| Indian River Community Foundation | 501(c)(3) | 2004 | $32.5 million | $114.6 million | 2025-06 |
| United Way of Indian River County Inc | 501(c)(3) | 1965 | $5.7 million | $3.9 million | 2025-06 |
| Quail Valley Charities Inc | 501(c)(3) | 2002 | $1.6 million | $1.3 million | 2025-08 |
| United Way Foundation of Indian River County Inc | 501(c)(3) | 2012 | $1.6 million | $7.2 million | 2025-06 |
| Grand Harbor Community Outreach Program Inc | 501(c)(3) | 2002 | $904,005 | $685,377 | 2025-08 |
| The Mardy Fish Childerns Foundation Inc | 501(c)(3) | 2006 | $303,810 | $242,802 | 2025-07 |
| McGinley Foundation Inc | 501(c)(3) | 2023 | $103,498 | $161,716 | 2025-12 |
| Vero Beach Airshow Inc | 501(c)(3) | 2012 | $77,071 | $177,829 | 2025-10 |
| Indian River Firefighters Benevolent Association Inc | 501(c)(3) | 2012 | $68,640 | $203,092 | 2025-12 |
| Indian River County Veterans Mall Foundation Inc | 501(c)(3) | 2012 | $31,782 | $48,437 | 2025-12 |
| Boulevard Charities Inc | 501(c)(3) | 2024 | $12,307 | $3,288 | 2025-12 |
| 82 Foundation | 501(c)(3) | 2026 | | | |
| Albert L Ueltschi Foundation | 501(c)(3) | 2003 | | $262.1 million | 2025-12 |
| Alden Family Foundation Inc | 501(c)(3) | 2001 | | $2.2 million | 2025-12 |
| Arthur and Gladys L Pancoe Foundation | 501(c)(3) | 2013 | | $2.6 million | 2024-12 |
| Ask Family Foundation | 501(c)(3) | 2000 | | $15,521 | 2025-12 |
| Ballydavid Foundation | 501(c)(3) | 2022 | | $1.2 million | 2025-12 |
| Berthold T D and Thyra Schwarz Foundation Inc | 501(c)(3) | 2004 | | $11,969 | 2024-12 |
| Bewkes Family Foundation | 501(c)(3) | 1999 | | $582,356 | 2025-12 |
| Blogoslawski Family Foundation Inc | 501(c)(3) | 1997 | | $844,879 | 2025-12 |
| Blue Trident Foundation Inc | 501(c)(3) | 2020 | | $849,620 | 2025-12 |
| Borduin Charitable Foundation Inc | 501(c)(3) | 2006 | | $457,066 | 2025-12 |
| Brackett Family Foundation Inc | 501(c)(3) | 2004 | | $2.9 million | 2024-12 |
| Burke Foundation | 501(c)(3) | 2026 | | $903,967 | 2025-12 |
| Carpenters Road Ministries Inc | 501(c)(3) | 2015 | | | |
| Charitable Trust Created Under Art V of the Anne H Cutler | 501(c)(3) | 2020 | | $3.1 million | 2024-12 |
| Christine and Jaime Yordan FNDN | 501(c)(3) | 1994 | | $1.2 million | 2025-07 |
| Corry Family Foundation | 501(c)(3) | 2022 | | $7.2 million | 2025-12 |
| Cotter Family Foundation | 501(c)(3) | 2003 | | $582,602 | 2024-12 |
| DSF Charitable Foundation | 501(c)(3) | 2000 | | $117.8 million | 2024-12 |
| Dagostino Family Foundation | 501(c)(3) | 2006 | | $2.2 million | 2025-12 |
| David & Harriet Dyer Fam Foundation | 501(c)(3) | 2004 | | $543,970 | 2025-12 |
| David and Robin Ryan Family Foundation | 501(c)(3) | 2002 | | $553,507 | 2025-12 |
| David and Vickie Smick Foundation | 501(c)(3) | 1995 | | $25.2 million | 2024-12 |
| Denise & Tony Gorman Family Foundation | 501(c)(3) | 2025 | | $3.9 million | 2024-12 |
| Dominick & Rose Ciampa Foundation Inc | 501(c)(3) | 1999 | | $5.2 million | 2024-12 |
| E Lafayette Quirin and Etiennette A Quirin Foundation Inc | 501(c)(3) | 1997 | | $646,073 | 2025-12 |
| E William and France Kenyon Foundation Inc | 501(c)(3) | 2017 | | $18.4 million | 2025-12 |
| Edward A Jesser Foundation Inc | 501(c)(3) | 1997 | | $1.1 million | 2025-12 |
| Florida Research Center for Agricultural Sustainability Inc | 501(c)(3) | 2003 | | $848,707 | 2025-12 |
