# Rectal Neoplasms trials: 261 new since Nov 2024

Updated November 6, 2026.

261 clinical studies in Rectal Neoplasms were first posted on ClinicalTrials.gov from November 12, 2024 to November 6, 2026; 18 have an industry sponsor and 208 are recruiting or about to. The newest, NCT07923682, was posted on November 6, 2026: Outcomes of Knife-Assisted Full-Thickness Resection for Rectal Lesions: A Multicenter Study (University Hospital, Ghent).

## The full list

New Rectal Neoplasms clinical trials: 261 rows for $13.05, first posted on ClinicalTrials.gov from November 12, 2024 to November 9, 2026. Columns: NCT ID, Title, Sponsor, Sponsor class, Phase, Status, Conditions, Condition groups (MeSH), Interventions, Start date, First posted, Enrollment, Enrollment type, Location countries, Central contact, Contact phone, Contact email, Last update posted, Read on, Source. The new rows each week by email, about 9 rows a month: $19 a month. Pay by card with no account. Prices exclude VAT. CSV and Excel files with the columns this page does not show (central contact, contact phone, contact email, sponsor class, condition groups (MeSH), interventions and 5 more), which open on your screen as soon as the payment clears and come by email. The rows on this page are a sample.

Buy: https://specstream.ai/data/clinical-trials/condition/rectal-neoplasms

SpecStream is the live web data engine for teams and agents. It reads every new study on ClinicalTrials.gov each morning, and this page is that reading. Ask for the conditions, phases or countries you follow and each new trial arrives in your sheet, CRM, Slack or agent with the sponsor, the sites and the listed contact.

- New trials: 261
- Industry sponsored: 18
- Recruiting or not yet: 208
- Latest posted: November 6, 2026

## Newest trials

The newest 100 of 261, each linked to its record. The full list holds every one with the sponsor class, interventions, start date and the central contact as the record prints it.

