| Childrens Hospital Corporation | 501(c)(3) | 1983 | $3.59 billion | $9.12 billion | 2025-09 |
| Boston Medical Center Corporation | 501(c)(3) | 1996 | $2.97 billion | $3.05 billion | 2025-09 |
| Commonwealth Care Alliance Inc | 501(c)(3) | 2005 | $2.77 billion | $538.4 million | 2024-12 |
| Harvard Medical Faculty Phys at Beth Israel Deaconess Med Center Inc | 501(c)(3) | 1988 | $809.8 million | $461.4 million | 2025-09 |
| Childrens Medical Center | 501(c)(3) | 1960 | $500.8 million | $4.22 billion | 2025-09 |
| Childrens Hospital Pediatric Associates Inc | 501(c)(3) | 2004 | $480.7 million | $687.3 million | 2025-09 |
| Boston Medical Center-South Corporation | 501(c)(3) | 2025 | $426.1 million | $251.8 million | 2025-09 |
| Boston Medical Center-Brighton Corporation | 501(c)(3) | 2025 | $335.7 million | $128.2 million | 2025-09 |
| BMC Health System | 501(c)(3) | 2014 | $298.3 million | $53.9 million | 2025-09 |
| Carequest Institute for Oral Health | 501(c)(4) | 2017 | $297.9 million | $2.60 billion | 2024-12 |
| Associated Physicians of Harvard Faculty Physicians at Beth Isreal | 501(c)(3) | 2003 | $286.2 million | $81.9 million | 2025-09 |
| Partners in Health A Nonprofit Corporation | 501(c)(3) | 2002 | $284.7 million | $386.6 million | 2025-06 |
| Hebrew Rehabilitation Center | 501(c)(3) | 1957 | $175.3 million | $63.8 million | 2025-09 |
| Community Care Cooperative Inc | 501(c)(3) | 2017 | $144.6 million | $136.6 million | 2024-12 |
| Childrens Hospital of Wisconsin Foundation Inc | 501(c)(3) | 1985 | $143.5 million | $1.72 billion | 2024-12 |
| Upstream USA Inc | 501(c)(3) | 2017 | $142.1 million | $339 million | 2025-12 |
| Fenway Community Health Center Inc | 501(c)(3) | 1975 | $113.3 million | $107 million | 2025-06 |
| Physicians Organization at Childrens Hospital Inc | 501(c)(3) | 1998 | $107.8 million | $97.3 million | 2025-09 |
| Boston Childrens Heart Foundation | 501(c)(3) | 1984 | $101.4 million | $142.8 million | 2025-09 |
| Childrens Orthopaedic Surgery Foundation Inc | 501(c)(3) | 1988 | $93.5 million | $129.4 million | 2025-09 |
| Commonwealth Clinical Alliance Inc | 501(c)(3) | 2004 | $85.7 million | $9.7 million | 2024-12 |
| CHMC Surgical Foundation Inc | 501(c)(3) | 1983 | $54.9 million | $115.5 million | 2025-09 |
| Childrens Hospital Radiology Foundation Inc | 501(c)(3) | 1996 | $50.5 million | $72.7 million | 2025-09 |
| CHMC Otolaryngologic Foundation Inc | 501(c)(3) | 2014 | $46.9 million | $71.1 million | 2025-09 |
| Blue Circle Charitable Foundation Inc | 501(c)(3) | 2025 | $42.9 million | $42.8 million | 2025-09 |
| Childrens Hospital Opthalmology Foundation Inc | 501(c)(3) | 2004 | $39.6 million | $51.9 million | 2025-09 |
| The Longwood Collective Inc | 501(c)(3) | 1993 | $38.4 million | $176.1 million | 2025-06 |
| Tufts Shared Services Inc | 501(c)(3) | 1968 | $34.3 million | $38 million | 2025-09 |
| Tufts Medical Center Physicians Organization Inc | 501(c)(3) | 1993 | $33.4 million | $284.8 million | 2025-09 |
| Planned Parenthood League of Massachusetts Inc | 501(c)(3) | 1980 | $32.8 million | $44.1 million | 2025-06 |
