# Osteoarthritis, Knee trials: 525 new since Nov 2024

Updated November 9, 2026.

525 clinical studies in Osteoarthritis, Knee were first posted on ClinicalTrials.gov from November 12, 2024 to November 9, 2026; 60 have an industry sponsor and 313 are recruiting or about to. The newest, NCT07926373, was posted on November 9, 2026: Proximal, Mid, and Distal Adductor Canal Block for Pain Control After Total Knee Arthroplasty (Bursa City Hospital).

## The full list

New Osteoarthritis, Knee clinical trials: 525 rows for $26.25, first posted on ClinicalTrials.gov from November 12, 2024 to November 9, 2026. Columns: NCT ID, Title, Sponsor, Sponsor class, Phase, Status, Conditions, Condition groups (MeSH), Interventions, Start date, First posted, Enrollment, Enrollment type, Location countries, Central contact, Contact phone, Contact email, Last update posted, Read on, Source. The new rows each week by email, about 30 rows a month: $19 a month. Pay by card with no account. Prices exclude VAT. CSV and Excel files with the columns this page does not show (central contact, contact phone, contact email, sponsor class, condition groups (MeSH), interventions and 5 more), which open on your screen as soon as the payment clears and come by email. The rows on this page are a sample.

Buy: https://specstream.ai/data/clinical-trials/condition/osteoarthritis-knee

SpecStream is the live web data engine for teams and agents. It reads every new study on ClinicalTrials.gov each morning, and this page is that reading. Ask for the conditions, phases or countries you follow and each new trial arrives in your sheet, CRM, Slack or agent with the sponsor, the sites and the listed contact.

- New trials: 525
- Industry sponsored: 60
- Recruiting or not yet: 313
- Latest posted: November 9, 2026

## Newest trials

The newest 100 of 525, each linked to its record. The full list holds every one with the sponsor class, interventions, start date and the central contact as the record prints it.