| First posted | NCT ID | Title | Sponsor | Phase | Status | Conditions | Enrollment | Countries | Source |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| November 6, 2026 | NCT07923682 | Outcomes of Knife-Assisted Full-Thickness Resection for Rectal Lesions: A Multicenter Study | University Hospital, Ghent | Observational | Recruiting | Colorectal Cancer | 150 | Belgium | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07923682) |
| November 6, 2026 | NCT07920770 | Pre- and On-treatment Multi-omics Profiling of Locally Advanced Rectal Cancer | Fujian Medical University Union Hospital | Observational | Recruiting | Rectal Neoplasms | 100 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07920770) |
| November 4, 2026 | NCT07916532 | Indocyanine Green Lymphatic Mapping in Minimally Invasive Sigmoid and Rectal Cancer Surgery | Jagiellonian University | Not applicable | Completed | Rectal Cancer, Sigmoid Colon Cancer | 29 | Poland | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07916532) |
| October 29, 2026 | NCT07903883 | Dose-Escalated Short-Course Proton Therapy for Locally Advanced Rectal Cancer | University of Aarhus | Not applicable | Not yet recruiting | Locally Advanced Rectal Cancer, Rectal Adenocarcinoma | 30 | Denmark | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07903883) |
| October 28, 2026 | NCT07900620 | T1 Colorectal Cancer After Local Excision: Decision Between Surgery and Active Surveillance (T1LDA Trial) | Tampere University Hospital | Not applicable | Not yet recruiting | Colorectal Cancer | 500 | Finland | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07900620) |
| October 28, 2026 | NCT07900061 | Modified Short-Course Radiotherapy Combined With Tislelizumab and CAPOX for pMMR/MSS Rectal Cancer | Sir Run Run Shaw Hospital | Phase 3 | Not yet recruiting | Rectal Cancer | 210 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07900061) |
| October 23, 2026 | NCT07892404 | Purse-String Versus Linear Closure After Ileostomy Reversal | Dnipro Regional Clinical Oncology Dispensary | Not applicable | Completed | Diverting Ileostomy, Rectal Cancer | 23 | Ukraine | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07892404) |
| October 22, 2026 | NCT07888309 | SCRT + Fruquintinib + Tislelizumab + CAPOX Versus SCRT + Tislelizumab + CAPOX as Neoadjuvant Therapy for Locally Advanced Low Rectal Cancer | Ruijin Hospital | Phase 2 | Recruiting | Rectal Neoplasms, Rectal Cancer, Adenocarcinoma | 50 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07888309) |
| October 13, 2026 | NCT07871227 | Follow-up After Oncological Resection by Endoscopic Colorectal ESD (Endoscopic Submucosal Dissection) | University Hospital, Bordeaux | Observational | Not yet recruiting | Colorectal Neoplasms | 1,200 | France | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07871227) |
| October 7, 2026 | NCT07862673 | Efficacy of a Novel High Intensive Percutaneous Tibial Nerve Stimulation on Faecal Incontinence in Patients With Low Anterior Resection... | Region Skane | Not applicable | Not yet recruiting | Faecal Incontinence With Faecal Urgency, Rectal Cancer, Radiotherapy Side Effects, Low Anterior Resection Syndrome... | 60 | Sweden | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07862673) |
| September 29, 2026 | NCT07847229 | A Prospective, Biomarker-Stratified Phase 2 Study: β-Hydroxybutyrate as a Predictive Biomarker for Short-Course Radiotherapy Followed by... | Tao Zhang | Phase 2 | Not yet recruiting | Rectal Cancer, Radiotherapy, Immunotherapy, Chemotherapy | 144 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07847229) |
| September 29, 2026 | NCT07846046 | Endoscopic (EID) Versus Surgical (TAMIS) Local Excision for Early Stage Rectal Cancer | Amsterdam UMC, location VUmc | Not applicable | Not yet recruiting | Rectal Cancer Stage I | 246 | Netherlands | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07846046) |
| September 22, 2026 | NCT07833319 | Local Methylene Blue Injection for Prevention of Anastomotic Leakage and Permanent Stoma After Low Anterior Resection for Rectal Cancer | Peking University Cancer Hospital & Institute | Phase 2 | Recruiting | Rectal Cancers | 26 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07833319) |
| September 16, 2026 | NCT07821775 | Robotic vs Laparoscopic and Open Surgery for Abdominopelvic Cancers | Asan Medical Center | Observational | Completed | Pancreatic Neoplasms, Stomach Neoplasms, Rectal Neoplasms, Uterine Cervical Neoplasms, Endometrial Neoplasms, Kidney... | 32,949 | South Korea | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07821775) |
| September 14, 2026 | NCT07817888 | mFOLFOXIRI Plus Bevacizumab for Organ Preservation in Locally Advanced Rectal Cancer | Sixth Affiliated Hospital, Sun Yat-sen University | Phase 2 | Not yet recruiting | Phase 2 Study | 119 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07817888) |
| September 9, 2026 | NCT07811128 | Leveraging Digital Health Solutions to Collect Patient-Reported Outcomes in Rectal Cancer | University of California, San Francisco | Observational | Not yet recruiting | Rectal Cancer, Non Metastatic Rectal Cancer | 150 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07811128) |
| September 9, 2026 | NCT07810114 | Total Neoadjuvant mFOLFOX6 Plus Suvemcitug and Enlonstobart With Selective Omission of Pelvic Radiotherapy for High-Risk Mid-Rectal Locally... | Fudan University | Phase 2 | Not yet recruiting | Rectal Cancer | 52 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07810114) |
| September 4, 2026 | NCT07805369 | A Phase 1 Study of DEM301 in Participants With Metastatic Colorectal Cancer | DEM BioPharma, Inc. | Phase 1 | Recruiting | Metastatic Colorectal Cancer, Colon Cancer, Rectal Cancer | 60 | Australia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07805369) |
| September 3, 2026 | NCT07802197 | Neoadjuvant Radiotherapy vs Upfront Surgery in Locally Advanced Proximal Rectal Cancer | Istanbul University | Not applicable | Recruiting | Rectal Adenocarcinoma | 100 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07802197) |
| September 2, 2026 | NCT07799740 | Examination of Rectal Blood Supply During Rectal Cancer Surgery Using Laser Speckle Contrast Imaging | University of Aarhus | Not applicable | Not yet recruiting | Rectal Cancer, Total Mesorectal Excision, Laser Speckle Contrast Imaging, Indocyanine Green (ICG), Optical Imaging | 100 | Denmark | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07799740) |
