Data / Federal grants / DE-FOA-0003612
The Genesis Mission: Transforming Science and Energy with AI
Office of Science (Department of Energy - Office of Science) is accepting applications until December 17, 2026. It lists awards of up to $16 million, $293.8 million in total. Cost sharing is required.
SpecStream is the live web data engine for teams and agents. It reads every open and forecast federal opportunity on Grants.gov each morning, and this page is that reading. Describe your organization once and the grants that fit arrive in your sheet, CRM, Slack or agent as they are posted.
Key facts
- Opportunity number
- DE-FOA-0003612
- Status
- Posted, open
- Posted
- March 17, 2026
- Closes
- December 17, 2026
- Award ceiling
- $16,000,000
- Award floor
- $500,000
- Total funding
- $293,760,000
- Cost sharing
- Required
- Funding instrument
- Other
- Category
- Science and Technology and other Research and Development
- Assistance listing
- 81.049 Office of Science Financial Assistance Program
- Contact
- Michael S Zarkin Grants Management Specialist · [email protected] · 301-903-4946
Who can apply
- Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"
What the agency says
The DOE Office of Science (SC), Office of Critical Minerals and Energy Innovation (CMEI), Office of Environmental Management (EM), Office of Nuclear Energy (NE), Office of Electricity (OE), and Hydrocarbons and Geothermal Office (HGEO) hereby announce interest in receiving applications from interdisciplinary teams addressing the Genesis Mission National Science and Technology Challenges to accelerate scientific discovery and research and development (R&D) workflows using novel artificial intelligence (AI) models and frameworks. By achieving AI advantage, these teams will advance the DOE's mission and ensure America’s security and prosperity by addressing energy, environmental, and nuclear challenges through science and technology. Teams are encouraged to leverage the extensive scientific and data resources of the DOE/National Nuclear Security Administration (NNSA), the National Laboratories, U.S. industry, and academia. The resulting AI models and workflows, if successful, may be integrated into the American Science Cloud.
DOE is soliciting new FY26 Phase I small team and Phase II large team applications in the following topic areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy (see specific focus areas in Section III Program Descriptions).
In addition, this RFA will remain available to allow the recipients of FY26 Phase I awards to apply for larger team Phase II awards. In a few weeks, DOE plans to amend the RFA to clarify the LOI and application guidelines for FY26 Phase II awards. In FY27, DOE plans to amend the RFA or to issue an alternative funding opportunity to update the topic and focus areas to allow a second competition of Phase I small team applications and Phase II large team applications.
Other open grants from the Department of Energy - Office of Science
| Opportunity | Status | Closes | Award ceiling | Total funding | Record |
|---|---|---|---|---|---|
| Genesis Mission Graduate Fellowship Pilot DE-FOA-0003673 | Open | Jan 12, 2027 | $20,000,000 | $100,000,000 | grants.gov |
| FY 2027 Continuation of Solicitation for the Office of Science Financial Assistance Program DE-FOA-0003665 | Open | Sep 30, 2027 | $10,000,000 | $400,000,000 | grants.gov |
All grants open to Anyone (unrestricted) · Everything closing in December 2026
Read from the Grants.gov API, last updated 2026-10-23. The agency's notice on Grants.gov is the official record; check it before you apply.