| Ah Georgia Inc | 501(c)(3) | 2019 | $213.6 million | $366.2 million | 2024-12 |
| Atrium Health Foundation | 501(c)(3) | 1960 | $150.1 million | $556.7 million | 2024-12 |
| Ahsnf Inc | 501(c)(3) | 2020 | $41.5 million | $30.7 million | 2024-12 |
| Hopeway Foundation | 501(c)(3) | 2014 | $24.7 million | $38.6 million | 2025-12 |
| Mercy Restorative Care Hospital Inc | 501(c)(3) | 2003 | $18.3 million | $19 million | 2025-06 |
| The C W Williams Community Health Center Inc | 501(c)(3) | 1980 | $13.6 million | $24.9 million | 2025-03 |
| Family Centered Treatment Foundation Inc | 501(c)(3) | 1992 | $10.8 million | $7.9 million | 2025-06 |
| Charlotte Community Health Clinic Inc | 501(c)(3) | 2001 | $9.8 million | $8.4 million | 2024-12 |
| Care Ring Inc | 501(c)(3) | 1957 | $7.8 million | $8 million | 2025-06 |
| North Carolina Association of Free and Charitable Clinics Inc | 501(c)(3) | 1999 | $6.4 million | $6.8 million | 2024-12 |
| The Katie Blessing Foundation | 501(c)(3) | 2022 | $5.6 million | $7.2 million | 2024-12 |
| Charlotte Speech and Hearing Center Inc | 501(c)(3) | 1968 | $3.3 million | $2.4 million | 2025-06 |
| Dilworth Center for Chemical Dependency Inc | 501(c)(3) | 2000 | $3.1 million | $6 million | 2024-12 |
| Teen Health Connection | 501(c)(3) | 1991 | $2.9 million | $3.9 million | 2025-12 |
| Friends Of@kijabe | 501(c)(3) | 2016 | $2.2 million | $661,913 | 2026-06 |
| Isabella Santos Foundation | 501(c)(3) | 2009 | $2 million | $540,983 | 2024-12 |
| The Kidney Transplant Collaborative Inc | 501(c)(4) | 2022 | $1.6 million | $978,132 | 2025-12 |
| Hospitality House of Charlotte | 501(c)(3) | 1987 | $1.4 million | $4 million | 2025-05 |
| World Shoe Fund Inc | 501(c)(3) | 2023 | $1.1 million | $814,185 | 2024-12 |
| Americas Toothfairy National Childrens Oral Health Foundation | 501(c)(3) | 2006 | $1.1 million | $1.1 million | 2025-06 |
| Charlotte Transgender Healthcare Group | 501(c)(3) | 2020 | $973,884 | $290,260 | 2025-12 |
| Charlotte City Market | 501(c)(3) | 2010 | $737,206 | $941,831 | 2025-06 |
| Assist Me | 501(c)(3) | 2016 | $511,625 | $45,394 | 2025-12 |
| Shelter Health Services Incorporated | 501(c)(3) | 2006 | $457,349 | $107,304 | 2025-06 |
| Advocate Health Inc | 501(c)(3) | 2022 | $333,741 | $105.1 million | 2024-12 |
| Piedmont Music Therapy Non-Profit Organization | 501(c)(3) | 2023 | $274,027 | $69,142 | 2025-12 |
| Project Life Inc | 501(c)(3) | 2011 | $267,993 | $38,175 | 2025-06 |
| Bless Into Unique Care Agency | 501(c)(3) | 2010 | $266,886 | $61,463 | 2025-12 |
| North Carolina Business Group On Health Inc | 501(c)(3) | 2023 | $252,130 | $204,372 | 2025-12 |
| Addiction Nursing Certification Board | 501(c)(6) | 2021 | $222,373 | $507,703 | 2026-06 |
| Operation Walk Carolinas | 501(c)(3) | 2022 | $149,179 | $271,505 | 2024-12 |
| Delta Health Foundation Inc | 501(c)(3) | 2001 | $134,516 | $118,128 | 2024-12 |
| Elizabeth House Foundation | 501(c)(3) | 2020 | $121,550 | $1 | 2024-12 |
| International Health Education for Local People | 501(c)(3) | 2016 | $115,256 | $15,041 | 2026-01 |
| Agape Dental Ministry | 501(c)(3) | 2013 | $112,645 | $188,369 | 2025-12 |
| Calvary Community Medical Clinic Inc | 501(c)(3) | 2014 | $99,511 | $21,935 | 2025-12 |
| Benjamin the Brave Medulloblastoma Cancer Foundation | 501(c)(3) | 2022 | $71,066 | $88,973 | 2025-12 |
| Tak Foundation | 501(c)(3) | 2008 | $68,282 | $229,022 | 2025-12 |
| Hope Street Free Clinic Inc | 501(c)(3) | 2023 | $67,995 | $15,656 | 2025-12 |
| Queen City Cocoa B E A N S Incorporated | 501(c)(3) | 2021 | $55,857 | $11,901 | 2025-12 |
| Health Guidance Center Foundation | 501(c)(3) | 2007 | $54,245 | $23,161 | 2026-06 |
| Biopharmaceutical Applied Statistics Symposium Inc | 501(c)(3) | 2012 | $31,196 | $234,262 | 2025-12 |
| Lionel Lee Jr Center for Wellness | 501(c)(3) | 2008 | $31,190 | $63,425 | 2025-12 |
| World Cardiac Vision | 501(c)(3) | 2021 | $10,250 | $6,823 | 2025-12 |