| August 26, 2026 | NCT07786493 | HDR Endorectal Brachytherapy With 3D-Printed Guidance and Local Shielding for Rectal Cancer Organ Preservation | Tianjin Medical University Cancer Institute and Hospital | Not applicable | Recruiting | Rectal Cancer, Adenocarcinoma | 50 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07786493) |
| August 24, 2026 | NCT07781774 | Improving Colorectal Cancer Screening Uptake Through Education and Stool-Based Testing Outreach | Washington University School of Medicine | Not applicable | Not yet recruiting | Colorectal Cancer (CRC) Screening, CRC Screening, Rectal Cancer, Colon Cancer, Colorectal Cancer | 200 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07781774) |
| August 21, 2026 | NCT07780305 | ABCSG R07 Rectal Cancer Registry | Austrian Breast & Colorectal Cancer Study Group | Observational | Recruiting | Rectal Cancer, Adenocarcinoma of Rectum | 600 | Austria | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07780305) |
| August 21, 2026 | NCT07779694 | 16-Hour Fasting Plus Serplulimab and CAPEOX as Neoadjuvant Therapy in pMMR/MSS Advanced Mid-to-Low Rectal Cancer | Zhejiang University | Phase 2 | Not yet recruiting | pMMR/MSS, Locally Advanced Rectal Carcinoma, Fasting, Intermittent | 51 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07779694) |
| August 19, 2026 | NCT07774754 | Radiotherapy Combined With Capeox Chemotherapy, Sintilimab and Suvemcitug in Locally Advanced pMMR Rectal Cancer:a Prospective Clinical... | Sun Yat-sen University | Phase 2 | Not yet recruiting | Rectal Cancer | 18 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07774754) |
| August 14, 2026 | NCT07765667 | NCT + PD1 + Ketogenic Diet and/or Vitamin C for LARC | Sixth Affiliated Hospital, Sun Yat-sen University | Phase 2 | Not yet recruiting | Rectal Adenocarcinoma, High-Risk Cancer, MSS | 100 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07765667) |
| August 13, 2026 | NCT07764120 | Quality of Life of Patients After Rectal Cancer Resection . | University Hospital, Grenoble | Observational | Not yet recruiting | Rectal Cancer | 22 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07764120) |
| August 12, 2026 | NCT07761169 | Randomized Controlled Trial of the SurgDiff Model for Predicting Surgical Difficulty to Help Choose Approach in Mid-Low Rectal Cancer | Peking Union Medical College Hospital | Not applicable | Not yet recruiting | Rectal Cancer | 68 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07761169) |
| August 10, 2026 | NCT07755124 | Dietary Arginine Deprivation Combined With Chemoradiotherapy for Neoadjuvant Treatment of Rectal Cancer: A Randomized Controlled Trial | West China Hospital | Phase 1/2 | Not yet recruiting | Rectal Neoplasms | 140 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07755124) |
| August 3, 2026 | NCT07740720 | A Study of the Duration of Dostarlimab in Untreated Mismatch Repair Deficient (dMMR)/ Microsatellite Instability-high (MSI-H) Locally... | GlaxoSmithKline | Phase 3 | Not yet recruiting | Neoplasms, Rectal | 90 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07740720) |
| July 30, 2026 | NCT07736131 | Learning Curve of SILS in CRC | Ruijin Hospital | Observational | Completed | Rectal Cancer, Colon Cancer, Single Port Laparoscopy | 280 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07736131) |
| July 30, 2026 | NCT07735624 | RECTIFY-1: Neoadjuvant Botensilimab + Balstilimab in MSS/pMMR Early Rectal Cancer | Dana-Farber Cancer Institute | Phase 2 | Recruiting | Early Rectal Cancer, Stage I Rectal Cancer, Microsatellite Stable Rectal Carcinoma | 16 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07735624) |
| July 29, 2026 | NCT07732894 | Aerobic Exercise and Guided Imagery in Low Anterior Resection Syndrome | Biruni University | Not applicable | Recruiting | Rectal Cancer, Fecal Incontinence and Constipation, Aerobic Exercise, Guided Imagery Exercise, Pelvic Floor Physical... | 50 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07732894) |
| July 28, 2026 | NCT07730541 | Hyperpolarized 13C-MRI and Radiomics in Rectal Cancer | Chang Gung Memorial Hospital | Observational | Recruiting | Neoadjuvant Chemoradiotherapy | 30 | Taiwan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07730541) |
| July 27, 2026 | NCT07726966 | Betacyanin for Early Diagnosis and Recovery of Anastomotic Leakage After Rectal Cancer Surgery: A Single-Center, Prospective, Controlled... | Southwest Hospital, China | Not applicable | Not yet recruiting | Rectum Cancer, Anastomotic Leak | 120 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07726966) |
| July 24, 2026 | NCT07725692 | Predictors of Rescue Surgery, Mortality, and Permanent Stoma After Anastomotic Leak Following Colorectal Cancer Resection | Alexandria University | Observational | Completed | Anastomotic Leak, Colorectal Cancer, Colon Cancer, Postoperative Complication, Intestinal Stoma | 3,200 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07725692) |
| July 22, 2026 | NCT07720505 | COLOFLOW: Laser Speckle Contrast Imaging Versus Near-infrared Fluorescence Imaging With Indocyanine Green | Leiden University Medical Center | Observational | Not yet recruiting | Leakage, Anastomotic, Colon Cancer, Colon Anastomosis, Colon and Rectal Cancer, Colon Benign Tumor, Colon and Rectal... | 30 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07720505) |
| July 17, 2026 | NCT07711509 | Autologous Fecal Microbiota Transplantation for Anal Function Recovery After Ileostomy Reversal in Rectal Cancer | Peking University People's Hospital | Not applicable | Active not recruiting | Rectal Cancer, Low Anterior Resection Syndrome, Fecal Incontinence, Diversion Colitis, Ileostomy, Gut Microbiota... | 35 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07711509) |
| July 10, 2026 | NCT07696689 | Evaluating the Optimal Timing of Trans-Anal Irrigation for Low Anterior Resection Syndrome Post-rectal Cancer Surgery | Simona Ascanelli | Not applicable | Not yet recruiting | Low Anterior Resection Syndrome (LARS) | 250 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07696689) |
| July 10, 2026 | NCT07695519 | SCARLET - Italian proSpeCtionAl obseRvationaL multicEntre Study on Treatment for recTal pT1 Cancer | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Observational | Not yet recruiting | Rectal Cancer, Rectal Adenocarcinoma, Rectal Cancer Patients, Rectal Cancer, Radiotherapy | 196 | Italy | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07695519) |
