Data / Drug companies / Central alpha-2 Adrenergic Agonist
Central alpha-2 Adrenergic Agonist drugs: 20 drugs from 123 companies in the FDA NDC directory
Central alpha-2 Adrenergic Agonist is an FDA established pharmacologic class. The FDA National Drug Code Directory lists 579 products in this class from 123 companies, covering 20 drugs by generic name. The main marketing category is generic drugs (ANDA), and the newest product started marketing on October 2, 2026.
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- 123Companies
- 579Products
- 20Drugs by generic name
Drugs in the Central alpha-2 Adrenergic Agonist class
Ranked by number of companies that list the drug.
| Drug | Products here | Companies listing it |
|---|---|---|
| Clonidine hydrochloride | 145 | 45 |
| Tizanidine | 112 | 38 |
| Guanfacine | 101 | 33 |
| Tizanidine hydrochloride | 66 | 25 |
| Dexmedetomidine hydrochloride | 53 | 21 |
| Dexmedetomidine | 17 | 11 |
| Clonidine | 16 | 9 |
| Tizanidne hydrochloride | 15 | 6 |
| Guanfacine hydrochloride | 10 | 6 |
| Dexmedetomidine hydrochloride in 0.9% sodium chloride | 8 | 4 |
| Gaunfacine | 5 | 3 |
| Clonidine transdermal system | 12 | 2 |
| Methyldopa | 4 | 2 |
| Dexmedetomidine hcl | 2 | 2 |
| Tizanidine hcl | 6 | 1 |
| Dexmedetomidine hydrochloride in sodium chloride | 2 | 1 |
| Guanfacine er | 2 | 1 |
| Clonidine hci | 1 | 1 |
| Clonidine hydrochloride oral | 1 | 1 |
| Tizandine | 1 | 1 |
Companies with the most products in this class
| Company | Products | Main dosage forms | Main marketing category | Newest product started |
|---|---|---|---|---|
| Bryant Ranch Prepack | 29 | tablet; capsule | Generic drugs (ANDA) | August 8, 2023 |
| Remedyrepack Inc. | 25 | tablet; tablet, extended release | Generic drugs (ANDA) | June 2, 2026 |
| A-S Medication Solutions | 20 | tablet; tablet, extended release | Generic drugs (ANDA) | December 15, 2024 |
| Bryant Ranch Prepack | 18 | tablet; capsule | Generic drugs (ANDA) | July 1, 2020 |
| Asclemed USA, Inc. | 16 | tablet; capsule | Generic drugs (ANDA) | June 15, 2021 |
| Bryant Ranch Prepack | 15 | tablet; tablet, extended release | Generic drugs (ANDA) | June 2, 2021 |
| Advanced Rx of Tennessee, LLC | 13 | tablet; capsule | Generic drugs (ANDA) | March 20, 2025 |
| Hospira, Inc. | 13 | injection, solution; injection, solution, concentrate | New drug applications (NDA) | March 24, 2025 |
| Preferred Pharmaceuticals Inc. | 13 | tablet; capsule | Generic drugs (ANDA) | July 16, 2026 |
| Alembic Pharmaceuticals Inc. | 11 | tablet; tablet, extended release | Generic drugs (ANDA) | September 22, 2026 |
| Alembic Pharmaceuticals Limited | 11 | tablet; tablet, extended release | Generic drugs (ANDA) | September 22, 2026 |
| NuCare Pharmaceuticals,Inc. | 11 | tablet | Generic drugs (ANDA) | March 4, 2021 |
| TruPharma, LLC | 11 | patch; tablet | Authorized generics (NDA) | April 13, 2026 |
| Unichem Pharmaceuticals (USA), Inc. | 11 | tablet; tablet, extended release | Generic drugs (ANDA) | November 19, 2024 |
| Advagen Pharma Ltd | 10 | capsule; tablet, extended release | Generic drugs (ANDA) | August 28, 2025 |
