# New Periodontitis clinical trials: 387 posted since Nov 2024

Updated November 9, 2026.

387 clinical studies in periodontitis were first posted on ClinicalTrials.gov from November 12, 2024 to November 9, 2026; 6 have an industry sponsor and 157 are recruiting or about to. The newest, NCT07926282, was posted on November 9, 2026: Adjunctive Melatonin Gel With MINST on GCF Galectin-3 and IL-1 in Stage III-IV Periodontitis (Badr University).

## The full list

New Periodontitis clinical trials: 387 rows for $19.35, first posted on ClinicalTrials.gov from November 12, 2024 to November 9, 2026. Columns: NCT ID, Title, Sponsor, Sponsor class, Phase, Status, Conditions, Condition groups (MeSH), Interventions, Start date, First posted, Enrollment, Enrollment type, Location countries, Central contact, Contact phone, Contact email, Last update posted, Read on, Source. The new rows each week by email, about 21 rows a month: $19 a month. Pay by card with no account. Prices exclude VAT. CSV and Excel files with the columns this page does not show (central contact, contact phone, contact email, sponsor class, condition groups (MeSH), interventions and 5 more), which open on your screen as soon as the payment clears and come by email. The rows on this page are a sample.

Buy: https://specstream.ai/data/clinical-trials/condition/periodontitis

SpecStream is the live web data engine for teams and agents. It reads every new study on ClinicalTrials.gov each morning, and this page is that reading. Ask for the conditions, phases or countries you follow and each new trial arrives in your sheet, CRM, Slack or agent with the sponsor, the sites and the listed contact.

- New trials: 387
- Industry sponsored: 6
- Recruiting or not yet: 157
- Latest posted: November 9, 2026

## Newest trials

The newest 100 of 387, each linked to its record. The full list holds every one with the sponsor class, interventions, start date and the central contact as the record prints it.