| First posted | NCT ID | Title | Sponsor | Phase | Status | Conditions | Enrollment | Countries | Source |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| November 9, 2026 | NCT07926373 | Proximal, Mid, and Distal Adductor Canal Block for Pain Control After Total Knee Arthroplasty | Bursa City Hospital | Not applicable | Not yet recruiting | Postoperative Pain, Arthroplasty, Replacement, Knee, Knee Osteoarthritis | 120 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07926373) |
| November 9, 2026 | NCT07924748 | Balance Training and Resting Brain Activity in Knee Osteoarthritis: A Randomized Controlled Trial | Qingdao Municipal Hospital | Not applicable | Completed | Osteoarthritis, Knee | 74 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07924748) |
| November 6, 2026 | NCT07921563 | The Feasibility of a Virtual/Home-based OA Treatment Program in Older Adults With OA and Multimorbidity | Dartmouth-Hitchcock Medical Center | Not applicable | Not yet recruiting | Osteoarthritis of the Knee | 50 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07921563) |
| November 5, 2026 | NCT07920120 | Effects of Virtual Reality Environments on Walking in Adults With and Without Knee Osteoarthritis | University of Primorska | Not applicable | Recruiting | Knee Osteoarthritis | 60 | Lithuania, Slovenia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07920120) |
| November 5, 2026 | NCT07919678 | A Study to Learn About Study Medicine Called Berobenatide in Adults With Knee Pain and Overweight or Obesity (VESPER-OA 1) | Pfizer | Phase 3 | Recruiting | Obesity, Overweight, Osteoarthritis of the Knee | 656 | Canada, United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07919678) |
| November 5, 2026 | NCT07919535 | Effect of Local Heat Applications on Musculoskeletal Pain, Stiffness and Physical Function for Patients With Knee Osteoarthritis | Ain Shams University | Not applicable | Completed | Knee Osteoarthritis (Knee OA) | 100 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07919535) |
| November 4, 2026 | NCT07917559 | EFFECT OF ADDING BLOOD FLOW RESTRICTION TRAINING TO CLOSED CHAIN EXERCISE IN KNEE OSTEOARTHRITIS | Rasha Abdel Kader Abdel Azeem Khtab | Not applicable | Not yet recruiting | Knee Osteoarthritis | 60 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07917559) |
| November 4, 2026 | NCT07915609 | A Study to Learn About Berobenatide Given Once Weekly in Adults With Knee Osteoarthritis and Overweight or Obesity With or Without Type 2... | Pfizer | Phase 3 | Recruiting | Obesity, Overweight and/or Obesity, Knee Osteoarthritis, Diabetes Melliuts, Type 2 | 756 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07915609) |
| November 3, 2026 | NCT07914036 | Patient Satisfaction After Robotic-Assisted Versus Conventional Total Knee Arthroplasty | Ain Shams University | Not applicable | Not yet recruiting | Osteoarthritis (Knee), Robotic Assisted Arthroplasty | 70 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07914036) |
| November 3, 2026 | NCT07913295 | Comparative Effect of Dual Task Training and Rhythmic Stabilization in Knee Osteoarthritis Patients | University of Management and Technology Lahore | Not applicable | Active not recruiting | Knee Osteoarthritis | 26 | Pakistan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07913295) |
| November 3, 2026 | NCT07912333 | Wearable Device Guided Exercise for Patients on Total Knee Arthroplasty Wait-list | Chinese University of Hong Kong | Not applicable | Not yet recruiting | Knee Osteoarthristis | 106 | Hong Kong | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07912333) |
| November 3, 2026 | NCT07911696 | Comparative Effectiveness and Safety of Two Hyaluronic Acid Products in Knee Osteoarthritis | Coordinación de Investigación en Salud, Mexico | Observational | Not yet recruiting | Osteoarthritis, Knee | 160 | Mexico | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07911696) |
| November 2, 2026 | NCT07908589 | Tempo-controlled Low-load Resistance Training in Patients With Knee Osteoarthritis. | University of Management and Technology Lahore | Not applicable | Not yet recruiting | Knee Osteoarthritis | 32 | Pakistan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07908589) |
| October 29, 2026 | NCT07904741 | The Effect of Different Exercise Training Programs on Muscle Oxygenation in Individuals With Knee Osteoarthritis | Bahçeşehir University | Not applicable | Recruiting | Osteoarthritis of Knee | 60 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07904741) |
| October 29, 2026 | NCT07903142 | Comparison of High-Intensity and Conventional Physical Therapy in Musculoskeletal Disorders | BTL Industries Ltd. | Not applicable | Not yet recruiting | Low Back Pain, Radicular Syndrome, Sacroiliac Joint Dysfunction, Shoulder Impingement Syndrome, Rotator Cuff... | 60 | Czechia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07903142) |
| October 28, 2026 | NCT07901881 | The Effect of Theory-driven Physiotherapy on Physical Activity in Knee OA. | Mark van Loo | Not applicable | Not yet recruiting | Knee Osteoarthritis | 20 | Netherlands | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07901881) |
| October 28, 2026 | NCT07901790 | Autologous Adipose-Derived Stem Cell Injections for Knee Osteoarthritis | Yonsei University | Not applicable | Recruiting | Osteoarthritis, Knee, Knee Osteoarthritis | 165 | South Korea | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07901790) |
| October 28, 2026 | NCT07901374 | Genicular Nerve Radiofrequency Ablation Versus Hyaluronic Acid Injection for Knee Osteoarthritis Pain | Hospital Universitari Joan XXIII de Tarragona. | Not applicable | Not yet recruiting | Knee Osteoarthritis, Chronic Knee Pain | 70 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07901374) |
| October 28, 2026 | NCT07901348 | GENIVS Block Versus Adductor Canal Block After Total Knee Arthroplasty | Bakirkoy Dr. Sadi Konuk Research and Training Hospital | Not applicable | Not yet recruiting | Arthroplasty, Replacement, Knee, Pain, Postoperative, Osteoarthritis, Knee | 74 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07901348) |