| Apotex Corp. | 9 | tablet, extended release; capsule, gelatin coated | Generic drugs (ANDA) | October 3, 2018 |
| Proficient Rx LP | 9 | tablet; tablet, extended release | Generic drugs (ANDA) | December 24, 2020 |
| Actavis Pharma, Inc. | 8 | capsule, gelatin coated; patch | Generic drugs (ANDA) | May 6, 2014 |
| Actavis Pharma, Inc. | 8 | tablet, extended release; tablet | Generic drugs (ANDA) | June 17, 2015 |
| Aurobindo Pharma Limited | 8 | tablet; capsule | Generic drugs (ANDA) | August 7, 2023 |
| Northwind Health Company, LLC | 8 | tablet | Generic drugs (ANDA) | December 6, 2022 |
| Direct_Rx | 7 | tablet, extended release; tablet | Generic drugs (ANDA) | October 2, 2026 |
| PD-Rx Pharmaceuticals, Inc. | 7 | tablet; capsule | Generic drugs (ANDA) | May 27, 2020 |
| Proficient Rx LP | 7 | tablet | Generic drugs (ANDA) | December 2, 2013 |
| AvPAK | 6 | tablet | Generic drugs (ANDA) | May 30, 2023 |
| Coupler LLC | 6 | tablet | Generic drugs (ANDA) | August 7, 2026 |
| Hikma Pharmaceuticals USA Inc. | 6 | injection, solution; injection | Generic drugs (ANDA) | March 3, 2026 |
| NorthStar Rx LLC | 6 | tablet, extended release; tablet | Generic drugs (ANDA) | September 17, 2021 |
| St. Mary's Medical Park Pharmacy | 6 | tablet; tablet, extended release | Generic drugs (ANDA) | May 19, 2025 |
| Technomed Inc. | 6 | patch | New drug applications (NDA) | March 30, 2026 |
| Upsher-Smith Laboratories, LLC | 6 | tablet, extended release; tablet | Generic drugs (ANDA) | September 1, 2022 |
| Aphena Pharma Solutions - Tennessee, LLC | 5 | tablet | Generic drugs (ANDA) | June 1, 2017 |
| Ascend Laboratories, LLC | 5 | capsule; tablet | Generic drugs (ANDA) | March 29, 2019 |
| Medical Purchasing Solutions, LLC | 5 | injection, solution; injection | Generic drugs (ANDA) | January 19, 2021 |
| NCS HealthCare of Ky, LLC DBA Vangard Labs | 5 | tablet | Generic drugs (ANDA) | March 4, 2021 |
| Redpharm Drug | 5 | tablet | Generic drugs (ANDA) | June 15, 2021 |
| Zydus Lifesciences Limited | 5 | capsule; tablet | Generic drugs (ANDA) | September 13, 2018 |
| American Health Packaging | 4 | tablet; tablet, extended release | Generic drugs (ANDA) | November 9, 2023 |
| Amneal Pharmaceuticals LLC | 4 | injection; injection, solution | Generic drugs (ANDA) | May 19, 2023 |
| Baxter Healthcare Corporation | 4 | injection | Generic drugs (ANDA) | August 27, 2019 |
| BluePoint Laboratories | 4 | tablet; tablet, extended release | Generic drugs (ANDA) | August 24, 2023 |
| Cardinal Health 107, LLC | 4 | tablet | Generic drugs (ANDA) | October 9, 2025 |
| Chartwell RX, LLC | 4 | tablet; tablet, film coated | Generic drugs (ANDA) | September 1, 2022 |
| Covis Pharma US, Inc | 4 | capsule; tablet | New drug applications (NDA) | August 1, 2018 |
| Fosun Pharma USA Inc. | 4 | tablet, extended release | Generic drugs (ANDA) | April 3, 2026 |
| Gland Pharma Limited | 4 | injection; injection, solution | Generic drugs (ANDA) | December 19, 2024 |
| Golden State Medical Supply, Inc. | 4 | tablet, extended release | Generic drugs (ANDA) | August 7, 2023 |