| July 9, 2026 | NCT07691489 | A Study of Trastuzumab Deruxtecan (T-DXd) and Cetuximab in People With Colorectal Cancer | Memorial Sloan Kettering Cancer Center | Phase 2 | Not yet recruiting | Colorectal Cancer, Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum | 27 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07691489) |
| July 7, 2026 | NCT07688135 | Quicksilver II Pilot Study | Mount Sinai Hospital, Canada | Not applicable | Not yet recruiting | Stage II Rectal Cancer, Stage III Rectal Cancer | 18 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07688135) |
| July 7, 2026 | NCT07687875 | Oncolytic Virotherapy to Enhance PReoperative IMmunotherapy Efficacy in Patients With Proficient Mismatch Repair (pMMR) Rectal Cancer | Henry Smith | Phase 1 | Recruiting | Rectal Cancer Patients | 20 | Denmark | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07687875) |
| June 25, 2026 | NCT07669298 | Active Surveillance vs Adjuvant Chemoradiotherapy for Locally Resected Intermediate-Risk T1 Rectal Cancer | Medical University of Gdansk | Not applicable | Recruiting | Rectal Cancer | 480 | France, Poland | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07669298) |
| June 25, 2026 | NCT07669220 | A Multicenter, Randomized Controlled Phase II Study of Short-Course Radiotherapy Followed by Sequential PD-1 Inhibitor and FOLFOX... | Sixth Affiliated Hospital, Sun Yat-sen University | Phase 2 | Recruiting | Rectal Adenocarcinoma, High-risk Locally Advanced, Short-course Radiotherapy (SCRT), Immunotherapy, FOLFOX | 76 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07669220) |
| June 16, 2026 | NCT07651553 | Transanal Total Mesorectal Excision vs Robotic Total Mesorectal Excision | Sun Yat-sen University | Not applicable | Recruiting | Rectal Cancer Patients, Robotic Assisted Intervention | 216 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07651553) |
| June 15, 2026 | NCT07646639 | Different-Dose SCRT Plus CAPOX, PD-1 Blockade and IL-2 in LARC | The First Affiliated Hospital with Nanjing Medical University | Phase 2 | Recruiting | Rectal Cancer, Radiotherapy | 122 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07646639) |
| June 8, 2026 | NCT07632196 | Efficacy and Safety of Transcutaneous Posterior Tibial Nerve Stimulation on Fecal Continence in Patients Undergoing Surgery for Rectal... | Althaia Xarxa Assistencial Universitària de Manresa | Not applicable | Recruiting | Low Anterior Resection Syndrome (LARS), Rectal Neoplasm Malignant, Quality of Life (QOL), Fecal Incontinence (FI)... | 84 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07632196) |
| June 5, 2026 | NCT07629960 | A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations | Blueprint Medicines Corporation | Phase 1/2 | Recruiting | Advanced Solid Tumor, Non-Small Cell Lung Cancer, Colorectal Neoplasms, Pancreatic Ductal Adenocarcinoma | 265 | Spain, United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07629960) |
| June 3, 2026 | NCT07622771 | Neoadjuvant Radiotherapy Combined With NALIRIFOX and Adebrelimab in pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Randomized... | Sun Yat-sen University | Phase 2 | Recruiting | Rectal Cancers | 84 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07622771) |
| June 2, 2026 | NCT07622017 | KORTUC (KRC-01) Plus Radiotherapy for Organ Preservation in Rectal Cancer | Gustave Roussy, Cancer Campus, Grand Paris | Phase 2 | Not yet recruiting | Rectal Cancer | 24 | France | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07622017) |
| June 2, 2026 | NCT07619768 | Self Regulation Hypnotic Intervention for Pain and Anxiety During Rectal Brachytherapy | Sir Mortimer B. Davis - Jewish General Hospital | Not applicable | Completed | Rectal Cancer | 52 | Canada | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07619768) |
| June 1, 2026 | NCT07616297 | Higher Radiation Dose to the Tumor May Help Avoid Surgery in Rectal Cancer Patients | Claudia Schuurhuizen | Not applicable | Recruiting | Rectal Cancer, Radiation Oncology | 25 | Netherlands | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07616297) |
| May 28, 2026 | NCT07610798 | A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of INV-8989 in Patients With Advanced... | Shenzhen Ionova Life Sciences Co., Ltd. | Phase 1/2 | Recruiting | Advance Solid Tumors, Colon and Rectal Cancer, Non - Small Cell Lung Cancer NSCLC, Pancreatic Adenocarcinoma Advanced... | 178 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07610798) |
| May 26, 2026 | NCT07605611 | Somatostatin Plus Clear Liquid Diet Versus Diverting Stoma in Patients With Rectal Cancer Undergoing Ultra-Low Anterior Resection | Tongji Hospital | Not applicable | Recruiting | Rectal Cancer, Anastomotic Leakage | 72 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07605611) |
| May 19, 2026 | NCT07596732 | Statewide Unified Network for Remote Intervention of Strength and Exercise | AdventHealth Translational Research Institute | Not applicable | Not yet recruiting | Gastric Cancer (Diagnosis), Esophagus Cancer, Pancreas Cancer, Colon Cancer, Rectal Cancer, Lung Cancer | 120 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07596732) |
| May 19, 2026 | NCT07595874 | Neoadjuvant Botensilimab and Balstilimab for the Treatment of Advanced Resectable Colorectal Cancer NEST3 | City of Hope Medical Center | Phase 2 | Recruiting | Advanced Colon Adenocarcinoma, Advanced Colorectal Adenocarcinoma, Advanced Rectal Adenocarcinoma, Stage IIB Colon... | 100 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07595874) |
| May 19, 2026 | NCT07595107 | Concordance Between Large Language Model and Multidisciplinary Team Recommendations in Rectal Cancer | Shandong Cancer Hospital and Institute | Observational | Recruiting | Rectal Cancer | 180 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07595107) |
| May 19, 2026 | NCT07594925 | Short-Course Radiotherapy Followed by Immunotherapy Combined With Chemotherapy for Microsatellite Stable Locally Advanced Rectal Cancer: A... | Tianjin Medical University Cancer Institute and Hospital | Phase 2 | Recruiting | Rectal Cancer | 130 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07594925) |
| May 12, 2026 | NCT07580339 | Combining DCSZ11 With Radiation and Chemotherapy as Neoadjuvant Treatment for pMMR Locally Advanced Rectal Cancer | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Phase 2 | Not yet recruiting | Rectal Cancer | 30 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07580339) |