| October 28, 2026 | NCT07901153 | Platelet-Rich Plasma, Hyaluronic Acid, or Their Combination for Knee Osteoarthritis in Athletes | University of Sao Paulo General Hospital | Not applicable | Not yet recruiting | Knee Osteoarthritis | 300 | Brazil | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07901153) |
| October 27, 2026 | NCT07898501 | SVF Cellular Composition, Secretome, and Responses in Knee Osteoarthritis | Yonsei University | Observational | Recruiting | Osteoarthritis, Knee | 20 | South Korea | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07898501) |
| October 23, 2026 | NCT07892144 | Effects of Low-Load Blood Flow Restriction Resistance Training With and Without Hip Abductor Strengthening in Patients With Knee... | University of Management and Technology Lahore | Not applicable | Not yet recruiting | Knee Osteoarthritis | 44 | Pakistan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07892144) |
| October 23, 2026 | NCT07891351 | Effects Of Sensor Assisted Neuro-muscular Exercise Vs Electrical Stimulation On Bio-mechnical And Functional Parameters In Grade II And III... | Ziauddin University | Not applicable | Completed | Knee Arthritis Osteoarthritis, Neuromuscular Adaptations | 40 | Pakistan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07891351) |
| October 22, 2026 | NCT07890155 | Effect of Resistance Exercises on Serum IGF-1 Levels in Knee Osteoarthritis | Sisli Hamidiye Etfal Training and Research Hospital | Not applicable | Recruiting | Osteoarthritis (Knee), Metabolic Syndrome (MetS) | 86 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07890155) |
| October 22, 2026 | NCT07888920 | Effects of Visual and Vestibular Rehabilitation in Individuals With Knee Osteoarthritis | Istanbul Aydın University | Not applicable | Not yet recruiting | Knee Osteoarthritis, Visual Rehabilitation, Vestibular Rehabilitation, Postural Stability, Balance, Pain, Functional... | 42 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07888920) |
| October 22, 2026 | NCT07887893 | Extracorporeal Shock Wave Therapy in the Treatment of Periarticular Bone Marrow Edema in Patients With Knee Osteoarthritis | Dokuz Eylul University | Not applicable | Recruiting | Knee Arthritis, Osteoarthritis, Bone Marrow Edema of the Knee, Bone Marrow Edema | 24 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07887893) |
| October 21, 2026 | NCT07886697 | Low-Dose Radiotherapy for Painful Knee Osteoarthritis | Universidad Rey Juan Carlos | Not applicable | Not yet recruiting | Knee Osteoarthritis | 283 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07886697) |
| October 20, 2026 | NCT07883824 | Aquatic Exercise in Patients With Knee Osteoarthritis | Kirsehir Ahi Evran Universitesi | Not applicable | Recruiting | Central Sensitization, Knee Osteoarthristis, Aquatic | 60 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07883824) |
| October 20, 2026 | NCT07882316 | Preoperative Multimorbidity and Functional Recovery After Total Knee Arthroplasty | Balikesir Ataturk City Hospital | Observational | Recruiting | Knee Osteoarthritis, Multimorbidity | 230 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07882316) |
| October 20, 2026 | NCT07881861 | Cartilage Biomarker Response to Acute Mechanical Loading in Women With Knee Osteoarthritis: Comparison by Antiresorptive Treatment Status | Sisli Hamidiye Etfal Training and Research Hospital | Observational | Recruiting | Knee Osteoarthritis | 105 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881861) |
| October 19, 2026 | NCT07881445 | Subchondral Drilling Diameter During CARTISTEM Implantation for Knee Cartilage Defects | Yonsei University | Not applicable | Recruiting | Osteoarthritis, Knee, Articular Cartilage Defects of the Knee | 60 | South Korea | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881445) |
| October 19, 2026 | NCT07879664 | Bipolar Versus Cooled Radiofrequency Ablation for Gonarthrosis | Saglik Bilimleri Universitesi | Not applicable | Not yet recruiting | Gonarthrosis | 80 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07879664) |
| October 15, 2026 | NCT07876752 | Clinical Importance of Occult Suprapatellar Effusion in Knee Osteoarthritis | Mardin Artuklu University | Observational | Not yet recruiting | Knee Osteoarthritis | 105 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07876752) |
| October 15, 2026 | NCT07876310 | A Randomized Comparison of the Efficacy of the IPACK Block Versus the Popliteal Plexus Block for Posterior Knee Analgesia, in Patients... | Clinica Santa Maria | Not applicable | Not yet recruiting | Osteoarthritis, Knee, Postoperative Pain | 136 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07876310) |
| October 15, 2026 | NCT07875725 | Wearable Knee-Assisted Rehabilitation for Range of Motion and Muscle Strength After Total Knee Arthroplasty | University of Chile | Not applicable | Not yet recruiting | Total Knee Arthroplasty Recovery, Knee Osteoarthritis | 80 | Chile | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07875725) |
| October 15, 2026 | NCT07875647 | Person-Centred Digital Rehabilitation for Knee Osteoarthritis | Mälardalen University | Observational | Not yet recruiting | Knee Osteoarthritis, Physical Activity Behaviour | 500 | Sweden | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07875647) |
| October 15, 2026 | NCT07875543 | Comparison of the Therapeutic Effects of Lyophilized Platelet-rich Plasma Lysate and Dextrose Prolotherapy in Knee Osteoarthritis | Taichung Veterans General Hospital | Phase 2 | Completed | Knee Osteoarthritis, Platelet-rich Plasma (PRP) | 39 | Taiwan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07875543) |
| October 15, 2026 | NCT07875296 | Lysyl Oxidase and Lysyl Hydroxylase Levels in Knee Osteoarthritis | Afyonkarahisar Health Sciences University | Observational | Recruiting | Knee Osteoarthritis | 200 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07875296) |
| October 15, 2026 | NCT07875231 | Dexmedetomidine Infusion and Iscemia and Reperfusion Injury | Diskapi Yildirim Beyazit Education and Research Hospital | Phase 4 | Completed | Gonarthrosis | 60 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07875231) |
| October 13, 2026 | NCT07872280 | Neuromuscular Facilitation Protocol on Pain, Range and Function in KOA | Riphah International University | Not applicable | Completed | Knee Osteoarthristis | 54 | Pakistan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07872280) |
