 | $898,921 | 2025-06 |
| Bull City Fair Trade | Human services | 501(c)(3) | 1992 | $255,049 | $75,281 | 2024-12 |
| D-3 Community Outreach Inc | Youth development | 501(c)(3) | 2006 | $251,700 | $121,811 | 2024-12 |
| Durham P R O U D Program | Human services | 501(c)(3) | 2000 | $250,646 | $293,354 | 2025-06 |
| North Carolina Coalition for Alternatives To the Death Penalty | Civil rights, social action and advocacy | 501(c)(3) | 2012 | $248,172 | $185,271 | 2025-12 |
| GASPARD&DANCERS Inc | Arts, culture and humanities | 501(c)(3) | 2014 | $247,765 | $298,268 | 2025-12 |
| American Federation of State County & Municipal Employees | 501(c)(5) | 1957 | $244,316 | $389,327 | 2025-06 | |
| Keep Durham Beautiful Inc | Community improvement and capacity building | 501(c)(3) | 2006 | $244,047 | $273,580 | 2024-06 |
| United Methodist Retirement Homes Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 1994 | $243,632 | $16.1 million | 2025-09 |
| Merrick Moore Community Development Corporation | Community improvement and capacity building | 501(c)(3) | 2023 | $243,427 | $199,332 | 2025-06 |
| Harpers Home | Health care | 501(c)(3) | 2024 | $242,696 | $265,381 | 2025-12 |
| North Carolina Presenters Consortium | Arts, culture and humanities | 501(c)(3) | 2000 | $239,413 | $168,742 | 2025-06 |
| Building From Below | Education | 501(c)(3) | 2006 | $236,855 | $1.8 million | 2024-12 |
| North Carolina Submarine Museum Foundation | Arts, culture and humanities | 501(c)(3) | 2022 | $236,750 | $136,991 | 2025-12 |
| Black Farmers Market | Human services | 501(c)(3) | 2022 | $235,001 | $21,134 | 2025-12 |
| NC Congress of Latino Organizations Ncclo | Civil rights, social action and advocacy | 501(c)(3) | 2006 | $233,682 | $1.6 million | 2025-12 |
| Bump Inc | Arts, culture and humanities | 501(c)(3) | 2006 | $231,271 | $69,555 | 2025-06 |
| McDevitt Research Initiatives Inc | Social science | 501(c)(3) | 2025 | $225,758 | $199,233 | 2025-06 |
| Southeastern Efforts Developing Sustainable Spaces Inc | Employment | 501(c)(3) | 1996 | $219,467 | $1.4 million | 2025-06 |
| Mettlesome Theater | Arts, culture and humanities | 501(c)(3) | 2024 | $209,217 | $41,006 | 2024-12 |
| Vets To Vets United Inc | Animal-related | 501(c)(3) | 2012 | $209,083 | $341,056 | 2024-12 |
| Durham Congregations in Action | Human services | 501(c)(3) | 1972 | $208,387 | $129,797 | 2024-12 |
| Religious Coalition for A Nonviolent Durham Inc | Education | 501(c)(3) | 2007 | $207,000 | $88,056 | 2024-12 |
| Duke Medicine Global Support Corp | Medical research | 501(c)(3) | 2010 | $206,881 | $89,126 | 2025-06 |
| Zing Life Services Inc | Health care | 501(c)(3) | 2018 | $206,161 | $4,809 | 2026-03 |
| Built2last Innovations Lab Inc | Community improvement and capacity building | 501(c)(3) | 2022 | $203,953 | $66,757 | 2023-12 |
| Sankofa Birth Foundation Inc | Health care | 501(c)(3) | 2022 | $199,074 | $55,484 | 2025-12 |
| Bodhisattva Nature | Religion-related | 501(c)(3) | 2025 | $199,065 | $178,064 | 2025-12 |
| Southeastern Association of Law Schools Inc | Education | 501(c)(3) | 2007 | $194,902 | $483,922 | 2024-12 |
| Northern High School Athletic Booster Club Inc | Education | 501(c)(3) | 2001 | $194,142 | $128,841 | 2025-05 |
