# New Smoking clinical trials: 158 posted since Nov 2024

Updated November 4, 2026.

158 clinical studies in smoking were first posted on ClinicalTrials.gov from November 14, 2024 to November 4, 2026; 19 have an industry sponsor and 95 are recruiting or about to. The newest, NCT07915570, was posted on November 4, 2026: Salivary IL-8 and Serum IL-6 as Biomarkers for Oral Potentially Malignant Disorders in Smokers and... (British University In Egypt).

## The full list

New Smoking clinical trials: 158 rows for $7.90, first posted on ClinicalTrials.gov from November 12, 2024 to November 9, 2026. Columns: NCT ID, Title, Sponsor, Sponsor class, Phase, Status, Conditions, Condition groups (MeSH), Interventions, Start date, First posted, Enrollment, Enrollment type, Location countries, Central contact, Contact phone, Contact email, Last update posted, Read on, Source. The new rows each week by email, about 8 rows a month: $19 a month. Pay by card with no account. Prices exclude VAT. CSV and Excel files with the columns this page does not show (central contact, contact phone, contact email, sponsor class, condition groups (MeSH), interventions and 5 more), which open on your screen as soon as the payment clears and come by email. The rows on this page are a sample.

Buy: https://specstream.ai/data/clinical-trials/condition/smoking

SpecStream is the live web data engine for teams and agents. It reads every new study on ClinicalTrials.gov each morning, and this page is that reading. Ask for the conditions, phases or countries you follow and each new trial arrives in your sheet, CRM, Slack or agent with the sponsor, the sites and the listed contact.

- New trials: 158
- Industry sponsored: 19
- Recruiting or not yet: 95
- Latest posted: November 4, 2026

## Newest trials

The newest 100 of 158, each linked to its record. The full list holds every one with the sponsor class, interventions, start date and the central contact as the record prints it.