| Childrens Urological Foundation Inc | 501(c)(3) | 1988 | $30.8 million | $42.6 million | 2025-09 |
| North End Community Health Committee Inc | 501(c)(3) | 1970 | $29.5 million | $24.5 million | 2025-09 |
| Boston Childrens Network Specialty Physicians Inc | 501(c)(3) | 2023 | $27.4 million | $14 million | 2025-09 |
| Charles River Community Health Inc | 501(c)(3) | 1973 | $24.6 million | $17 million | 2025-06 |
| Last Mile Health | 501(c)(3) | 2014 | $21.6 million | $29.6 million | 2025-06 |
| Community Catalyst Inc | 501(c)(3) | 1997 | $19 million | $48.4 million | 2024-12 |
| Economic Mobility Pathways Inc | 501(c)(3) | 1962 | $16 million | $15.6 million | 2025-06 |
| Health Leads Inc | 501(c)(3) | 2003 | $15 million | $9.1 million | 2025-12 |
| Edgar P Benjamin Healthcare Center Inc | 501(c)(3) | 1941 | $13.8 million | $5.8 million | 2024-12 |
| Evidence for Healthcare Improvement | 501(c)(3) | 2014 | $9.2 million | $11.9 million | 2024-12 |
| Make-A-Wish Foundation of Massachusetts and Rhode Island Inc | 501(c)(3) | 1993 | $8.9 million | $18.9 million | 2025-08 |
| Boston University Eye Associates Inc | 501(c)(3) | 1997 | $8 million | $3 million | 2003-06 |
| Mass Insight Education and Research Institute Inc | 501(c)(3) | 1997 | $7.6 million | $2 million | 2025-06 |
| Federation for Children With Special Needs Inc | 501(c)(3) | 1975 | $7.4 million | $5.4 million | 2025-10 |
| Community Health Center Capital Fund Inc | 501(c)(3) | 1991 | $7 million | $38.5 million | 2025-06 |
| T1D Exchange Inc | 501(c)(3) | 2013 | $5.4 million | $11 million | 2024-12 |
| Blue Circle Health Clinical Inc | 501(c)(3) | 2025 | $4.6 million | $1.8 million | 2025-09 |
| Asian Healthcare Foundation Ofmassachusetts Inc | 501(c)(3) | 2007 | $4.5 million | $27.6 million | 2025-06 |
| Bostons Community Medical Group Inc | 501(c)(3) | 2006 | $4.4 million | $1.3 million | 2024-12 |
| Capital Link Inc | 501(c)(3) | 1992 | $4.1 million | $6.2 million | 2025-06 |
| Public Responsibility in Medicine and Research | 501(c)(3) | 1976 | $4 million | $9.1 million | 2025-12 |
| International Consortium for Health Outcomes Measurement Inc | 501(c)(3) | 2013 | $3.9 million | $1.9 million | 2024-12 |
| Izumi Foundation | 501(c)(3) | 1999 | $2.8 million | $73.4 million | 2020-12 |
| Solvandria Foundation Inc | 501(c)(3) | 2023 | $2.7 million | $2 million | 2025-12 |
| Beth Israel Deaconess Department of Medicine Foundation Inc | 501(c)(3) | 2000 | $1.8 million | $16.1 million | 2025-09 |
| Boston Accountable Care Organization Inc | 501(c)(3) | 2016 | $1.8 million | $30.4 million | 2025-09 |
| Voice Health Institute | 501(c)(3) | 2004 | $1.6 million | $3.1 million | 2025-06 |
| Dana-Farber Cancer Care Network Inc | 501(c)(3) | 2015 | $1.5 million | $2 million | 2025-09 |
| Massachusetts Public Health Association | 501(c)(3) | 1997 | $1.4 million | $1.1 million | 2025-06 |
| Vincent Memorial Hospital Foundation Inc | 501(c)(3) | 1932 | $1.4 million | $39.7 million | 2025-09 |
| Boetheo Foundation Inc | 501(c)(3) | 2026 | $1.4 million | $1.4 million | 2025-12 |
