| Trustees of Mount Holyoke College | Education | 501(c)(3) | 1942 | $242.2 million | $1.59 billion | 2025-06 |
| Loomis Housing Corporation | Human services | 501(c)(3) | 1988 | $23.1 million | $124.4 million | 2024-12 |
| Berkshire Hills Music Academy Inc | Education | 501(c)(3) | 1999 | $6.6 million | $13.4 million | 2025-06 |
| Associated Kyoto Program Inc | International, foreign affairs and national security | 501(c)(3) | 1989 | $2.6 million | $18.3 million | 2025-06 |
| Alumnae Association of Mount Holyoke College Inc | Education | 501(c)(3) | 1979 | $2 million | $11.6 million | 2025-06 |
| Willits Hallowell Center Inc | | 501(c)(3) | 1975 | $1.8 million | $297,823 | 2025-06 |
| Center Redevelopmemt Corporation | Community improvement and capacity building | 501(c)(3) | 1989 | $1.7 million | $3.5 million | 2025-06 |
| Eldercare Initiatives Inc | Housing and shelter | 501(c)(3) | 2005 | $608,625 | $4.9 million | 2025-12 |
| Friends of Pioneer Valley | | 501(c)(3) | 2005 | $371,011 | $5.4 million | 2025-06 |
| All Our Kids Inc | Human services | 501(c)(3) | 2017 | $237,442 | $625,621 | 2024-12 |
| Neighbors Helping Neighbors Inc | Food, agriculture and nutrition | 501(c)(3) | 2013 | $237,216 | $257,133 | 2024-12 |
| Hampshire Christian Academy | Education | 501(c)(3) | 1996 | $171,615 | $283,750 | 2025-06 |
| South Hadley and Granby Chamber of Commerce | Community improvement and capacity building | 501(c)(6) | 2010 | $136,767 | $104,190 | 2025-12 |
| South Hadley Historical Inc | Arts, culture and humanities | 501(c)(3) | 1998 | $134,192 | $486,178 | 2024-12 |
| South Hadley Swimming Club Inc | | 501(c)(7) | 1960 | $107,744 | $123,694 | 2025-10 |
| Amherst Japanese Language School Inc | Education | 501(c)(3) | 2000 | $87,491 | $134,688 | 2026-03 |
| Friends of Buttery Book Park Inc | Community improvement and capacity building | 501(c)(3) | 2014 | $85,306 | $163,102 | 2024-12 |
| Body Mind Centering Association Inc | | 501(c)(3) | 1988 | $82,692 | $12,685 | 2024-12 |
| Institute for the Study of Religion in the Middle East Inc | Religion-related | 501(c)(3) | 2013 | $62,709 | $57,908 | 2024-12 |
| Evergreen Cemetery Association | | 501(c)(13) | 1971 | $53,277 | $326,707 | 2025-12 |
| Joshua Generation Fellowship | Religion-related | 501(c)(3) | 2006 | $46,506 | $378,347 | 2025-12 |
| Friends of the South Hadley Seniors Inc | | 501(c)(3) | 1981 | $38,634 | $412,484 | 2025-12 |
| Gaylord Memorial Library Association | | 501(c)(3) | 1987 | $34,237 | $381,224 | 2024-12 |
| South Hadley Education Association | | 501(c)(5) | | $33,324 | $69,370 | 2025-06 |
| Friends of the Holyoke Range Inc | | 501(c)(3) | 1983 | $31,739 | $189,540 | 2025-08 |
| The Proprietors of the South Hadley Falls Cemetery | Mutual and membership benefit | 501(c)(13) | 2009 | $26,626 | $178,808 | 2025-12 |
| Luke Stronger | Health care | 501(c)(3) | 2018 | $23,587 | $5,039 | 2025-12 |
| Friends of the South Hadley Public Library System | | 501(c)(3) | 1981 | $12,828 | $50,272 | 2026-05 |
| Daniel A Larson Foundation Inc | Crime and legal-related | 501(c)(3) | 1996 | $1,054 | $30,414 | 2025-06 |
| Adams Foundation | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2005 | | $394,944 | 2025-08 |
| Alumnae Association of Mount Holyoke College | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College | | 501(c)(3) | 1979 | $0 | $0 | 2025-06 |
| Alumnae Association of Mount Holyoke College | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2023-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-12 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-06 |
| Alumnae Association of Mount Holyoke College Inc | Education | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1972 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2023-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | Education | 501(c)(3) | 1979 | | | |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-12 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | Education | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2025-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College Inc | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Alumnae Association of Mount Holyoke College in | | 501(c)(3) | 1979 | $0 | $0 | 2026-06 |
| Amherst Project Inc | | 501(c)(3) | 1964 | | | |
| Anthony M and Lea Scibelli Charitable Foundation Trust | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2022 | | $7.3 million | 2025-12 |
