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Data / Medical devices / Filler, Bone Void, Calcium Compound

Filler, Bone Void, Calcium Compound (MQV): 145 FDA-registered makers in 15 countries

145 establishments in 15 countries are registered with the FDA to make Filler, Bone Void, Calcium Compound (product code MQV, Class 2, 21 CFR 888.3045). 93 of them have a 510(k) clearance or PMA approval on file and 17 have a recall event. The FDA has issued 493 510(k) clearances under this code, the latest on September 11, 2026, and lists 46 recall events (0 Class I). FDA data exported November 2, 2026.

SpecStream is the live web data engine for teams and agents. It reads the FDA registration and listing, 510(k), PMA, recall and enforcement files from openFDA every week, and this page is that reading, joined by the FDA's own numbers. Ask for the makers of any device type in any country and new clearances, approvals and recalls arrive in your sheet, CRM, Slack or agent as the FDA publishes them.

Get every maker of this deviceMakers in the United StatesWatch this device
Product code
MQV
Device class
2
Regulation
888.3045
Medical specialty
Orthopedic
Implant
Yes

Makers by country

CountryMakers
United States94
Germany9
Taiwan6
United Kingdom5
Switzerland5
France5
Japan4
Finland4
Netherlands3
Malaysia3
Sweden2
Ireland2
South Korea1
China1
Poland1

Makers of Filler, Bone Void, Calcium Compound

Registered establishments that manufacture, contract manufacture, remanufacture, reprocess or own the specification of this device, with the 510(k) clearances, PMA approvals and recalls the FDA files under each. Best documented first.

