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Data / Drug companies / Opioid Agonist

Opioid Agonist drugs: 65 drugs from 207 companies in the FDA NDC directory

Opioid Agonist is an FDA established pharmacologic class. The FDA National Drug Code Directory lists 1,455 products in this class from 207 companies, covering 65 drugs by generic name. The main marketing category is generic drugs (ANDA), and the newest product started marketing on November 3, 2026.

SpecStream is the live web data engine for teams and agents. It reads the National Drug Code Directory that FDA publishes, and this page is that reading. Ask for the companies that make a drug, a class or a dosage form, with their headquarters, website and size added from the web, and new listings and discontinued products arrive in your sheet, CRM, Slack or agent as FDA posts them.

  • 207Companies
  • 1,455Products
  • 65Drugs by generic name

Drugs in the Opioid Agonist class

Ranked by number of companies that list the drug.

DrugProducts hereCompanies listing it
Loperamide hydrochloride12582
Tramadol hydrochloride11944
Loperamide hcl6542
Hydrocodone bitartrate and acetaminophen20237
Oxycodone hydrochloride13336
Oxycodone and acetaminophen11832
Morphine sulfate15031
Acetaminophen and codeine phosphate6824
Methadone hydrochloride4921
Hydromorphone hydrochloride7420
Loperamide hydrochloride, simethicone2220
Tramadol hydrochloride and acetaminophen1513
Loperamide hydrochloride and simethicone1411
Oxymorphone hydrochloride279
Levorphanol tartrate108
Codeine phosphate and guaifenesin77
Tapentadol hydrochloride266
Oxycodone196
Oxycodone hydrochloride and acetaminophen146
Acetaminophen and codeine76
Fentanyl citrate175
Meperidine hydrochloride105
Hydrocodone bitartrate and homatropine methylbromide75
Promethazine hydrochloride and codeine phosphate55
Fentanyl294
Remifentanil hydrochloride134
Guaifenesin and codeine phosphate64
Butalbital, acetaminophen, caffeine and codeine phosphate54
Butalbital, aspirin, caffeine and codeine phosphate33
Hydrocodone bitartrate192
Tramadol hcl72
Codeine sulfate62
Hydrocodone bitartrate and ibuprofen52
Butalbital, acetaminophen, caffeine, and codeine phosphate32
Hydrocodone polistirex and chlorpheniramine polistirex32
Loperamide hydrochloride 2mg, simethicone 125mg22
Morphine22
Morphine tincture22
Oxycodone hydchloride22
Fentanyl transdermal71
Hydrocodone/apap51
Oxycodone hcl51
Loperamide hcl tablet21
Oxycodone and acetaminophen tablets21
Oxycodone hydrochloride oral solution21
Oxycodone/apap21
Acetaminophen, caffeine, dihydrocodeine bitartrate11
Butalbital, aspirin, cafeine, and codeine phosphate11
Codeine phosphate and chlorpheniramine maleate11
Codeine phosphate, dexbrompheniramine maleate11
First aid direct anti-diarrheal11
Hydrocodone apap11
Loperamide hci11
Loperamide hcl 2 mg11
Loperamide hcl and simethicone11
Loperamide hydrochloride and dimethicone11
Loperamide hydrochloride oral11
Loperamide hydrochloride tablets usp, 2mg11
Marc glassman11
Methadone11
Oxycodone and aspirin11
Promethazine, phenylephrine, codeine11
Sufentanil citrate11
Tramadol hcl er11
Tramadol/apap11