| October 13, 2026 | NCT07870967 | Undenatured Type II Collagen for Knee Osteoarthritis Pain | Universidad Católica San Antonio de Murcia | Not applicable | Recruiting | Osteoarthritis, Knee | 120 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07870967) |
| October 13, 2026 | NCT07870031 | Clinical Evaluation of TrHCROSS® for Different Joints | i+Med S.Coop. | Not applicable | Not yet recruiting | Joint Osteoarthritis, Knee Osteoarthristis, Hip Ostearthritis, Shoulder Osteoarthritis | 150 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07870031) |
| October 13, 2026 | NCT07869771 | The Effect of Pulsed Radiofrequency Ablation of the Genicular Nerve on Pain, Balance, and Proprioception in Patients With Chronic Knee... | Ankara City Hospital Bilkent | Not applicable | Completed | Knee Osteoarthritis (OA), Genicular Nerves Block, Radiofrequency Ablation | 28 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07869771) |
| October 9, 2026 | NCT07869680 | Functional Capacity Differences in Knee Osteoarthritis With Similar Pain Severity | Mardin Artuklu University | Observational | Recruiting | Knee Osteoarthritis | 120 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07869680) |
| October 9, 2026 | NCT07868770 | US-Guided Saphenous Block in Knee OA | Gaziler Physical Medicine and Rehabilitation Education and Research Hospital | Not applicable | Not yet recruiting | Knee Osteoarthritis, Osteoarthritis, Knee, Gonarthrosis, Knee Pain | 60 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07868770) |
| October 9, 2026 | NCT07868224 | Validating Blinding Maintenance of a Sham-Sensitization Control Design for Sensitization Acupuncture Trials | Jiangxi University of Traditional Chinese Medicine | Not applicable | Not yet recruiting | Knee Osteoarthritis; Insomnia; Cervical Spondylosis; Chronic Low Back Pain; Allergic Rhinitis | 30 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07868224) |
| October 9, 2026 | NCT07867405 | The Effect of Tail Fat Application on Joint Pain, Joint Stiffness, and Daily Living Activities in Patients With Gonarthrosis | Inonu University | Not applicable | Recruiting | Gonarthrosis | 66 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07867405) |
| October 8, 2026 | NCT07866378 | The Bone Cement Penetration in Medial Fixed-bearing Unicompartmental Knee Arthroplasty | Tianjin Union Medical Center | Observational | Completed | Knee Osteoarthritis | 88 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07866378) |
| October 6, 2026 | NCT07859878 | Efficacy of High-Intensity Laser Therapy in Early-Stage Symptomatic Knee Osteoarthritis | Ege University | Not applicable | Completed | Osteoarthritis, Knee | 39 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07859878) |
| October 5, 2026 | NCT07857954 | Comparison of Leucocyte-rich PRP and Leucocyte-poor PRP in Treating Mild to Moderate Knee Osteoarthritis | St. Catherine Specialty Hospital | Not applicable | Completed | Knee Osteoarthritis (Kellgren-Lawrence Grade 1-3), Knee Osteoarthritis, PRP, Platelet-rich Plasma (PRP) | 59 | Croatia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07857954) |
| October 2, 2026 | NCT07855367 | Cryoneurolysis Versus Bipolar Radiofrequency Ablation of Genicular Nerves for Pain Relief in Symptomatic Knee Osteoarthritis | National Cancer Institute, Egypt | Not applicable | Recruiting | Cryoneurolysis, Bipolar Radiofrequency Ablation, Genicular Nerves, Pain Relief, Symptomatic, Knee Osteoarthritis | 30 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07855367) |
| October 2, 2026 | NCT07853885 | Intraosseous Tranexamic Acid for Reducing Blood Loss in Total Knee Arthroplasty | The Second Affiliated Hospital of Kunming Medical University | Phase 4 | Not yet recruiting | Knee Osteoarthritis | 70 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07853885) |
| October 1, 2026 | NCT07853170 | 3-Needle vs 5-Needle of Genicular Nerve Block on Pain and Quality of Life in Knee Osteoarthritis | Tanta University | Not applicable | Recruiting | 3-Needle, 5-Needle, Genicular Nerve Block, Pain, Quality of Life, Knee Osteoarthritis | 80 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07853170) |
| September 29, 2026 | NCT07845838 | The Effect of Training on Oxidative Stress in Patients With kneeOA. | Mariette Boshuis | Not applicable | Recruiting | Knee Osteoarthritis, Oxidative Stress | 20 | Netherlands | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07845838) |
| September 28, 2026 | NCT07843784 | Chatbot-based Pain Management for People With Knee Osteoarthritis | The Hong Kong Polytechnic University | Not applicable | Enrolling by invitation | Knee Osteoarthritis | 36 | Hong Kong | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07843784) |
| September 24, 2026 | NCT07838012 | Feasibility of an Early Home-based Cycling Intervention After Knee Arthroplasty | Central Jutland Regional Hospital | Not applicable | Recruiting | Knee Osteoarthritis, Knee Arthroplasty | 24 | Denmark | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07838012) |
| September 23, 2026 | NCT07837284 | Medication vs. Meditation for Chronic Knee Osteoarthritis | Florida State University | Early phase 1 | Not yet recruiting | Knee Osteoarthristis | 30 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07837284) |
| September 23, 2026 | NCT07835672 | Selective Nerve Ablation for Chronic Knee Pain: A Retrospective Study | Michał Bartoszewicz | Observational | Completed | Knee Osteoarthritis, Chronic Knee Pain | 746 | Poland | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07835672) |
| September 22, 2026 | NCT07834827 | Popliteus and Quadriceps Muscle Thickness and Clinical Parameters in Knee Osteoarthritis | Afyonkarahisar Health Sciences University | Observational | Active not recruiting | Knee Arthritis Osteoarthritis, Balance Assessment | 130 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07834827) |
| September 22, 2026 | NCT07834034 | Daycase Hip and Knee Arthroplasty in Møre and Romsdal Trial | Helse Møre og Romsdal HF | Observational | Not yet recruiting | Knee Osteoarthritis, Hip Osteoarthritis, Osteonecrosis, Osteoarthritis | 300 | Norway | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07834034) |