MakerLocationRole510(k) clearancesLatest clearancePMA approvalsRecall eventsClass ISource
Wright Medical Technology, Inc.Arlington, TN, United StatesComplaint file establishment, Specification developer25September 30, 2025000api.fda.gov
Wright Medical Technology, Inc.Arlington, TN, United StatesManufacturer, Repackager or relabeler24September 30, 2025000api.fda.gov
Isotis Orthobiologics, IncIrvine, CA, United StatesComplaint file establishment, Manufacturer16September 25, 2024030api.fda.gov
Depuy Spine, Inc.Raynham, MA, United StatesComplaint file establishment, Specification developer12October 22, 2025000api.fda.gov
Apatech Ltd.ELSTREE Hertfordshire, United KingdomManufacturer, Specification developer11August 2, 2024010api.fda.gov
Kuros Biosciences BVBilthoven Utrecht, NetherlandsComplaint file establishment, Manufacturer11May 23, 2025000api.fda.gov
Novabone Products, LLCAlachua, FL, United StatesManufacturer11March 5, 2024000api.fda.gov
Medtronic Sofamor Danek Usa, Inc.Memphis, TN, United StatesSpecification developer10August 14, 2015010api.fda.gov
Berkeley Advanced BiomaterialsBerkeley, CA, United StatesManufacturer9October 30, 2017010api.fda.gov
Collagen Matrix, Inc.Mahwah, NJ, United StatesContract manufacturer, Repackager or relabeler8March 12, 2024000api.fda.gov
Nuvasive, Inc.San Diego, CA, United StatesManufacturer, Repackager or relabeler8March 20, 2024000api.fda.gov
Stryker SpineAllendale, NJ, United StatesComplaint file establishment, Specification developer8February 12, 2016010api.fda.gov
Abyrx, Inc.Stamford, CT, United StatesComplaint file establishment, Manufacturer7December 5, 2024000api.fda.gov
Depuy Orthopaedics, Inc.Raynham, MA, United StatesManufacturer7October 22, 2025000api.fda.gov
Globus Medical, Inc.Audubon, PA, United StatesManufacturer7August 26, 2014010api.fda.gov
Bioventus LLCDurham, NC, United StatesRepackager or relabeler, Specification developer6June 18, 2020000api.fda.gov
Highridge Medical, LLCWestminster, CO, United StatesSpecification developer6April 2, 2009000api.fda.gov
Synthes (USA) Products LLCWest Chester, PA, United StatesComplaint file establishment, Specification developer6January 27, 2011030api.fda.gov
Biocomposites Ltd.Keele Staffordshire, United KingdomManufacturer5February 4, 2022010api.fda.gov
Biogennix, LLCIrvine, CA, United StatesManufacturer5March 30, 2020000api.fda.gov
Collagen Matrix, Inc.Oakland, NJ, United StatesContract manufacturer, Specification developer5March 12, 2024000api.fda.gov
Collagen Matrix, IncAllendale, NJ, United StatesContract manufacturer, Manufacturer5March 12, 2024000api.fda.gov
DSM Biomedical, Inc.Exton, PA, United StatesContract manufacturer, Manufacturer5March 21, 2023000api.fda.gov
Formosa Biomedical Technology CorporationTaipei, TaiwanManufacturer5February 5, 2013000api.fda.gov
Globus Medical, Inc.Memphis, TN, United StatesManufacturer5October 8, 2015000api.fda.gov
Nuvasive, Inc.Guaynabo, PR, United StatesManufacturer5March 20, 2024000api.fda.gov
Surgentec LLCBoca Raton, FL, United StatesManufacturer5July 2, 2025000api.fda.gov
Synthes GMBHZuchwil Solothurn, SwitzerlandSpecification developer5January 27, 2011000api.fda.gov
Xtant Medical Holdings, Inc.Belgrade, MT, United StatesManufacturer, Repackager or relabeler5August 18, 2015010api.fda.gov
ZavationFlowood, MS, United StatesComplaint file establishment, Manufacturer, Repackager or relabeler, Specification developer5January 18, 2023000api.fda.gov
Arthrex, Inc.Naples, FL, United StatesSpecification developer4January 10, 2011000api.fda.gov
Arteriocyte Medical Systems, Inc.Hopkinton, MA, United StatesManufacturer4September 26, 2011000api.fda.gov
RTI Surgical, Inc. (dba RTI Biologics, Inc.)Alachua, FL, United StatesManufacturer4October 24, 2007050api.fda.gov
Synergy BiomedicalWayne, PA, United StatesComplaint file establishment, Specification developer4September 12, 2018000api.fda.gov