| Brothas Organization Inc | 501(c)(3) | 2024 | $5,205 | $1,470 | 2025-12 |
| Charlotte Health Initiative Inc | 501(c)(3) | 2016 | $9 | $4.5 million | 2026-02 |
| 22Q of the Carolinas | 501(c)(3) | 2025 | | | |
| 5009 Beatties Ford Road Suite 107 | 501(c)(3) | 2025 | | | |
| A Night for Smiles Inc | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| A Place of Lok Inc | 501(c)(3) | 2021 | $0 | $0 | 2024-12 |
| Above Down Inc | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Adam & Eve Garden Recovery House | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Adelines Aid | 501(c)(3) | 2021 | $0 | $0 | 2024-12 |
| American Scientific Academy | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Ashley Care Homes II | 501(c)(3) | 2021 | $0 | $0 | 2023-12 |
| Atrium Health Childrens Specialty Network Inc | 501(c)(3) | 2026 | | | |
| Atrium Health Fort Mill Ems Inc | 501(c)(3) | 2025 | | | |
| Atrium Health Hospitals Inc | 501(c)(3) | 2026 | | | |
| Atrium Health Inc | 501(c)(3) | 2023 | $0 | $1 | 2024-12 |
| Atrium Health Specialty Network Inc | 501(c)(3) | 2026 | | | |
| Black & Brown Myeloma Physicians Consortium BMPC | 501(c)(3) | 2026 | $0 | $0 | 2025-12 |
| Blackburn Chasing the Cure | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Borrowed Hope Foundation | 501(c)(3) | 2026 | | | |
| Breast Cancer Awareness for Us Inc | 501(c)(3) | 2024 | | | |
| Breath of Life Wellness & Yoga Cent Er | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Brighter Onward Beliefs Inc | 501(c)(3) | 2024 | $0 | $0 | 2024-12 |
| Bubbles Cares | 501(c)(3) | 2025 | | | |
| Care Compass Network Corp | 501(c)(3) | 2025 | | | |
| Carlas Calls | 501(c)(3) | 2024 | | | |
| Carolina Adventist Retirement Systems Inc | 501(c)(3) | 1947 | $0 | $0 | 2025-09 |
| Champion House of Care Project One Inc | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Charlotte Association of Deaf | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Charlotte Community Health Clinic Foundation Inc | 501(c)(3) | 2015 | $0 | $178 | 2024-12 |
| Charlotte Healthcare Coalition Inc | 501(c)(3) | 2024 | $0 | $0 | 2024-12 |
| Cherry Fund | 501(c)(3) | 2022 | $0 | $0 | 2023-12 |
| Christophers House of Refuge Inc | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| Club Lama Kids Fund Inc | 501(c)(3) | 2016 | $0 | $0 | 2024-12 |
| Complete Wellness Community Services Inc | 501(c)(3) | 2021 | $0 | $1 | 2023-12 |
| Corrective Care Wellness Inc | 501(c)(3) | 2013 | $0 | $0 | 2026-06 |
| Covilab Community | 501(c)(3) | 2022 | $0 | $0 | 2024-12 |
| Cycling for A Cause | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| DBM Caregiving Services Inc | 501(c)(3) | 2025 | | | |
| Diphda Medical Co | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Earth Holistic Center | 501(c)(3) | 2025 | | | |
| Eat 2 Grow Rich | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Eternity Foundation Inc | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Fight Life | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Fight the Good Fight Corporation | 501(c)(3) | 2015 | $0 | $0 | 2023-12 |
| Fillings of Hope Inc | 501(c)(3) | 2026 | | | |
| Fit-N-Go | 501(c)(3) | 2023 | $0 | $0 | 2024-12 |
| Foundation for the Development of Rural Communities Inc | 501(c)(3) | 2009 | | $103,267 | 2024-12 |
| Fractal On Earth | 501(c)(3) | 2022 | $0 | $0 | 2024-12 |
| Green Box Solutions | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Have A Heart for Heroes Inc | 501(c)(3) | 2026 | | | |
| Health By Hands Inc | 501(c)(3) | 2023 | $0 | $0 | 2024-12 |
| Health Empowerment Renewal | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Health Equity Acceleration Partners Hip Inc | 501(c)(3) | 2026 | | | |
| Healthy Hands Initiative | 501(c)(3) | 2019 | $0 | $0 | 2025-01 |
| Hear the Word | 501(c)(3) | 2024 | $0 | $0 | 2024-12 |
| Hello Seven Foundation | 501(c)(3) | 2022 | $0 | $1 | 2024-12 |