| September 22, 2026 | NCT07833488 | Exploring Factors Linked to Worsening Over Time in People With Early-stage Knee Osteoarthritis and Those With Prior Proven Acute Knee... | Imperial College London | Observational | Recruiting | Knee Osteoarthritis | 200 | United Kingdom | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07833488) |
| September 22, 2026 | NCT07833462 | Efficacy of Thread-Embedding Acupuncture Using the Longitudinal Oblique Technique From BL40 Toward BL57 on KOOS Scores and Joint Range of... | Universitas Indonesia | Not applicable | Not yet recruiting | Knee Osteoarthritis | 44 | Indonesia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07833462) |
| September 22, 2026 | NCT07832682 | Neurofeedback for Pain Sensitization in Knee Osteoarthritis | Northeastern University | Not applicable | Not yet recruiting | Knee Osteoarthritis | 50 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07832682) |
| September 18, 2026 | NCT07828561 | Clinical Outcomes of Intraarticular Platelet-Rich Plasma Injection in Knee Osteoarthritis | KIST Medical and Teaching Hospital | Not applicable | Completed | Knee Osteoarthritis, Osteoarthritis (OA), Degenerative Joint Disease of Knee, Knee Pain | 59 | Nepal | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07828561) |
| September 18, 2026 | NCT07827443 | mFFE MRI Versus CT for Cortical Bone Evaluation in Knee Osteoarthritis | Assiut University | Observational | Not yet recruiting | Osteoarthritis, Knee, Bone Diseases | 80 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07827443) |
| September 17, 2026 | NCT07825350 | HTO and Tranexamic Acid Study | Western University, Canada | Phase 3 | Not yet recruiting | Osteoarthritis, Knee | 200 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07825350) |
| September 16, 2026 | NCT07823673 | Comparing Pain Science Education to Biomedical Education for People With Knee Osteoarthritis: A Randomized Controlled Trial | McMaster University | Not applicable | Not yet recruiting | Knee Arthritis Osteoarthritis | 82 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07823673) |
| September 15, 2026 | NCT07819461 | A Study to Evaluate Efficacy and Safety of a Single Intra-Articular Injection of HL-01 in the Treatment of Pain in Symptomatic Knee... | IBSA Institut Biochimique SA | Phase 3 | Not yet recruiting | Osteo Arthritis of the Knee | 704 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07819461) |
| September 10, 2026 | NCT07813078 | Anti-Gravity Treadmill Gait Training for Knee Osteoarthritis | University of Rzeszow | Not applicable | Recruiting | Knee Osteoarthritis | 80 | Poland | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07813078) |
| September 8, 2026 | NCT07806318 | Coach2Move: Physical Therapy to Improve Physical Activity in Individuals With Chronic MSK Conditions | University of Utah | Observational | Completed | Osteoarthritis,Knee, Osteoarthritis Knees Both, Osteoarthritis Hip, Low Back Pain, Chronic Pain, Hip Pain Chronic, Knee... | 94 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07806318) |
| September 4, 2026 | NCT07805161 | Bipolar RFA Versus Phenol Neurolysis for Knee Osteoarthritis Pain | Saglik Bilimleri Universitesi | Not applicable | Completed | Gonarthrosis | 69 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07805161) |
| September 4, 2026 | NCT07804446 | Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection | University of Chicago | Not applicable | Recruiting | Osteoarthitis, Osteoarthritic Knee Pain, Osteoarthritis (OA), Osteoarthritis (OA) of the Knee, Osteoarthritis in the... | 140 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07804446) |
| September 4, 2026 | NCT07804212 | The Effectiveness of Strength Training and Self-management in Reducing Symptoms for Individuals With Knee Osteoarthritis | Pingtung Veterans General Hospital | Not applicable | Not yet recruiting | Osteoarthritis | 100 | Taiwan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07804212) |
| September 4, 2026 | NCT07804199 | taVNS in Veterans With Knee OA (AVAHCS) | VA Office of Research and Development | Not applicable | Recruiting | Knee Osteoarthritis | 40 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07804199) |
| September 4, 2026 | NCT07803887 | Effect of Adding a Biceps Femoris Short Head Block to Adductor Canal Block for Analgesia After Total Knee Arthroplasty | Antalya Training and Research Hospital | Not applicable | Not yet recruiting | Knee Osteoarthritis (OA), Postoperative Pain | 122 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07803887) |
| September 2, 2026 | NCT07800780 | Effects of Different Collagen Formulations on Knee Osteoarthritis | Cihangir Türemiş | Not applicable | Not yet recruiting | Osteoarthritis, Knee | 45 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07800780) |
| September 2, 2026 | NCT07798973 | Effects of Tele Rehabilitation vs Onsite Rehabilitation on Balance, Mobility, and Risk of Fall Among Geriatric Population With Knee... | Ibadat International University, Islamabad | Not applicable | Completed | Knee Osteoarthritis, Falls, Balance Impairment, Mobility Limitation | 44 | Pakistan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07798973) |
| August 27, 2026 | NCT07790146 | Improvement of Total Knee Arthroplasty Effectiveness Using Preoperative Prehabilitation | Samara State Medical University | Not applicable | Completed | Knee Osteoarthritis, Total Knee Arthroplasty | 64 | Russia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07790146) |
| August 27, 2026 | NCT07789340 | Unipolar Versus Bipolar Radiofrequency Ablation in Knee Osteoarthritis Pain | Tanta University | Not applicable | Recruiting | Bipolar Radiofrequency Ablation, Unipolar Radiofrequency Ablation, Knee Osteoarthritis, Pain | 64 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07789340) |
| August 25, 2026 | NCT07786038 | E-Health Lifestyle Intervention for Arthritis: A Pilot RCT on Feasibility | The University of Hong Kong | Not applicable | Not yet recruiting | Knee Osteoarthristis, Obesity & Overweight | 50 | Hong Kong | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07786038) |
