# Opioid-Related Disorders trials: 183 new since Nov 2024

Updated October 28, 2026.

183 clinical studies in Opioid-Related Disorders were first posted on ClinicalTrials.gov from November 12, 2024 to October 28, 2026; 12 have an industry sponsor and 131 are recruiting or about to. The newest, NCT07900828, was posted on October 28, 2026: Peer-led, Mobile App Supported Linkage to Opioid Use Disorder Treatment (Johns Hopkins University).

## The full list

New Opioid-Related Disorders clinical trials: 183 rows for $9.15, first posted on ClinicalTrials.gov from November 12, 2024 to November 9, 2026. Columns: NCT ID, Title, Sponsor, Sponsor class, Phase, Status, Conditions, Condition groups (MeSH), Interventions, Start date, First posted, Enrollment, Enrollment type, Location countries, Central contact, Contact phone, Contact email, Last update posted, Read on, Source. The new rows each week by email, about 7 rows a month: $19 a month. Pay by card with no account. Prices exclude VAT. CSV and Excel files with the columns this page does not show (central contact, contact phone, contact email, sponsor class, condition groups (MeSH), interventions and 5 more), which open on your screen as soon as the payment clears and come by email. The rows on this page are a sample.

Buy: https://specstream.ai/data/clinical-trials/condition/opioid-related-disorders

SpecStream is the live web data engine for teams and agents. It reads every new study on ClinicalTrials.gov each morning, and this page is that reading. Ask for the conditions, phases or countries you follow and each new trial arrives in your sheet, CRM, Slack or agent with the sponsor, the sites and the listed contact.

- New trials: 183
- Industry sponsored: 12
- Recruiting or not yet: 131
- Latest posted: October 28, 2026

## Newest trials

The newest 100 of 183, each linked to its record. The full list holds every one with the sponsor class, interventions, start date and the central contact as the record prints it.