| May 5, 2026 | NCT07566559 | Rectal Cancer Neoadjuvant Therapy-Real World Study | Beijing Friendship Hospital | Observational | Recruiting | Rectal Cancer | 869 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07566559) |
| May 4, 2026 | NCT07563907 | Total Neoadjuvant Therapy With Additional Consolidation Chemotherapy Followed by Local Excision Versus Total Neoadjuvant Therapy Followed... | Seoul National University Hospital | Not applicable | Not yet recruiting | Organ Preservation, Rectal Cancer Stage I, Total Neoadjuvant Treatment, Consolidation Therapy, Capecitabine | 292 | South Korea | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07563907) |
| May 1, 2026 | NCT07561060 | Low Rectal Cancer Treated With Total Neoadjuvant Therapy Plus Concurrent Tislelizumab Immunotherapy | Fudan University | Phase 1/2 | Recruiting | Rectal Cancer | 50 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07561060) |
| April 27, 2026 | NCT07552207 | Comparison of \[68Ga\]Ga-CTR-FAPI and 18F-FDG PET/MRI for Lymph Node Staging in Rectal Cancer | Peking University Cancer Hospital & Institute | Not applicable | Not yet recruiting | Rectal Cancer, Lymph Node Metastases, PET / MR | 30 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07552207) |
| April 24, 2026 | NCT07549399 | SCRT + Chemo Targeted Immuno-neoadjuvant Therapy for High-risk pMMR/MSS RC | Sixth Affiliated Hospital, Sun Yat-sen University | Phase 3 | Recruiting | Rectal Adenocarcinoma, High-Risk Cancer, MSS | 204 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07549399) |
| April 23, 2026 | NCT07548736 | Improvement Effect of Dexamethasone Enema for Acute Radiation-induced Rectal Injury | Sixth Affiliated Hospital, Sun Yat-sen University | Phase 2 | Not yet recruiting | Acute Radiation Enteritis | 40 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07548736) |
| April 22, 2026 | NCT07543848 | A Prospective, Multicenter, Single-Arm Phase II Exploratory Study of Serplulimab Combined With Oncolytic Virus H101, Short-Course... | Chongqing University Cancer Hospital | Phase 2 | Not yet recruiting | Rectal Neoplasms, Rectal Adenocarcinoma | 20 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07543848) |
| April 17, 2026 | NCT07537998 | Antegrade Intestinal Fluid Reinfusion for Prevention of Low Anterior Resection Syndrome After Low Anterior Resection: a Single-Center... | Pei-Rong Ding | Phase 2/3 | Recruiting | Low Anterior Resection Syndrome, Rectal Cancer | 160 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07537998) |
| April 17, 2026 | NCT07536321 | Diagnostic Accuracy and Prognostic Value of 18F FDG PET-CT in the Follow up of Patients With Colorectal Carcinoma. | Assiut University | Observational | Not yet recruiting | Rectal Cancer (Stage III) | 46 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07536321) |
| April 14, 2026 | NCT07528209 | Neoadjuvant CAPOX With or Without Pucotenlimab Plus Selective Radiotherapy for Locally Advanced Rectal Cancer | Sun Yat-sen University | Phase 3 | Recruiting | Rectal Cancer, pMMR (Microsatellite Stable Rectal Cancer) | 556 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07528209) |
| April 14, 2026 | NCT07527520 | Neoadjuvant Moderately Hypofractionated Radiotherapy Combined With Chemotherapy and Immunotherapy for High-risk pMMR/MSS Locally Advanced... | Fudan University | Phase 2 | Not yet recruiting | Rectal Cancer, Moderately Hypofractionated Radiotherapy, Serplulimab, pMMR/MSS | 165 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07527520) |
| April 13, 2026 | NCT07522294 | Optimization and Standardization of Single-Port Robotic Transanal Minimally Invasive Surgery for Rectal Tumor Excision | Jeng-Fu You | Not applicable | Active not recruiting | Rectal Neoplasms, Rectal Cancer Patients, Rectal Benign Lesions | 20 | Taiwan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07522294) |
| April 7, 2026 | NCT07516210 | Adaptive Radiotherapy for Safe Hypofractionation | Centre hospitalier de l'Université de Montréal (CHUM) | Phase 2 | Not yet recruiting | Cancer, Endometrial Cancer, Prostate Cancer, Cervical Cancer, Rectal Cancers | 264 | Canada | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07516210) |
| April 6, 2026 | NCT07512232 | Intraoperative Rectal Lavage to Prevent Local Recurrence After Laparoscopic Mid-to-Low Rectal Cancer Resection: A Multicenter Randomized... | Sun Yat-sen University | Not applicable | Recruiting | Middle and Low Rectal Cancer, Rectal Cancer Surgery | 1,598 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07512232) |
| April 3, 2026 | NCT07509632 | Predicting Pathological Complete Response in Rectal Cancer Using Machine Learning | Peking University People's Hospital | Observational | Active not recruiting | Rectal Cancers, Pathological Complete Response, Neoadjuvant Chemoradiotherapy, Machine Learning | 320 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07509632) |
| April 3, 2026 | NCT07509424 | Neoadjuvant Short-course Radiotherapy Followed by a Combination of Disitamab Vedotin, Sintilimab, and Capecitabine in Locally Advanced... | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Phase 2 | Not yet recruiting | Rectal Cancer | 29 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07509424) |
| April 1, 2026 | NCT07505472 | Efficacy and Safety Comparison of Short-course Radiotherapy Followed by CapeOX Chemotherapy Plus Toripalimab With or Without Concurrent... | The First Hospital of Jilin University | Phase 2/3 | Recruiting | Rectal Cancer | 212 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07505472) |
| March 30, 2026 | NCT07501845 | Registry Maastro Applicator | Maastricht Radiation Oncology | Observational | Recruiting | Rectal Cancer | 999 | Netherlands | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07501845) |
| March 30, 2026 | NCT07499921 | Clinical and BIOgical Analyses of RECtal Tumors | Centre Leon Berard | Not applicable | Not yet recruiting | Rectal Cancer | 300 | France | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07499921) |
| March 27, 2026 | NCT07494201 | MIMICC Study in Patients With Colorectal Cancer | Fondazione del Piemonte per l'Oncologia | Not applicable | Recruiting | Colorectal Cancer, Colon Cancer, Rectal Cancers | 2,500 | Italy | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07494201) |
| March 20, 2026 | NCT07486180 | The Application of a Novel Endoluminal Robotic System for Colorectal Endoscopic Submucosal Dissection | Chinese University of Hong Kong | Not applicable | Not yet recruiting | Early Rectal Neoplasms | 10 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07486180) |
