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Data / Drug companies / Histamine-1 Receptor Antagonist

Histamine-1 Receptor Antagonist drugs: 183 drugs from 351 companies in the FDA NDC directory

Histamine-1 Receptor Antagonist is an FDA established pharmacologic class. The FDA National Drug Code Directory lists 2,360 products in this class from 351 companies, covering 183 drugs by generic name. The main marketing category is over the counter monograph drugs, and the newest product started marketing on November 1, 2026.

SpecStream is the live web data engine for teams and agents. It reads the National Drug Code Directory that FDA publishes, and this page is that reading. Ask for the companies that make a drug, a class or a dosage form, with their headquarters, website and size added from the web, and new listings and discontinued products arrive in your sheet, CRM, Slack or agent as FDA posts them.

  • 351Companies
  • 2,360Products
  • 183Drugs by generic name

Drugs in the Histamine-1 Receptor Antagonist class

Ranked by number of companies that list the drug.

DrugProducts hereCompanies listing it
Acetaminophen2214
Diphenhydramine hydrochloride339127
Cetirizine hydrochloride275119
Naproxen sodium1100
Diphenhydramine hcl33399
Fexofenadine hydrochloride12565
Levocetirizine dihydrochloride8052
Cetirizine hcl9848
Acetaminophen, diphenhydramine hcl6542
Fexofenadine hcl7539
Olopatadine hydrochloride5535
Chlorpheniramine maleate3531
Acetaminophen and diphenhydramine hydrochloride3729
Dimenhydrinate2421
Diphenhydramine hydrochloride, zinc acetate2020
Diphenhydramine citrate, ibuprofen2019
Chlorpheniramine maleate, dextromethorphan hbr1919
Cetirizine hydrochloride, pseudoephedrine hydrochloride2018
Azelastine hydrochloride2217
Olopatadine hydrochloride ophthalmic3016
Aspirin, chlorpheniramine maleate, phenylephrine bitartrate2416
Fexofenadine hydrochloride and pseudoephedrine hydrochloride2416
Acetaminophen, diphenhydramine hydrochloride2014
Ibuprofen, diphenhydramine hcl1513
Diphenhydramine hydrochloride and zinc acetate1612
Diphenhydramine hydrochloride, naproxen sodium1212
Desloratadine1511
Diphenhydramine hcl, zinc acetate1111
Cetirizine hydrochloride and pseudoephedrine hydrochloride1110
Carbinoxamine maleate109
Acetaminophen, chlorpheniramine maleate, phenylephrine hcl118
Cetirizine hydrochloride tablets98
Olopatadine hydrochloride ophthalmic solution88
Acetaminophen, diphenhydramine hcl, phenylephrine hcl137
Ibuprofen and diphenhydramine citrate107
Acetaminophen diphenhydramine hcl97
Fexofenadine hcl and pseudoephedrine hci97
Chlorpheniramine maleate, phenylephrine hcl77
Diphenhydramine citrate and ibuprofen77
Diphenhydramine hcl 25 mg146
Acetaminophen and diphenhydramine hcl86
Diphenhydramine hcl, phenylephrine hcl46
Cetirizine115
Acetaminophen, chlorpheniramine maleate55
Acetaminophen, diphenhydramine, phenylephrine55
Bepotastine besilate64
Itch relief gel64
Acetaminophen, diphenhydramine54
Alcaftadine54
Azelastine44
Azelastine hydrochloride and fluticasone propionate44
Diphenhydramine hydrochloride and acetaminophen44
Extra strength itch relief44
Fexofenadine hydrochloride, pseudoephedrine hydrochloride44
Allergy relief34
Acetaminophen and chlorpheniramine maleate43
Sleep aid43
Azelastine hydrochloride, fluticasone propionate33
Cetirizine hydrochloride oral solution33
Chlorpheniramine maleate and dextromethorphan hydrobromide33
Chlorpheniramine maleate, dextrometrorphan hbr33
Diphenhydramine hcl 50mg33
Diphenhydramine hcl and zinc acetate33
Diphenhydramine hcl oral42
Diphenhydramine hcl 25mg32
Diphenhydramine hydrochloride 2%, zinc acetate 0.1%32
Hydrocodone polistirex and chlorpheniramine polistirex32
Phenylephrine hcl and chlorpheniramine maleate32
Acetaminophen and diphenhydramine22
Acetaminophen and diphenhydramine citrate22
Acetaminophen pm22
Acetaminophen, aspirin, diphenhydramine citrate22
Acetaminophen, diphenhydramine hci, phenylephrine hci22
Acetaminophen, diphenhydramine hcl and phenylephrine hcl22
Anti itch cream22
Aspirin, chlorpheniramine maleate, phylephrine bitartrate22
Bepotastine besilate ophthalmic solution 1.5%22
Cetirizine hydrochloride 10 mg22
Cetirizine tablets22
Chlorpheniramine maleate 4mg22
Chlorpheniramine maleate and phenylephrine hcl22
Chlorpheniramine maleate, dextromethorphan hydrobromide22
Chlorpheniramine maleate, dextromethorphan hydrochloride22
Chlorpheniramine maleate, pseudoephedrine hcl22
Diphenhydramine22
Diphenhydramine hcl 2%, zinc acetate 0.1%22
Diphenhydramine hcl, acetaminophen22
Diphenhydramine hydrochloride 25mg22
Diphenhydramine hydrochloride, menthol22
Diphenhydramine, zinc acetate22
Diphenhyramine hydrochloride22
Giltuss d22
Ibuprofen and diphenhydramine hcl22
Naproxen sodium and diphenhydramine hcl22
Naproxen sodium diphenhydramine hcl22
Nighttime sleep aid22
Olopatadine22
Olopatadine hcl22
Olopatadine hydrochloride and mometasone furoate22
Diphenhydramine hcl and ibuprofen31