| First posted | NCT ID | Title | Sponsor | Phase | Status | Conditions | Enrollment | Countries | Source |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| November 4, 2026 | NCT07915570 | Salivary IL-8 and Serum IL-6 as Biomarkers for Oral Potentially Malignant Disorders in Smokers and Never-Smokers | British University In Egypt | Observational | Recruiting | Oral Potentially Malignant Disorders, Oral Lichen Planus, Oral Leukoplakia, Oral Squamous Cell Carcinoma, Smoking | 250 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07915570) |
| November 2, 2026 | NCT07910214 | Effectiveness of Volitional Help Sheets as an Adjunct to Treatment to Promote Behavior Change: A Pilot Study on Smoking | Clinique de la Mitterie | Not applicable | Recruiting | Tobacco Dependence | 376 | France | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07910214) |
| October 30, 2026 | NCT07907601 | Impact of Multidisciplinary Care, Structured and Targeted on the COPD Patient's Clinical Pathway. | Centre Hospitalier Universitaire de Nīmes | Not applicable | Not yet recruiting | Chronic Obstructive Pulmonary Disease, Lung Diseases, Obstructive, Lung Disease Chronic | 116 | France | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07907601) |
| October 27, 2026 | NCT07897162 | Effect of Smoking on Salivary and Serum Metabolomic Profiles in Periodontitis | Ankara University | Observational | Completed | Periodontitis | 48 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07897162) |
| October 21, 2026 | NCT07887217 | THE EFFECT OF A TRANSTHEORETICAL MODEL-BASED CHATBOT SUPPORT INTERVENTION ON SMOKING BEHAVIOR IN UNIVERSITY STUDENTS | Seher DÖNER | Not applicable | Active not recruiting | Smoking ( Cigarette), Smoking (Tobacco) Addiction, Smoking Behaviors, Smoking Cessation, Tobacco Smoking | 100 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07887217) |
| October 20, 2026 | NCT07881848 | A Study to Assess Nicotine Uptake From a Menthol Electronic Nicotine Delivery System Product | RAI Services Company | Not applicable | Not yet recruiting | Smoking Behaviors, Smoking ( Cigarette), Tobacco Use, Abuse Liability | 28 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881848) |
| October 19, 2026 | NCT07880717 | Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 Years | Mahidol University | Observational | Recruiting | Diabete Mellitus, Dyslipidaemia, Chronic Kidney Disease, Psychiatric Disorder, Hypertension, Hypothyroidism, Smoking... | 93 | Thailand | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07880717) |
| October 19, 2026 | NCT07879638 | A Study to Determine the Effect of Access to Multiple Tobacco Flavor Options on Smoking Abstinence Among Primary Cigarette Smokers Using an... | RAI Services Company | Not applicable | Recruiting | Smoking, Tobacco | 480 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07879638) |
| October 13, 2026 | NCT07871656 | Lung Cancer Detection in Never Smokers Using Urine Volatile Organic Compound (VOCs) | Thomas Jefferson University | Observational | Recruiting | Lung Cancer | 87 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07871656) |
| October 6, 2026 | NCT07860359 | Impact of Lung Cancer Screening With Chest Scans Combined With Coaching on Smoking Cessation in Heavy Smokers | Hôpital Fribourgeois | Not applicable | Not yet recruiting | Lung Cancer (Diagnosis), Smoking Cessation, Lung Neoplasm | 116 | Switzerland | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07860359) |
| October 1, 2026 | NCT07851584 | Er,Cr:YSGG Laser in Smokers With Stage III Periodontitis | Okan University | Not applicable | Completed | Periodontitis (Stage 3) | 20 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07851584) |
| September 24, 2026 | NCT07840118 | Smartphone-based Incentives Intervention to Increase Smoking Cessation During Pregnancy | University of Vermont | Not applicable | Not yet recruiting | Smoking During Pregnancy and Postpartum, Perinatal Cigarette Smoking | 137 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07840118) |
| September 18, 2026 | NCT07828990 | Cardiovascular Risk Factors and Lipid Profile in Hospitalized Mexican Adults | Hospital General de Chihuahua - Dr. Salvador Zubirán Anchondo | Observational | Completed | Dyslipidemia | 107 | Mexico | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07828990) |
| September 17, 2026 | NCT07826728 | SMOKING AND GINGIVAL CREVICULAR FLUID MFN1 AND NLRP3 LEVELS IN PERIODONTAL HEALTH AND PERIODONTITIS | Abant Izzet Baysal University | Observational | Recruiting | Periodontitis, Smoking | 88 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07826728) |
| September 14, 2026 | NCT07819318 | C-Raven LDCT: Lung Cancer Screening Intervention | Johns Hopkins University | Not applicable | Not yet recruiting | Lung Cancer Screening | 300 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07819318) |
| August 31, 2026 | NCT07794969 | Pancreatic Cancer Lifestyle Evolution And Resistance | IRCCS San Raffaele | Observational | Not yet recruiting | Pancreatic Cancer | 150 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07794969) |
| August 27, 2026 | NCT07789132 | Evaluation of Community Health Worker Support to Help People With Serious Mental Illness to Quit Smoking | Massachusetts General Hospital | Not applicable | Not yet recruiting | Nicotine Dependance, Serious Mental Illness, Smoking (Tobacco) Addiction, Tobacco Cessation, Community Health Workers... | 937 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07789132) |
| August 24, 2026 | NCT07782879 | DoubleTake: Effect of Message Exposure Via a Discrete Choice Experiment With Eye-Tracking on Quit Attempts Among Adults Who Smoke Menthol... | Georgia State University | Not applicable | Recruiting | Menthol Cigarettes, Smoking Behavior, Cigarette Use | 200 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07782879) |