| First posted | NCT ID | Title | Sponsor | Phase | Status | Conditions | Enrollment | Countries | Source |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| November 9, 2026 | NCT07926282 | Adjunctive Melatonin Gel With MINST on GCF Galectin-3 and IL-1 in Stage III-IV Periodontitis | Badr University | Phase 2 | Not yet recruiting | Periodontitis, Periodontitis (Stage 3), Periodontitis Stage IV | 40 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07926282) |
| November 6, 2026 | NCT07923708 | Ozone Gel Versus Chlorohexidine Gel as an Adjunct to Non-Surgical Treatment of Stage II Periodontitis Grade B Among Smokers Patients | October 6 University | Not applicable | Recruiting | Ozone Gel, Chlorohexidine Gel, Non-Surgical Treatment, Stage II Periodontitis, Smokers | 30 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07923708) |
| November 6, 2026 | NCT07922577 | Bioactive Glass With or Without a Collagen Membrane for Periodontal Intrabony Defects | Medical University of Bialystok | Not applicable | Completed | Periodontitis | 40 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07922577) |
| November 5, 2026 | NCT07917936 | IL-4 and IL-17 Responses to Periodontal Therapy in Patients With Type 2 Diabetes | Dicle University | Observational | Completed | Periodontitis, Type 2 Diabetes Mellitus | 45 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07917936) |
| November 3, 2026 | NCT07914400 | Timing of Oral Hygiene Improvement Relative to Subgingival Instrumentation | University of Ljubljana | Not applicable | Completed | Periodontal Diseases Inflammation, Periodontal Disease, Periodontal Attachment Loss, Periodontal Pocket, Oral Hygiene... | 10 | Slovenia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07914400) |
| October 30, 2026 | NCT07907224 | Characterization of Small Intestinal Bacterial Overgrowth and Intestinal Barrier-Related Biomarkers in Patients With Severe Periodontitis | Iuliu Hatieganu University of Medicine and Pharmacy | Observational | Recruiting | Periodontitis (Stage 3), Periodontitis Stage IV, SIBO | 20 | Romania | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07907224) |
| October 29, 2026 | NCT07905209 | Evaluation of MTHFR and DNMT3B Gene Polymorphisms Along With Periodontal Clinical Parameters in Healthy Individuals and Individuals With... | Akdeniz University | Observational | Active not recruiting | Periodontitis, Type 2 Diabetes Mellitus (DM) | 200 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07905209) |
| October 29, 2026 | NCT07904455 | Trabecular Bone Changes After Periodontal Treatment in Patients With and Without Bruxism | Mustafa Kemal University | Observational | Completed | Periodontitis, Bruxism | 65 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07904455) |
| October 28, 2026 | NCT07900802 | Comparing Aloe Vera Gel and Clindamycin Gel Added to Scaling and Root Planing for Periodontitis | Suez Canal University | Not applicable | Completed | Periodontitis, Clindamycin Gel, Aloe Vera Gel, Scaling and Root Planing | 30 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07900802) |
| October 27, 2026 | NCT07897292 | The Efficacy of Exosomes Combined With Synthetic Bone Graft for the Treatment of Periodontal Intra-bony Defects | Khoshoe Al-mokhtar Mohammed | Early phase 1 | Not yet recruiting | Intra-Bony Defects in Periodontitis Patients | 30 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07897292) |
| October 27, 2026 | NCT07897162 | Effect of Smoking on Salivary and Serum Metabolomic Profiles in Periodontitis | Ankara University | Observational | Completed | Periodontitis | 48 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07897162) |
| October 26, 2026 | NCT07893587 | Spirulina Gel in the Treatment of Periodontitis | Misr University for Science and Technology | Not applicable | Not yet recruiting | Periodontitis, Periodontitis Stage II | 20 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07893587) |
| October 21, 2026 | NCT07887204 | Antibiotic Resistance Genes in Periodontitis | Istanbul University | Observational | Active not recruiting | Periodontal Disease, Periodontitis, Antibiotic Resistance Genes | 50 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07887204) |
| October 19, 2026 | NCT07881406 | Salivary and GCF Biomarkers in Periodontal Health, Gingivitis and Periodontitis | Yuzuncu Yil University | Observational | Not yet recruiting | Periodontal Health, Gingivitis, Periodontitis | 60 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881406) |
| October 19, 2026 | NCT07880717 | Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 Years | Mahidol University | Observational | Recruiting | Diabete Mellitus, Dyslipidaemia, Chronic Kidney Disease, Psychiatric Disorder, Hypertension, Hypothyroidism, Smoking... | 93 | Thailand | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07880717) |
| October 14, 2026 | NCT07873697 | Association Between Periodontitis and Dry Eye Disease: A Cross-Sectional Study | University of Sulaimani | Observational | Recruiting | Periodontitis, Dry Eye Disease (DED) | 80 | Iraq | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07873697) |
| October 14, 2026 | NCT07873385 | Evaluation of MTHFR Gene Polymorphism and Periodontal Clinical Parameters in Healthy, Hypertensive, and Periodontitis Individuals | Akdeniz University | Observational | Completed | Hypertension, Periodontitis | 200 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07873385) |
| October 13, 2026 | NCT07870473 | Evaluation of the Effect of Smoking on Apelin, Periostin, and High-Sensitivity CRP Levels in Gingival Crevicular Fluid and Serum | Pamukkale University | Observational | Active not recruiting | Periodontitis (Stage 3), Periodontal Health, Smoking Cigarette | 85 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07870473) |
| October 9, 2026 | NCT07869277 | Obesity and Clinical and Cytokine Responses to Periodontal Therapy | Emine Çifcibaşı | Not applicable | Completed | Periodontitis, Obesity (Body Mass Index \>30 kg/m2) | 80 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07869277) |