| Ingenus Pharmaceuticals, LLC | 4 | capsule; tablet, extended release | Generic drugs (ANDA) | March 20, 2019 |
| Legacy Pharma USA Inc. | 4 | capsule; tablet | New drug applications (NDA) | August 1, 2018 |
| Major Pharmaceuticals | 4 | tablet | Generic drugs (ANDA) | November 21, 2025 |
| Mylan Institutional LLC | 4 | injection, solution; injection, solution, concentrate | Generic drugs (ANDA) | November 13, 2020 |
| PD-Rx Pharmaceuticals, Inc. | 4 | tablet | Generic drugs (ANDA) | April 1, 2013 |
| Piramal Critical Care Inc | 4 | injection, solution; injection | Generic drugs (ANDA) | May 1, 2021 |
| Precision Dose, Inc. | 4 | injection, solution; tablet | Generic drugs (ANDA) | January 31, 2023 |
| Rising Pharma Holdings, Inc. | 4 | tablet | Generic drugs (ANDA) | April 4, 2025 |
| Slate Run Pharmaceuticals, LLC | 4 | tablet, extended release | Generic drugs (ANDA) | August 1, 2022 |
| Solco Healthcare US, LLC | 4 | tablet; tablet, extended release | Generic drugs (ANDA) | January 5, 2023 |
| Takeda Pharmaceuticals America, Inc. | 4 | tablet, extended release | New drug applications (NDA) | September 2, 2009 |
| WG Critical Care, LLC | 4 | injection, solution, concentrate; injection | New drug applications (NDA) | April 19, 2016 |
| Ajanta Pharma USA Inc. | 3 | tablet; tablet, extended release | Generic drugs (ANDA) | April 27, 2023 |
| Asclemed USA Inc. | 3 | tablet | Generic drugs (ANDA) | December 24, 2020 |
| Cadila Pharmaceuticals Limited | 3 | capsule | Generic drugs (ANDA) | December 29, 2017 |
| Direct RX | 3 | tablet | Generic drugs (ANDA) | August 13, 2019 |
| Dr. Reddy's Laboratories Inc. | 3 | patch, extended release | Generic drugs (ANDA) | February 10, 2024 |
| Eugia US LLC | 3 | injection, solution | Generic drugs (ANDA) | December 7, 2020 |
| Golden State Medical Supply, Inc. | 3 | tablet, extended release | Generic drugs (ANDA) | June 2, 2015 |
| Kanchan Healthcare Inc | 3 | capsule | Generic drugs (ANDA) | December 29, 2017 |
| Method Pharmaceuticals, LLC | 3 | tablet | Generic drugs (ANDA) | July 1, 2020 |
| Modavar Pharmaceuticals LLC | 3 | capsule | Generic drugs (ANDA) | December 29, 2017 |
| Mylan Pharmaceuticals Inc. | 3 | patch | Generic drugs (ANDA) | March 4, 2013 |
| Par Health USA, LLC | 3 | injection, solution; injection, solution, concentrate | Generic drugs (ANDA) | December 4, 2020 |
| ProPharma Distribution | 3 | injection, solution; injection | Generic drugs (ANDA) | January 19, 2021 |
| Sandoz Inc | 3 | injection | Generic drugs (ANDA) | June 12, 2020 |
| Somerset Therapeutics, LLC | 3 | injection, solution; tablet, extended release | Generic drugs (ANDA) | March 4, 2025 |
| Sun Pharmaceutical Industries, Inc. | 3 | tablet; injection, solution | Generic drugs (ANDA) | April 8, 2015 |
| Zydus Pharmaceuticals USA Inc. | 3 | capsule | Generic drugs (ANDA) | April 27, 2017 |
| A2A Integrated Pharmaceuticals | 2 | tablet | Generic drugs (ANDA) | April 8, 2025 |
| American Health Packaging | 2 | tablet | Generic drugs (ANDA) | January 25, 2016 |