| Beth Israel Hospital Obstetrics & Gynecology Foundation Inc | 501(c)(3) | 1986 | $1.3 million | $23.1 million | 2025-09 |
| VHL Alliance Inc | 501(c)(3) | 1993 | $1.2 million | $2.6 million | 2025-06 |
| Thomas Morgan Rotch Jr Memorial Hospital for Infants Trust | 501(c)(3) | 1933 | $1.2 million | $9.6 million | 2024-12 |
| Vital CXNS Inc | 501(c)(3) | 2021 | $1.1 million | $895,200 | 2025-12 |
| Bih Radiologic Foundation Inc | 501(c)(3) | 2003 | $1 million | $19.2 million | 2025-09 |
| Vincent Club | 501(c)(3) | 1959 | $838,854 | $3.5 million | 2025-06 |
| Health Equity Compact Inc | 501(c)(3) | 2024 | $750,725 | $736,214 | 2024-12 |
| Accompany Doula Care Inc | 501(c)(3) | 2021 | $750,469 | $493,701 | 2025-06 |
| Mountain Valley Place Inc | 501(c)(3) | 1993 | $611,158 | $1.9 million | 2025-06 |
| Wezesha Us Inc | 501(c)(3) | 2022 | $516,881 | $1.9 million | 2024-12 |
| Hands Across the Sea Inc | 501(c)(3) | 2007 | $514,433 | $513,896 | 2025-12 |
| Carriage House at Acushnet Heights Inc | 501(c)(3) | 2002 | $493,921 | $2.8 million | 2024-12 |
| BMC Integrated Care Services Inc | 501(c)(3) | 2014 | $465,350 | $14.2 million | 2025-09 |
| Massachusetts Sickle Cell Association Inc | 501(c)(3) | 2013 | $447,815 | $308,430 | 2024-12 |
| American Society of Law Medicine & Ethics Inc | 501(c)(3) | 1973 | $443,307 | $626,403 | 2024-12 |
| The Childrens Hospital League Corporation | 501(c)(3) | 1984 | $338,254 | $2.3 million | 2025-09 |
| Beth Israel Deaconess Department of Surgery Foundation Inc | 501(c)(3) | 2003 | $243,491 | $5 million | 2025-09 |
| Boston Firefighter and Family Cancer Foundation | 501(c)(3) | 2021 | $197,143 | $197,143 | 2025-12 |
| International Geriatric Diabetes Society Inc | 501(c)(3) | 2020 | $181,237 | $291,550 | 2024-12 |
| 470 Pleasant Street Holdings Company Inc | 501(c)(3) | 2015 | $150,000 | $6.2 million | 2025-06 |
| Beth Israel Deaconess Department of Neurology Foundation Inc | 501(c)(3) | 2007 | $146,546 | $2.4 million | 2025-09 |
| Childrens Glaucoma Foundation Inc | 501(c)(3) | 1999 | $123,071 | $1.7 million | 2025-12 |
| Beth Israel Deaconess Department of Emergency Medicine Foundation in | 501(c)(3) | 2016 | $120,953 | $2.8 million | 2025-09 |
| Sadie Ethel Macdonald Charitable Trust | 501(c)(3) | 2011 | $115,875 | $1.1 million | 2025-12 |
| Bay Cove Moseley Group Home Inc | 501(c)(3) | 1991 | $113,762 | $236,978 | 2025-06 |
| Global Healthcare Leaders Foundation | 501(c)(3) | 2024 | $112,437 | $1,125 | 2025-12 |
| W Hardy Hendren Pediatric Surgical and Urological Education | 501(c)(3) | 2012 | $105,001 | $69,599 | 2025-12 |
| Esophageal Cancer Awareness Association Inc | 501(c)(3) | 2004 | $94,410 | $881,380 | 2025-06 |
| New England Congenital Cardiology Research Foundation | 501(c)(3) | 2010 | $91,194 | $1.6 million | 2025-09 |
| Howard Vardeman Irrev Trust 2 Shriners Hospitals for Children | 501(c)(3) | 2006 | $84,199 | $950,252 | 2025-12 |
| Cabo Verdean American Medical Society | 501(c)(3) | 2021 | $82,969 | $47,185 | 2024-12 |
| Beth Israel Deaconess Department Oforthopaedic Surgery Foundation Inc | 501(c)(3) | 2008 | $44,642 | $1.3 million | 2025-09 |
| Neshamacare | 501(c)(3) | 2024 | $33,100 | $7,267 | 2024-12 |
