Data / Drug companies / Phosphodiesterase 4 Inhibitor
Phosphodiesterase 4 Inhibitor drugs: 5 drugs from 21 companies in the FDA NDC directory
Phosphodiesterase 4 Inhibitor is an FDA established pharmacologic class. The FDA National Drug Code Directory lists 39 products in this class from 21 companies, covering 5 drugs by generic name. The main marketing category is generic drugs (ANDA), and the newest product started marketing on June 24, 2026.
SpecStream is the live web data engine for teams and agents. It reads the National Drug Code Directory that FDA publishes, and this page is that reading. Ask for the companies that make a drug, a class or a dosage form, with their headquarters, website and size added from the web, and new listings and discontinued products arrive in your sheet, CRM, Slack or agent as FDA posts them.
- 21Companies
- 39Products
- 5Drugs by generic name
Drugs in the Phosphodiesterase 4 Inhibitor class
Ranked by number of companies that list the drug.
| Drug | Products here | Companies listing it |
|---|---|---|
| Roflumilast | 33 | 17 |
| Apremilast | 3 | 1 |
| Crisaborole | 1 | 1 |
| Difamilast | 1 | 1 |
| Ensifentrine | 1 | 1 |
Companies with the most products in this class
| Company | Products | Main dosage forms | Main marketing category | Newest product started |
|---|---|---|---|---|
| Arcutis Biotherapeutics, Inc. | 4 | cream; aerosol, foam | New drug applications (NDA) | October 4, 2025 |
| Amgen, Inc | 3 | tablet, film coated | New drug applications (NDA) | August 29, 2025 |
| Major Pharmaceuticals | 3 | tablet | Generic drugs (ANDA) | October 27, 2025 |
| Amici Pharma, Inc. | 2 | tablet | Generic drugs (ANDA) | February 5, 2026 |
| Ascend Laboratories, LLC | 2 | tablet | Generic drugs (ANDA) | March 14, 2025 |
| AstraZeneca Pharmaceuticals LP | 2 | tablet | New drug applications (NDA) | July 1, 2015 |
| Aurobindo Pharma Limited | 2 | tablet | Generic drugs (ANDA) | January 31, 2025 |
| AvKARE | 2 | tablet | Generic drugs (ANDA) | June 24, 2026 |
| Camber Pharmaceuticals, Inc. | 2 | tablet | Generic drugs (ANDA) | April 18, 2023 |
| Jubilant Cadista Pharmaceuticals Inc. | 2 | tablet | Generic drugs (ANDA) | February 2, 2026 |
| Micro Labs Limited | 2 | tablet | Generic drugs (ANDA) | May 1, 2023 |
| Novadoz Pharmaceuticals LLC | 2 | tablet | Generic drugs (ANDA) | September 7, 2022 |
| Zydus Lifesciences Limited | 2 | tablet | Generic drugs (ANDA) | May 18, 2023 |
| Zydus Pharmaceuticals USA Inc. | 2 | tablet | Generic drugs (ANDA) | May 18, 2023 |
| Acrotech Biopharma Inc | 1 | ointment | New drug applications (NDA) | February 25, 2026 |
| American Health Packaging | 1 | tablet | Generic drugs (ANDA) | December 7, 2023 |
| Bryant Ranch Prepack | 1 | tablet | Generic drugs (ANDA) | October 19, 2022 |
| Golden State Medical Supply, Inc. | 1 | tablet | Generic drugs (ANDA) | April 18, 2023 |
| Merck Sharp & Dohme LLC | 1 | suspension | New drug applications (NDA) | June 26, 2024 |
| Pfizer Laboratories Div Pfizer Inc | 1 | ointment | New drug applications (NDA) | January 30, 2017 |
| Solco Healthcare US, LLC | 1 | tablet | Generic drugs (ANDA) | May 10, 2022 |
Dosage forms
| Dosage form | Products | Share |
|---|---|---|
| Tablet | 29 | 74.4% |
| Cream | 3 | 7.7% |
| Tablet, film coated | 3 | 7.7% |
| Ointment | 2 | 5.1% |
| Suspension | 1 | 2.6% |
| Aerosol, foam | 1 | 2.6% |
Updated November 6, 2026. Read from US Food and Drug Administration, National Drug Code Directory (openFDA). CC0 1.0 public domain dedication (openFDA). Counts are products in the FDA National Drug Code Directory on November 6, 2026: 138,262 products in commercial distribution, meaning without a marketing end date in the past. A company is a labeler code; one company can hold several codes, and the directory carries no address. Inclusion in the directory is not FDA approval, and the marketing category says under which kind of application or rule a product is sold. This page uses openFDA data and is not endorsed or certified by FDA. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.