| August 18, 2026 | NCT07770633 | Negative Pressure Wound Therapy Devices in Total Knee Arthroplasty | The Cleveland Clinic | Not applicable | Not yet recruiting | Wound Surgical, Diabetes, Obesity, Chronic Kidney Diseases, Smoking | 300 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07770633) |
| August 14, 2026 | NCT07766655 | Studying NMDA and Sigma-1 in Smoking Cessation Treatment (SUMMIT) | Axsome Therapeutics, Inc. | Phase 3 | Recruiting | Smoking Cessation | 705 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07766655) |
| August 14, 2026 | NCT07765251 | Angiogenesis in Periodontal Disease | Inonu University | Observational | Completed | Gingivitis | 114 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07765251) |
| August 14, 2026 | NCT07764549 | Salivary TNF-α, FoxO-1, and SIRT-1 Levels in Periodontitis and Smoking | Zehra Hasgül | Observational | Completed | Periodontitis (Stage 3), Smoking ( Cigarette) | 80 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07764549) |
| August 11, 2026 | NCT07758998 | The Effect of Motivational Interviewing on Smoking Behavior Among Nursing Students | Meral Feratoğlu Research | Not applicable | Not yet recruiting | Tobacco Use, Smoking Cessation | 87 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07758998) |
| August 10, 2026 | NCT07754578 | DOSE-UP: Dose Optimization for Smoking and E-Cigarette Use Pharmacotherapy | Medical University of South Carolina | Phase 2 | Not yet recruiting | Dual Use of Cigarettes and E-cigarettes | 321 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07754578) |
| August 6, 2026 | NCT07750171 | Impact of Smoking on Immune Responses in Peri-implant Health and Disease | Gazi University | Observational | Recruiting | Peri-Implant Health, Peri Implant Mucositis, Peri-implantitis | 216 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07750171) |
| August 5, 2026 | NCT07746492 | Just-in-Time Support for Smoking, Vaping, and Eating Urges During High-Stress Moments Among Gender and Sexual Minority Adults in Dhaka | International Centre for Diarrhoeal Disease Research, Bangladesh | Not applicable | Not yet recruiting | Tobacco Use, Electronic Cigarette Use, Emotional Eating, Stress, Psychological | 115 | Bangladesh | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07746492) |
| July 31, 2026 | NCT07739797 | A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery System Products | RAI Services Company | Not applicable | Not yet recruiting | Smoking Behaviors, Smoking ( Cigarette), Tobacco Use | 50 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07739797) |
| July 30, 2026 | NCT07737587 | Yoga-Based Breathing Exercises in a Salt-Cave Environment Versus a Standard Clinical Setting in Smokers | Sinop University | Not applicable | Completed | Tobacco Smoking, Respiratory Function | 60 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07737587) |
| July 20, 2026 | NCT07714200 | Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness | VA Office of Research and Development | Not applicable | Not yet recruiting | Tobacco Use Disorder | 120 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07714200) |
| July 17, 2026 | NCT07711691 | Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+) | University of California, Irvine | Not applicable | Recruiting | Lung Cancer Screening, Lung Neoplasms, Smoking ( Cigarette), Early Detection of Cancer | 80 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07711691) |
| July 17, 2026 | NCT07710820 | A Multi-Site Study to Assess the Effect of Availability of a Heated Tobacco Product on Smoking Abstinence Among Current Primary Cigarette... | RAI Services Company | Not applicable | Recruiting | Smoking, Tobacco | 1,060 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07710820) |
| July 13, 2026 | NCT07698470 | Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use | University of Southern California | Not applicable | Recruiting | Nicotine Dependence | 45 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07698470) |
| July 6, 2026 | NCT07685795 | Abuse Liability of Four Modern Oral Nicotine Products | RAI Services Company | Not applicable | Not yet recruiting | Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking | 50 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07685795) |
| June 30, 2026 | NCT07676435 | Ongoing Lung Decline With Age Intensified Response | Cedars-Sinai Medical Center | Phase 2 | Recruiting | Age-Related Lung Function Decline | 40 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07676435) |
| June 29, 2026 | NCT07673926 | Turkish Adaptation of the Pain and Smoking Inventory | Hacettepe University | Observational | Recruiting | Chronic Pain | 200 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07673926) |
| June 29, 2026 | NCT07673185 | Omega-3 Plus Low-Dose Aspirin in Smokers With Stage III Periodontitis | Al-Azhar University | Not applicable | Recruiting | Periodontal Disease, Periodontitis (Stage 3), Smoking Behaviors | 40 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07673185) |
| June 25, 2026 | NCT07668947 | Impact of E-Cigarette Smoking on Healing Response to Non-Surgical Periodontal Therapy | Ain Shams University | Not applicable | Completed | Periodontitis | 117 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07668947) |
| June 22, 2026 | NCT07661823 | QAIAx - SGI/SI Smart Health Cities: Microcity Enclave Program (Quantum SI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos.... | Veterans Recovery Network Inc. | Not applicable | Not yet recruiting | Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism, ADHD - Attention Deficit Disorder With Hyperactivity... | 1,000,000 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07661823) |
| June 8, 2026 | NCT07631624 | Methylated Biomarkers of Smoking as a Selection Tool in Participants for Lung Cancer Screening | University Hospital, Antwerp | Not applicable | Recruiting | Epigenetics, DNA Methylation, Lung Cancer Screening, Risk Stratification With Biomarker, Saliva | 1,000 | Belgium | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07631624) |
