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Data / Drug companies / Sigma-1 Agonist

Sigma-1 Agonist drugs: 146 drugs from 231 companies in the FDA NDC directory

Sigma-1 Agonist is an FDA established pharmacologic class. The FDA National Drug Code Directory lists 1,997 products in this class from 231 companies, covering 146 drugs by generic name. The main marketing category is over the counter monograph drugs, and the newest product started marketing on October 27, 2026.

SpecStream is the live web data engine for teams and agents. It reads the National Drug Code Directory that FDA publishes, and this page is that reading. Ask for the companies that make a drug, a class or a dosage form, with their headquarters, website and size added from the web, and new listings and discontinued products arrive in your sheet, CRM, Slack or agent as FDA posts them.

  • 231Companies
  • 1,997Products
  • 146Drugs by generic name

Drugs in the Sigma-1 Agonist class

Ranked by number of companies that list the drug.

DrugProducts hereCompanies listing it
Acetaminophen3214
Benzocaine5110
Dextromethorphan hbr, guaifenesin13867
Dextromethorphan hydrobromide, guaifenesin8649
Acetaminophen, dextromethorphan hbr, phenylephrine hcl7945
Acetaminophen, dextromethorphan hbr, doxylamine succinate8340
Dextromethorphan hbr, guaifenesin, phenylephrine hcl4428
Dextromethorphan polistirex6427
Guaifenesin and dextromethorphan hbr5126
Guaifenesin, dextromethorphan hbr3626
Dextromethorphan hbr3422
Acetaminophen, dextromethorphan hydrobromide3720
Acetaminophen, dextromethorphan hbr3420
Chlorpheniramine maleate, dextromethorphan hbr1919
Dextromethorphan hydrobromide / guaifenesin1918
Brompheniramine maleate, dextromethorphan hydrobromide1818
Dextromethorphan hydrobromide2817
Dextromethorphan hbr and guaifenesin2017
Dextromethorphan hydrobromide and guaifenesin3416
Guaifenesin and dextromethorphan hydrobromide2013
Dextromethorphan hbr, doxylamine succinate1812
Promethazine hydrochloride and dextromethorphan hydrobromide1412
Dextromethorphan hydrobromide, doxylamine succinate119
Acetaminophen, dextromethorphan hbr, triprolidine hcl98
Acetaminophen, dextromethorphan hydrobromide, guaifenesin87
Acetaminophen and dextromethorphan hydrobromide96
Acetaminohpen, dextromethorphan hbr, phenylephrine hcl76
Dextromethorphan85
Acetaminophen dextromethorphan hbr phenylephrine hcl75
Acetaminophen, dextromethorphan hbr and doxylamine succinate55
Acetaminophen, doxylamine succinate, dextromethorphan hbr55
Dextromethorphan, guaifenesin55
Acetaminophen dextromethorphan hbr doxylamine succinate84
Guaifenesin and dextromethorphan84
Dextromethorphan hydrobromide and quinidine sulfate44
Acetaminophen, dextromethorphan, phenylephrine43
Brompheniramine maleate, dextromethorphan hbr43
Dextromethorphan hbr guaifenesin phenylephrine hcl43
Acetaminophen, dextromethorphan hbr, guaifenesin33
Chlorpheniramine maleate and dextromethorphan hydrobromide33
Chlorpheniramine maleate, dextrometrorphan hbr33
Dextromethorphan hbr, guaifensin33
Mucus relief dm33
Acetaminophen, dextromethorphan hydrobromide tablet, coated42
Acetaminophen, dextromethorphan, doxylamine succinate32
Dextromethorphan hbr. and guaifenesin32
Acetaminophen dextromethorphan hbr22
Acetaminophen, dextromethorphan22
Acetaminophen, dextromethorphan hbr, phenylephrine hcl ,22
Chlorpheniramine maleate, dextromethorphan hydrobromide22
Chlorpheniramine maleate, dextromethorphan hydrochloride22
Dextromethorphan hbr 20mg guaifenesin 400mg22
Dextromethorphan hbr doxylamine succinate22
Dextromethorphan hbr guaifenesin22
Dextromethorphan hbr, guaifenesin, and phenylephrine hcl22
Dextromethorphan hbr, guaifenesin, phenylephrine22
Dextromethorphan hbr, guaifenesin, phenylephrine hci22
Dextromethorphan hbr, phenylephrine hcl22
Dextromethorphan hydrobromide and quinidine sulphate22
Dextromethorphan hydrobromide guaifenesin22
Guaifenesin 400mg and dextromethorphan hbr 20mg22
Guaifensin, dextromethorphan22
Dextromethorphan hbr and pyrilamine maleate31
Dextromethorphan, guiafenesin, pseudoephedrine hcl31
Acetaminophen, dextromethrophan hbr, doxylamine succinate21
Dextromethorphan hbr,guaifenesin,pseudoephedrine hcl21
Dextromethorphan hbr-gyaifenesin21
Dextromethorphan hbr-pyrilamine maleate21
Dextromethorphan hydrobromide, and guaifenesin21
Dextromethorphan hydrobromide, bupropion hydrochloride21
Dextromethorphan hydrobromide, menthol21
Dextromethorphan, guaifenesin, and phenylephrine21
Guaifenesin syrup and dextromethorphan21
Guaifenesin, dextromethorphan21
Guaifenesin, phenylephrine hcl,dextromethorphan hydrobromide21
Menthol and benzocaine and dextromethorphan hydrobromide21
Aacetaminophen, dextromethorphan hbr and guaifenesi11
Acetaminohpen, dextromethorphan hydrobromide11
Acetaminophen, dextromethorphan hbr ,guaifenesin11
Acetaminophen, dextromethorphan hbr and phenylephrine hcl11
Acetaminophen, dextromethorphan hbr, phenylephrine11
Acetaminophen, dextromethorphan hbr, phenylephrine hci11
Acetaminophen, dextromethorphan hbr, pseudoephedrine hcl11
Acetaminophen, dextromethorphan hydrobromide liquid11
Acetaminophen, dextromethorphan, phenylephrine hcl11
Acetaminophen, dextromethrophan hbr, phenylephrine hcl11
Acetaminophen, doxylamine succinate and dextromethorphan hbr11
Acetaminophen, phenylephrine, dextromethorphan11
Acetaminophen,dextromethorphan,doxylamine11
Acetaminophen,dextromethrophan hbr11
Acetaminophen,dextromethrophan hbr,doxylamine succinate11
Acetaminophine dextromethorphan hbr phenylphrine hcl11
Acetaminphen11
Alka-seltzer plus severe cough mucus and congestion11
Benzocaine and dextromethorphan hbr11
Benzocaine and dextromethorphan hydrobromide11
Brompheniramine maleate, dextromethorphan, phenylephrine hcl11
Brompheniramine maleate, pseudoephedrine hydrochloride,11
Brompheniramine, pseudoephedrine, dextromethorphan11
Children cough and chest congestion11