| First posted | NCT ID | Title | Sponsor | Phase | Status | Conditions | Enrollment | Countries | Source |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| October 28, 2026 | NCT07900828 | Peer-led, Mobile App Supported Linkage to Opioid Use Disorder Treatment | Johns Hopkins University | Not applicable | Not yet recruiting | Opioid Use Disorder | 90 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07900828) |
| October 26, 2026 | NCT07894276 | Pain Sensitivity, Alcohol-Induced Analgesia, and Heavy Drinking in Individuals With Opioid Use Disorder | Ohio State University | Early phase 1 | Not yet recruiting | Opioid Use Disorder, Alcohol Intoxication, Pain | 90 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07894276) |
| October 21, 2026 | NCT07886944 | PATH to Reducing Burnout Among Peers Who Deliver Overdose Prevention Services (R33 Phase Clinical Trial) | Chestnut Health Systems | Not applicable | Enrolling by invitation | Burnout, Secondary Trauma, Compassion Fatigue, Opioid Use Disorder, Stimulant Use Disorder, Substance Use Disorder | 200 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07886944) |
| October 21, 2026 | NCT07886606 | Cannabidiol in Opioid Use Disorder and Chronic Pain With Buprenorphine | Yale University | Early phase 1 | Recruiting | Chronic Pain, Opioid Use Disorder | 34 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07886606) |
| October 15, 2026 | NCT07875361 | Disease Intervention Specialist (DIS) for SUD | Ohio State University | Observational | Not yet recruiting | Substance Use Disorder (SUD), Opioid Use Disorder, Alcohol Use Disorder (AUD), Drug Use, Overdose | 1,200 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07875361) |
| October 15, 2026 | NCT07874620 | A Study of Cebranopadol for Opioid Withdrawal Symptoms in Adults With Chronic Pain | Adneuris Therapeutics, Inc. | Phase 2 | Recruiting | Chronic Pain, Pain, Opioid Withdrawal (Disorder), Opioid Use Disorder | 45 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07874620) |
| October 14, 2026 | NCT07873944 | Recovery Management Checkup Scalability and Sustainability Hybrid Experiment | Chestnut Health Systems | Phase 3 | Not yet recruiting | Substance Use Disorder (SUD), Opioid Use Disorders, Stimulant Overdose, Overdose Risk, Alcohol Use Disorder | 600 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07873944) |
| October 13, 2026 | NCT07871877 | Medically Supervised Ibogaine With 12-Month Digital Recovery Support for Opioid Use Disorder | Clive Michelsen | Phase 1/2 | Not yet recruiting | Opioid Use Disorder, Opioid Withdrawal, Substance Use Disorders | 60 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07871877) |
| October 8, 2026 | NCT07865078 | Adapting and Implementing a Chronic Disease Self-Management Program for Primary Care Patients With Opioid Use Disorder and Serious Mental... | University of Utah | Not applicable | Not yet recruiting | Implementation Science, Chronic Disease Self-management, Mental Illness, Addiction, Primary Care Patients With Chronic... | 40 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07865078) |
| September 29, 2026 | NCT07846735 | Youth Overdose & Use Reduction in Rural Systems | Seattle Children's Hospital | Not applicable | Not yet recruiting | Substance Abuse, Opioid Abuse (Disorder), Overdose Prevention, Substance Use Disorder (SUD), Adolescent Substance Use... | 550 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07846735) |
| September 25, 2026 | NCT07842601 | Helping Kentuckians Overcome Depression and Opioid Addiction With Brain Stimulation | University of Kentucky | Not applicable | Not yet recruiting | Opioid Use Disorder, Major Depressive Disorder (MDD) | 60 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07842601) |
| September 24, 2026 | NCT07839182 | Measurement-Based Care to Support Buprenorphine-Naloxone Treatment in Outpatient Addiction Clinics | Vanderbilt University Medical Center | Not applicable | Not yet recruiting | Opioid Use Disorder | 140 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07839182) |
| September 9, 2026 | NCT07810322 | Pilot Testing of the emPath Platform to Improve Medication for Opioid Use Disorder (MOUD) Linkage and Retention Among Adults With Opioid... | Duke University | Not applicable | Recruiting | Opioid Use Disorder, Digital Health Intervention, Telemedicine, Outreach Intervention | 80 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07810322) |
| September 2, 2026 | NCT07800520 | Characterization of CB1 Receptors Using \[11-C\]OMAR in Opioid Use Disorder | Yale University | Phase 1 | Recruiting | Opioid Use Disorder, OAT | 110 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07800520) |
| August 31, 2026 | NCT07795840 | The ConCERN Intervention for Loved Ones of Those With Opioid Use Disorder | University of Michigan | Not applicable | Not yet recruiting | Opioid Use Disorder | 700 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07795840) |
| August 28, 2026 | NCT07793383 | Adaptive Decision Support for Addiction Treatment (ADAPT) Serial Randomized Testing for Usability, Round 3 | Yale University | Not applicable | Recruiting | Opioid Abuse (Disorder), Clinical Decision Support | 100 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07793383) |