| October 9, 2026 | NCT07868042 | Evaluation of Changes in Oral Health-related Quality of Life During the Treatment of Periodontitis. | University Hospital, Clermont-Ferrand | Observational | Not yet recruiting | Periodontitis, Adult, Periodontitis, Oral Disease, Quality of Life | 100 | France | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07868042) |
| October 8, 2026 | NCT07866664 | Association Between Periodontal Status and the Interrupted Supportive Periodontal Therapy During the COVID-19 Pandemic | University of Zagreb | Observational | Completed | Compliance, Periodontitis, Periodontal Therapy | 60 | Croatia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07866664) |
| October 7, 2026 | NCT07864220 | Periodontal Pathogens and Inflammatory Biomarkers in Missed Abortion | Necmettin Erbakan University | Observational | Recruiting | Missed Abortion, Periodontitis | 160 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07864220) |
| October 5, 2026 | NCT07859358 | Injectable Platelet-Rich Fibrin (i-PRF) and Oxygen-Releasing Gel in the Treatment of Stage II Periodontitis. | Assiut University | Phase 1/2 | Completed | Stage III Periodontitis | 24 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07859358) |
| October 5, 2026 | NCT07856901 | Retinal and Choroidal Changes in Periodontal Disease | Zeliha Başak Çakır Erdil | Observational | Not yet recruiting | Periodontal Diseases, Periodontal Diseases Inflammation, Retinal Thickening | 80 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07856901) |
| October 1, 2026 | NCT07853469 | Optical Coherence Tomography Findings Associated With the Glaucoma-periodontitis Stage | Recep Tayyip Erdogan University Training and Research Hospital | Observational | Completed | Glaucoma, GLAUCOMA 1, OPEN ANGLE, D (Disorder), Periodontitis | 66 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07853469) |
| October 1, 2026 | NCT07852520 | Breaking Force of Periodontal Suture Materials After Intraoral Exposure | Cukurova University | Not applicable | Completed | Periodontitis | 120 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07852520) |
| October 1, 2026 | NCT07851584 | Er,Cr:YSGG Laser in Smokers With Stage III Periodontitis | Okan University | Not applicable | Completed | Periodontitis (Stage 3) | 20 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07851584) |
| September 30, 2026 | NCT07849647 | Diode Laser 635 nm and 810 nm Photodynamic Therapy as Adjuncts to Non-Surgical Periodontal Treatment | Damascus University | Not applicable | Not yet recruiting | Periodontitis | 12 | Syria | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07849647) |
| September 28, 2026 | NCT07844564 | Effects of Nonsurgical Periodontal Treatment on GCF Calprotectin and IL-10 in Rheumatoid Arthritis | Ondokuz Mayıs University | Not applicable | Completed | Rheumatoid Arthritis (RA), Periodontitis, Gingivitis | 54 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07844564) |
| September 25, 2026 | NCT07841301 | PRF Versus Emdogain for Class II Furcation Defects of Mandibular Molars | Medical University of Sofia | Not applicable | Completed | Peridontal Disease, Furcation Defects | 21 | Bulgaria | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07841301) |
| September 25, 2026 | NCT07840859 | Clinical Effectiveness of Oxygen-Releasing Oral Gel as an Adjunct to Scaling and Root Debridement in Patients With Severe Periodontal... | Universiti Sains Malaysia | Not applicable | Not yet recruiting | Periodontitis | 38 | Malaysia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07840859) |
| September 25, 2026 | NCT07840716 | Active Oxygen Gel vs Chlorhexidine Gel in Stage II Grade B Periodontitis | Kafrelsheikh University | Not applicable | Not yet recruiting | Stage II Grade B Periodontitis | 60 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07840716) |
| September 24, 2026 | NCT07837947 | Air Polishing for Pain and Compliance in Supportive Periodontal Therapy | Octavi Camps-Font | Not applicable | Not yet recruiting | Periodontitis | 40 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07837947) |
| September 23, 2026 | NCT07835477 | TBC1D15 / Rab7 / Fis1 Pathway in Periodontal Disease | Inonu University | Observational | Completed | Gingivitis, Periodontitis | 72 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07835477) |
| September 21, 2026 | NCT07832110 | The Effect of Dexamethasone on Short Term Patient Response: IV vs Oral Administration | The University of Texas Health Science Center at San Antonio | Phase 1/2 | Not yet recruiting | Post Operative Pain, Acute, Periodontitis | 40 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07832110) |
| September 18, 2026 | NCT07827391 | A Retrospective Comparative Evaluation of Omega-3 and Resveratrol Supplementation in Patients With Periodontitis | Izmir Katip Celebi University | Observational | Active not recruiting | Periodontitis | 60 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07827391) |
| September 17, 2026 | NCT07826728 | SMOKING AND GINGIVAL CREVICULAR FLUID MFN1 AND NLRP3 LEVELS IN PERIODONTAL HEALTH AND PERIODONTITIS | Abant Izzet Baysal University | Observational | Recruiting | Periodontitis, Smoking | 88 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07826728) |
| September 17, 2026 | NCT07824921 | The Role Oral Microbiome in the Development and Progression of Aorta Aneurysm and Carotid Atherosclerosis | Semmelweis University | Observational | Enrolling by invitation | Aorta Aneurysm, Carotid Arteriosclerosis | 100 | Hungary | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07824921) |
| September 16, 2026 | NCT07822269 | Dental Loupe Versus Dental Operating Microscope for Non-Surgical Periodontal Treatment | Saglik Bilimleri Universitesi | Not applicable | Recruiting | Periodontitis, Periodontitis and Treatment Need, Periodontal Disease, Periodontal Pocket, Periodontitis (Stage 3) | 30 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07822269) |