Biomet, Inc.Warsaw, IN, United StatesManufacturer3June 10, 2019000api.fda.gov
Curasan AGKLEINOSTHEIM Bavaria, GermanySpecification developer3September 17, 2018000api.fda.gov
Curasan AG, Frankfurt FacilityFRANKFURT Hesse, GermanyManufacturer3September 17, 2018000api.fda.gov
Geistlich Pharma AGWOLHUSEN Luzern, SwitzerlandComplaint file establishment, Manufacturer3June 2, 2026000api.fda.gov
Hans Biomed Corp.Daejeon, South KoreaManufacturer3February 22, 2018000api.fda.gov
Medtronic Sofamor Danek Deggendorf GMBHDEGGENDORF Bavaria, GermanyManufacturer3April 19, 2013000api.fda.gov
Musculoskeletal Transplant Foundation d/b/a/ MTF BiologicsOlyphant, PA, United StatesManufacturer3September 28, 2009000api.fda.gov
Musculoskeletal Transplant Foundation d/b/a/ MTF BiologicsEdison, NJ, United StatesManufacturer3September 28, 2009040api.fda.gov
Musculoskeletal Transplant Foundation d/b/a/ MTF BiologicsJessup, PA, United StatesManufacturer3September 28, 2009000api.fda.gov
NorakerLYON Auvergne-Rhone-Alpes, FranceManufacturer3December 23, 2024000api.fda.gov
Orthorebirth Co., Ltd.Yokohama Kanagawa, JapanExporter to the US, Specification developer3March 4, 2024010api.fda.gov
Secada Medical, LLC D.B.A Ventris MedicalNewport Beach, CA, United StatesComplaint file establishment, Specification developer3March 21, 2025000api.fda.gov
Acro Biomedical Co., Ltd.Kaohsiung, TaiwanManufacturer2October 8, 2021000api.fda.gov
Agnovos Healthcare Usa, LLCRockville, MD, United StatesComplaint file establishment, Manufacturer2July 20, 2018000api.fda.gov
AllosourceCentennial, CO, United StatesContract manufacturer, Manufacturer2January 10, 2011010api.fda.gov
Amend Surgical, Inc.Alachua, FL, United StatesManufacturer2February 16, 2017000api.fda.gov
Arthrex Manufacturing Inc.Pendleton, SC, United StatesContract manufacturer, Manufacturer2January 10, 2011000api.fda.gov
Bonalive LtdTurku Varsinais-Suomi, FinlandManufacturer2July 11, 2023000api.fda.gov
Biocomposites GmbH (former ARTOSS GmbH)Rostock Mecklenburg-Western Pomerania, GermanyManufacturer2April 7, 2025000api.fda.gov
Dimensional Bioceramics, LLCScotts Valley, CA, United StatesManufacturer, Specification developer2April 22, 2020000api.fda.gov
Elute, Inc.Salt Lake City, UT, United StatesSpecification developer2February 26, 2025000api.fda.gov
ETEX CorporationBraintree, MA, United StatesSpecification developer2June 10, 2019000api.fda.gov
Exactech, Inc.Gainesville, FL, United StatesManufacturer2November 27, 2012010api.fda.gov
Inion OYTAMPERE Pirkanmaa, FinlandContract manufacturer, Manufacturer2July 31, 2019000api.fda.gov
LDR MedicalSainte-Savine Aube, FranceSpecification developer2December 15, 2006000api.fda.gov
Medtronic Puerto Rico Operations Co., HumacaoHumacao, PR, United StatesManufacturer2February 9, 2009000api.fda.gov
OssdsignUppsala, SwedenSpecification developer2September 15, 2023000api.fda.gov
Osteonovus, Inc.Toledo, OH, United StatesManufacturer2April 6, 2018000api.fda.gov
Osteotech, Inc.Eatontown, NJ, United StatesManufacturer2October 16, 2008000api.fda.gov
Science & Bio Materials, S.B.M. SASLOURDES Hautes-Pyrenees, FranceComplaint file establishment, Manufacturer2July 3, 2007010api.fda.gov
SYNTHES GMBH / Synthes Produktions GmbHOberdorf, Baselland Basel-Landschaft, SwitzerlandManufacturer2January 7, 2005000api.fda.gov
Teknimed SASL Union Haute-Garonne, FranceComplaint file establishment, Manufacturer2May 3, 2004010api.fda.gov
Xenco Medical LLCSan Diego, CA, United StatesComplaint file establishment, Manufacturer, Specification developer2September 13, 2018000api.fda.gov
Acuitive TechnologiesAllendale, NJ, United StatesManufacturer1November 6, 2024000api.fda.gov
Anika Therapeutics, Inc.Bedford, MA, United StatesManufacturer1December 26, 2017000api.fda.gov
Austin Medical Ventures, Inc.Germantown, TN, United StatesSpecification developer1October 30, 2003000api.fda.gov