Companies with the most products in this class

CompanyProductsMain dosage formsMain marketing categoryNewest product started
Walgreen Company113tablet, film coated; tabletOver the counter monograph drugsAugust 27, 2026
Dolgencorp, Inc. (dollar General & Rexall)51tablet, film coated; tabletOver the counter monograph drugsJune 24, 2025
Walmart Inc.47tablet; solutionOver the counter monograph drugsNovember 1, 2026
CVS Woonsocket Prescription Center, Incorporated45tablet; solutionOver the counter monograph drugsAugust 24, 2026
Rite Aid Corporation45tablet, film coated; solutionOver the counter monograph drugsOctober 25, 2024
A-S Medication Solutions41tablet; solutionGeneric drugs (ANDA)March 7, 2025
CVS Pharmacy40tablet, film coated; solutionOver the counter monograph drugsApril 3, 2025
Topco Associates LLC40tablet, film coated; tablet, coatedOver the counter monograph drugsMay 30, 2026
Cardinal Health 110, LLC. DBA Leader39tablet, film coated; solutionOver the counter monograph drugsAugust 14, 2026
Safeway38tablet; tablet, film coatedGeneric drugs (ANDA)December 29, 2025
Aurohealth LLC37tablet; solutionGeneric drugs (ANDA)August 31, 2026
Kroger Company36solution; tabletGeneric drugs (ANDA)June 25, 2026
Strategic Sourcing Services LLC34tablet; tablet, film coatedGeneric drugs (ANDA)February 11, 2026
Amerisource Bergen33solution; tablet, film coatedOver the counter monograph drugsMay 30, 2026
Chain Drug Marketing Association32tablet, coated; tabletOver the counter monograph drugsMarch 28, 2023
Kenvue Brands LLC31tablet, film coated; solutionOver the counter monograph drugsJune 2, 2025
Lil' Drug Store Products, Inc.30tablet, film coated; tablet, coatedOver the counter monograph drugsJuly 10, 2024
H E B29solution; tablet, coatedGeneric drugs (ANDA)October 31, 2023
Allegiant Health28tablet; capsule, liquid filledOver the counter monograph drugsJune 4, 2026
Chain Drug Marketing Association, Inc.28tablet, coated; tabletOver the counter monograph drugsJune 5, 2026
Wal-Mart Stores Inc28solution; tablet, film coatedOver the counter monograph drugsJuly 1, 2020
Amazon.com Services LLC27tablet, film coated; solutionGeneric drugs (ANDA)October 16, 2026
Valu Merchandisers Company26capsule, liquid filled; tabletOver the counter monograph drugsJanuary 1, 2025
Bayer HealthCare LLC.25tablet, effervescent; capsule, liquid filledOver the counter monograph drugsJune 1, 2026
Target Corporation25tablet; liquidOver the counter monograph drugsDecember 9, 2025
Meijer Distribution Inc23tablet, film coated; solutionOver the counter monograph drugsJune 6, 2024
United Natural Foods, Inc. DBA Unfi23tablet, coated; tablet, film coatedOver the counter monograph drugsOctober 29, 2021
Chattem, Inc.22tablet, film coated; tabletNew drug applications (NDA)May 1, 2026
Preferred Pharmaceuticals Inc.22solution; capsuleGeneric drugs (ANDA)March 17, 2026
CVS Pharmacy21tablet, film coated; liquidOver the counter monograph drugsAugust 31, 2016
Cabinet Health P.B.C.21tabletGeneric drugs (ANDA)October 1, 2026
Discount Drug Mart21tablet, coated; capsule, liquid filledOver the counter monograph drugsMay 20, 2026
Major Pharmaceuticals21tablet, film coated; solutionOver the counter monograph drugsOctober 15, 2026
Pioneer Life Sciences, LLC21tablet; capsule, liquid filledOver the counter monograph drugsJune 22, 2026
Bryant Ranch Prepack19tablet; tablet, film coatedGeneric drugs (ANDA)April 22, 2023
Proficient Rx LP19tablet; tablet, film coatedGeneric drugs (ANDA)January 7, 2022