| September 16, 2026 | NCT07821528 | Possible Association Between Behçet's Disease and Periodontal Diseases | Gazi University | Observational | Completed | Behcet Syndrome, Periodontitis, Gingival Diseases | 87 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07821528) |
| September 9, 2026 | NCT07809477 | Integrated Diabetes and Oral Health Care in Oman | Oman Ministry of Health | Not applicable | Not yet recruiting | Type 2 Diabetes Mellitus, Periodontitis, T2DM, Periodontal Disease, Type 2 Diabetes, Gum Inflammation, Non Insulin... | 290 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07809477) |
| September 8, 2026 | NCT07807215 | Laser Assisted Open Flap Debridement | University of Bari Aldo Moro | Not applicable | Not yet recruiting | Periodontal Disease, Periodontal Bone Loss | 20 | Italy | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07807215) |
| September 4, 2026 | NCT07805317 | Alb-PRF as an Adjunct to Regenerative Periodontal Surgery | Halil Ata BIÇAKÇIOĞLU | Not applicable | Not yet recruiting | Periodontitis, Periodontitis Stage III, Periodontal Intrabony Defects | 24 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07805317) |
| September 3, 2026 | NCT07803484 | Efficacy of Oral Hygiene Regimens in Patients Undergoing Non-Surgical Periodontal Treatment | Colgate Palmolive | Phase 3 | Not yet recruiting | Periodontal Disease, Gingival Inflammation and Bleeding | 100 | Brazil | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07803484) |
| September 1, 2026 | NCT07797127 | Evaluation of the Effects of Routine Phase I Periodontal Therapy on Clinical Parameters and Levels of Gremlin-1, CTHRC1, and Tenascin-C in... | Adiyaman University | Observational | Not yet recruiting | Periimplantitis, Periodontitis | 30 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07797127) |
| August 31, 2026 | NCT07794046 | Alb-PRF as an Adjunct to Nonsurgical Periodontal Therapy | Halil Ata BIÇAKÇIOĞLU | Not applicable | Not yet recruiting | Periodontitis | 24 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07794046) |
| August 28, 2026 | NCT07793370 | Evaluation of PTHrP, RANKL, and OPG Levels in Periodontal Health and Diseases | Abant Izzet Baysal University | Observational | Completed | Periodontitis, Gingivitis, Periodontal Disease | 81 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07793370) |
| August 28, 2026 | NCT07792902 | Microbiological Modulation Of The Oral-Gut Axis After Treatment With Or Without Systemic Use Of Probiotics In Patients With Periodontitis... | University of Sao Paulo | Phase 1 | Completed | Periodontitis Stage IV, Periodontitis | 40 | Brazil | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07792902) |
| August 28, 2026 | NCT07791927 | Effect of Non-Surgical Periodontal Therapy on Inflammation in Heart Transplant Recipients | Baskent University | Not applicable | Completed | Heart Transplant, Periodontitis, Gingivitis, Systemic Inflammation | 20 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07791927) |
| August 27, 2026 | NCT07791238 | Minimally Invasive Non-Surgical Periodontal Therapy Alone vs. Minimally Invasive Non-Surgical Periodontal Therapy With I-PRF With or... | Cairo University | Phase 1/2 | Not yet recruiting | Bony Defects, Periodontal Disease | 63 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07791238) |
| August 27, 2026 | NCT07788937 | Effect of Guided Biofilm Therapy in Patients With Stage 3 Periodontitis | Ataturk University | Not applicable | Completed | Periodontitis, Periodontitis (Stage 3) | 60 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07788937) |
| August 25, 2026 | NCT07785115 | Full-Mouth vs. Quadrant-Wise Scaling and Root Planing: Clinical Effectiveness, Environmental Sustainability, and Patient-Reported Outcomes | Selcuk University | Not applicable | Active not recruiting | Stage III Periodontitis | 52 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07785115) |
| August 24, 2026 | NCT07782736 | Advanced Platelet-Rich Fibrin Plus in Nonsurgical Periodontal Therapy | University of Medicine and Pharmacy at Ho Chi Minh City | Not applicable | Completed | Periodontitis | 14 | Vietnam | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07782736) |
| August 20, 2026 | NCT07775378 | Boron Levels, Oxidative Stress, and Inflammation in Periodontitis | Marmara University | Observational | Recruiting | Periodontitis | 60 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07775378) |
| August 19, 2026 | NCT07772115 | Occlusal Force and Chewing After Periodontal Therapy | Mohammed Bin Rashid University of Medicine and Health Sciences | Not applicable | Not yet recruiting | Periodontitis | 30 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07772115) |
| August 18, 2026 | NCT07770256 | Morphological Characteristics of Mandibular Molar Furcation Involvement and Efficacy of Regenerative Surgical Treatment | University of Medicine and Pharmacy at Ho Chi Minh City | Not applicable | Recruiting | Periodontitis, Periodontitis (Stage 3), Furcation Defects | 98 | Vietnam | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07770256) |
| August 14, 2026 | NCT07765251 | Angiogenesis in Periodontal Disease | Inonu University | Observational | Completed | Gingivitis | 114 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07765251) |
| August 14, 2026 | NCT07764549 | Salivary TNF-α, FoxO-1, and SIRT-1 Levels in Periodontitis and Smoking | Zehra Hasgül | Observational | Completed | Periodontitis (Stage 3), Smoking ( Cigarette) | 80 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07764549) |
| August 13, 2026 | NCT07764029 | Efficacy of PRF and Xenograft in Treating Mandibular Molar Furcation Involvements | University of Medicine and Pharmacy at Ho Chi Minh City | Not applicable | Recruiting | Periodontitis, Furcation Defects | 22 | Vietnam | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07764029) |