| Flow Tide Foundation | 501(c)(3) | 2009 | | $1 | 2024-12 |
| Foster Fam Foundation Trust | 501(c)(3) | 2009 | | $1.2 million | 2024-12 |
| Foundation 33 11 | 501(c)(3) | 2002 | | $17.7 million | 2025-12 |
| Frazier Foundation | 501(c)(3) | 2001 | | $621,586 | 2025-06 |
| Friends of Maitland Farm Preschool Inc | 501(c)(3) | 2026 | | | |
| Fundacion Educar Inc | 501(c)(3) | 2003 | | $28,112 | 2024-12 |
| Gerry Fam Foundation Trust | 501(c)(3) | 2001 | | $129,373 | 2024-12 |
| Good Place Foundation | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Grassano Family Foundation Inc | 501(c)(3) | 2016 | | $35,957 | 2025-12 |
| Graymer Phoenix Foundation | 501(c)(3) | 2024 | | $4.1 million | 2025-12 |
| Hardee Family Foundation Inc | 501(c)(3) | 2000 | | $1.8 million | 2025-12 |
| Hastings Family Foundation Inc | 501(c)(3) | 2012 | | $592,716 | 2025-12 |
| Hawkins Family Foundation | 501(c)(3) | 1997 | | $2.2 million | 2025-12 |
| Herbert D Condie III Family Charitable Foundation | 501(c)(3) | 1998 | | $16,166 | 2024-12 |
| High Poplars Foundation Inc | 501(c)(3) | 2008 | | $2.8 million | 2025-12 |
| Hitt Family Foundation Inc | 501(c)(3) | 2009 | | $169,946 | 2025-12 |
| Holloway Family Foundation | 501(c)(3) | 2001 | | $1.2 million | 2025-06 |
| Hope Foundation of Indian River County Inc | 501(c)(3) | 2007 | | $763,192 | 2025-12 |
| Jacobs Family Foundation Inc | 501(c)(3) | 1998 | | $129,432 | 2025-12 |
| James T Ueltschi Foundation | 501(c)(3) | 1999 | | $5.7 million | 2025-12 |
| James and Theresa Nolan Family Foundation | 501(c)(3) | 2012 | | $331,877 | 2025-12 |
| Janke Charitable Foundation | 501(c)(3) | 2007 | | $7.9 million | 2024-12 |
| Jean and Scott Bridge Foundation | 501(c)(3) | 2002 | | $519,266 | 2024-12 |
| Kahle Foundation Inc | 501(c)(3) | 1998 | | $1.9 million | 2025-12 |
| Karen Williams Fox & Gerald J Fox Foundation Inc | 501(c)(3) | 2016 | | $1.1 million | 2025-12 |
| Kelly Family Foundation | 501(c)(3) | 2005 | | $4.5 million | 2024-12 |
| Kleinschmidt Family Foundation | 501(c)(3) | 2007 | | $11 million | 2025-12 |
| Kommunity Kids Inc | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Kurt & Marilyn Wallach Family Foundation Inc | 501(c)(3) | 2022 | | $818 | 2025-12 |
| Laird C Cleaver and Jeanne B Cleaver Foundation | 501(c)(3) | 2012 | | $33,162 | 2025-12 |
| Leggott Foundation | 501(c)(3) | 2002 | | $621,834 | 2025-12 |
| Leo and Yuki Graham Foundation | 501(c)(3) | 2015 | | $8.2 million | 2025-12 |
| Linda Sue Pfarrer Nortillo Charitable Foundation | 501(c)(3) | 2009 | | $1.2 million | 2025-12 |
| Love and Mercy Foundation Inc | 501(c)(3) | 2022 | | $1 | 2025-08 |
| Luther Family Foundation Inc | 501(c)(3) | 1998 | | $2 million | 2026-04 |
| Mangrove Garden Foundation | 501(c)(3) | 2002 | | $193,341 | 2024-12 |
| Mark R and Patricia A Mulvoy Foundation | 501(c)(3) | 2002 | | $78,408 | 2025-12 |
| Mark and Catherine Ensio Family Foundation Inc | 501(c)(3) | 1998 | | $1.5 million | 2025-12 |
| Marshall Family Charitable Foundation | 501(c)(3) | 2003 | | $982,466 | 2024-12 |
| Marvin Davidson Family Foundation Inc | 501(c)(3) | 2024 | | $5.2 million | 2024-12 |
| Mary and Daniel Dolan Family Foundation | 501(c)(3) | 2000 | | $25,746 | 2025-12 |
| McDonald-Anderson Foundation Inc | 501(c)(3) | 2019 | | $50.8 million | 2025-12 |