| June 4, 2026 | NCT07625111 | Effect of Smoking and Time of Day on Eosinophils | Marek Lommatzsch | Not applicable | Recruiting | Healthy | 20 | Germany | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07625111) |
| May 22, 2026 | NCT07604584 | Effects of Platelet-Rich Fibrin After Mandibular Third Molar Surgery in Smokers and Nonsmokers | Ankara University | Not applicable | Completed | Impacted Mandibular Third Molar, Postoperative Pain, Trismus, Facial Swelling | 30 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07604584) |
| May 22, 2026 | NCT07604493 | Oral Health and Systemic Diseases: Survey of General Practitioners | University of Roma La Sapienza | Observational | Recruiting | Periodontal Disease, Diabete Mellitus | 100 | Italy | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07604493) |
| May 22, 2026 | NCT07602699 | Multi-Site Trial of Tirzepatide for Smoking Cessation | University of Southern California | Phase 2 | Recruiting | Smoking Cessation, Smoking Behaviors | 300 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07602699) |
| May 20, 2026 | NCT07598136 | A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers | RAI Services Company | Not applicable | Recruiting | Smoking, Tobacco | 1,280 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07598136) |
| May 19, 2026 | NCT07595055 | Abuse Liability of Two Modern Oral Nicotine Pouched Products | RAI Services Company | Not applicable | Not yet recruiting | Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking | 40 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07595055) |
| May 18, 2026 | NCT07593742 | Smoking Cessation With Wearables to Improve General, Oral Health and Quality of Life | University of Salerno | Not applicable | Not yet recruiting | Smoking ( Cigarette), Smoking (Tobacco) Addiction, Smoking Behaviors, Smoking Cessation, Smoking Dependence, Smoking... | 102 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07593742) |
| May 7, 2026 | NCT07571941 | Effects of CO Level on Pain, Sensory Function, and Subjective Health | Izmir Democracy University | Observational | Not yet recruiting | Carbon Monoxide, Pain Perception, Sensory Thresholds, Anxiety, Depression, Tobacco Smoking | 70 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07571941) |
| May 6, 2026 | NCT07569432 | Investigation of Macrophage Polarization in Peri-implant Health and Peri-implantitis | Biruni University | Observational | Recruiting | Peri-implantitis | 120 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07569432) |
| May 5, 2026 | NCT07568483 | TUBSIS 2.0 - Tobacco Use Behavioral Support and Intervention System | University of Zurich | Not applicable | Recruiting | Tobacco Use Disorder, Nicotine Dependence, Vaping, Smoking Tobacco | 406 | Switzerland | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07568483) |
| May 5, 2026 | NCT07566221 | Increasing Lung Cancer Screening Among Emergency Department Patients - LCS R01 | University of Rochester | Not applicable | Not yet recruiting | Smoking History, Current Smoker, Lung Cancer Screening | 1,036 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07566221) |
| May 1, 2026 | NCT07562295 | Periodontal Health Among Cigarette, Electronic Cigarettes, and Narghile Smokers | Al-Hawash Private University | Observational | Completed | Smokers, Periodontal Status | 90 | Syria | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07562295) |
| April 30, 2026 | NCT07558187 | Systematic Examination of Health Inequalities: Documentation, Patterns, and Determinants | University of Thessaly | Observational | Recruiting | Non-communicable Diseases (NCD), Addiction to Opioids, Incarceration, Opioid-use Disorders | 2,000 | Greece | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07558187) |
| April 28, 2026 | NCT07553962 | Measuring Communal Coping in Dual-smoking Couples Making a Quit Attempt | University of Colorado, Denver | Observational | Recruiting | Smoking (Tobacco) Addiction, Smoking ( Cigarette), Tobacco, Tobacco Abstinence, Quitting Smoking, Smoking Cessation | 250 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07553962) |
| April 24, 2026 | NCT07550491 | Influence of Residual Bone Height on Marginal Bone Loss Around Implants Following Lateral Sinus Floor Augmentation With Deproteinized... | Saint-Joseph University | Observational | Completed | Residual Bone Height, Marginal Bone Loss, Implant Type, Smoking, Diabetes | 142 | Lebanon | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07550491) |
| April 23, 2026 | NCT07547202 | Effect of Non-Surgical Periodontal Therapy on Salivary Biomarkers in Smokers and Non-Smokers With Periodontitis | Al-Mustansiriyah University | Not applicable | Recruiting | Periodontitis, Smoking ( Cigarette) | 44 | Iraq | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07547202) |
| April 15, 2026 | NCT07530211 | The Effect of Systemic Factors on Peri-implant Health Status and Clinical Indices | Inonu University | Observational | Completed | Peri-implantitis, Dental Implants, Peri-implant Mucositis | 93 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07530211) |
| April 9, 2026 | NCT07520981 | Functional Capacity, Subjective Dyspnea and Fatigue in Smokers | Istinye University | Observational | Completed | Smoking | 103 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07520981) |
| March 30, 2026 | NCT07501624 | Engaging Pharmacists to Advance Tobacco Treatment Service Delivery | Medical University of South Carolina | Not applicable | Enrolling by invitation | Smoking Cessation, Tobacco Use Disorder, Smoking, HIV, AIDS, Pharmacy | 172 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07501624) |
| March 24, 2026 | NCT07489443 | Feasibility and Acceptability Trial to Reduce Tobacco and Cannabis Use During Pregnancy and Postpartum | University of Pittsburgh | Not applicable | Recruiting | Perinatal, Cannabis Use, Tobacco Use, Smoking Cessation | 25 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07489443) |