| August 13, 2026 | NCT07763223 | Sub-junctional Pinhole Technique | Al-Azhar University | Not applicable | Completed | Periodontal Intrabony Defects, Stage III Grade B Periodontitis | 10 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07763223) |
| August 12, 2026 | NCT07759466 | Hippo Signaling Pathway Proteins in Gingival Crevicular Fluid of Individuals With Periodontal Disease | Inonu University | Observational | Completed | Periodontal Disease, Gingivitis and Periodontal Diseases, Biomarker Discovery and Validation, Pathways | 75 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07759466) |
| August 11, 2026 | NCT07758374 | GFI-1 and Periodontal Disease | Inonu University | Observational | Completed | Periodontitis, Gingivitis | 60 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07758374) |
| August 10, 2026 | NCT07755644 | Minimally Invasive Non-Surgical Periodontal Treatment | Ataturk University | Not applicable | Not yet recruiting | Periodontitis, Periodontitis (Stage 3) | 23 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07755644) |
| August 10, 2026 | NCT07755228 | Salivary Gasdermin E and Granzyme B Levels in Patients With Periodontitis | Medipol University | Observational | Completed | Periodontitis, Periodontal Health | 46 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07755228) |
| August 7, 2026 | NCT07753317 | Clinical and Radiographic Evaluation of Subgingival 1% Metformin Gel Versus 0.05% Zoledronate Gel as an Adjunct to MINST of Intrabony... | Cairo University | Not applicable | Not yet recruiting | Controlled Type 2 Diabetic Patients With Periodontitis | 30 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07753317) |
| August 7, 2026 | NCT07751419 | Endoplasmic Reticulum Stress Response in Periodontal Disease | Inonu University | Observational | Completed | Periodontitis, Gingivitis | 72 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07751419) |
| August 7, 2026 | NCT07751393 | Signal-Transducing Adaptor Proteins in Periodontal Disease | Inonu University | Observational | Completed | Periodontitis, Gingivitis | 75 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07751393) |
| August 5, 2026 | NCT07747545 | Caffeine Intake and Periodontal Treatment Outcomes | Haoran Feng | Not applicable | Not yet recruiting | Periodontitis | 90 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07747545) |
| July 31, 2026 | NCT07740447 | Impact of Non-surgical Periodontal Treatment on Targeted Metabolomics | University of Catania | Not applicable | Recruiting | Periodontitis | 60 | Italy | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07740447) |
| July 31, 2026 | NCT07739732 | Periodontitis on Gingival Crevicular Fluid Metobolomics | University of Catania | Observational | Recruiting | Periodontitis | 60 | Italy | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07739732) |
| July 29, 2026 | NCT07735312 | Effects of Periodontitis on Heart Rate Variability | University of Sao Paulo | Not applicable | Active not recruiting | Periodontitis, Cardiac Electrophysiology | 50 | Brazil | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07735312) |
| July 28, 2026 | NCT07731412 | Short-Term Changes in Salivary IL-6, TNF-α, and Periodontal Inflammation Following Sleeve Gastrectomy in Patients With Obesity: A... | George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures | Not applicable | Completed | Obesity, Periodontitis | 32 | Romania | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07731412) |
| July 28, 2026 | NCT07731113 | Evaluation of Hyaluronic Acid and Chlorhexidine Gel as an Adjunct to Minimally Invasive Non-surgical Therapy in the Treatment of Stage III... | Cairo University | Not applicable | Active not recruiting | Periodontology, Periodontal Disease, Periodontal Diseases, Periodontitis (Stage 3), Gingivitis and Periodontal... | 72 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07731113) |
| July 28, 2026 | NCT07729904 | Restorative and Periodontal Evaluation of Fiber-Reinforced Periodontal Splints | Emre Taşlı | Observational | Active not recruiting | Periodontitis, Tooth Mobility | 68 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07729904) |
| July 24, 2026 | NCT07725393 | Adjunctive Subgingival Pomegranate Peel Extract Gel for Stage II-III Periodontitis | gehad samy | Not applicable | Recruiting | Periodontitis | 32 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07725393) |
| July 23, 2026 | NCT07721428 | Salivary Angiotensin-Converting Enzyme and Periodontal Disease in Cardiovascular Disease | Suleyman Demirel University | Observational | Completed | Periodontal Disease, Cardiovascular Disease | 76 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07721428) |
| July 23, 2026 | NCT07721337 | Periodontitis Severity and Associated Factors Among Egyptian Males and Females | Al-Azhar University | Observational | Completed | Periodontitis | 380 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07721337) |
| July 22, 2026 | NCT07719686 | Effect of Menstrual Cycle Phase on Pain Perception and Anxiety During Non-Surgical Periodontal Treatment | Karadeniz Technical University | Observational | Completed | Periodontitis | 36 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07719686) |
| July 17, 2026 | NCT07712627 | Hypochlorous Acid in Non-Surgical Periodontal Therapy | Ataturk University | Not applicable | Completed | Periodontitis, Periodontitis Stage I, Periodontitis Stage II | 44 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07712627) |
| July 17, 2026 | NCT07711431 | Association Between Periodontal Disease and Chronic Neck Pain | Nigde Omer Halisdemir University | Observational | Recruiting | Periodontal Disease, Chronic Neck Pain | 123 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07711431) |