Bionpharma Inc.18capsule, liquid filled; tablet, film coatedOver the counter monograph drugsMay 25, 2026
WinCo Foods, LLC17tablet; tablet, film coatedOver the counter monograph drugsMarch 28, 2024
Family Dollar (family Wellness)16tablet; tablet, film coatedOver the counter monograph drugsJune 20, 2024
HyVee Inc16solution; tablet, film coatedOver the counter monograph drugsAugust 20, 2026
L. Perrigo Company16tablet, film coated; solutionGeneric drugs (ANDA)October 2, 2025
Meijer, Inc.16tablet; capsule, liquid filledOver the counter monograph drugsMay 1, 2026
American Sales Company15tablet, film coated; solutionGeneric drugs (ANDA)December 31, 2024
Yyba Corp15tablet; solutionGeneric drugs (ANDA)September 10, 2026
Haleon US Holdings LLC14powder, for solution; syrupOver the counter monograph drugsSeptember 30, 2024
Strive Pharmaceuticals Inc.14tablet; tablet, film coatedOver the counter monograph drugsAugust 15, 2026
Publix Super Markets Inc13tablet, film coated; solutionGeneric drugs (ANDA)July 15, 2026
Chain Drug Consortium, LLC12tablet; solutionGeneric drugs (ANDA)October 25, 2018
Gil Pharmaceutical Corp12tablet; solutionOver the counter monograph drugsSeptember 1, 2026
Marc Glassman, Inc.12tablet, coated; tabletOver the counter monograph drugsOctober 5, 2022
Nuvicare LLC12tablet; capsule, liquid filledGeneric drugs (ANDA)July 30, 2026
Retail Business Services, LLC12tablet, coated; capsuleGeneric drugs (ANDA)March 1, 2024
Army and Air Force Exchange Service11tablet, film coated; tabletOver the counter monograph drugsDecember 29, 2021
Bryant Ranch Prepack11suspension, extended release; tabletGeneric drugs (ANDA)March 1, 2021
CalmCo LLC11chewable gel; solutionOver the counter monograph drugsJune 26, 2026
Dr. Reddy's Laboratories Inc.11tablet, coated; solution/ dropsGeneric drugs (ANDA)December 1, 2020
Dr. Reddy's Laboratories Limited11tablet; tablet, extended releaseGeneric drugs (ANDA)November 18, 2014
L.N.K. International, Inc.11tablet, film coated; solutionOver the counter monograph drugsJune 28, 2024
Perrigo Direct, Inc11tablet; capsuleOver the counter monograph drugsMay 1, 2025
Shield Pharmaceuticals Corp11capsule, liquid filled; tablet, film coatedOver the counter monograph drugsOctober 6, 2026
Bi-Mart10tablet; tablet, film coatedOver the counter monograph drugsFebruary 1, 2026
Bjwc10tablet, film coated; tabletOver the counter monograph drugsSeptember 4, 2025
Bryant Ranch Prepack10solution; tabletGeneric drugs (ANDA)October 15, 2022
Harris Teeter10tablet, coated; tabletOver the counter monograph drugsAugust 5, 2022
Kroger Company10liquid; tablet, film coatedOver the counter monograph drugsSeptember 15, 2026
Topco Associates LLC10solution; capsule, liquid filledOver the counter monograph drugsSeptember 24, 2026
Medtech Products Inc.9tablet, chewable; tabletOver the counter monograph drugsFebruary 17, 2025
NuCare Pharmaceuticals,Inc.9tablet; tablet, film coatedGeneric drugs (ANDA)December 6, 2024
P & L Development, LLC9capsule; tablet, coatedGeneric drugs (ANDA)August 20, 2021
Padagis Israel Pharmaceuticals Ltd9solution; tablet, film coatedGeneric drugs (ANDA)January 7, 2022
Amneal Pharmaceuticals LLC8tablet; solutionGeneric drugs (ANDA)February 3, 2020
Navajo Manufacturing Company Inc.8tablet, film coated; tablet, coatedOver the counter monograph drugsMarch 11, 2025
Opmx LLC8tabletOver the counter monograph drugsJune 18, 2026
Prodose, Inc.8tablet, film coated; capsule, liquid filledGeneric drugs (ANDA)July 30, 2025