| Cbu Christian Fellowship Inc | 501(c)(3) | 1975 | $194,047 | $529,075 | 2025-12 | |
| Rotary International | 501(c)(4) | 1942 | $191,166 | $113,642 | 2025-06 | |
| Peace Hill at Avila | Religion-related | 501(c)(3) | 2022 | $190,880 | $1.3 million | 2025-12 |
| Migrant Roots Media | Arts, culture and humanities | 501(c)(3) | 2021 | $187,397 | $275,006 | 2025-12 |
| Empowered Minds Academy | Education | 501(c)(3) | 2020 | $186,581 | $86,085 | 2024-06 |
| Bull City Woodshop | Youth development | 501(c)(3) | 2021 | $186,528 | $72,969 | 2025-06 |
| North Carolina Center for Public Policy Research Inc | 501(c)(3) | 1975 | $185,000 | $19,273 | 2025-06 | |
| Amalgamated Transit Union | 501(c)(5) | 1940 | $184,746 | $141,748 | 2023-12 | |
| North Carolina Alliance for Athletics Health Physical Educatio | Education | 501(c)(3) | 2017 | $184,450 | $370,918 | 2025-05 |
| Voa Foundation | Medical research | 501(c)(3) | 2024 | $183,364 | $140,112 | 2025-12 |
| American Legion | 501(c)(19) | 1954 | $183,305 | $1 million | 2025-06 | |
| The Ivy Community Center Inc | Human services | 501(c)(3) | 1996 | $183,209 | $1.3 million | 2025-12 |
| Royal School of Church Music | Arts, culture and humanities | 501(c)(3) | 1981 | $180,559 | $135,926 | 2025-10 |
| Fond Doux Foundation | International, foreign affairs and national security | 501(c)(3) | 2014 | $180,475 | $158,927 | 2025-12 |
| Journey for Life | Human services | 501(c)(3) | 2016 | $179,958 | $16,752 | 2025-12 |
| Kappa Alpha Order | 501(c)(7) | 1940 | $179,093 | $4,005 | 2025-06 | |
| German Shepherd Dog Rescue and Adoption Service | Animal-related | 501(c)(3) | 2015 | $177,470 | $1.5 million | 2025-12 |
| Chihuahua Rescue & Transport Inc | Animal-related | 501(c)(3) | 2016 | $177,443 | $169,351 | 2024-12 |
| The Historic Preservation Society of Durham Inc | 501(c)(3) | 1974 | $175,784 | $204,533 | 2025-06 | |
| Climate Competition Project Inc | Environment | 501(c)(3) | 2024 | $175,289 | $175,289 | 2024-12 |
| Vault Theatre Limited | Arts, culture and humanities | 501(c)(3) | 2022 | $173,729 | $22,994 | 2025-05 |
| Unfailing Love Christian Church | Religion-related | 501(c)(3) | 2015 | $170,031 | $86,812 | 2025-12 |
| Links Inc | 501(c)(4) | 1961 | $169,642 | $64,215 | 2025-04 | |
| Fraternal Order of Police | 501(c)(8) | 1972 | $168,046 | $438,633 | 2025-12 | |
| Womens Institute for Secondary Education and Research-Wiser-Intl | International, foreign affairs and national security | 501(c)(3) | 2012 | $167,556 | $43,405 | 2025-12 |
| Carolinas Parking Association | Community improvement and capacity building | 501(c)(6) | 2011 | $165,450 | $59,485 | 2023-12 |
| Grepbeat | Arts, culture and humanities | 501(c)(3) | 2025 | $159,000 | $144,611 | 2025-12 |
| Instepp Inc | Human services | 501(c)(3) | 2004 | $156,569 | $64,696 | 2025-12 |
| Truth Education Foundation | Human services | 501(c)(3) | 2021 | $155,644 | $10,200 | 2024-12 |
| Affordable Community Residence Association Inc | Housing and shelter | 501(c)(3) | 2012 | $153,863 | $457,990 | 2025-12 |
| Hbot 4 Heroes | Health care | 501(c)(3) | 2023 | $151,641 | $41,881 | 2025-12 |