| July 16, 2026 | NCT07707063 | This a Clinical Trial to Evaluate the Efficacy of I-PRF, Povidone-Iodine and Laser as Adjuncts to Non-surgical Periodontal Treatment in... | Military Hospital of Tunis | Phase 4 | Recruiting | Periodontitis, Smokers, Non Smokers, Periodontal Disease | 50 | Tunisia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07707063) |
| July 15, 2026 | NCT07706387 | Virgin Coconut Oil Versus Chlorhexidine Mouthwash in Non-Surgical Periodontal Therapy of Periodontitis Patients. A Randomized Controlled... | Ain Shams University | Not applicable | Not yet recruiting | Stage II Periodontitis | 42 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07706387) |
| July 15, 2026 | NCT07705048 | PTPIP51-VAPB Complex in the Periodontal Disease | Inonu University | Observational | Completed | Periodontitis, Gingivitis | 60 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07705048) |
| July 14, 2026 | NCT07703345 | Salivary Apelin, Chemerin, Ghrelin, and Lipocalin-2 Levels in Diabetic Patients With Periodontitis | Necmettin Erbakan University | Observational | Recruiting | Periodontitis, Type 2 Diabetes Mellitus (T2DM) | 88 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07703345) |
| July 14, 2026 | NCT07700628 | Treatment of Periodontal and Peri-Implant Pockets With a Novel Collagen Hydrogel, H42 Medical Device | Studio Odontoiatrico Dott. G. Tarquini | Observational | Completed | Periodontal Pocket, Peri-implantitis | 52 | Italy | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07700628) |
| July 13, 2026 | NCT07699978 | Maternal Periodontal Inflammation and Pregnancy Outcomes: Salivary and Amniotic Biomarkers | Saglik Bilimleri Universitesi | Observational | Not yet recruiting | Periodontal Disease, Pregnancy, Preterm Birth | 80 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07699978) |
| July 10, 2026 | NCT07696845 | C-PRF With Minimally Invasive Non-Surgical Periodontal Therapy | Altinbas University | Not applicable | Active not recruiting | Periodontitis, Intrabony Periodontal Defect, Non Surgical Periodontal Treatment | 30 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07696845) |
| July 10, 2026 | NCT07695857 | Adropin Levels in Periodontal Disease | Giresun University | Observational | Completed | Periodontitis | 60 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07695857) |
| July 9, 2026 | NCT07693725 | Effect of Periodontitis on the Quality and Quantity of Leukocyte- and Platelet-Rich Fibrin (L-PRF) | Suleyman Demirel University | Observational | Active not recruiting | Periodontitis | 32 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07693725) |
| July 8, 2026 | NCT07691437 | Effect of Non-Surgical Periodontal Treatment on Oral Health in Hemophilia Patients | Karadeniz Technical University | Not applicable | Completed | Hemophilia A and B, Periodontitis, Hemophilia | 146 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07691437) |
| July 8, 2026 | NCT07691060 | Asprosin and Total Antioxidant/Oxidant Status in Diabetes and Periodontal Disease | Saglik Bilimleri Universitesi | Observational | Completed | Periodontal Diseases, Gingival Diseases, Type 2 Diabetes | 67 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07691060) |
| July 7, 2026 | NCT07688408 | Short Implants in Unitary Implant-supported Rehabilitations in the Posterior Maxilla and Mandible: 5 Years of Follow-up | University of Guarulhos | Observational | Not yet recruiting | Periodontitis, Periodontal Disease | 100 | Brazil | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07688408) |
| July 6, 2026 | NCT07683741 | Hydrolyzed Collagen As A Host Modulation Agent in Non-Surgical Periodontal Treatment | Hatice Yemenoglu | Not applicable | Completed | Periodontitis (Stage 3) | 52 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07683741) |
| July 1, 2026 | NCT07678125 | Influence of Re-evaluation Timing After Phase I Periodontal Therapy on Clinical and Periodontal Outcomes. | Gulf Medical University | Not applicable | Not yet recruiting | Periodontal Diseases, Periodontitis (Stage 3), Subgingival Debridement | 24 | United Arab Emirates | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07678125) |
| June 30, 2026 | NCT07674888 | Breaking the Cycle: Real-Time Family Oral Microbial Transmission Patterns as Intervention Targets | University of Alberta | Not applicable | Not yet recruiting | Dental Caries, Periodontitis, Oral Microbiome, Bacterial Transmission | 225 | Canada | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07674888) |
| June 29, 2026 | NCT07673185 | Omega-3 Plus Low-Dose Aspirin in Smokers With Stage III Periodontitis | Al-Azhar University | Not applicable | Recruiting | Periodontal Disease, Periodontitis (Stage 3), Smoking Behaviors | 40 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07673185) |
| June 29, 2026 | NCT07672665 | Sterify Gel as an Adjunct to Non-Surgical Periodontal Therapy in Periodontitis | IRCCS San Raffaele | Observational | Not yet recruiting | Periodontitis | 20 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07672665) |
| June 26, 2026 | NCT07672379 | Effects of Adjunctive Synbiotic Supplementation to Non-Surgical Periodontal Therapy in Smokers With Periodontitis | Biruni University | Not applicable | Not yet recruiting | Periodontal Disease | 92 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07672379) |
| June 26, 2026 | NCT07671963 | Bone Substitutes and NIPSA in Intrabony Periodontal Defects: A Randomized Controlled Trial | University of Belgrade | Not applicable | Recruiting | Periodontitis (Stage 3), Minimally Invasive Surgical Procedures, Bone Substitutes | 30 | Italy, Serbia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07671963) |
| June 26, 2026 | NCT07671274 | Comparison of the Efficacy of Conventional Versus Minimally Invasive Non-Surgical Periodontal Therapy in Periodontitis Patients | Mansoura University | Early phase 1 | Recruiting | Periodontal Disease, Stage III Periodontitis | 30 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07671274) |