Companies with the most products in this class

CompanyProductsMain dosage formsMain marketing categoryNewest product started
Walgreen Company98liquid; solutionOver the counter monograph drugsApril 30, 2026
CVS Woonsocket Prescription Center, Incorporated77solution; liquidOver the counter monograph drugsJuly 14, 2026
Dolgencorp, Inc. (dollar General & Rexall)46solution; liquidOver the counter monograph drugsJuly 1, 2026
Lil' Drug Store Products, Inc.44tablet, coated; tablet, film coatedOver the counter monograph drugsJuly 3, 2025
Bayer HealthCare LLC.41capsule, liquid filled; tablet, effervescentOver the counter monograph drugsJune 1, 2026
Reckitt Benckiser LLC41solution; tablet, film coatedOver the counter monograph drugsJanuary 27, 2022
Amazon.com Services LLC39solution; suspensionOver the counter monograph drugsOctober 16, 2026
CVS Pharmacy37solution; liquidOver the counter monograph drugsJuly 12, 2022
Opmx LLC37capsule, liquid filled; syrupOver the counter monograph drugsSeptember 7, 2026
Haleon US Holdings LLC36solution; liquidOver the counter monograph drugsJune 19, 2024
Chain Drug Marketing Association, Inc.35liquid; capsule, liquid filledOver the counter monograph drugsSeptember 9, 2026
Cardinal Health 110, LLC. DBA Leader34solution; tablet, film coatedOver the counter monograph drugsJuly 1, 2026
Reckitt Benckiser LLC34capsule, liquid filled; solutionOver the counter monograph drugsJuly 1, 2026
Safeway34liquid; solutionOver the counter monograph drugsSeptember 30, 2026
The Procter & Gamble Manufacturing Company32liquid; capsule, liquid filledOver the counter monograph drugsJuly 9, 2024
Wal-Mart Stores Inc32liquid; solutionOver the counter monograph drugsJuly 16, 2020
Topco Associates LLC31tablet, coated; solutionOver the counter monograph drugsDecember 8, 2022
H E B29solution; capsule, liquid filledOver the counter monograph drugsApril 30, 2023
Topco Associates LLC27solution; capsule, liquid filledOver the counter monograph drugsAugust 4, 2026
Rite Aid Corporation26tablet, film coated; solutionOver the counter monograph drugsJune 30, 2023
United Natural Foods, Inc. DBA Unfi26solution; capsule, liquid filledOver the counter monograph drugsOctober 2, 2025
HyVee Inc25solution; capsule, liquid filledOver the counter monograph drugsAugust 20, 2026
Pharmadel LLC25liquid; capsule, liquid filledOver the counter monograph drugsJuly 1, 2026
Target Corporation24liquid; capsule, liquid filledOver the counter monograph drugsOctober 7, 2026
Valu Merchandisers Company24liquid; tablet, coatedOver the counter monograph drugsJanuary 1, 2025
Family Dollar (family Wellness)23liquid; solutionOver the counter monograph drugsNovember 1, 2025
L. Perrigo Company23solution; tablet, extended releaseOver the counter monograph drugsJune 19, 2026
Meijer Distribution Inc23solution; tablet, film coatedOver the counter monograph drugsJune 2, 2020
Meijer, Inc.23solution; tablet, film coatedOver the counter monograph drugsAugust 28, 2026
Kramer Novis22syrup; solutionOver the counter monograph drugsOctober 6, 2026
Walmart Inc.22solution; tablet, film coatedOver the counter monograph drugsJuly 8, 2026
Haleon US Holdings LLC21powder, for solution; syrupOver the counter monograph drugsJune 19, 2024
Kroger Company21solution; tablet, extended releaseOver the counter monograph drugsFebruary 16, 2026
WinCo Foods, LLC21liquid; capsule, liquid filledOver the counter monograph drugsJune 22, 2026
Amerisource Bergen20solution; tablet, extended releaseOver the counter monograph drugsMay 4, 2026