| March 23, 2026 | NCT07488741 | Comparison of the Effects of Different Chest Techniques on University Students With Smoking Addiction | University of Yalova | Not applicable | Recruiting | Smoking | 30 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07488741) |
| March 23, 2026 | NCT07487818 | A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation | Mayo Clinic | Phase 2/3 | Recruiting | Smoking Cessation | 150 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07487818) |
| March 17, 2026 | NCT07476144 | Nicotine Pouch Pharmacokinetics Abuse Liability | JT International SA | Phase 1 | Active not recruiting | Smoking Behaviors | 55 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07476144) |
| March 10, 2026 | NCT07459621 | Evaluation of a Novel mHealth Intervention for People Who Are Ambivalent About Quitting Smoking | Kaiser Permanente | Not applicable | Recruiting | Smoking Behaviors | 800 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07459621) |
| March 9, 2026 | NCT07457892 | Nicotine Dependence, Periodontal Awareness, and Clinical Periodontal Parameters in Smokers With Gingivitis and Periodontitis | Erzincan University | Observational | Completed | Periodontal Disease, Gingivitis and Periodontal Diseases, Periodontitis | 350 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07457892) |
| March 2, 2026 | NCT07443631 | Assessment of HPHC Exposure in Smokers Switching to THS/TP18 With Different Device Variants | Philip Morris Products S.A. | Not applicable | Active not recruiting | Smoking | 108 | United Kingdom | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07443631) |
| March 2, 2026 | NCT07441603 | Efficacy of the Proactive Automatized Lifestyle Intervention | University Medicine Greifswald | Not applicable | Recruiting | Health Risk Behaviors, Tobacco Smoking, Alcohol Use, Unhealthy Diet, Exercise, Smoking, and Alcohol Use, Unhealthy... | 788 | Germany | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07441603) |
| February 24, 2026 | NCT07429825 | Effect of a Mobile-Based Anti-Smoking Nursing Intervention on Nursing Students (HDDN) | LÜTFİYE GÖKÇE | Not applicable | Completed | Tobacco Abuse Cigarette | 43 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07429825) |
| February 23, 2026 | NCT07427745 | SMOKING AND PRESENCE OF FRANK'S SIGN | Samsun University | Observational | Completed | Smoking ( Cigarette), Cardiovascular Disease | 404 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07427745) |
| February 23, 2026 | NCT07427706 | Effect of Tobacco Use on the Health of the Newborn up to 24 Months. | Institut Investigacio Sanitaria Pere Virgili | Observational | Completed | Apgar Score, Motor Coordination or Function; Developmental Disorder, Lactation, Weight Control, Cardiopulmonary... | 105 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07427706) |
| February 20, 2026 | NCT07424443 | Pilot Study of a Brain Health Program in Senior Centers | Massachusetts General Hospital | Not applicable | Completed | Memory Loss (Excluding Dementia), Lifestyle (Sedentary Behavior and Physical Activity), Lifestyle Risk Reduction... | 60 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07424443) |
| February 17, 2026 | NCT07414355 | Switching to E-Cigarettes After Type 2 Diabetes Diagnosis and Health Outcomes | Samsung Medical Center | Observational | Completed | Diabete Type 2, E Cigarette Use, Clinical Outcomes | 133,320 | South Korea | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07414355) |
| February 17, 2026 | NCT07412639 | Tabata Exercise on Nitric Oxide Synthases and Maresin | Ataturk University | Not applicable | Completed | Smoking, Smoking, Cigarette | 40 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07412639) |
| January 29, 2026 | NCT07375459 | Community-based Mobile-assisted Brief Intervention for Smoking Cessation | National University of Singapore | Not applicable | Active not recruiting | Smoking &Amp; Tobacco Cessation | 100 | Singapore | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07375459) |
| January 16, 2026 | NCT07348679 | Cigarette Filter Study | Rutgers, The State University of New Jersey | Not applicable | Recruiting | Smoking ( Cigarette) | 252 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07348679) |
| January 15, 2026 | NCT07342920 | Study of the Prevalence of Active/Passive Smoking and Vaping Among Patients With Cystic Fibrosis | University Hospital, Strasbourg, France | Observational | Recruiting | Cystic Fibrosis | 100 | France | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07342920) |
| January 15, 2026 | NCT07341945 | Oral Health Literacy and Periodontal Status Among Turkish Adults | Biruni University | Observational | Completed | Periodontal Diseases, Oral Health Literacy, Periodontitis, Health Behaviour, Health Education | 108 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07341945) |
| January 13, 2026 | NCT07338318 | Effects of E-Cigarette Use on Oxidative Stress and Matrix Degradation | Ankara Medipol University | Observational | Completed | Smoking Behaviors, Periodontal Health | 60 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07338318) |
| January 9, 2026 | NCT07328594 | Impact of Daridorexant on Sleep, Daytime Alertness, and Smoking | Legacy Health System | Phase 4 | Not yet recruiting | Smoking, Nicotine, Tobacco, Addiction, Substance Use Disorders, Insomnia, Sleep | 44 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07328594) |
| January 7, 2026 | NCT07323563 | A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery Systems | RAI Services Company | Not applicable | Not yet recruiting | Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking | 40 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07323563) |
| January 7, 2026 | NCT07323511 | Abuse Liability for Eight Electronic Nicotine Products | RAI Services Company | Not applicable | Not yet recruiting | Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking | 70 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07323511) |