| March 19, 2026 | NCT07483060 | Next Generation STAR-TREC (NG-ST) - Organ Preservation in Early Rectal Cancer | Vastra Gotaland Region | Phase 4 | Not yet recruiting | Rectal Cancer | 90 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07483060) |
| March 16, 2026 | NCT07474103 | SCRT-NALIRIXELOX+Sintilimab as TNT for High-Risk LARC | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Not applicable | Recruiting | Rectal Cancer, Adenocarcinoma | 49 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07474103) |
| March 12, 2026 | NCT07467434 | FOLFIRINOX Induction Chemotherapy for Synchronous Liver Metastases | Assistance Publique - Hôpitaux de Paris | Observational | Recruiting | Rectal Cancer, Synchronous Liver Metastases, Antineoplastic Combined Chemotherapy Protocols, Surgical Therapy | 550 | France | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07467434) |
| March 11, 2026 | NCT07463261 | REsults of LOw Anterior Resections With or Without Preventive Stoma in Nonemergency Department | ANO Scientific and Practical Club for the Development of Modern Medical Technologies | Not applicable | Recruiting | TME, Rectal Cancer Surgery, Low Rectal Cancer, Middle Rectal Cancer, Local Advanced Rectal Cancer | 442 | Russia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07463261) |
| March 10, 2026 | NCT07460596 | Concentrated Complex Plant Dietary Elements for Chemotherapy-Induced Diarrhea | Tianjin Medical University Cancer Institute and Hospital | Phase 2 | Completed | Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma or Esophageal Carcinoma, Colon and Rectal Cancer | 30 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07460596) |
| March 9, 2026 | NCT07458529 | Neoadjuvant Chemoradiotherapy Plus Tislelizumab With or Without Probio-M9 in pMMR/MSS Locally Advanced Rectal Cancer | Seventh Medical Center of PLA General Hospital | Phase 2 | Recruiting | Rectal Cancer, Adenocarcinoma, Neoadjuvant Therapy, Immunotherapy, Probio-M9, Tislelizumab, Randomized | 50 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07458529) |
| March 9, 2026 | NCT07458347 | A Phase 1 Dose Escalation and Dose Expansion Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral... | Kestrel Therapeutics, Inc. | Phase 1 | Recruiting | KRAS-mutant Non-small Cell Lung Cancer (NSCLC), KRAS-mutant Pancreatic Ductal Adenocarcinoma (PDAC), KRAS-mutant... | 545 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07458347) |
| March 4, 2026 | NCT07448662 | Local Treatment Strategies for Brain Metastases of Colorectal Cancer | Blokhin's Russian Cancer Research Center | Observational | Active not recruiting | Colorectal Cancer, Brain Metastases, Adult | 700 | Belarus, Russia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07448662) |
| February 25, 2026 | NCT07433673 | Gemcitabine, Cisplatin, Nab-paclitaxel (GAP) and Cemiplimab for Locally Advanced Biliary Tract Cancer (BTC) | Columbia University | Phase 2 | Recruiting | Colon and Rectal Cancer | 20 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07433673) |
| February 25, 2026 | NCT07432542 | Pelvic Floor Peritoneal Closure to Prevent Postoperative Ileus in Mid-Low Rectal Cancer Surgery | Sun Yat-sen University | Not applicable | Active not recruiting | Rectal Cancer Surgery, Middle and Low Rectal Cancer, Intestinal Obstruction, Ileus | 516 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07432542) |
| February 24, 2026 | NCT07429110 | ColoSeal™ ICD System Anastomotic Protection Pivotal Study | Averto Medical, Inc. | Not applicable | Active not recruiting | Rectal Cancer Surgery | 250 | New Zealand, United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07429110) |
| February 23, 2026 | NCT07428239 | Pilot Study of Individualized Comprehensive Rehabilitation in Patients With Colorectal Cancer | Institute of Oncology Ljubljana | Not applicable | Completed | Colon Cancer, Rectal Cancer | 150 | Slovenia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07428239) |
| February 23, 2026 | NCT07427901 | Quality Of Life In Colorectal Cancer Survivors | Institute of Oncology Ljubljana | Not applicable | Recruiting | Colorectal Cancer, Colon Cancer, Rectal Cancer | 368 | Slovenia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07427901) |
| February 19, 2026 | NCT07419516 | MRA Diameter as a Predictor for LLN Metastasis in Rectal Cancer. | First Affiliated Hospital of Fujian Medical University | Observational | Completed | Rectal Neoplasms | 690 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07419516) |
| February 19, 2026 | NCT07419490 | Utero-ovarian Transposition in Patients With Pelvic Malignancies Undergoing Whole Pelvic Radiotherapy | University of South Florida | Not applicable | Recruiting | Colorectal (Colon or Rectal) Cancer, Pelvic Malignancies, Oncofertility | 26 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07419490) |
| February 13, 2026 | NCT07410767 | Advanced Endoscopic Resections for Rectal Neoplasms | Jagiellonian University | Observational | Not yet recruiting | Rectal Cancer, Rectal Adenocarcinoma, Rectal Adenoma, Rectal Neuroendocrine Neoplasm, Recurrent Rectal Adenocarcinoma | 300 | Poland | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07410767) |
| February 12, 2026 | NCT07407647 | Vaginal DHEA to Improve Vaginal Health After Radiation for Women With Gynecologic, Anal or Rectal Cancer | Ohio State University Comprehensive Cancer Center | Phase 2 | Recruiting | Anal Carcinoma, Cervical Carcinoma, Malignant Female Reproductive System Neoplasm, Rectal Carcinoma, Vaginal Carcinoma... | 25 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07407647) |
| February 12, 2026 | NCT07407465 | Upfront Trastuzumab-Deruxtecan Plus Capecitabine and Bevacizumab for Patients With HER-2 Positive Metastatic Colorectal Cancer. | Gruppo Oncologico del Nord-Ovest | Phase 2 | Recruiting | Colorectal Cancer, Colorectal Adenocarcinoma, Rectal Adenocarcinoma, Rectal Cancer, Adenocarcinoma, Rectal Cancer... | 42 | France, Germany, Italy, Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07407465) |
| February 12, 2026 | NCT07405476 | Zanidatamab Before Surgery for the Treatment of HER2 Positive Colon and Rectal Cancer in Patients Planned for Curative Intent Treatment | Emory University | Phase 2 | Recruiting | Colon Carcinoma, Colorectal Carcinoma, Rectal Carcinoma, Stage I Colon Cancer AJCC v8, Stage I Colorectal Cancer AJCC... | 38 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07405476) |