Chain Drug Marketing Association19liquid; tablet, coatedOver the counter monograph drugsAugust 3, 2022
Discount Drug Mart19liquid; tablet, coatedOver the counter monograph drugsNovember 8, 2023
Gil Pharmaceutical Corp19solution; tabletOver the counter monograph drugsOctober 1, 2026
Kenvue Brands LLC19tablet, film coated; suspensionOver the counter monograph drugsJune 18, 2026
Strategic Sourcing Services LLC18solution; tablet, film coatedOver the counter monograph drugsJanuary 18, 2026
The Procter & Gamble Manufacturing Company18liquid; capsule, liquid filledOver the counter monograph drugsAugust 17, 2026
Kroger Company17liquid; capsule, liquid filledOver the counter monograph drugsApril 30, 2026
AptaPharma Inc.16liquid; capsule, liquid filledOver the counter monograph drugsJanuary 1, 2026
A-S Medication Solutions15tablet, extended release; solutionGeneric drugs (ANDA)April 16, 2025
Dextrum Laboratories, Inc15solution; liquidOver the counter monograph drugsOctober 1, 2023
Genomma Lab USA15syrup; liquidOver the counter monograph drugsJuly 30, 2026
Raritan Pharmaceuticals Inc15solution; liquidOver the counter monograph drugsJune 1, 2026
Softgel Healthcare Pvt Ltd14capsule, liquid filledOver the counter monograph drugsJune 6, 2026
American Sales Company13solution; tablet, coatedOver the counter monograph drugsOctober 22, 2018
Humanwell PuraCap Pharmaceutical (Wuhan), Ltd.13capsule, liquid filledOver the counter monograph drugsDecember 28, 2025
Llorens Pharmaceutical International Division, Inc.13liquid; solution/ dropsOver the counter monograph drugsDecember 1, 2025
Major Pharmaceuticals13solution; capsule, liquid filledOver the counter monograph drugsMarch 10, 2025
Menper Distributors, Inc.13liquid; solutionOver the counter monograph drugsMay 1, 2025
Retail Business Services, LLC13capsule, liquid filled; tablet, coatedOver the counter monograph drugsJuly 16, 2025
Aurohealth LLC12tablet, extended release; suspension, extended releaseGeneric drugs (ANDA)April 17, 2026
Publix Super Markets Inc12solution; tablet, coatedOver the counter monograph drugsJuly 28, 2025
Shield Pharmaceuticals Corp11capsule, liquid filledOver the counter monograph drugsSeptember 2, 2026
Efficient Laboratories Inc10liquidOver the counter monograph drugsApril 1, 2026
Laboratorio Magnachem International SRL10syrup; tablet, coatedOver the counter monograph drugsApril 21, 2025
Army and Air Force Exchange Service9tablet, film coated; capsule, liquid filledOver the counter monograph drugsJanuary 1, 2025
CVS Pharmacy9solution; suspensionOver the counter monograph drugsJuly 20, 2015
P & L Development, LLC9liquidOver the counter monograph drugsJuly 31, 2024
Sportpharm LLC9tablet, extended release; tablet, film coatedGeneric drugs (ANDA)March 7, 2026
Demoulas Super Markets, Inc8liquid; solutionOver the counter monograph drugsJanuary 1, 2026
Harris Teeter8tablet, coated; tablet, extended releaseOver the counter monograph drugsAugust 16, 2024
Harris Teeter, LLC8liquid; capsule, liquid filledOver the counter monograph drugsMay 28, 2021
Poly Pharmaceuticals, Inc.8liquid; tabletOver the counter monograph drugsApril 23, 2026
Rugby Laboratories8tablet, extended release; capsule, liquid filledOver the counter monograph drugsMay 8, 2026
The Procter & Gamble Manufacturing Company8solution; capsule, liquid filledOver the counter monograph drugsMarch 23, 2020
Vivunt Pharma LLC8liquid; capsule, liquid filledOver the counter monograph drugsMay 14, 2024
Actipharma, LLC7solution; liquidOver the counter monograph drugsFebruary 12, 2026
Advanced Rx LLC7capsule, liquid filled; capsule, gelatin coatedOver the counter monograph drugsJanuary 1, 2025
