Data / Nonprofits / South Dakota / Diseases, disorders and medical disciplines
Diseases, disorders and medical disciplines nonprofits in South Dakota: 45 registered with the IRS
45 diseases, disorders and medical disciplines nonprofits are registered with the IRS in South Dakota, 43 of them 501(c)(3) charities; the 20 that report revenue took in $4.8 million. The most are in Sioux Falls (16), Rapid City (8), Pierre (2). The largest by revenue: Voices Against Cancer ($935,841), Friends of the Children - He Sapa ($877,222), National Pancreatic Cancer Foundation ($653,976).
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Every organization, largest by revenue first
| Organization | City | Type | Since | Revenue | Assets | Filing |
|---|---|---|---|---|---|---|
| Voices Against Cancer | Harrisburg | 501(c)(3) | 2020 | $935,841 | $105,079 | 2024-12 |
| Friends of the Children - He Sapa | Rapid City | 501(c)(3) | 2022 | $877,222 | $970,212 | 2025-08 |
| National Pancreatic Cancer Foundation | Rapid City | 501(c)(3) | 2009 | $653,976 | $897,109 | 2025-12 |
| Healing Words Foundation | Brookings | 501(c)(3) | 2011 | $366,526 | $392,974 | 2025-12 |
| It Only Takes A Spark | Milbank | 501(c)(3) | 2010 | $296,369 | $1 million | 2025-07 |
| Lifesight | Rapid City | 501(c)(3) | 1983 | $259,141 | $2.7 million | 2024-12 |
| South Dakota Parkinson Foundation | Sioux Falls | 501(c)(3) | 2017 | $253,164 | $354,021 | 2025-12 |
| South Dakota Foundation for the Blind and Visually Impaired | Aberdeen | 501(c)(3) | 2002 | $192,495 | $1.1 million | 2025-12 |
| South Dakota Lions Foundation Inc | Sioux Falls | 501(c)(3) | 1966 | $176,396 | $910,475 | 2025-06 |
| Accelerate | Sioux Falls | 501(c)(3) | 2009 | $159,214 | $121,833 | 2024-12 |
| Breathe Bravely Inc | Sioux Falls | 501(c)(3) | 2015 | $115,369 | $25,451 | 2024-12 |
| Sioux Falls Pride | Sioux Falls | 501(c)(3) | 2015 | $108,782 | $69,118 | 2024-12 |
| Diabetes Incorporated | Rapid City | 501(c)(3) | 1998 | $96,301 | $193,151 | 2025-06 |
| Corson Pink Ladies Inc | Corson | 501(c)(3) | 2016 | $75,502 | $159,761 | 2025-12 |
| Steps for Hope Inc | Highmore | 501(c)(3) | 2005 | $66,953 | $166,256 | 2024-12 |
| Black Hills Roadtrip of Hope | Rapid City | 501(c)(3) | 2021 | $63,539 | $82,121 | 2025-12 |
| Central South Dakota Bras for A Cause | Pierre | 501(c)(3) | 2025 | $63,309 | $51,896 | 2025-12 |
| Jy6 Foundation | Sioux Falls | 501(c)(3) | 2015 | $28,900 | $50,068 | 2024-12 |
| Elk Point Pink Ladies | Elk Point | 501(c)(3) | 2020 | $16,366 | $86,754 | 2025-03 |
| Allergy Aware | Dell Rapids | 501(c)(3) | 2022 | $0 | $0 | 2024-12 |
| Autism Residential Inc | Yankton | 501(c)(3) | 2020 | $0 | $0 | 2024-12 |
| Black Hills Center for Equality Inc | Rapid City | 501(c)(3) | 2009 | $0 | $0 | 2025-07 |
| Brain Injury Alliance of South Dakota | Sioux Falls | 501(c)(3) | 2015 | $0 | $0 | 2025-12 |
| Cell Molecular Institute | Brandon | 501(c)(3) | 2014 | $101,666 | 2025-12 | |
| Delivering Hope Inc | Sioux Falls | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Divinity Foundation Inc | Sioux Falls | 501(c)(3) | 2025 | $0 | $0 | 2025-12 |
| Grants Crusade Inc | Rapid City | 501(c)(3) | 2022 | $60,940 | 2025-06 | |
| Huron MS Society | Huron | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| International Association of Lions Clubs | Aberdeen | 501(c)(4) | 1969 | $0 | $0 | 2026-06 |
| Lions Sight and Services of Rapid City Inc | Rapid City | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| Madison Area Pink Ladies | Madison | 501(c)(3) | 2023 | $0 | $0 | 2025-12 |
| Midwest Section of the American Assoc for Clinical Chemistry Inc | Sioux Falls | 501(c)(3) | 1994 | $0 | $0 | 2025-12 |
| Pedal Farr Inc | Sioux Falls | 501(c)(3) | 2019 | $0 | $0 | 2023-12 |
| Pierre Area Pink Ladies Dart League | Pierre | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| Putting for Prostates | N Sioux City | 501(c)(3) | 2024 | $0 | $0 | 2025-12 |
| SD Big Bucks Foundation | Sioux Falls | 501(c)(3) | 2025 | |||
| Sea the Vision Inc | Sioux Falls | 501(c)(3) | 2021 | $0 | $0 | 2025-12 |
| South Dakota Diabetes Coalition | Sioux Falls | 501(c)(3) | 2011 | $0 | $0 | 2026-05 |
| Team Zaidee | Gettysburg | 501(c)(3) | 2019 | $0 | $0 | 2025-12 |
| Trinity Lutheran Cemetery Association of Oldham South Dakota | Oldham | 501(c)(13) | 2014 | $0 | $0 | 2025-12 |
| Ty Eschenbaum Foundation | Arlington | 501(c)(3) | 2023 | |||
| Volunteer Optometric Services To Humanity-South Dakota Chapter Inc | Sioux Falls | 501(c)(3) | 2018 | $0 | $0 | 2025-12 |
| Watertown Breast Cancer Support Group | Watertown | 501(c)(3) | 2016 | $0 | $0 | 2025-12 |
| You LL Never Walk Alone | Mitchell | 501(c)(3) | 2010 | $0 | $0 | 2025-12 |
| Rivere Foundation | Sioux Falls | 501(c)(3) | 2017 | $-21,353 | $50,341 | 2023-12 |
Every nonprofit in South Dakota
Read from the IRS Exempt Organizations Business Master File, updated by the IRS on October 24, 2026 and rebuilt here every morning. Revenue and assets are from each organization's latest filing as the IRS lists it; the IRS record is the official one. Organizations only: no people are named on these pages.