Advanced Medical Solutions (Nantes) SASVIGNEUX DE BRETAGNE Loire-Atlantique, FranceManufacturer1January 20, 2006000api.fda.gov
Allgens Medical Technology Co.,Ltd.Beijing, ChinaComplaint file establishment, Manufacturer1July 9, 2015000api.fda.gov
ArthroCare CorporationAustin, TX, United StatesSpecification developer1April 22, 2010000api.fda.gov
Biomendex OYTampere Pirkanmaa, FinlandManufacturer1February 17, 2026000api.fda.gov
Biomet MicrofixationJacksonville, FL, United StatesComplaint file establishment, Specification developer1April 2, 2009000api.fda.gov
Biostone Co. Ltd.Nottingham Nottinghamshire, United KingdomManufacturer1April 21, 2021000api.fda.gov
Bone Solutions, Inc.Colleyville, TX, United StatesManufacturer1October 13, 2025000api.fda.gov
Bone Support ABLUND Skane, SwedenComplaint file establishment, Manufacturer1October 16, 2020000api.fda.gov
Cytophil, IncEast Troy, WI, United StatesContract manufacturer, Manufacturer1December 27, 2010000api.fda.gov
Depuy CMWBlackpool, Lancashire, United KingdomSpecification developer1March 8, 2002000api.fda.gov
Heraeus Medical LLC - BioresobablesYardley, PA, United StatesSpecification developer1May 16, 2025000api.fda.gov
Medos International SarlLe Locle Neuchatel, SwitzerlandSpecification developer1September 3, 2008000api.fda.gov
Molecular MatrixCarlsbad, CA, United StatesComplaint file establishment, Manufacturer, Repackager or relabeler1December 29, 2017000api.fda.gov
Oriental Resources Development LimitedHukou Township Hsinchu(County), TaiwanManufacturer1February 17, 2015000api.fda.gov
OsteomedAddison, TX, United StatesManufacturer1May 21, 2009010api.fda.gov
OSferionBiomaterials Corp. Mishima FactorySunto-gun Shizuoka, JapanManufacturer1May 2, 2008000api.fda.gov
Revogen BiologicsSan Antonio, TX, United StatesSpecification developer1April 6, 2018000api.fda.gov
Riverside Medical Packaging Company LtdDerby Derbyshire, United KingdomContract manufacturer, Repackager or relabeler1April 21, 2021000api.fda.gov
Signus Medizintechnik GMBHALZENAU Bavaria, GermanyComplaint file establishment, Exporter to the US, Manufacturer, Specification developer1September 28, 2009000api.fda.gov
SpineSmith Holdings, LLCAustin, TX, United StatesComplaint file establishment, Manufacturer, Specification developer1May 21, 2014000api.fda.gov
Synthes GMBHSelzach Solothurn, SwitzerlandManufacturer1November 26, 2002000api.fda.gov
Warsaw Orthopedic, Inc.Warsaw, IN, United StatesManufacturer1December 16, 2005000api.fda.gov
Wiltrom Corporation LimitedZhubei City Hsinchu(County), TaiwanComplaint file establishment, Manufacturer1February 2, 2018000api.fda.gov
ARCH Medical Solutions - MemphisBartlett, TN, United StatesContract manufacturer0000api.fda.gov
ARCH Medical Solutions - MemphisLexington, TN, United StatesContract manufacturer0000api.fda.gov
ARCH Medical Solutions - SeabrookSeabrook, NH, United StatesContract manufacturer0000api.fda.gov
Arctic Biomaterials OYTampere Pirkanmaa, FinlandContract manufacturer0000api.fda.gov
Argon Medical Devices, Inc.Wheeling, IL, United StatesContract manufacturer0000api.fda.gov
Aptyx - CharlotteCharlotte, NC, United StatesContract manufacturer0000api.fda.gov
Arthrex, Inc.Ave Maria, FL, United StatesContract manufacturer, Contract sterilizer0000api.fda.gov
BBF Sterilisationsservice GMBHKernen Baden-Wurttemberg, GermanyContract manufacturer, Contract sterilizer0000api.fda.gov
Bioplate, Inc.Placentia, CA, United StatesContract manufacturer0000api.fda.gov
BiosealPlacentia, CA, United StatesContract manufacturer0000api.fda.gov
Cam BioceramicsLEIDEN Zuid-Holland, NetherlandsContract manufacturer0000api.fda.gov
Citra Labs LLCBraintree, MA, United StatesContract manufacturer0000api.fda.gov
Eptam West LLCColorado Springs, CO, United StatesContract manufacturer0000api.fda.gov
Eurofins STERIPAC GMBHCalw-Altburg Baden-Wurttemberg, GermanyContract manufacturer0000api.fda.gov
Friedrich Daniels GMBHSOLINGEN North Rhine-Westphalia, GermanyContract manufacturer0000api.fda.gov