## Sponsors posting most

| Sponsor | New trials | Latest |
| --- | --- | --- |
| Sixth Affiliated Hospital, Sun Yat-sen University | 13 | September 14, 2026 |
| Sun Yat-sen University | 11 | August 19, 2026 |
| Fudan University | 5 | September 9, 2026 |
| Sir Run Run Shaw Hospital | 4 | October 28, 2026 |
| Ruijin Hospital | 4 | October 22, 2026 |
| Peking University Cancer Hospital & Institute | 4 | September 22, 2026 |
| Chang Gung Memorial Hospital | 4 | July 28, 2026 |
| Yanhong Deng | 4 | March 28, 2025 |
| Tao Zhang | 3 | September 29, 2026 |
| Tianjin Medical University Cancer Institute and Hospital | 3 | August 26, 2026 |
| West China Hospital | 3 | August 10, 2026 |
| GlaxoSmithKline | 3 | August 3, 2026 |
| City of Hope Medical Center | 3 | May 19, 2026 |
| Beijing Friendship Hospital | 3 | May 5, 2026 |
| The First Hospital of Jilin University | 3 | April 1, 2026 |
| Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 3 | December 29, 2025 |
| Alliance for Clinical Trials in Oncology | 3 | December 16, 2025 |
| Jagiellonian University | 2 | November 4, 2026 |
| University of Aarhus | 2 | October 29, 2026 |
| Amsterdam UMC, location VUmc | 2 | September 29, 2026 |

