Data / Federal rules / 2025-16720
Procedures for Transportation Workplace Drug and Alcohol Testing Programs: Addition of Fentanyl to the Department of Transportation's Drug-Testing Panel; Harmonization With Certain Items in the HHS Mandatory Guidelines for Urine and Oral Fluid; and Technical Amendments
The Transportation Department published this proposed rule in the Federal Register on September 2, 2025. Comments closed on October 17, 2025.
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What the agency says
The U.S. Department of Transportation (Department or DOT) proposes to amend its drug-testing program regulation, 49 CFR part 40 (part 40), to add fentanyl (a synthetic opioid) and norfentanyl (a metabolite of fentanyl) to its drug testing panels. The proposed rulemaking would harmonize part 40 with the U.S. Department of Health and Human Services (HHS) Mandatory Guidelines for Federal Workplace Drug Testing Programs (Mandatory Guidelines), which DOT must follow for the minimum list of drugs for which DOT requires testing, and the comprehensive standards for laboratory drug testing per the Omnibus Employee Testing Act of 1991. Adding fentanyl and norfentanyl is also in the interest of transportation safety, given compelling information regarding the number of overdose deaths in the United States involving fentanyl. The Department also proposes to amend certain provisions of part 40 to harmonize, as appropriate, with the current HHS Mandatory Guidelines using urine (UrMG) and oral fluid (OFMG). This NPRM also proposes to clarify certain existing part 40 drug testing program provisions and to make technical amendments.
Key facts
- Document number
- 2025-16720
- Type
- Proposed rule
- Action
- Notice of proposed rulemaking (NPRM)
- Agency
- Transportation Department
- Published
- September 2, 2025
- Comments due
- October 17, 2025
- Dates
- Comments to this notice of proposed rulemaking should be submitted by October 17, 2025. Late-filed comments will be considered to the extent possible.
- Docket
- Docket DOT-OST-2025-0049
- Regulation ID (RIN)
- 2105-AF26
- Code of Federal Regulations
- 49 CFR 40
- Topics
- Administrative practice and procedure; Alcohol abuse; Drug abuse; Drug testing; Laboratories; Reporting and recordkeeping requirements; Safety; Transportation
- Pages
- 19
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Everything from the Transportation Department · Rules on administrative practice and procedure · Rules on alcohol abuse · Rules on drug abuse · Published in September 2025
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