| January 7, 2026 | NCT07323277 | Effect of Smoking on Macrophage Polarization in Periodontitis | Suleyman Demirel University | Observational | Completed | Periodontitis | 80 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07323277) |
| January 7, 2026 | NCT07322796 | Smoking Cessation Before Bronchoscopy or CT-guided Puncture | RWTH Aachen University | Observational | Recruiting | Pulmonary Nodule, Solitary, Smoking Behaviors | 25 | Germany | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07322796) |
| January 2, 2026 | NCT07314957 | Impact of Lifestyle on Health Maintenance: A Randomized Controlled Trial | University of Zadar | Not applicable | Not yet recruiting | Metabolic Syndrome, Inactivity/Low Levels of Exercise, Unhealthy Diet, Unhealthy Alcohol Use, Smoking Behaviors... | 120 | Croatia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07314957) |
| December 31, 2025 | NCT07312552 | Association of Periodontal Status and Smoking With Salivary Inflammasome Markers | Uskudar University | Observational | Recruiting | Periodontitis, Periodontal Disease, Periodontal Health, Smoking, Inflammasomes | 116 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07312552) |
| December 30, 2025 | NCT07309484 | Lifestyle and Its Association With Maintaining Health | University of Zadar | Observational | Enrolling by invitation | Lifestyle (Sedentary Behavior and Physical Activity), Mental Health, Nutrition, Sleep, Stress, Unhealthy Diet... | 2,500 | Croatia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07309484) |
| December 24, 2025 | NCT07301151 | PASCAL Feasibility Study | University of Minnesota | Not applicable | Recruiting | Smoking Cessation, Smoking (Tobacco) Addiction | 120 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07301151) |
| December 22, 2025 | NCT07295756 | The Role of Smoking in Periodontal Status | Tuğba ŞAHİN | Observational | Completed | Periodontal Diseases | 484 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07295756) |
| December 15, 2025 | NCT07282756 | Evaluation Of The Efficacy Of Subgingival Application Of Lovastatin Gel As An Adjunct To Non-Surgical Treatment Of Periodontitis In... | Medical University of Silesia | Not applicable | Recruiting | Periodontal Diseases, Periodontitis, Periodontal Disease, Smokers | 44 | Poland | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07282756) |
| December 12, 2025 | NCT07279896 | Determination of RNA/DNA Damage Associated With Oxidative Stress in Periodontitis Patients | Zehra Hasgül | Observational | Completed | Periodontitis (Stage 3), Smoking | 88 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07279896) |
| December 5, 2025 | NCT07267195 | Abuse Liability for Four Heated Tobacco Product (HTP) Consumables and Two HTP Devices | RAI Services Company | Not applicable | Not yet recruiting | Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking | 40 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07267195) |
| December 3, 2025 | NCT07262606 | Salivary Mitofusin-1 Levels in Periodontitis: Associations With Disease Severity, Smoking, and Treatment Response | Ömer Faruk Okumuş | Not applicable | Completed | Periodontal Disease, Chronic Periodontitis (Disorder) | 104 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07262606) |
| November 3, 2025 | NCT07223840 | A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid Relapse | Eli Lilly and Company | Phase 2 | Recruiting | Smoking | 222 | China, Japan, United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07223840) |
| October 27, 2025 | NCT07221214 | GLP-1 Receptor Agonists to Decrease Ethanol and CVD Risk in HIV | Vanderbilt University Medical Center | Phase 2 | Recruiting | HIV, Alcohol, Smoking Cigarette, Cardiovascular Disease Prevention | 200 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07221214) |
| October 9, 2025 | NCT07214168 | Vape Use Among Younger & Older Smokers | Abramson Cancer Center at Penn Medicine | Observational | Completed | Smoking Cigarette, Smoking Behaviors, Vaping, Vaping Behaviors | 62 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07214168) |
| October 9, 2025 | NCT07213752 | Diode Laser-Assisted Periodontal Therapy Enhances Clinical Outcomes for Deep Periodontal Pockets in Smokers | Selcuk University | Not applicable | Completed | Periodontitis, Periodontitis Stage III, Periodontal Disease, Diode Laser Therapy, Smoking, Malondialdehyde | 33 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07213752) |
| October 1, 2025 | NCT07200895 | Acute IMT Intensity Effects in Male Smokers | FATMA DİLARA AKAR ÇAMYAR | Not applicable | Completed | Smokers | 34 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07200895) |
| September 22, 2025 | NCT07186049 | Impact of Exercise Associated With Cognitive-behavioral Therapy in Smokers | Agnaldo José Lopes | Not applicable | Not yet recruiting | Smoking (Tobacco) Addiction | 66 | Brazil | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07186049) |
| September 17, 2025 | NCT07178899 | Designing a Smoking Intervention for Youth Smokers | The University of Hong Kong | Not applicable | Not yet recruiting | Smoking (Tobacco) Addiction, Young Adult, RCT | 100 | Hong Kong | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07178899) |
| September 15, 2025 | NCT07173335 | Integrated Healthy Lifestyle and Pain Care for People With Musculoskeletal Conditions Living in Rural Areas. | University of Sydney | Not applicable | Recruiting | Musculoskeletal Pain, Osteoarthritis, Low Back Pain | 354 | Australia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07173335) |
| September 15, 2025 | NCT07172438 | A RCT to Determine the Effect of ENDS Flavor Availability on Abstinence Within Smokers | RAI Services Company | Not applicable | Terminated | Smoking, Tobacco | 668 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07172438) |