## Sponsors posting most

| Sponsor | New trials | Latest |
| --- | --- | --- |
| Saglik Bilimleri Universitesi | 14 | September 16, 2026 |
| Inonu University | 11 | September 23, 2026 |
| Recep Tayyip Erdogan University Training and Research Hospital | 9 | October 1, 2026 |
| Postgraduate Institute of Dental Sciences Rohtak | 9 | June 9, 2026 |
| Cairo University | 7 | August 27, 2026 |
| Ataturk University | 7 | August 27, 2026 |
| Mansoura University | 7 | June 26, 2026 |
| Akdeniz University | 6 | October 29, 2026 |
| Abant Izzet Baysal University | 6 | September 17, 2026 |
| Ain Shams University | 6 | July 15, 2026 |
| Ondokuz Mayıs University | 5 | September 28, 2026 |
| Izmir Katip Celebi University | 5 | September 18, 2026 |
| University of Sao Paulo | 5 | August 28, 2026 |
| Al-Azhar University | 5 | August 13, 2026 |
| University of Catania | 5 | July 31, 2026 |
| Suleyman Demirel University | 5 | July 23, 2026 |
| Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | 5 | April 24, 2026 |
| University of Baghdad | 5 | March 9, 2026 |
| Kafrelsheikh University | 4 | September 25, 2026 |
| University of Bari Aldo Moro | 4 | September 8, 2026 |