| August 25, 2026 | NCT07785401 | Efficacy of Platelet-Rich Plasma Added to Hyaluronic Acid in Knee Osteoarthritis | Implai Sp z o.o | Not applicable | Recruiting | Knee Osteoarthritis, Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA), Osteoarthritis (OA) of the Knee | 50 | Poland | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07785401) |
| August 25, 2026 | NCT07784998 | Gender Based Comparison of the Effects of Sensory Modulated Graded Weight Bearing Physiotherapy In Adults With Knee Osteoarthritis | Shifa Tameer-e-Millat University | Not applicable | Recruiting | Knee Osteoarthristis | 52 | Pakistan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07784998) |
| August 25, 2026 | NCT07784907 | Efficacy of Platelet-Rich Plasma Combined With Hyaluronic Acid in Knee Osteoarthritis | Implai Sp z o.o | Not applicable | Recruiting | Knee Osteoarthritis, Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA), Osteoarthritis (OA) of the Knee | 100 | Poland | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07784907) |
| August 21, 2026 | NCT07779122 | Wearable Electrogoniometry-Based Telerehabilitation After Total Knee Arthroplasty | University of Chile | Not applicable | Completed | TKA, Knee Osteoarthritis | 82 | Chile | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07779122) |
| August 20, 2026 | NCT07777757 | New Robotic Knee Surgery: Does Implant Type Affect Alignment Accuracy? | The University of Hong Kong | Not applicable | Recruiting | Knee Osteoarthristis | 100 | Hong Kong | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07777757) |
| August 19, 2026 | NCT07774195 | Efficacy of AI-Driven and Traditional Physical Therapy Programs in Patients With Knee Osteoarthritis | Cairo University | Not applicable | Not yet recruiting | Knee Osteoarthritis | 40 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07774195) |
| August 19, 2026 | NCT07773480 | Formative Evaluation of a Mobile Application Facilitated Self-directed Rehabilitation Programme for Knee Osteoarthritis | Singapore General Hospital | Not applicable | Not yet recruiting | Knee Osteoarthritis | 30 | Singapore | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07773480) |
| August 18, 2026 | NCT07769593 | MORA Cure for Knee Osteoarthritis With Anterior Knee Pain | EverEx Inc. | Not applicable | Active not recruiting | Knee Osteoarthritis, Anterior Knee Pain | 44 | South Korea | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07769593) |
| August 17, 2026 | NCT07768709 | Holistic Healing for Knee Osteoarthritis | All India Institute of Medical Sciences, Jodhpur | Not applicable | Not yet recruiting | Knee Osteoarthritis (Knee OA) | 300 | India | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07768709) |
| August 17, 2026 | NCT07767812 | Effects of Motivational Interviewing on Pain Self-Efficacy and Exercise Behavior in Individuals With Knee Osteoarthritis | Kutahya Health Sciences University | Not applicable | Recruiting | Knee Arthritis Osteoarthritis | 56 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767812) |
| August 17, 2026 | NCT07767409 | Outpatient Physiotherapy vs. mHealth Exercise and Self-Management for Knee Osteoarthritis (MOKneeTOR) | Singapore General Hospital | Not applicable | Recruiting | Knee Osteoarthristis | 160 | Singapore | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07767409) |
| August 14, 2026 | NCT07766330 | Effect of Nonsteroidal Anti-Inflammatory Drug Restriction on the Efficacy of Platelet-Rich Plasma in Knee Osteoarthritis | Federal University of São Paulo | Not applicable | Not yet recruiting | Osteoarthritis, Knee | 90 | Brazil | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07766330) |
| August 12, 2026 | NCT07759336 | Personalized Analgesia Through Central Nervous System Engagement to Unlock Performance | Benedict Alter | Phase 4 | Recruiting | Knee Osteoarthritis (Knee OA), Chronic Pain, Chronic Knee Pain | 85 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07759336) |
| August 11, 2026 | NCT07757581 | Customized Knee Arthroplasty With or Without Posterior Cruciate Ligament Retention: A CR-PS Approach | Groupe Hospitalier Diaconesses Croix Saint-Simon | Not applicable | Active not recruiting | Knee Arthroplasty, Osteoarthritis, Knee | 140 | France | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07757581) |
| August 11, 2026 | NCT07757464 | Pre-emptive Insulin to Prevent High Glucose After a Knee Steroid Injection in Adults With Type 2 Diabetes | Shifa International Hospital | Phase 1/2 | Active not recruiting | Diabetes Mellitus, Type 2, Hyperglycemia Due to Type 2 Diabetes Mellitus, Osteoarthritis, Knee | 125 | Pakistan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07757464) |
| August 10, 2026 | NCT07754175 | A Multicenter, Open-Label, Single-Arm Extension Study to Evaluate the Safety and Efficacy of FURESTEM-OA-Kit Inj. in Knee Osteoarthritis... | Kang Stem Biotech Co., Ltd. | Observational | Recruiting | Knee Osteoarthritis | 36 | South Korea | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07754175) |
| August 5, 2026 | NCT07746843 | The Efficacy and Safety Study of 2107 Injection in Subjects With Mild to Moderate Knee Osteoarthritis | BioRegen Biomedical (Changzhou) Co., Ltd | Not applicable | Not yet recruiting | Mild Knee Osteoarthritis, Moderate Knee Osteoarthritis | 286 | Poland, Spain, United Kingdom | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07746843) |
| August 5, 2026 | NCT07746466 | Efficacy of Bioactive Collagen Peptide Compared to Glucosamine and Chondroitin Sulphate in Grade I-III Knee Osteoarthritis | Liaquat National Hospital & Medical College | Not applicable | Completed | Knee Osteoarthritis (Kellgren-Lawrence Grade 1-3) | 150 | Pakistan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07746466) |
| August 4, 2026 | NCT07745387 | Effect of a Topical Cetylated Fatty Acid Cream on Pain Relief in Patients With Knee Osteoarthritis | Pharmanutra S.p.a. | Not applicable | Completed | Knee Osteoarthristis | 156 | Georgia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07745387) |
| August 4, 2026 | NCT07744789 | Knee Ligament Stiffness Across Ethnicities Before and After Osteoarthritis Treatment | National Taiwan University Hospital | Observational | Recruiting | Knee Osteoarthritis | 208 | Taiwan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07744789) |

