Data / Drug companies / Opioid Antagonist
Opioid Antagonist drugs: 22 drugs from 95 companies in the FDA NDC directory
Opioid Antagonist is an FDA established pharmacologic class. The FDA National Drug Code Directory lists 267 products in this class from 95 companies, covering 22 drugs by generic name. The main marketing category is generic drugs (ANDA), and the newest product started marketing on October 28, 2026.
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- 95Companies
- 267Products
- 22Drugs by generic name
Drugs in the Opioid Antagonist class
Ranked by number of companies that list the drug.
| Drug | Products here | Companies listing it |
|---|---|---|
| Naloxone hydrochloride | 80 | 40 |
| Naltrexone hydrochloride | 45 | 24 |
| Buprenorphine and naloxone | 65 | 22 |
| Alvimopan | 4 | 4 |
| Buprenorphine hydrochloride and naloxone hydrochloride | 14 | 3 |
| Nalxone hydrochloride | 4 | 3 |
| Naloxone hcl | 3 | 3 |
| Naloxone hydrochloride nasal | 3 | 3 |
| Nalmefene hydrochloride | 3 | 2 |
| Naloxegol oxalate | 3 | 2 |
| Pentazocine hydrochloride and naloxone hydrochloride | 2 | 2 |
| Buprenorphine hydrochloride, naloxone hydrochloride | 4 | 1 |
| Olanzapine and samidorphan l-malate | 4 | 1 |
| Methylnaltrexone bromide | 3 | 1 |
| Nalmefene hydrochloride injection | 2 | 1 |
| Naldemedine | 1 | 1 |
| Naloxone | 1 | 1 |
| Naloxone hci | 1 | 1 |
| Naltrexone hydrochloride and bupropion hydrochloride | 1 | 1 |
| Narcan naloxone hci | 1 | 1 |
| Narcan naloxone hcl | 1 | 1 |
| Pentazocine and naloxone | 1 | 1 |
Companies with the most products in this class
| Company | Products | Main dosage forms | Main marketing category | Newest product started |
|---|---|---|---|---|
| Bryant Ranch Prepack | 22 | tablet, film coated; tablet | Generic drugs (ANDA) | August 15, 2025 |
| HF Acquisition Co LLC, DBA HealthFirst | 15 | injection, solution; injection | Generic drugs (ANDA) | August 28, 2023 |
| Medical Purchasing Solutions, LLC | 9 | injection, solution; injection | Generic drugs (ANDA) | January 29, 2021 |
| A-S Medication Solutions | 8 | spray; injection, solution | Generic drugs (ANDA) | July 30, 2023 |
| Redpharm Drug | 8 | film; tablet | Generic drugs (ANDA) | August 29, 2023 |
| Bryant Ranch Prepack | 7 | tablet, film coated; tablet | Generic drugs (ANDA) | August 15, 2025 |
| Remedyrepack Inc. | 7 | tablet; tablet, film coated | Generic drugs (ANDA) | October 28, 2026 |
| Camber Pharmaceuticals, Inc. | 6 | film, soluble; tablet | Generic drugs (ANDA) | May 1, 2026 |
| Edenbridge Pharmaceuticals LLC. | 6 | tablet, orally disintegrating | New drug applications (NDA) | June 12, 2026 |
| Orexo US, Inc. | 6 | tablet, orally disintegrating | New drug applications (NDA) | December 11, 2014 |
| Bryant Ranch Prepack | 5 | tablet; tablet, film coated | Generic drugs (ANDA) | April 13, 2020 |
| Clinical Solutions Wholesale, LLC | 5 | tablet | Generic drugs (ANDA) | September 1, 2020 |
| Dr. Reddy's Laboratories Inc. | 5 | film, soluble; injection | Generic drugs (ANDA) | March 18, 2020 |
| Indivior Inc. | 5 | film, soluble; spray | New drug applications (NDA) | October 2, 2023 |
| Alkermes, Inc. | 4 | tablet, film coated | New drug applications (NDA) | September 20, 2021 |
| Alvogen Inc. | 4 | film | Generic drugs (ANDA) | February 11, 2019 |
| Aveva Drug Delivery Systems Inc. | 4 | film | Generic drugs (ANDA) | March 7, 2025 |
| Golden State Medical Supply, Inc. | 4 | tablet; capsule | Generic drugs (ANDA) | August 31, 2023 |
| Hikma Pharmaceuticals USA Inc. | 4 | injection | Generic drugs (ANDA) | July 25, 2025 |
| Ingenus Pharmaceuticals, LLC | 4 | film | Generic drugs (ANDA) | August 29, 2023 |
| International Medication Systems, Limited | 4 | injection; spray | Generic drugs (ANDA) | May 7, 2024 |
| Mylan Pharmaceuticals Inc. | 4 | film | Generic drugs (ANDA) | April 17, 2020 |