| Hacking Medicine Institute | 501(c)(3) | 2015 | $32,007 | $100,151 | 2024-12 |
| Zeola Home Care Services | 501(c)(3) | 2020 | $28,888 | $217,415 | 2024-12 |
| Sweet Readers Inc | 501(c)(3) | 2011 | $17,526 | $10,670 | 2024-06 |
| Steward Health Care Disaster Relief Foundation | 501(c)(3) | 2020 | $9,920 | $189,590 | 2024-12 |
| Blue Circle Health Inc | 501(c)(3) | 2022 | $8,477 | $4 million | 2025-09 |
| Garfield Park Wellness Center Support Corporation | 501(c)(3) | 2024 | $7,127 | $35.2 million | 2024-12 |
| Autism Research Foundation | 501(c)(3) | 2015 | $5,931 | $150,212 | 2025-12 |
| Mission Hope Inc | 501(c)(3) | 2014 | $3,887 | $15,192 | 2024-12 |
| Harvard Medical Center | 501(c)(3) | 1958 | $3,585 | $205,808 | 2025-09 |
| Devon Nicoles House Inc | 501(c)(3) | 2001 | $24 | $26,703 | 2024-12 |
| A Thousand Ways Global Health Organization Corp | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Abrahamic Womens Health Organization Inc | 501(c)(3) | 2024 | | | |
| American Medical Extended Reality Association Inc | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Aniksha Love in Action Inc | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Atlantic Health Resources Inc | 501(c)(3) | 1947 | | | 1999-09 |
| Atrius Health Equity Foundation Inc | 501(c)(3) | 2010 | | $146.6 million | 2025-12 |
| Bay State Birth Coalition | 501(c)(4) | 2022 | $0 | $0 | 2025-12 |
| Better Oral Health for Massachusetts Coalition Inc | 501(c)(3) | 2012 | $0 | $0 | 2026-06 |
| Boston University Dermatology Inc | 501(c)(3) | 1997 | | | 2025-09 |
| Boston University Dermatology Support Services I Inc | 501(c)(3) | 1997 | | | 1999-06 |
| Boston University Dermatology Support Services II Inc | 501(c)(3) | 1997 | | | 1999-06 |
| Boston University Obstetrics and Gynecology Foundation Inc | 501(c)(3) | 1997 | | | 1999-06 |
| Boston University Radiation Oncology Inc | 501(c)(3) | 1997 | | | |
| Bridges To Health Inc | 501(c)(3) | 2026 | $0 | $0 | 2025-12 |
| Center for Wellness and Wisdom Inc | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Community Intensive Care Inc | 501(c)(3) | 2023 | $0 | $1 | 2024-12 |
| Dana-Farber Childrens Hospital Cancer Care Inc | 501(c)(3) | 2002 | $0 | $0 | 2025-09 |
| Eldercarecompass Inc | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Eleemos Inc | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Employer Coalition On Health | 501(c)(4) | 2025 | | | |
| Ensia Inc | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Evans Medical Foundation Inc | 501(c)(3) | 1997 | | | 2016-06 |
| Goingwell Inc | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Hahnemann Hospital | 501(c)(3) | 2001 | | $314,533 | 2025-09 |
| Healing Hair Foundation | 501(c)(3) | 2026 | $0 | $0 | 2026-03 |
| Healing Hands Foundation Inc | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Health Equity Corps | 501(c)(3) | 2025 | | | |
| Healthpair Health Literacy Solutions Incorporated | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Healthy Hearts for Life Inc | 501(c)(3) | 2013 | $0 | $0 | 2023-12 |
| Hippocrates Mission Corporation | 501(c)(3) | 2026 | $0 | $0 | 2025-12 |