| Bahais of South Hadley Town | | 501(c)(3) | 1995 | | | |
| Branch Pond Association Inc | Environment | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Brittneys Believers Inc | Youth development | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Committee To Preserve St Mary of the Assumption Chuurch Inc | Religion-related | 501(c)(3) | 2013 | $0 | $0 | 2025-12 |
| Conexiones Latinx-Ma Inc | Human services | 501(c)(3) | 2022 | $0 | $0 | 2026-06 |
| Conn Valley Mineral Club | | 501(c)(7) | 1992 | $0 | $0 | 2023-12 |
| First Congregational Church of South Hadley | | 501(c)(3) | 1964 | | | 2013-12 |
| Flora and Fauna Wildlife Rehabilita Tion Inc | Animal-related | 501(c)(3) | 2026 | | | |
| Foundation for Advancement of Essential Diagnostics Limited | Medical research | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Frederick S Thompson College Scholarship | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2002 | | $26,063 | 2024-12 |
| Friends of CSGC | Recreation and sports | 501(c)(3) | 2024 | $0 | $0 | 2025-10 |
| Habib Foundation Inc | Arts, culture and humanities | 501(c)(3) | 2025 | | | |
| Hampden County District Three | Philanthropy, voluntarism and grantmaking foundations | 501(c)(19) | 2025 | $0 | $0 | 2024-12 |
| Ishah El Theatre Arts Collaborative Inc | Arts, culture and humanities | 501(c)(3) | 2006 | $0 | $0 | 2024-12 |
| Korea in Amherst | Education | 501(c)(3) | 2015 | $0 | $0 | 2025-06 |
| Massachusetts Outlaws | Recreation and sports | 501(c)(3) | 2022 | $0 | $0 | 2024-07 |
| Master Wardens & Members of the Grand Lodge of Masons in Mass | | 501(c)(10) | 1954 | $0 | $0 | 2026-08 |
| Master Wardens & Members of the Grand Lodge of Masons in Mass | | 501(c)(10) | 1954 | $0 | $0 | 2026-08 |
| Michael E Smith Endowment for Excellence in Education Inc | Education | 501(c)(3) | 2002 | $0 | $0 | 2025-12 |
| Michael E Smith Middle School Pto | Education | 501(c)(3) | 2026 | | | |
| Mosier Elementary School Parent Teacher Association | Education | 501(c)(3) | 2022 | $0 | $0 | 2023-12 |
| Music Arts South Hadley | Human services | 501(c)(3) | 2015 | $0 | $0 | 2024-12 |
| Nechps Inc | Science and technology | 501(c)(3) | 2014 | $0 | $0 | 2023-06 |
| New England Chapter Society of Nuclear Medicine Inc | | 501(c)(6) | 1984 | $0 | $0 | 2026-06 |
| Our Saviors Lutheran Church | | 501(c)(3) | 1988 | | | |
| Pioneer Valley Mycological Association Inc | Environment | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Roman Catholic Bishop of Springfield A Corp Sole for | | 501(c)(3) | 1946 | | | |
| Scandinavian Seminar | International, foreign affairs and national security | 501(c)(3) | 1957 | | $2.4 million | 2025-12 |
| Second Baptist Church | | 501(c)(3) | 1955 | | | |
| Society for the Study of Muslim Ethics | Human services | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| South Hadley Ahpc | Philanthropy, voluntarism and grantmaking foundations | 501(c)(3) | 2013 | $0 | $0 | 2025-12 |
| South Hadley Family Center Inc | Human services | 501(c)(3) | 2010 | $0 | $0 | 2025-06 |
| South Hadley Fire District 2 Firefighters Association | Public safety, disaster preparedness and relief | 501(c)(3) | 2025 | $0 | $0 | 2025-06 |
| South Hadley Music Parents Association Inc | Education | 501(c)(3) | 2003 | $0 | $0 | 2025-06 |
| South Hadley Police Relief Associat Ion Inc | Public and societal benefit | 501(c)(3) | 2026 | | | |
| St Patricks Parish | | 501(c)(3) | 1946 | | | |
| Summitview Church of Christ | Religion-related | 501(c)(3) | 2009 | | | |
| Swallow Conservation | Animal-related | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Synaptic Commons Inc | Science and technology | 501(c)(3) | 2025 | | | |
| The Morning Star Church | | 501(c)(3) | 1955 | | | |
| The South Hadley Community Chorus Inc | Arts, culture and humanities | 501(c)(3) | 1991 | $0 | $0 | 2025-06 |
| Thompsons Gymnastics Parents Association | Recreation and sports | 501(c)(3) | 2021 | $0 | $0 | 2023-12 |
| Trustees of Dartmouth College | | 501(c)(3) | 1997 | $0 | $0 | 2026-06 |
| Valley Church Inc | Religion-related | 501(c)(3) | 2011 | | | |
| Veterans of Foreign Wars Department of Massachusetts | | 501(c)(19) | 1965 | $0 | $0 | 2026-06 |
| Veterans of Foreign Wars Department of Massachusetts | | 501(c)(19) | 1965 | $0 | $0 | 2024-06 |
| Western Massachusetts Board of Approved Football Officials | Recreation and sports | 501(c)(4) | 2001 | $0 | $0 | 2025-12 |