| Accord Healthcare Inc. | 3 | tablet; tablet, film coated | Generic drugs (ANDA) | September 1, 2020 |
| Actavis Pharma, Inc. | 3 | capsule; tablet | Generic drugs (ANDA) | January 17, 2025 |
| Eugia US LLC | 3 | injection, solution | Generic drugs (ANDA) | January 14, 2021 |
| Henry Schein, Inc. | 3 | injection, solution; injection | Generic drugs (ANDA) | October 28, 2025 |
| Hikma Pharmaceuticals USA Inc. | 3 | tablet; capsule | Generic drugs (ANDA) | February 6, 2024 |
| Hospira, Inc. | 3 | injection, solution | Generic drugs (ANDA) | September 23, 2005 |
| Major Pharmaceuticals | 3 | tablet; tablet, film coated | Generic drugs (ANDA) | June 27, 2014 |
| Mylan Institutional LLC | 3 | injection, solution | Generic drugs (ANDA) | December 2, 2022 |
| Salix Pharmaceuticals, Inc. | 3 | injection, solution; tablet | New drug applications (NDA) | August 1, 2008 |
| SpecGx LLC | 3 | tablet; tablet, film coated | Generic drugs (ANDA) | December 13, 2017 |
| Unit Dose Solutions, Inc. | 3 | tablet | Generic drugs (ANDA) | April 13, 2026 |
| Actavis Pharma, Inc. | 2 | tablet | Generic drugs (ANDA) | March 4, 2013 |
| American Health Packaging | 2 | tablet | Generic drugs (ANDA) | March 14, 2022 |
| Amneal Pharmaceuticals LLC | 2 | tablet | Generic drugs (ANDA) | February 22, 2013 |
| Aphena Pharma Solutions - Tennessee, LLC | 2 | tablet, film coated | Generic drugs (ANDA) | March 22, 2002 |
| Aphena Pharma Solutions - Tennessee, LLC | 2 | tablet, film coated | Generic drugs (ANDA) | August 15, 2025 |
| Ascend Laboratories, LLC | 2 | tablet | Generic drugs (ANDA) | July 3, 2026 |
| Asclemed USA, Inc. | 2 | spray, metered; tablet | Generic drugs (ANDA) | September 23, 2024 |
| AvKARE | 2 | tablet, film coated; spray | Generic drugs (ANDA) | May 1, 2024 |
| AvPAK | 2 | tablet | Generic drugs (ANDA) | December 8, 2016 |
| Averitas Pharma, Inc. | 2 | tablet, film coated | New drug applications (NDA) | March 28, 2023 |
| Baxter Healthcare Corporation | 2 | injection, solution | Generic drugs (ANDA) | November 7, 2022 |
| Chengdu Shuode Pharmaceutical Co., Ltd | 2 | solution | Generic drugs (ANDA) | November 15, 2023 |
| Coupler LLC | 2 | tablet, film coated | Generic drugs (ANDA) | June 15, 2026 |
| Emergent Devices Inc. | 2 | spray | New drug applications (NDA) | August 28, 2023 |
| Fresenius Kabi USA, LLC | 2 | injection, solution | Generic drugs (ANDA) | April 2, 2024 |
| Knoa Pharma LLC | 2 | injection, solution | New drug applications (NDA) | August 7, 2025 |
| Lannett Company, Inc. | 2 | tablet | Generic drugs (ANDA) | September 19, 2016 |
| Lifestar Pharma LLC | 2 | injection, solution | Generic drugs (ANDA) | February 19, 2026 |
| Pai Holdings, LLC DBA Pai Pharma | 2 | tablet | Generic drugs (ANDA) | September 5, 2023 |
| Precision Dose, Inc. | 2 | tablet, film coated | Generic drugs (ANDA) | February 15, 2024 |
| ProPharma Distribution | 2 | injection, solution | Generic drugs (ANDA) | August 8, 2017 |
| Proficient Rx LP | 2 | spray | New drug applications (NDA) | June 21, 2022 |
| Rhodes Pharmaceuticals LLC | 2 | tablet | Generic drugs (ANDA) | April 13, 2020 |
| Somerset Therapeutics, LLC | 2 | injection, solution | Generic drugs (ANDA) | August 8, 2017 |
| Sportpharm LLC | 2 | spray, metered; spray | Generic drugs (ANDA) | September 23, 2024 |
| Sun Pharmaceutical Industries, Inc. | 2 | tablet | Generic drugs (ANDA) | July 18, 2017 |
| Advanced Rx of Tennessee, LLC | 1 | spray | Generic drugs (ANDA) | June 27, 2024 |
| American Health Packaging | 1 | tablet, film coated | Generic drugs (ANDA) | June 3, 2013 |
| Amerisource Bergen | 1 | spray | Generic drugs (ANDA) | March 12, 2025 |
| Amneal Pharmaceuticals NY LLC | 1 | spray | Generic drugs (ANDA) | April 24, 2024 |
| Amneal Pharmaceuticals NY LLC | 1 | spray | Generic drugs (ANDA) | April 24, 2024 |
| Baxter Healthcare Corporation | 1 | injection, solution | Generic drugs (ANDA) | June 3, 2025 |