Companies with the most products in this class

CompanyProductsMain dosage formsMain marketing categoryNewest product started
Bryant Ranch Prepack90tablet; capsuleGeneric drugs (ANDA)September 10, 2024
Bryant Ranch Prepack69tablet; tablet, film coated, extended releaseGeneric drugs (ANDA)February 11, 2021
SpecGx LLC47tablet; patch, extended releaseGeneric drugs (ANDA)September 1, 2023
Bryant Ranch Prepack40tablet; tablet, film coated, extended releaseGeneric drugs (ANDA)November 2, 2020
Asclemed USA, Inc.38tablet; tablet, extended releaseGeneric drugs (ANDA)September 10, 2024
Hikma Pharmaceuticals USA Inc.33tablet; solutionGeneric drugs (ANDA)December 15, 2025
NuCare Pharmaceuticals,Inc.32tablet; capsuleGeneric drugs (ANDA)December 1, 2024
Direct_Rx28tablet; tablet, extended releaseGeneric drugs (ANDA)August 25, 2026
Hikma Pharmaceuticals USA Inc.28injection; injection, solutionGeneric drugs (ANDA)August 29, 2025
Rhodes Pharmaceuticals LLC27tablet; tablet, film coated, extended releaseGeneric drugs (ANDA)May 15, 2017
Aurolife Pharma, LLC26tablet; solutionGeneric drugs (ANDA)January 27, 2020
Camber Pharmaceuticals, Inc.25tablet; tablet, extended releaseGeneric drugs (ANDA)November 14, 2025
Alvogen Inc.24tablet, extended release; tabletGeneric drugs (ANDA)March 3, 2021
St. Mary's Medical Park Pharmacy24tablet; tablet, film coatedGeneric drugs (ANDA)August 6, 2026
KVK-Tech, Inc.23tablet; solutionGeneric drugs (ANDA)December 5, 2019
Lupin Pharmaceuticals,Inc.22tablet; tablet, film coated, extended releaseGeneric drugs (ANDA)June 12, 2017
XLCare Pharmaceuticals, Inc.22tablet; tablet, extended releaseGeneric drugs (ANDA)September 24, 2020
Epic Pharma, LLC21tablet; tablet, film coatedGeneric drugs (ANDA)December 31, 2021
Hospira, Inc.21injection, solutionNew drug applications (NDA)April 21, 2025
Redpharm Drug20tablet; solutionGeneric drugs (ANDA)September 10, 2024
Proficient Rx LP19tablet; tablet, coatedGeneric drugs (ANDA)January 5, 2017
American Health Packaging16tablet; solutionGeneric drugs (ANDA)September 9, 2026
Fresenius Kabi USA, LLC16injection, solution; injection, powder, lyophilized, for solutionNew drug applications (NDA)January 15, 2021
Major Pharmaceuticals16tablet; tablet, film coated, extended releaseGeneric drugs (ANDA)December 20, 2024
Preferred Pharmaceuticals Inc.16tablet; tablet, film coatedGeneric drugs (ANDA)June 8, 2026
Advanced Rx of Tennessee, LLC15tablet; tablet, extended releaseGeneric drugs (ANDA)June 26, 2026
Amneal Pharmaceuticals of New York LLC15tablet, film coated, extended release; capsule, extended releaseGeneric drugs (ANDA)October 5, 2018
Eywa Pharma Inc15tablet; solutionGeneric drugs (ANDA)August 2, 2019
Proficient Rx LP14tablet, extended release; tabletGeneric drugs (ANDA)September 23, 2020
Collegium Pharmaceutical, Inc.13capsule, extended release; tablet, film coated, extended releaseNew drug applications (NDA)April 19, 2019
Knoa Pharma LLC13tablet, film coated, extended release; tablet, extended releaseNew drug applications (NDA)January 15, 2015
Pai Holdings, LLC DBA Pai Pharma13solutionGeneric drugs (ANDA)September 15, 2025
Strides Pharma Science Limited13tabletGeneric drugs (ANDA)September 1, 2026
Cranbury Pharmaceuticals, LLC12tablet; solutionGeneric drugs (ANDA)December 22, 2024