G-5 Florida LLCJax, FL, United StatesContract manufacturer0000api.fda.gov
HCM MedicalNijmegen Gelderland, NetherlandsContract manufacturer0000api.fda.gov
Howmedica International S. De R.L.LIMERICK Munster, IrelandContract manufacturer0000api.fda.gov
Himed, LLCOld Bethpage, NY, United StatesContract manufacturer0000api.fda.gov
Instru-Med TechnologiesWarsaw, IN, United StatesContract manufacturer0000api.fda.gov
Ipax, Inc.Englewood, CO, United StatesContract manufacturer0000api.fda.gov
J & J Precision Technologies, LLCLititz, PA, United StatesContract manufacturer0000api.fda.gov
Kaigen Pharma Co., Ltd. Tenjin FactoryOtaru-shi Hokkaido, JapanContract manufacturer0000api.fda.gov
Life Science Outsourcing, Inc.Brea, CA, United StatesContract manufacturer0000api.fda.gov
Lifenet HealthVirginia Beach, VA, United StatesManufacturer0000api.fda.gov
Lyophilization Services Of New England, Inc.Manchester, NH, United StatesContract manufacturer0000api.fda.gov
LifeNet HealthVirginia Bch, VA, United StatesManufacturer0000api.fda.gov
LifeNet HealthPlainfield, IN, United StatesManufacturer0000api.fda.gov
LifeNet Health NorthwestRenton, WA, United StatesManufacturer0000api.fda.gov
Maxigen Biotech, Inc.Taoyuan City, TaiwanContract manufacturer0000api.fda.gov
Millstone Medical Outsourcing LLC.Fall River, MA, United StatesContract manufacturer0000api.fda.gov
MedSkin Solutions Dr. Suwelack AGBILLERBECK North Rhine-Westphalia, GermanyContract manufacturer0000api.fda.gov
Millstone Medical Outsourcing LLCOlive Branch, MS, United StatesContract manufacturer0000api.fda.gov
Millstone Medical Testing - CT, LLCWillington, CT, United StatesContract manufacturer0000api.fda.gov
NML Medical, LLCWest Carrollton, OH, United StatesContract manufacturer0000api.fda.gov
Nelipak Healthcare PackagingCLARA, Offaly, IrelandContract manufacturer0000api.fda.gov
Nissha Precision and Technologies, Inc.Kyoto, JapanContract manufacturer0000api.fda.gov
Nolato Stargard Sp. z o.o.Stargard Zachodniopomorskie, PolandContract manufacturer0000api.fda.gov
Olive Branch Distribution CenterOlive Branch, MS, United StatesContract manufacturer0000api.fda.gov
PDV MedTechMorgan Hill, CA, United StatesContract manufacturer0000api.fda.gov
Poly-Med, Inc.Anderson, SC, United StatesContract manufacturer0000api.fda.gov
Quality Bioresources, IncSeguin, TX, United StatesContract manufacturer0000api.fda.gov
Quality Tech Services, LLCBloomington, MN, United StatesContract manufacturer0000api.fda.gov
Remington Medical, Inc.Alpharetta, GA, United StatesContract manufacturer0000api.fda.gov
Roechling Medical Lancaster, LLCDenver, PA, United StatesContract manufacturer0000api.fda.gov
Straits Orthopaedics (MFG) Sdn BhdSimpang Ampat Pulau Pinang, MalaysiaContract manufacturer0000api.fda.gov
Straits Orthopaedics (MFG) Sdn BhdPerai Pulau Pinang, MalaysiaContract manufacturer0000api.fda.gov
Straits Orthopaedics (MFG) Sdn BhdBandar Cassia Pulau Pinang, MalaysiaContract manufacturer0000api.fda.gov
Syntec Scientific Corp.CHANG HUA Changhua, TaiwanContract manufacturer0000api.fda.gov
The E F PRECISION GROUPWillow Grove, PA, United StatesContract manufacturer0000api.fda.gov
Tissue Transplant Technology, Ltd. d/b/a Bone Bank AllograftsSan Antonio, TX, United StatesContract manufacturer0000api.fda.gov
WHK Biosystems, LLCClearwater, FL, United StatesContract manufacturer0000api.fda.gov

Updated September 11, 2026. Read from openFDA bulk downloads (device registration and listing, 510(k), PMA, recall and enforcement files). CC0 1.0, public domain (openFDA terms of service). The files are joined on FDA identifiers: the 510(k) and PMA numbers a registration lists, and the recalling firm's FEI for recalls. Recall class comes from the FDA enforcement report. The FDA states that openFDA data is unvalidated and is not for decisions about medical care. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.