Allegiant Health7tablet; capsuleOver the counter monograph drugsJanuary 9, 2026
Genexa Inc.7suspension; solutionOver the counter monograph drugsAugust 20, 2026
L.N.K. International, Inc.7tablet, film coated; solutionOver the counter monograph drugsAugust 7, 2023
Nuvicare LLC7capsule, liquid filled; tabletOver the counter monograph drugsJune 17, 2026
Unifirst First Aid Corporation7tablet, film coated; tabletOver the counter monograph drugsMay 1, 2023
Chain Drug Consortium, LLC6capsule; solutionOver the counter monograph drugsNovember 29, 2019
Geri-Care Pharmaceuticals, Corp6liquidOver the counter monograph drugsDecember 1, 2025
Grocery Outlet, Inc.6liquid; capsuleOver the counter monograph drugsMarch 25, 2026
Guardian Drug Company6liquidOver the counter monograph drugsDecember 1, 2012
Preferred Pharmaceuticals Inc.6solutionOver the counter monograph drugsMarch 18, 2026
PuraCap Pharmaceutical LLC6capsule, liquid filledOver the counter monograph drugsMarch 12, 2025
Rnv LLC6liquidOver the counter monograph drugsSeptember 1, 2025
Salado Sales, Inc.6liquid; capsule, liquid filledOver the counter monograph drugsDecember 23, 2025
Sato Pharmaceutical Co., Ltd.6tablet; syrupOver the counter monograph drugsNovember 24, 2004
Select Consumer Group6tablet, coated; tablet, extended releaseOver the counter monograph drugsJune 1, 2025
Amneal Pharmaceuticals LLC5suspension; tablet, extended releaseGeneric drugs (ANDA)November 1, 2018
Atlantic Biologicals Corp.5tablet, extended release; liquidGeneric drugs (ANDA)April 7, 2025
Bi-Mart5liquid; capsule, liquid filledOver the counter monograph drugsJune 1, 2025
Cabinet Health P.B.C.5capsule, liquid filled; capsule, gelatin coatedOver the counter monograph drugsOctober 5, 2026
Capital Pharmaceutical, LLC5tablet; liquidOver the counter monograph drugsJune 11, 2025
DXM Pharmacuetical, Inc.5tablet; liquidOver the counter monograph drugsSeptember 10, 2024
H E B5solutionOver the counter monograph drugsNovember 4, 2025
Kramer Laboratories5liquid; tabletOver the counter monograph drugsMay 17, 2024
Perrigo Direct, Inc5tablet, film coated; liquidOver the counter monograph drugsNovember 5, 2024
Target Corporation5liquid; suspensionOver the counter monograph drugsMay 16, 2025
Advanced Generic Corporation4liquidOver the counter monograph drugsDecember 1, 2024
Amerisource Bergen4solution; capsule, liquid filledOver the counter monograph drugsAugust 2, 2012
Bayer HealthCare LLC.4tablet; tablet, film coatedOver the counter monograph drugsOctober 23, 2020

Dosage forms

Dosage formProductsShare
Solution45822.9%
Liquid45022.5%
Capsule, liquid filled31115.6%
Tablet, film coated1417.1%
Syrup1145.7%
Tablet, extended release1115.6%
Tablet, coated964.8%
Tablet944.7%
Suspension643.2%
Powder, for solution321.6%
Suspension, extended release281.4%
Tablet, effervescent241.2%

Updated November 6, 2026. Read from US Food and Drug Administration, National Drug Code Directory (openFDA). CC0 1.0 public domain dedication (openFDA). Counts are products in the FDA National Drug Code Directory on November 6, 2026: 138,262 products in commercial distribution, meaning without a marketing end date in the past. A company is a labeler code; one company can hold several codes, and the directory carries no address. Inclusion in the directory is not FDA approval, and the marketing category says under which kind of application or rule a product is sold. This page uses openFDA data and is not endorsed or certified by FDA. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.