Elite Laboratories, Inc.12tabletGeneric drugs (ANDA)September 10, 2019
Remedyrepack Inc.12tablet; tablet, extended releaseGeneric drugs (ANDA)November 3, 2026
A-S Medication Solutions11tablet; tablet, film coatedGeneric drugs (ANDA)September 5, 2023
Precision Dose, Inc.11solution; tabletNew drug applications (NDA)September 1, 2025
Amneal Pharmaceuticals LLC10tablet; syrupGeneric drugs (ANDA)June 30, 2016
Asclemed USA Inc.10tablet; tablet, film coatedGeneric drugs (ANDA)August 9, 2019
Amneal Pharmaceuticals of New York LLC9tabletGeneric drugs (ANDA)February 18, 2010
Fresenius Kabi USA, LLC9injection, solutionNew drug applications (NDA)December 4, 2018
Mylan Pharmaceuticals Inc.9patch; capsuleGeneric drugs (ANDA)February 26, 2015
Padagis US LLC9suppository; tablet, extended releaseOther unapproved drugsMay 22, 2015
Proficient Rx LP9tablet; tablet, film coated, extended releaseGeneric drugs (ANDA)September 1, 2025
Upsher-Smith Laboratories, LLC9capsule, extended release; tabletGeneric drugs (ANDA)July 22, 2019
Amazon.com Services LLC8tablet; solutionGeneric drugs (ANDA)September 24, 2026
American Health Packaging8tablet; tablet, film coated, extended releaseGeneric drugs (ANDA)February 25, 2020
AvPAK8tablet; capsuleGeneric drugs (ANDA)April 5, 2023
Aveva Drug Delivery Systems Inc.8patch, extended releaseGeneric drugs (ANDA)February 11, 2025
Genus Lifesciences8solution; tabletGeneric drugs (ANDA)May 15, 2026
Ingenus Pharmaceuticals, LLC8patch, extended releaseGeneric drugs (ANDA)February 11, 2025
Amneal Pharmaceuticals LLC7tablet, film coated, extended releaseGeneric drugs (ANDA)January 2, 2013
Granules Pharmaceuticals Inc.7tabletGeneric drugs (ANDA)January 1, 2022
Trigen Laboratories, LLC7tablet, extended release; capsuleGeneric drugs (ANDA)September 15, 2016
Actavis Pharma, Inc.6capsule, extended releaseGeneric drugs (ANDA)February 4, 2014
Ascent Pharmaceuticals, Inc.6solution; tabletGeneric drugs (ANDA)May 4, 2019
Aurohealth LLC6tablet; capsule, liquid filledGeneric drugs (ANDA)December 29, 2025
Bionpharma Inc.6capsule, liquid filled; tabletGeneric drugs (ANDA)March 2, 2026
Dolgencorp, Inc. (dollar General & Rexall)6solution; tabletGeneric drugs (ANDA)March 30, 2026
L. Perrigo Company6tablet, film coated; tabletGeneric drugs (ANDA)August 9, 2022
Lannett Company, Inc.6tablet; concentrateGeneric drugs (ANDA)November 2, 2020
Lupin Pharmaceuticals, Inc.6tablet, extended releaseGeneric drugs (ANDA)August 19, 2014
Nortec Development Associates, Inc.6capsule, extended releaseGeneric drugs (ANDA)April 7, 2009
Sun Pharmaceutical Industries, Inc.6tablet, extended releaseGeneric drugs (ANDA)December 30, 2011
VistaPharm, LLC6tablet; concentrateGeneric drugs (ANDA)September 11, 2020
Walgreen Company6tablet; capsule, liquid filledGeneric drugs (ANDA)August 3, 2022
Yyba Corp6tablet; capsuleGeneric drugs (ANDA)September 1, 2026
Advagen Pharma Ltd5tablet, coated; capsuleGeneric drugs (ANDA)November 28, 2023
American Health Packaging5solutionGeneric drugs (ANDA)May 1, 2026
Aphena Pharma Solutions - Tennessee, LLC5capsule; tablet, film coatedGeneric drugs (ANDA)October 6, 2021
Cardinal Health 110, LLC. DBA Leader5tablet, film coated; solutionGeneric drugs (ANDA)October 7, 2021