| North Carolina Good Better Best Academy | 501(c)(3) | 2021 | $151,570 | $1,588 | 2024-12 | |
| Herpetologists League Inc | 501(c)(3) | 1978 | $151,379 | $570,474 | 2025-04 | |
| Autoimmune Encephalitis Alliance Inc | Diseases, disorders and medical disciplines | 501(c)(3) | 2013 | $150,758 | $70,579 | 2025-12 |
| Digital Durham | Community improvement and capacity building | 501(c)(3) | 2023 | $150,329 | $109,818 | 2025-06 |
| Wall Street Juniors Inc | Community improvement and capacity building | 501(c)(3) | 2019 | $150,284 | $68,095 | 2024-12 |
| Laplace Institute | Health care | 501(c)(3) | 2024 | $150,100 | $79,607 | 2025-12 |
| National Association of Letter Carriers | 501(c)(5) | 1944 | $150,051 | $288,802 | 2025-12 | |
| NCSSM Student and Constituent Support Services Inc | Education | 501(c)(3) | 2007 | $148,387 | $499,945 | 2025-06 |
| Believers United for Progress | Human services | 501(c)(3) | 2008 | $148,331 | $294,724 | 2023-12 |
| Peoples Alliance | Human services | 501(c)(4) | 2015 | $148,156 | $100,427 | 2024-12 |
| Duke Scholarly Exhibits Inc | Education | 501(c)(3) | 1991 | $145,485 | $1 | 2025-06 |
| Longleaf Farm and Forest School | Education | 501(c)(3) | 2026 | $145,361 | $45,629 | 2026-06 |
| Durham Parks Foundation | Recreation and sports | 501(c)(3) | 2016 | $142,517 | $610,736 | 2025-06 |
| Ruritan National Corp | 501(c)(4) | 1973 | $139,172 | $32,000 | 2024-12 | |
| A Wombmans Way Warrior Midwife Training Program Inc | Education | 501(c)(3) | 2022 | $138,652 | $70,465 | 2024-12 |
| Debutante Ball Society | 501(c)(7) | 1974 | $138,129 | $50,420 | 2026-02 | |
| Bull City Legal Services Inc | Crime and legal-related | 501(c)(3) | 2022 | $138,089 | $40,346 | 2024-12 |
| Children First Inc | Human services | 501(c)(3) | 1991 | $137,548 | $114,769 | 2025-08 |
| Windy Hill Play | Human services | 501(c)(3) | 2024 | $137,446 | $399,286 | 2025-12 |
| Gather Good | Human services | 501(c)(3) | 2024 | $135,094 | $1 | 2024-12 |
| Southeastern Angiographic Society Incorporated | 501(c)(3) | 1975 | $133,791 | $76,293 | 2025-12 | |
| Dr Charles Van Der Horst Water Safety Initiative | Recreation and sports | 501(c)(3) | 2019 | $133,118 | $189,763 | 2025-06 |
| Self Discovery Transitional Living Program | Mental health and crisis intervention | 501(c)(3) | 2020 | $133,039 | $6,325 | 2024-12 |
| Root Wellness Center | Mental health and crisis intervention | 501(c)(3) | 2022 | $132,923 | $768,710 | 2025-06 |
| Shining Light in Darkness | Crime and legal-related | 501(c)(3) | 2019 | $131,894 | $82,142 | 2025-12 |
| Durham Art Guild Inc | Arts, culture and humanities | 501(c)(3) | 1952 | $130,327 | $46,361 | 2023-06 |
| The Stagville Memorial Project | Arts, culture and humanities | 501(c)(3) | 2022 | $129,089 | $85,752 | 2025-12 |
| Lenox Baker Childrens Hospital Foundation Inc | Health care | 501(c)(3) | 1993 | $128,548 | $817,273 | 2024-12 |
| Triangle Fellows | Religion-related | 501(c)(3) | 2021 | $127,671 | $48,219 | 2026-06 |
| Parkwood Swim Club Inc | 501(c)(7) | 1983 | $125,326 | $136,782 | 2025-12 | |
| Friends of Mukhanyo | Education | 501(c)(3) | 2001 | $124,175 | $71,291 | 2024-12 |
| North Carolina Counseling Association | 501(c)(6) | 1971 | $123,110 | $65,362 | 2025-06 | |