| Amneal Pharmaceuticals LLC | 2 | tablet | Generic drugs (ANDA) | November 25, 1998 |
| Amneal Pharmaceuticals of New York LLC | 2 | tablet | Generic drugs (ANDA) | April 15, 2022 |
| Aurobindo Pharma Limited | 2 | tablet | Generic drugs (ANDA) | September 1, 2026 |
| Baxter Healthcare Corporation | 2 | injection | Generic drugs (ANDA) | August 21, 2018 |
| BioXcel Therapeutics, Inc. | 2 | film | New drug applications (NDA) | July 1, 2022 |
| Civica, Inc. | 2 | injection | Generic drugs (ANDA) | August 23, 2021 |
| Dr. Reddy's Laboratories Inc. | 2 | injection, solution | Generic drugs (ANDA) | August 17, 2020 |
| Dr. Reddy's Laboratories Limited | 2 | tablet | Generic drugs (ANDA) | July 3, 2002 |
| Epic Pharma, LLC | 2 | tablet | Generic drugs (ANDA) | December 2, 2013 |
| Hawaii Repack, Inc. | 2 | tablet | Generic drugs (ANDA) | July 3, 2002 |
| I3 Pharmaceuticals, LLC | 2 | tablet | Generic drugs (ANDA) | October 31, 2022 |
| Medcore LLC | 2 | tablet | Generic drugs (ANDA) | April 10, 2026 |
| NorthStar RxLLC | 2 | tablet | Generic drugs (ANDA) | July 15, 2024 |
| Sagent Pharmaceuticals | 2 | injection; injection, solution | Generic drugs (ANDA) | July 15, 2025 |
| Trifluent Pharma, LLC | 2 | capsule | Generic drugs (ANDA) | September 16, 2025 |
| Unit Dose Solutions, Inc. | 2 | tablet | Generic drugs (ANDA) | June 17, 2026 |
| Verityrx, LLC | 2 | tablet | Generic drugs (ANDA) | December 24, 2020 |
| Viona Pharmaceuticals Inc | 2 | tablet | Generic drugs (ANDA) | March 4, 2021 |
| Wilshire Pharmaceuticals, Inc. | 2 | injection | Generic drugs (ANDA) | January 30, 2025 |
| XGen Pharmaceuticals DJB, Inc. | 2 | injection, solution | Generic drugs (ANDA) | October 29, 2013 |
| Xiromed, LLC | 2 | tablet | Generic drugs (ANDA) | February 24, 2024 |
| Accord Healthcare Inc. | 1 | injection, solution | Generic drugs (ANDA) | December 21, 2016 |
Dosage forms
| Dosage form | Products | Share |
|---|---|---|
| Tablet | 293 | 50.6% |
| Tablet, extended release | 90 | 15.5% |
| Capsule | 73 | 12.6% |
| Injection, solution | 52 | 9% |
| Injection | 26 | 4.5% |
| Patch | 18 | 3.1% |
| Injection, solution, concentrate | 8 | 1.4% |
| Capsule, gelatin coated | 7 | 1.2% |
| Patch, extended release | 4 | 0.7% |
| Solution | 3 | 0.5% |
| Film | 2 | 0.3% |
| Tablet, film coated | 2 | 0.3% |
Updated November 6, 2026. Read from US Food and Drug Administration, National Drug Code Directory (openFDA). CC0 1.0 public domain dedication (openFDA). Counts are products in the FDA National Drug Code Directory on November 6, 2026: 138,262 products in commercial distribution, meaning without a marketing end date in the past. A company is a labeler code; one company can hold several codes, and the directory carries no address. Inclusion in the directory is not FDA approval, and the marketing category says under which kind of application or rule a product is sold. This page uses openFDA data and is not endorsed or certified by FDA. Free to reuse with credit to SpecStream under CC BY 4.0. Spot a wrong value? Write to [email protected] with the link to this page.