Direct RX5tablet; tablet, extended releaseGeneric drugs (ANDA)August 21, 2019
FH2 Pharma LLC5tablet; solutionGeneric drugs (ANDA)March 2, 2021
Forte Bio-Pharma LLC5tablet; solutionGeneric drugs (ANDA)March 1, 2020
H E B5tablet; tablet, film coatedGeneric drugs (ANDA)December 4, 2018
Lil' Drug Store Products, Inc.5tabletGeneric drugs (ANDA)August 1, 2023
Quality Care Products, LLC5tablet; tablet, coatedGeneric drugs (ANDA)April 6, 2023
Safeway5tablet; solutionGeneric drugs (ANDA)April 7, 2025
Sun Pharmaceutical Industries, Inc.5tablet, film coated, extended releaseGeneric drugs (ANDA)May 11, 2012
Amerisource Bergen4tablet; capsule, liquid filledGeneric drugs (ANDA)July 5, 2023
Ascend Laboratories, LLC4tabletGeneric drugs (ANDA)July 1, 2025
Atlantic Biologicals Corp.4concentrate; solutionGeneric drugs (ANDA)November 2, 2020
Civica, Inc.4injectionNew drug applications (NDA)October 7, 2020
Coupler LLC4tablet, coated; tablet, extended releaseGeneric drugs (ANDA)June 22, 2026
Discount Drug Mart4tablet; capsule, liquid filledGeneric drugs (ANDA)February 26, 2025
Kenvue Brands LLC4solution; tabletNew drug applications (NDA)July 11, 2016
Kroger Company4tablet; capsule, liquid filledGeneric drugs (ANDA)May 6, 2020
Meijer Distribution Inc4tablet; solutionGeneric drugs (ANDA)February 1, 2019
Mylan Institutional LLC4injection, powder, lyophilized, for solution; injection, solutionNew drug applications (NDA)April 15, 2020
Par Health USA, LLC4tabletGeneric drugs (ANDA)March 6, 2003
Protega Pharmaceuticals Inc4tablet, coatedNew drug applications (NDA)April 20, 2017
Rite Aid Corporation4tablet; capsule, liquid filledGeneric drugs (ANDA)January 24, 2020
Strategic Sourcing Services LLC4capsule, liquid filled; tablet, film coatedGeneric drugs (ANDA)November 8, 2023
Target Corporation4tablet, film coated; tabletGeneric drugs (ANDA)October 9, 2019
Wal-Mart Stores Inc4suspension; tabletGeneric drugs (ANDA)September 3, 2020
American Sales Company3suspension; tabletGeneric drugs (ANDA)January 31, 2019
Ani Pharmaceuticals, Inc.3solution; capsuleGeneric drugs (ANDA)June 10, 2016
AvKARE3tablet, film coatedGeneric drugs (ANDA)September 14, 2026
Breckenridge Pharmaceutical, Inc.3capsule; injection, solutionGeneric drugs (ANDA)December 30, 2024

Dosage forms

Dosage formProductsShare
Tablet74451.1%
Solution1329.1%
Tablet, extended release865.9%
Tablet, film coated, extended release775.3%
Tablet, film coated664.5%
Capsule654.5%
Injection, solution503.4%
Tablet, coated402.7%
Capsule, extended release402.7%
Injection342.3%
Capsule, liquid filled322.2%
Patch, extended release231.6%

Updated November 6, 2026. Read from US Food and Drug Administration, National Drug Code Directory (openFDA). CC0 1.0 public domain dedication (openFDA). Counts are products in the FDA National Drug Code Directory on November 6, 2026: 138,262 products in commercial distribution, meaning without a marketing end date in the past. A company is a labeler code; one company can hold several codes, and the directory carries no address. Inclusion in the directory is not FDA approval, and the marketing category says under which kind of application or rule a product is sold. This page uses openFDA data and is not endorsed or certified by FDA. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.