## By phase

| Phase | New trials | Latest |
| --- | --- | --- |
| [Not applicable](https://specstream.ai/data/clinical-trials/phase/not-applicable) | 202 | November 6, 2026 |
| [Observational](https://specstream.ai/data/clinical-trials/phase/observational) | 154 | November 5, 2026 |
| [Early phase 1](https://specstream.ai/data/clinical-trials/phase/early-phase-1) | 7 | October 27, 2026 |
| [Phase 1/2](https://specstream.ai/data/clinical-trials/phase/phase-1-2) | 6 | October 5, 2026 |
| [Phase 4](https://specstream.ai/data/clinical-trials/phase/phase-4) | 6 | July 16, 2026 |
| [Phase 2](https://specstream.ai/data/clinical-trials/phase/phase-2) | 5 | November 9, 2026 |
| [Phase 3](https://specstream.ai/data/clinical-trials/phase/phase-3) | 3 | September 3, 2026 |
| [Phase 1](https://specstream.ai/data/clinical-trials/phase/phase-1) | 3 | August 28, 2026 |
| [Phase 2/3](https://specstream.ai/data/clinical-trials/phase/phase-2-3) | 1 | February 20, 2026 |

## By country

| Country | New trials | Latest |
| --- | --- | --- |
| [Turkey (Türkiye)](https://specstream.ai/data/clinical-trials/country/turkey-t-rkiye) | 143 | November 5, 2026 |
| [Egypt](https://specstream.ai/data/clinical-trials/country/egypt) | 47 | November 6, 2026 |
| [Italy](https://specstream.ai/data/clinical-trials/country/italy) | 28 | September 8, 2026 |
| [China](https://specstream.ai/data/clinical-trials/country/china) | 12 | August 5, 2026 |
| [Brazil](https://specstream.ai/data/clinical-trials/country/brazil) | 11 | September 3, 2026 |
| [India](https://specstream.ai/data/clinical-trials/country/india) | 10 | June 9, 2026 |
| [Iraq](https://specstream.ai/data/clinical-trials/country/iraq) | 9 | October 14, 2026 |
| [United States](https://specstream.ai/data/clinical-trials/country/united-states) | 9 | September 21, 2026 |
| [Spain](https://specstream.ai/data/clinical-trials/country/spain) | 6 | September 24, 2026 |
| [Vietnam](https://specstream.ai/data/clinical-trials/country/vietnam) | 6 | August 24, 2026 |
| [Romania](https://specstream.ai/data/clinical-trials/country/romania) | 4 | October 30, 2026 |
| [France](https://specstream.ai/data/clinical-trials/country/france) | 4 | October 9, 2026 |
| [Malaysia](https://specstream.ai/data/clinical-trials/country/malaysia) | 4 | September 25, 2026 |
| [United Arab Emirates](https://specstream.ai/data/clinical-trials/country/united-arab-emirates) | 4 | July 1, 2026 |
| [Chile](https://specstream.ai/data/clinical-trials/country/chile) | 4 | April 17, 2026 |
| [Belgium](https://specstream.ai/data/clinical-trials/country/belgium) | 4 | March 24, 2026 |
| [Germany](https://specstream.ai/data/clinical-trials/country/germany) | 4 | March 2, 2026 |
| [Syria](https://specstream.ai/data/clinical-trials/country/syria) | 3 | September 30, 2026 |
| [Hungary](https://specstream.ai/data/clinical-trials/country/hungary) | 3 | September 17, 2026 |
| [United Kingdom](https://specstream.ai/data/clinical-trials/country/united-kingdom) | 3 | February 12, 2026 |
| [Poland](https://specstream.ai/data/clinical-trials/country/poland) | 3 | December 15, 2025 |
| [Hong Kong](https://specstream.ai/data/clinical-trials/country/hong-kong) | 3 | May 18, 2025 |
| [Slovenia](https://specstream.ai/data/clinical-trials/country/slovenia) | 2 | November 3, 2026 |
| [Bulgaria](https://specstream.ai/data/clinical-trials/country/bulgaria) | 2 | September 25, 2026 |
| [Serbia](https://specstream.ai/data/clinical-trials/country/serbia) | 2 | June 26, 2026 |

## Where the register publishes

- [ClinicalTrials.gov](https://clinicaltrials.gov/)
- [ClinicalTrials.gov API](https://clinicaltrials.gov/data-api/api)

Source: [ClinicalTrials.gov API v2 (U.S. National Library of Medicine)](https://clinicaltrials.gov/data-api/api). U.S. government data; ClinicalTrials.gov terms of use. Studies are as their sponsors registered them on ClinicalTrials.gov, read through its API. Condition groups are the MeSH terms ClinicalTrials.gov assigns to each study's conditions; a study with several is in several groups. Sponsor class is the register's class of the lead sponsor. The central contact is in the full list only as the record prints it.

Free to reuse with credit to SpecStream under [CC BY 4.0](https://creativecommons.org/licenses/by/4.0/).