| T Greg Doucette Foundation Inc | 501(c)(3) | 2020 | $122,723 | $6,382 | 2024-12 | |
| Friends of the Durham Library Inc | 501(c)(3) | 1984 | $122,560 | $380,390 | 2025-12 | |
| Projects of Hope | Community improvement and capacity building | 501(c)(3) | 2015 | $122,209 | $407 | 2025-12 |
| National Emergency Child Care Network Inc | Human services | 501(c)(3) | 2024 | $122,053 | $36,182 | 2025-12 |
| Greater Ascension Community and Economic Development Inc | Housing and shelter | 501(c)(3) | 2021 | $121,975 | $7,379 | 2025-12 |
| Empower Dance Foundation | 501(c)(3) | 2017 | $121,812 | $58,514 | 2025-12 | |
| International English & Cultural Studies Inc | Arts, culture and humanities | 501(c)(3) | 2008 | $117,758 | $30,882 | 2024-12 |
| Jordan High School Theatre Arts Booster | Education | 501(c)(3) | 2019 | $116,578 | $9,576 | 2025-06 |
| Experience Reality Inc | Religion-related | 501(c)(3) | 2021 | $114,778 | $6.2 million | 2024-12 |
| Judea Reform Congregation Cemetery | Mutual and membership benefit | 501(c)(13) | 2013 | $114,723 | $1.3 million | 2025-12 |
| North Carolina Folklife Institute | Arts, culture and humanities | 501(c)(3) | 1974 | $114,688 | $24,644 | 2025-06 |
| Awareguatemala Inc | Animal-related | 501(c)(3) | 2002 | $112,268 | $6,447 | 2024-12 |
| American Federation of Government Employees | 501(c)(5) | 2024 | $111,631 | $157,165 | 2025-12 | |
| Beth El Preschool | Education | 501(c)(3) | 2009 | $110,212 | $47,064 | 2023-07 |
| Parktown Food Hub | Food, agriculture and nutrition | 501(c)(3) | 2022 | $110,200 | $59,151 | 2025-10 |
| Area 6 Uspsa | Human services | 501(c)(3) | 2024 | $107,412 | $12,157 | 2025-12 |
| Lifting Individuals and Families To Excel | Human services | 501(c)(3) | 2011 | $107,281 | $122,184 | 2024-12 |
| Young Peoples Performing Company Inc | Arts, culture and humanities | 501(c)(3) | 1987 | $106,614 | $4,549 | 2026-06 |
| Ministerios Impacto de Restauracion | Religion-related | 501(c)(3) | 2018 | $106,360 | $126,236 | 2025-12 |
By cause in Durham, NC
- Education 285
- Religion-related 283
- Human services 196
- Arts, culture and humanities 144
- Community improvement and capacity building 102
- Recreation and sports 94
- Health care 89
- Philanthropy, voluntarism and grantmaking foundations 79
- Youth development 72
- International, foreign affairs and national security 47
- Environment 38
- Crime and legal-related 32
- Public and societal benefit 32
- Mental health and crisis intervention 28
- Food, agriculture and nutrition 27
- Civil rights, social action and advocacy 25
- Housing and shelter 25
- Animal-related 23
- Employment 22
- Diseases, disorders and medical disciplines 20
- Science and technology 17
- Medical research 14
- Social science 10
- Mutual and membership benefit 9
- Public safety, disaster preparedness and relief 6
Nonprofits in every city of the state
Read from the IRS Exempt Organizations Business Master File, updated by the IRS on October 24, 2026 and rebuilt here every morning. Revenue and assets are from each organization's latest filing as the IRS lists it; the IRS record is the official one. Organizations only: no people are named on these pages.