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Data / Drug companies / Phosphodiesterase 4 Inhibitor

Phosphodiesterase 4 Inhibitor drugs: 5 drugs from 21 companies in the FDA NDC directory

Phosphodiesterase 4 Inhibitor is an FDA established pharmacologic class. The FDA National Drug Code Directory lists 39 products in this class from 21 companies, covering 5 drugs by generic name. The main marketing category is generic drugs (ANDA), and the newest product started marketing on June 24, 2026.

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  • 21Companies
  • 39Products
  • 5Drugs by generic name

Drugs in the Phosphodiesterase 4 Inhibitor class

Ranked by number of companies that list the drug.

DrugProducts hereCompanies listing it
Roflumilast3317
Apremilast31
Crisaborole11
Difamilast11
Ensifentrine11

Companies with the most products in this class

CompanyProductsMain dosage formsMain marketing categoryNewest product started
Arcutis Biotherapeutics, Inc.4cream; aerosol, foamNew drug applications (NDA)October 4, 2025
Amgen, Inc3tablet, film coatedNew drug applications (NDA)August 29, 2025
Major Pharmaceuticals3tabletGeneric drugs (ANDA)October 27, 2025
Amici Pharma, Inc.2tabletGeneric drugs (ANDA)February 5, 2026
Ascend Laboratories, LLC2tabletGeneric drugs (ANDA)March 14, 2025
AstraZeneca Pharmaceuticals LP2tabletNew drug applications (NDA)July 1, 2015
Aurobindo Pharma Limited2tabletGeneric drugs (ANDA)January 31, 2025
AvKARE2tabletGeneric drugs (ANDA)June 24, 2026
Camber Pharmaceuticals, Inc.2tabletGeneric drugs (ANDA)April 18, 2023
Jubilant Cadista Pharmaceuticals Inc.2tabletGeneric drugs (ANDA)February 2, 2026
Micro Labs Limited2tabletGeneric drugs (ANDA)May 1, 2023
Novadoz Pharmaceuticals LLC2tabletGeneric drugs (ANDA)September 7, 2022
Zydus Lifesciences Limited2tabletGeneric drugs (ANDA)May 18, 2023
Zydus Pharmaceuticals USA Inc.2tabletGeneric drugs (ANDA)May 18, 2023
Acrotech Biopharma Inc1ointmentNew drug applications (NDA)February 25, 2026
American Health Packaging1tabletGeneric drugs (ANDA)December 7, 2023
Bryant Ranch Prepack1tabletGeneric drugs (ANDA)October 19, 2022
Golden State Medical Supply, Inc.1tabletGeneric drugs (ANDA)April 18, 2023
Merck Sharp & Dohme LLC1suspensionNew drug applications (NDA)June 26, 2024
Pfizer Laboratories Div Pfizer Inc1ointmentNew drug applications (NDA)January 30, 2017
Solco Healthcare US, LLC1tabletGeneric drugs (ANDA)May 10, 2022

Dosage forms

Dosage formProductsShare
Tablet2974.4%
Cream37.7%
Tablet, film coated37.7%
Ointment25.1%
Suspension12.6%
Aerosol, foam12.6%

Updated November 6, 2026. Read from US Food and Drug Administration, National Drug Code Directory (openFDA). CC0 1.0 public domain dedication (openFDA). Counts are products in the FDA National Drug Code Directory on November 6, 2026: 138,262 products in commercial distribution, meaning without a marketing end date in the past. A company is a labeler code; one company can hold several codes, and the directory carries no address. Inclusion in the directory is not FDA approval, and the marketing category says under which kind of application or rule a product is sold. This page uses openFDA data and is not endorsed or certified by FDA. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.