## Sponsors posting most

| Sponsor | New trials | Latest |
| --- | --- | --- |
| RAI Services Company | 13 | October 20, 2026 |
| University of Minnesota | 4 | December 24, 2025 |
| Massachusetts General Hospital | 3 | August 27, 2026 |
| Georgia State University | 3 | August 24, 2026 |
| Medical University of South Carolina | 3 | August 10, 2026 |
| Ankara University | 2 | October 27, 2026 |
| Inonu University | 2 | August 14, 2026 |
| Zehra Hasgül | 2 | August 14, 2026 |
| VA Office of Research and Development | 2 | July 20, 2026 |
| University of Southern California | 2 | July 13, 2026 |
| Biruni University | 2 | May 6, 2026 |
| University of Rochester | 2 | May 5, 2026 |
| Mayo Clinic | 2 | March 23, 2026 |
| Philip Morris Products S.A. | 2 | March 2, 2026 |
| Rutgers, The State University of New Jersey | 2 | January 16, 2026 |
| University of Zadar | 2 | January 2, 2026 |
| The University of Hong Kong | 2 | September 17, 2025 |
| Virginia Polytechnic Institute and State University | 2 | July 30, 2025 |
| British University In Egypt | 1 | November 4, 2026 |
| Clinique de la Mitterie | 1 | November 2, 2026 |