## Sponsors posting most

| Sponsor | New trials | Latest |
| --- | --- | --- |
| Riphah International University | 25 | October 13, 2026 |
| Ankara City Hospital Bilkent | 8 | October 13, 2026 |
| Tanta University | 7 | October 1, 2026 |
| Assiut University | 7 | September 18, 2026 |
| Cairo University | 7 | August 19, 2026 |
| Yonsei University | 6 | October 28, 2026 |
| VA Office of Research and Development | 6 | September 4, 2026 |
| The Hong Kong Polytechnic University | 5 | September 28, 2026 |
| Poznan University of Medical Sciences | 5 | June 30, 2026 |
| Ain Shams University | 4 | November 5, 2026 |
| Universitas Indonesia | 4 | September 22, 2026 |
| Lahore University of Biological and Applied Sciences | 4 | July 28, 2026 |
| University of Lahore | 4 | July 14, 2026 |
| Kanuni Sultan Suleyman Training and Research Hospital | 4 | June 16, 2026 |
| Vastra Gotaland Region | 4 | February 3, 2026 |
| Superior University | 4 | March 30, 2025 |
| University of Management and Technology Lahore | 3 | November 3, 2026 |
| Sisli Hamidiye Etfal Training and Research Hospital | 3 | October 22, 2026 |
| University of Chicago | 3 | September 4, 2026 |
| The University of Hong Kong | 3 | August 25, 2026 |