| Hope Street Foundation | 501(c)(3) | 2020 | $0 | $0 | 2023-12 |
| Japhet and Juliana Uzoeghelu Foundation Inc | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Kidney Disease Screening and Awareness Program Inc | 501(c)(3) | 2021 | $0 | $0 | 2022-12 |
| Latino Surgical Society Inc | 501(c)(3) | 2021 | $0 | $0 | 2025-04 |
| Livjoy Foundation Inc | 501(c)(3) | 2023 | | $930,252 | 2025-12 |
| Massachusetts Association of Community Health Inc | 501(c)(4) | 2001 | $0 | $0 | 2023-06 |
| Merciful Hands Corporation | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| National Association of Community Health Workers | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| November Project Inc | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| On With Living and Learning Inc | 501(c)(3) | 2001 | $0 | $0 | 2024-12 |
| One Health Stroke Awareness Inc | 501(c)(3) | 2024 | $0 | $0 | 2024-07 |
| Pharmate Inc | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Project Life International Inc | 501(c)(3) | 2023 | | $758,792 | 2025-12 |
| Quetzales Health Inc | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Radiance Clinic Inc | 501(c)(3) | 2022 | $0 | $0 | 2025-12 |
| Rotary 7930 Rotaplast | 501(c)(3) | 2025 | $0 | $0 | 2024-12 |
| Rowens Legacy Inc | 501(c)(3) | 2025 | | | |
| Self Action Healing Foundation | 501(c)(3) | 2026 | | | |
| Small Steps for Health | 501(c)(3) | 2026 | | | |
| Strobe Alert Foundation | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Tufts Medical Center Parent Inc | 501(c)(3) | 2008 | $0 | $1 million | 2025-09 |
| Tufts Medical Center Parent Inc | 501(c)(3) | 2008 | | | 2025-09 |
| Tufts Medical Center Physicians Organization Inc | 501(c)(3) | 1993 | | | 2025-09 |
| Tufts Medical Center Physicians Organization Inc | 501(c)(3) | 1993 | | | 2025-09 |
| Tufts Medical Center Physicians Organization Inc | 501(c)(3) | 1993 | | | 2025-09 |
| Tufts Medical Center Physicians Organization Inc | 501(c)(3) | 1993 | | | 2025-09 |
| Tufts Medical Center Physicians Organization Inc | 501(c)(3) | 1993 | | | 2025-09 |
| Tufts Medical Center Physicians Organization Inc | 501(c)(3) | 1993 | | | 2025-09 |
| Tufts Medical Center Physicians Organization Inc | 501(c)(3) | 1993 | | | 2025-09 |
| Tufts Medical Center Physicians Organization Inc | 501(c)(3) | 1993 | | | 2025-09 |
| Tufts Medical Center Physicians Organization Inc | 501(c)(3) | 1993 | | | 2025-09 |
| Tufts Medical Center Physicians Organization Inc | 501(c)(3) | 1993 | | | 2025-09 |
| Tufts Medical Center Physicians Organization Inc | 501(c)(3) | 1993 | | | 2025-09 |
| Tufts Medical Center Physicians Organization Inc | 501(c)(3) | 1993 | | | 2025-09 |
| Tufts Medical Center Physicians Organization Inc | 501(c)(3) | 1993 | | | 2025-09 |
| Tufts Medical Center Physicians Organization Inc | 501(c)(3) | 1993 | | | 2025-09 |
| Tufts Medical Center Physicians Organization Inc | 501(c)(3) | 1993 | | | 2025-09 |
| Tufts Medical Center Physicians Organization Inc | 501(c)(3) | 1993 | | | 2025-09 |
| CHB Properties Inc | 501(c)(3) | 1996 | $-113,212 | $453.5 million | 2025-09 |