## By phase

| Phase | New trials | Latest |
| --- | --- | --- |
| [Not applicable](https://specstream.ai/data/clinical-trials/phase/not-applicable) | 93 | November 2, 2026 |
| [Observational](https://specstream.ai/data/clinical-trials/phase/observational) | 49 | November 4, 2026 |
| [Phase 2](https://specstream.ai/data/clinical-trials/phase/phase-2) | 7 | August 10, 2026 |
| [Phase 4](https://specstream.ai/data/clinical-trials/phase/phase-4) | 4 | January 9, 2026 |
| [Phase 3](https://specstream.ai/data/clinical-trials/phase/phase-3) | 2 | August 14, 2026 |
| [Phase 1](https://specstream.ai/data/clinical-trials/phase/phase-1) | 2 | March 17, 2026 |
| [Phase 2/3](https://specstream.ai/data/clinical-trials/phase/phase-2-3) | 1 | March 23, 2026 |

## By country

| Country | New trials | Latest |
| --- | --- | --- |
| [United States](https://specstream.ai/data/clinical-trials/country/united-states) | 59 | October 19, 2026 |
| [Turkey (Türkiye)](https://specstream.ai/data/clinical-trials/country/turkey-t-rkiye) | 34 | October 27, 2026 |
| [France](https://specstream.ai/data/clinical-trials/country/france) | 5 | November 2, 2026 |
| [Egypt](https://specstream.ai/data/clinical-trials/country/egypt) | 4 | November 4, 2026 |
| [Germany](https://specstream.ai/data/clinical-trials/country/germany) | 4 | June 4, 2026 |
| [Switzerland](https://specstream.ai/data/clinical-trials/country/switzerland) | 3 | October 6, 2026 |
| [United Kingdom](https://specstream.ai/data/clinical-trials/country/united-kingdom) | 3 | March 2, 2026 |
| [Poland](https://specstream.ai/data/clinical-trials/country/poland) | 3 | December 15, 2025 |
| [China](https://specstream.ai/data/clinical-trials/country/china) | 3 | November 3, 2025 |
| [Italy](https://specstream.ai/data/clinical-trials/country/italy) | 2 | May 22, 2026 |
| [Spain](https://specstream.ai/data/clinical-trials/country/spain) | 2 | February 23, 2026 |
| [Croatia](https://specstream.ai/data/clinical-trials/country/croatia) | 2 | January 2, 2026 |
| [Japan](https://specstream.ai/data/clinical-trials/country/japan) | 2 | November 3, 2025 |
| [Hong Kong](https://specstream.ai/data/clinical-trials/country/hong-kong) | 2 | September 17, 2025 |
| [Thailand](https://specstream.ai/data/clinical-trials/country/thailand) | 1 | October 19, 2026 |
| [Mexico](https://specstream.ai/data/clinical-trials/country/mexico) | 1 | September 18, 2026 |
| [Bangladesh](https://specstream.ai/data/clinical-trials/country/bangladesh) | 1 | August 5, 2026 |
| [Belgium](https://specstream.ai/data/clinical-trials/country/belgium) | 1 | June 8, 2026 |
| [Syria](https://specstream.ai/data/clinical-trials/country/syria) | 1 | May 1, 2026 |
| [Greece](https://specstream.ai/data/clinical-trials/country/greece) | 1 | April 30, 2026 |
| [Lebanon](https://specstream.ai/data/clinical-trials/country/lebanon) | 1 | April 24, 2026 |
| [Iraq](https://specstream.ai/data/clinical-trials/country/iraq) | 1 | April 23, 2026 |
| [South Korea](https://specstream.ai/data/clinical-trials/country/south-korea) | 1 | February 17, 2026 |
| [Singapore](https://specstream.ai/data/clinical-trials/country/singapore) | 1 | January 29, 2026 |
| [Brazil](https://specstream.ai/data/clinical-trials/country/brazil) | 1 | September 22, 2025 |

## Where the register publishes

- [ClinicalTrials.gov](https://clinicaltrials.gov/)
- [ClinicalTrials.gov API](https://clinicaltrials.gov/data-api/api)

Source: [ClinicalTrials.gov API v2 (U.S. National Library of Medicine)](https://clinicaltrials.gov/data-api/api). U.S. government data; ClinicalTrials.gov terms of use. Studies are as their sponsors registered them on ClinicalTrials.gov, read through its API. Condition groups are the MeSH terms ClinicalTrials.gov assigns to each study's conditions; a study with several is in several groups. Sponsor class is the register's class of the lead sponsor. The central contact is in the full list only as the record prints it.

Free to reuse with credit to SpecStream under [CC BY 4.0](https://creativecommons.org/licenses/by/4.0/).