Rising Pharma Holdings, Inc.8solution; capsule, liquid filledOver the counter monograph drugsJanuary 27, 2026
Target Corporation8solution; capsuleGeneric drugs (ANDA)August 15, 2026
The Procter & Gamble Manufacturing Company8liquidOver the counter monograph drugsMay 7, 2024
Camber Consumer Care Inc7tablet; tablet, film coatedGeneric drugs (ANDA)December 8, 2021
Cardinal Health 107, LLC7capsule; tablet, film coatedGeneric drugs (ANDA)August 7, 2026
Fortune Pharmacal Company Limited7tabletOver the counter monograph drugsJuly 1, 2025
Fsa Store Inc.7tablet, coated; capsuleOver the counter monograph drugsAugust 19, 2025
Granules India Limited7tablet; tablet, film coatedGeneric drugs (ANDA)January 2, 2024
Haleon US Holdings LLC7tablet, coated; capsule, liquid filledNew drug applications (NDA)January 15, 2025
New World Imports, Inc7tablet; tablet, coatedOver the counter monograph drugsAugust 23, 2024
Rugby Laboratories7solution/ drops; tablet, film coated, extended releaseGeneric drugs (ANDA)July 8, 2026
Sam's West Inc7solution; tablet, coatedGeneric drugs (ANDA)September 23, 2024
Sato Pharmaceutical Co., Ltd.7tablet; creamOver the counter monograph drugsMarch 11, 2005
Sportpharm LLC7tablet; tablet, film coatedGeneric drugs (ANDA)October 28, 2020
The Procter & Gamble Manufacturing Company7liquid; capsule, liquid filledOver the counter monograph drugsMarch 17, 2026
Aaa Pharmaceutical, Inc.6tablet, coated; tabletOver the counter monograph drugsJuly 6, 2021
Advance Pharmaceutical Inc.6tablet; capsuleOver the counter monograph drugsSeptember 1, 2012
Advanced Rx LLC6tablet; liquidOver the counter monograph drugsMay 1, 2025
Apotex Corp.6solution/ drops; spray, meteredGeneric drugs (ANDA)October 6, 2022
Costco Wholesale Company6tablet, film coated; tablet, coatedGeneric drugs (ANDA)October 4, 2022
Farmacias De Similares TX LLC6tablet; tablet, film coatedOver the counter monograph drugsApril 20, 2026
Geri-Care Pharmaceuticals, Corp6tablet; tablet, film coatedOver the counter monograph drugsApril 24, 2025
Gland Pharma Limited6solution/ drops; solutionGeneric drugs (ANDA)January 6, 2026
Grocery Outlet, Inc.6tablet, coated; liquidOver the counter monograph drugsMarch 17, 2026
Humanwell PuraCap Pharmaceutical (Wuhan), Ltd.6capsule, liquid filledOver the counter monograph drugsMarch 24, 2017
Laboratorio Magnachem International SRL6syrup; tablet, coatedOver the counter monograph drugsMay 1, 2017

Dosage forms

Dosage formProductsShare
Tablet49821.1%
Tablet, film coated40417.1%
Solution31613.4%
Tablet, coated2018.5%
Capsule1616.8%
Capsule, liquid filled1476.2%
Liquid1315.6%
Tablet, film coated, extended release522.2%
Solution/ drops512.2%
Cream492.1%
Tablet, effervescent482%
Tablet, chewable451.9%

Updated November 6, 2026. Read from US Food and Drug Administration, National Drug Code Directory (openFDA). CC0 1.0 public domain dedication (openFDA). Counts are products in the FDA National Drug Code Directory on November 6, 2026: 138,262 products in commercial distribution, meaning without a marketing end date in the past. A company is a labeler code; one company can hold several codes, and the directory carries no address. Inclusion in the directory is not FDA approval, and the marketing category says under which kind of application or rule a product is sold. This page uses openFDA data and is not endorsed or certified by FDA. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.