## By phase

| Phase | New trials | Latest |
| --- | --- | --- |
| [Not applicable](https://specstream.ai/data/clinical-trials/phase/not-applicable) | 357 | November 9, 2026 |
| [Observational](https://specstream.ai/data/clinical-trials/phase/observational) | 89 | November 3, 2026 |
| [Phase 3](https://specstream.ai/data/clinical-trials/phase/phase-3) | 21 | November 5, 2026 |
| [Phase 2](https://specstream.ai/data/clinical-trials/phase/phase-2) | 17 | October 15, 2026 |
| [Phase 4](https://specstream.ai/data/clinical-trials/phase/phase-4) | 14 | October 15, 2026 |
| [Phase 1](https://specstream.ai/data/clinical-trials/phase/phase-1) | 9 | June 17, 2026 |
| [Phase 1/2](https://specstream.ai/data/clinical-trials/phase/phase-1-2) | 7 | August 11, 2026 |
| [Phase 2/3](https://specstream.ai/data/clinical-trials/phase/phase-2-3) | 6 | July 14, 2026 |
| [Early phase 1](https://specstream.ai/data/clinical-trials/phase/early-phase-1) | 5 | September 23, 2026 |

## By country

| Country | New trials | Latest |
| --- | --- | --- |
| [Turkey (Türkiye)](https://specstream.ai/data/clinical-trials/country/turkey-t-rkiye) | 102 | October 29, 2026 |
| [United States](https://specstream.ai/data/clinical-trials/country/united-states) | 61 | November 6, 2026 |
| [Pakistan](https://specstream.ai/data/clinical-trials/country/pakistan) | 54 | November 3, 2026 |
| [Egypt](https://specstream.ai/data/clinical-trials/country/egypt) | 34 | November 5, 2026 |
| [China](https://specstream.ai/data/clinical-trials/country/china) | 25 | November 9, 2026 |
| [Poland](https://specstream.ai/data/clinical-trials/country/poland) | 19 | September 23, 2026 |
| [Spain](https://specstream.ai/data/clinical-trials/country/spain) | 17 | October 28, 2026 |
| [Taiwan](https://specstream.ai/data/clinical-trials/country/taiwan) | 14 | October 15, 2026 |
| [South Korea](https://specstream.ai/data/clinical-trials/country/south-korea) | 13 | October 28, 2026 |
| [Canada](https://specstream.ai/data/clinical-trials/country/canada) | 12 | November 5, 2026 |
| [Hong Kong](https://specstream.ai/data/clinical-trials/country/hong-kong) | 10 | November 3, 2026 |
| [France](https://specstream.ai/data/clinical-trials/country/france) | 10 | August 11, 2026 |
| [United Kingdom](https://specstream.ai/data/clinical-trials/country/united-kingdom) | 9 | September 22, 2026 |
| [Brazil](https://specstream.ai/data/clinical-trials/country/brazil) | 7 | October 28, 2026 |
| [Sweden](https://specstream.ai/data/clinical-trials/country/sweden) | 7 | October 15, 2026 |
| [Denmark](https://specstream.ai/data/clinical-trials/country/denmark) | 7 | September 24, 2026 |
| [Indonesia](https://specstream.ai/data/clinical-trials/country/indonesia) | 7 | September 22, 2026 |
| [Italy](https://specstream.ai/data/clinical-trials/country/italy) | 7 | July 2, 2026 |
| [Australia](https://specstream.ai/data/clinical-trials/country/australia) | 6 | April 15, 2026 |
| [Belgium](https://specstream.ai/data/clinical-trials/country/belgium) | 6 | March 18, 2026 |
| [Mexico](https://specstream.ai/data/clinical-trials/country/mexico) | 5 | November 3, 2026 |
| [Saudi Arabia](https://specstream.ai/data/clinical-trials/country/saudi-arabia) | 5 | June 10, 2026 |
| [Netherlands](https://specstream.ai/data/clinical-trials/country/netherlands) | 4 | October 28, 2026 |
| [Chile](https://specstream.ai/data/clinical-trials/country/chile) | 4 | October 15, 2026 |
| [Norway](https://specstream.ai/data/clinical-trials/country/norway) | 4 | September 22, 2026 |

## Where the register publishes

- [ClinicalTrials.gov](https://clinicaltrials.gov/)
- [ClinicalTrials.gov API](https://clinicaltrials.gov/data-api/api)

Source: [ClinicalTrials.gov API v2 (U.S. National Library of Medicine)](https://clinicaltrials.gov/data-api/api). U.S. government data; ClinicalTrials.gov terms of use. Studies are as their sponsors registered them on ClinicalTrials.gov, read through its API. Condition groups are the MeSH terms ClinicalTrials.gov assigns to each study's conditions; a study with several is in several groups. Sponsor class is the register's class of the lead sponsor. The central contact is in the full list only as the record prints it.

Free to reuse with credit to SpecStream under [CC BY 4.0](https://creativecommons.org/licenses/by/4.0/).