| Helping Outcomes for Parents of Exceptional Children Inc | 501(c)(3) | 2014 | $0 | $0 | 2024-12 |
| Heritage House Human Services Inc | 501(c)(3) | 2016 | $0 | $0 | 2024-12 |
| Holy Unmercenaries Medical Society | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Hope for All Hfa of Charlotte Inc | 501(c)(3) | 2018 | $0 | $0 | 2024-12 |
| Ihcpt Cares Inc | 501(c)(3) | 2025 | | | |
| Immigrant and Family Health Inc | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| International Alliance for Pediatric Stroke Inc | 501(c)(3) | 2012 | $0 | $0 | 2025-12 |
| Ircad North America Inc | 501(c)(3) | 2024 | $0 | $0 | 2024-12 |
| Its Zen Us Inc | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| K Is for Kidneys | 501(c)(3) | 2025 | | | |
| Kamitic Life Center | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Kates Courage Foundation | 501(c)(3) | 2026 | $0 | $0 | 2025-12 |
| Krishya Kares | 501(c)(3) | 2024 | $0 | $2,000 | 2025-12 |
| Kujiponya | 501(c)(3) | 2026 | $0 | $0 | 2025-12 |
| Kydens Keepers Inc | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| Lanes Light | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Life for the Hopeless Foundation | 501(c)(3) | 2021 | $0 | $0 | 2024-12 |
| Liquid Gold Foundation | 501(c)(3) | 2025 | | | |
| Lucas Light Foundation | 501(c)(3) | 2021 | $0 | $0 | 2024-12 |
| Massage for All Foundation Inc | 501(c)(3) | 2026 | $0 | $0 | 2025-12 |
| Maximizing Hope | 501(c)(3) | 2021 | $0 | $0 | 2024-12 |
| Mecklenburg County Medical Society Foundation Inc | 501(c)(3) | 2005 | $0 | $0 | 2025-12 |
| Medical Charities of Tennessee | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Melanin in Medicine Network | 501(c)(3) | 2026 | $0 | $0 | 2025-12 |
| Mign 2 Give | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Mission Positive | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Moriah Hemingsway Health Foundation Inc | 501(c)(3) | 2020 | $0 | $278,000 | 2025-12 |
| NC Mountain Holistic Center | 501(c)(3) | 2025 | | | |
| No Black Man Left Behind Inc | 501(c)(3) | 2026 | | | |
| Pearl Innovation District Management Company | 501(c)(3) | 2022 | $0 | $0 | 2024-12 |
| Pink Soles Inc | 501(c)(3) | 2012 | $0 | $0 | 2023-12 |
| Place of Love and Light | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Pregnant Care Charities Inc | 501(c)(3) | 2024 | $0 | $0 | 2023-12 |
| Project Think | 501(c)(3) | 2024 | | | |
| Prosperous Home Care PHC | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Queen City Amputees | 501(c)(3) | 2025 | | | |
| Radiant Recovery RX | 501(c)(3) | 2024 | $0 | $0 | 2024-12 |
| Regnaud Family Foundation LTD | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Rootz of Power | 501(c)(3) | 2025 | $0 | $0 | 2026-06 |
| Salama Foundation | 501(c)(3) | 2025 | | | |
| Sarcoidoisis of North Carolina Sarcoidois of Queen City | 501(c)(3) | 2015 | $0 | $0 | 2024-12 |
| Scope Institute | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Serve To Save Women Health | 501(c)(3) | 2026 | $0 | $0 | 2025-12 |
| Sharon Elizabeth Dialysis Center of Hope | 501(c)(3) | 2018 | $0 | $0 | 2023-12 |
| Shesa Silver Jubilee SSJ Foundation | 501(c)(3) | 2021 | $0 | $0 | 2024-12 |
| Smart Moves To Aspires Restore and Thrive Inc | 501(c)(3) | 2025 | | | |
| Styles for Smilz Inc | 501(c)(3) | 2023 | $0 | $0 | 2024-12 |
| Tagge Medical | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| The Cradle Collective | 501(c)(3) | 2026 | | | |
| The Encrowd Project Incorporated | 501(c)(3) | 2026 | | | |
| Thrive Beyond Inc | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Tops Club Inc | 501(c)(3) | 2008 | $0 | $0 | 2026-03 |
| Trusted Parents | 501(c)(3) | 2013 | $0 | $0 | 2025-06 |
| Warriors of Strength | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Willow Haven Inspirational Spa | 501(c)(3) | 2017 | $0 | $0 | 2025-12 |
| With Love and Healing | 501(c)(3) | 2026 | | | |
| Young Risk Professionals Charlotte Inc | 501(c)(6) | 2023 | $0 | $0 | 2024-12 |