| Michael F and Joan G Hoben Family Foundation | 501(c)(3) | 2002 | | $57,812 | 2025-12 |
| Nancy and Richard Dorschel Family Foundation Inc | 501(c)(3) | 2003 | | $204,793 | 2025-06 |
| Nortons Foundation Inc | 501(c)(3) | 1997 | | $8,667 | 2025-05 |
| Oglethorpe Family Foundation Inc | 501(c)(3) | 2000 | | $1 | 2025-12 |
| Olena Duda Foundation Inc | 501(c)(3) | 2025 | | $220,696 | 2025-12 |
| Oliver Family Foundation | 501(c)(3) | 2006 | | $143,457 | 2025-12 |
| Pass It On To Kids Foundation | 501(c)(3) | 2016 | | $20 million | 2025-06 |
| Patricia and Clarke Bailey Foundation Inc | 501(c)(3) | 1997 | | $314,157 | 2024-11 |
| Peace and Compassion Foundation Inc | 501(c)(3) | 2017 | $0 | $0 | 2024-12 |
| Planned Giving Council of Indian River Inc | 501(c)(3) | 2014 | $0 | $0 | 2025-12 |
| Red Stick Foundation Inc | 501(c)(3) | 2000 | | $588 | 2025-12 |
| Richard E and Lillian M Beckerfamily Foundation Inc | 501(c)(3) | 2006 | | $2.4 million | 2025-12 |
| Robert Lockwood Solley Foundation | 501(c)(3) | 1999 | | $24,272 | 2025-12 |
| Rossway Swan Tierney Barry Foundation Inc | 501(c)(3) | 2006 | | $787 | 2024-12 |
| Rosswood Foundation | 501(c)(3) | 2002 | | $10 million | 2025-12 |
| Rotary Club of Orchid Island Charit Able Foundation Inc | 501(c)(3) | 2002 | | $4,561 | 2025-06 |
| Sai Maa Foundation | 501(c)(3) | 2015 | | $739,433 | 2025-12 |
| Sanderson Foundation Inc | 501(c)(3) | 2018 | | $277,204 | 2025-12 |
| Sands Family Foundation | 501(c)(3) | 2000 | | $540,696 | 2025-12 |
| Schell Family Foundation | 501(c)(3) | 2003 | | $4.8 million | 2025-12 |
| Scott and Susan Davidson Foundation Inc | 501(c)(3) | 2000 | | $3.1 million | 2024-12 |
| Serving His Servants Foundation | 501(c)(3) | 2016 | | $339,823 | 2025-12 |
| Sheiffer Family Foundation Inc | 501(c)(3) | 2000 | | $849,696 | 2025-12 |
| Squier Family Foundation | 501(c)(3) | 2000 | | $6.8 million | 2024-12 |
| Susan and Scott Deal Charitable Foundation Inc | 501(c)(3) | 2022 | | $738,987 | 2025-12 |
| The Manuel and Mary Johnson Foundation | 501(c)(3) | 1995 | | $4.1 million | 2024-12 |
| The Osborne Family Foundation | 501(c)(3) | 2022 | | $70,385 | 2025-12 |
| The Ripp Family Foundation Inc | 501(c)(3) | 2002 | | $1 million | 2025-12 |
| The Sexton Family Foundation | 501(c)(3) | 1997 | | $15 million | 2024-12 |
| The@michael J Pierce and Kathleen R Pierce Foundation | 501(c)(3) | 2000 | | $31,047 | 2025-12 |
| Trinity Trust | 501(c)(3) | 2000 | | $598,094 | 2024-11 |
| Twin Beeches Foundation Charitable Trust 120297 | 501(c)(3) | 1998 | | $980,321 | 2025-11 |
| Valencia Family Foundation Inc | 501(c)(3) | 2025 | | $1 | 2025-12 |
| W Y Campbell Family Foundation | 501(c)(3) | 2007 | | $1.6 million | 2025-12 |
| Welsh Family Foundation Inc | 501(c)(3) | 1996 | | $9.4 million | 2025-12 |
| Wheeler Family Foundation | 501(c)(3) | 2006 | | $78,616 | 2025-12 |
| Wheeler Foundation | 501(c)(3) | 1998 | | $2.3 million | 2024-12 |
| Whelan Family Foundation Inc | 501(c)(3) | 2010 | | $130,672 | 2024-12 |
| William W and Pamela C Lane Foundation | 501(c)(3) | 2008 | | $2.3 million | 2025-12 |
| Willie and Lisa Bullock Foundation | 501(c)(3) | 2020 | | $1.1 million | 2025-12 |
| World Missions Foundation Inc | 501(c)(3) | 2010 | | $311,972 | 2025-12 |
| Zeitgeist Foundation Inc | 501(c)(3) | 2012 | | $1 | 2024-12 |