| BioDelivery Sciences International Inc | 1 | tablet | New drug applications (NDA) | June 14, 2019 |
| BluePoint Laboratories | 1 | spray | Generic drugs (ANDA) | May 1, 2025 |
| Bpi Labs LLC | 1 | injection, solution | Generic drugs (ANDA) | November 15, 2023 |
| CVS Woonsocket Prescription Center, Incorporated | 1 | spray | Generic drugs (ANDA) | April 24, 2024 |
| Chartwell RX, LLC | 1 | tablet, film coated | Generic drugs (ANDA) | July 21, 2017 |
| Civica, Inc. | 1 | injection | Generic drugs (ANDA) | November 11, 2019 |
| Elite Laboratories, Inc. | 1 | tablet, film coated | Generic drugs (ANDA) | August 15, 2025 |
| Harm Reduction Therapeutics, Inc. | 1 | spray | New drug applications (NDA) | January 2, 2024 |
| Heritage Pharmaceuticals Inc. D/B/A Avet Pharmaceuticals Inc. | 1 | tablet, film coated | Generic drugs (ANDA) | October 6, 2023 |
| Hikma Specialty USA Inc. | 1 | spray | New drug applications (NDA) | August 3, 2021 |
| Kaleo, Inc | 1 | injection, solution | New drug applications (NDA) | February 28, 2022 |
| Lupin Pharmaceuticals,Inc. | 1 | tablet | Generic drugs (ANDA) | May 11, 2011 |
| NCS HealthCare of Ky, LLC DBA Vangard Labs | 1 | tablet, film coated | Generic drugs (ANDA) | February 29, 2012 |
| Nalpropion Pharmaceuticals LLC | 1 | tablet, extended release | New drug applications (NDA) | October 22, 2014 |
| NorthStar RxLLC | 1 | injection, solution | Generic drugs (ANDA) | July 1, 2024 |
| NuCare Pharmaceuticals,Inc. | 1 | tablet, film coated | Generic drugs (ANDA) | February 15, 2024 |
| Padagis Israel Pharmaceuticals Ltd | 1 | spray | Generic drugs (ANDA) | July 30, 2023 |
| Par Health USA, LLC | 1 | injection | Generic drugs (ANDA) | November 5, 2024 |
| Par Health USA, LLC | 1 | capsule | Generic drugs (ANDA) | May 3, 2023 |
| Proficient Rx LP | 1 | tablet, film coated | Generic drugs (ANDA) | February 29, 2012 |
| RedHill Biopharma Ltd | 1 | tablet, film coated | New drug applications (NDA) | October 1, 2020 |
| Scienture LLC | 1 | spray | New drug applications (NDA) | January 29, 2026 |
| Sina Health Inc | 1 | injection, solution | Generic drugs (ANDA) | August 8, 2017 |
| Strategic Sourcing Services LLC | 1 | spray | Generic drugs (ANDA) | April 1, 2025 |
| Sun Pharmaceutical Industries, Inc. | 1 | tablet | Generic drugs (ANDA) | July 31, 2018 |
| Sun Pharmaceutical Industries, Inc. | 1 | tablet, film coated | Generic drugs (ANDA) | February 29, 2012 |
| Tagi Pharma, Inc. | 1 | tablet, film coated | Generic drugs (ANDA) | September 23, 2013 |
| Teva Pharmaceuticals, Inc. | 1 | spray, metered | Generic drugs (ANDA) | September 23, 2024 |
| Walgreen Company | 1 | spray | Generic drugs (ANDA) | April 24, 2024 |
| Zmi Pharma Inc. | 1 | injection, solution | New drug applications (NDA) | January 15, 2022 |
Dosage forms
| Dosage form | Products | Share |
|---|---|---|
| Tablet | 64 | 24% |
| Tablet, film coated | 52 | 19.5% |
| Injection, solution | 47 | 17.6% |
| Spray | 28 | 10.5% |
| Film | 21 | 7.9% |
| Injection | 19 | 7.1% |
| Film, soluble | 12 | 4.5% |
| Tablet, orally disintegrating | 12 | 4.5% |
| Capsule | 4 | 1.5% |
| Spray, metered | 4 | 1.5% |
| Solution | 2 | 0.7% |
| Inhalant | 1 | 0.4% |
Updated November 6, 2026. Read from US Food and Drug Administration, National Drug Code Directory (openFDA). CC0 1.0 public domain dedication (openFDA). Counts are products in the FDA National Drug Code Directory on November 6, 2026: 138,262 products in commercial distribution, meaning without a marketing end date in the past. A company is a labeler code; one company can hold several codes, and the directory carries no address. Inclusion in the directory is not FDA approval, and the marketing category says under which kind of application or rule a product is sold. This page uses openFDA data and is not endorsed or certified by FDA. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.