## By phase

| Phase | New trials | Latest |
| --- | --- | --- |
| [Not applicable](https://specstream.ai/data/clinical-trials/phase/not-applicable) | 83 | November 4, 2026 |
| [Phase 2](https://specstream.ai/data/clinical-trials/phase/phase-2) | 72 | October 22, 2026 |
| [Observational](https://specstream.ai/data/clinical-trials/phase/observational) | 67 | November 6, 2026 |
| [Phase 3](https://specstream.ai/data/clinical-trials/phase/phase-3) | 14 | October 28, 2026 |
| [Phase 1/2](https://specstream.ai/data/clinical-trials/phase/phase-1-2) | 8 | August 10, 2026 |
| [Phase 1](https://specstream.ai/data/clinical-trials/phase/phase-1) | 7 | September 4, 2026 |
| [Phase 2/3](https://specstream.ai/data/clinical-trials/phase/phase-2-3) | 6 | April 17, 2026 |
| [Phase 4](https://specstream.ai/data/clinical-trials/phase/phase-4) | 3 | March 19, 2026 |
| [Early phase 1](https://specstream.ai/data/clinical-trials/phase/early-phase-1) | 1 | April 17, 2025 |

## By country

| Country | New trials | Latest |
| --- | --- | --- |
| [China](https://specstream.ai/data/clinical-trials/country/china) | 94 | November 6, 2026 |
| [United States](https://specstream.ai/data/clinical-trials/country/united-states) | 35 | September 9, 2026 |
| [France](https://specstream.ai/data/clinical-trials/country/france) | 15 | October 13, 2026 |
| [Turkey (Türkiye)](https://specstream.ai/data/clinical-trials/country/turkey-t-rkiye) | 10 | September 3, 2026 |
| [Taiwan](https://specstream.ai/data/clinical-trials/country/taiwan) | 10 | July 28, 2026 |
| [Italy](https://specstream.ai/data/clinical-trials/country/italy) | 10 | July 10, 2026 |
| [Spain](https://specstream.ai/data/clinical-trials/country/spain) | 9 | June 8, 2026 |
| [Netherlands](https://specstream.ai/data/clinical-trials/country/netherlands) | 8 | September 29, 2026 |
| [South Korea](https://specstream.ai/data/clinical-trials/country/south-korea) | 7 | September 16, 2026 |
| [Germany](https://specstream.ai/data/clinical-trials/country/germany) | 7 | February 12, 2026 |
| [Belgium](https://specstream.ai/data/clinical-trials/country/belgium) | 5 | November 6, 2026 |
| [Poland](https://specstream.ai/data/clinical-trials/country/poland) | 5 | November 4, 2026 |
| [Egypt](https://specstream.ai/data/clinical-trials/country/egypt) | 5 | July 24, 2026 |
| [Canada](https://specstream.ai/data/clinical-trials/country/canada) | 5 | June 2, 2026 |
| [United Kingdom](https://specstream.ai/data/clinical-trials/country/united-kingdom) | 5 | January 15, 2026 |
| [Denmark](https://specstream.ai/data/clinical-trials/country/denmark) | 4 | October 29, 2026 |
| [Sweden](https://specstream.ai/data/clinical-trials/country/sweden) | 4 | October 7, 2026 |
| [Australia](https://specstream.ai/data/clinical-trials/country/australia) | 3 | September 4, 2026 |
| [Puerto Rico](https://specstream.ai/data/clinical-trials/country/puerto-rico) | 3 | December 16, 2025 |
| [Japan](https://specstream.ai/data/clinical-trials/country/japan) | 3 | October 9, 2025 |
| [Brazil](https://specstream.ai/data/clinical-trials/country/brazil) | 3 | May 30, 2025 |
| [Finland](https://specstream.ai/data/clinical-trials/country/finland) | 2 | October 28, 2026 |
| [Ukraine](https://specstream.ai/data/clinical-trials/country/ukraine) | 2 | October 23, 2026 |
| [Russia](https://specstream.ai/data/clinical-trials/country/russia) | 2 | March 11, 2026 |
| [Slovenia](https://specstream.ai/data/clinical-trials/country/slovenia) | 2 | February 23, 2026 |

## Where the register publishes

- [ClinicalTrials.gov](https://clinicaltrials.gov/)
- [ClinicalTrials.gov API](https://clinicaltrials.gov/data-api/api)

Source: [ClinicalTrials.gov API v2 (U.S. National Library of Medicine)](https://clinicaltrials.gov/data-api/api). U.S. government data; ClinicalTrials.gov terms of use. Studies are as their sponsors registered them on ClinicalTrials.gov, read through its API. Condition groups are the MeSH terms ClinicalTrials.gov assigns to each study's conditions; a study with several is in several groups. Sponsor class is the register's class of the lead sponsor. The central contact is in the full list only as the record prints it.

Free to reuse with credit to SpecStream under [CC BY 4.0](https://creativecommons.org/licenses/by/4.0/).