| August 26, 2026 | NCT07787039 | Supporting Treatment for Opioids and Recovery Capital (STORC) - R61 Phase | Friends Research Institute, Inc. | Not applicable | Recruiting | Opioid Use Disorder | 10 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07787039) |
| August 21, 2026 | NCT07780097 | TRTME: Improving Outpatient Initiation of Medication for Opioid Use Disorder Following Hospitalization | T. John Winhusen, PhD | Not applicable | Enrolling by invitation | Opioid Use Disorder, Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe | 30 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07780097) |
| August 21, 2026 | NCT07778511 | How Does the Opioid System Shape Stress and Social Behaviour in Men and Women and What Role Does Childhood Unpredictability Play? | Sara L. Kroll | Not applicable | Recruiting | Stress, Early Life Stress, Sex Differences, Opioid | 72 | Switzerland | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07778511) |
| August 21, 2026 | NCT07778394 | Personalized Addiction Treatment enHancement | Rhode Island Hospital | Not applicable | Recruiting | Opioid Use Disorder, mHealth, Peer Support | 40 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07778394) |
| August 18, 2026 | NCT07770555 | Deep Transcranial Magnetic Stimulation for Tobacco Cessation in Adults With Opioid Use Disorder | Payel Roy | Not applicable | Not yet recruiting | Opioid Use Disorder, Tobacco Use Disorder | 12 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07770555) |
| August 6, 2026 | NCT07750639 | Reducing Opioid Use After Upper Extremity Surgery: Testing Lower Prescriptions and Pill Quantity | AdventHealth | Phase 4 | Enrolling by invitation | Opioid Abuse (Disorder), Opioid Analgesia, Opioid Analgesic Adverse Reaction, Opioid Consumption | 300 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07750639) |
| July 30, 2026 | NCT07737652 | Microcurrent Neurofeedback as an Adjunct to Standard Care for Substance Use Disorders | University of Alabama, Tuscaloosa | Not applicable | Completed | Depression, Anxiety, Substance Use Disorder (SUD), Post Traumatic Stress Disorder | 61 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07737652) |
| July 29, 2026 | NCT07734623 | Applying Low-Intensity Focused Ultrasound in Treating Severe Substance Use Disorder: Tolerability and Effectiveness | National Taiwan University Hospital | Not applicable | Recruiting | Opioid Use Disorder, Severe, Amphetamine Use Disorder | 60 | Taiwan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07734623) |
| July 24, 2026 | NCT07725289 | Clinician Practice Companion to Address Youth Substance Use | Massachusetts General Hospital | Not applicable | Not yet recruiting | Substance Use, Substance-Related Disorders, Adolescent Substance Use, Cannabis Use, Opioid Use Disorder, Drug Overdose... | 60 | Canada, United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07725289) |
| July 17, 2026 | NCT07711795 | Mindfulness Texting for Medication Adherence and Chronic Pain Management | University of New Mexico | Not applicable | Recruiting | Opioid Use Disorder (OUD), Chronic Pain | 60 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07711795) |
| July 16, 2026 | NCT07707934 | Methadone Expansion in Detention Though the Hospital/Clinic Designation | Brendan Saloner | Not applicable | Not yet recruiting | Opioid Use Disorder, Incarcerated Individuals, Methadone Maintenance | 30 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07707934) |
| July 9, 2026 | NCT07693270 | Identifying Biomarkers Related to Opioid Use and Pain Response Following Traumatic Injury and Surgery | University of California, San Diego | Observational | Recruiting | Opioid Use Disorder, Opioid Consumption, Persistent Opioid Use, Persistent Postsurgical Pain | 100 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07693270) |
| June 25, 2026 | NCT07668635 | Cannabis Effects on Opioid Self-Administration | Shanna Babalonis, PhD | Phase 1 | Not yet recruiting | Opioid Use Disorder, Cannabis Use | 30 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07668635) |
| June 24, 2026 | NCT07665502 | Pre-Pilot (R61) WINGS+++: mHealth to Improve MOUD Uptake in Women Experiencing Intimate Partner Violence and PTSD | Dawn A. Goddard-Eckrich | Not applicable | Enrolling by invitation | Opioid-Related Disorders, Substance-Related Disorders, Intimate Partner Violence (IPV), Stress Disorders... | 7 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07665502) |
| June 22, 2026 | NCT07661823 | QAIAx - SGI/SI Smart Health Cities: Microcity Enclave Program (Quantum SI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos.... | Veterans Recovery Network Inc. | Not applicable | Not yet recruiting | Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism, ADHD - Attention Deficit Disorder With Hyperactivity... | 1,000,000 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07661823) |
| June 22, 2026 | NCT07661446 | Cannabis and Opioid Use Disorder, Study 2 | University of Kentucky | Phase 1 | Not yet recruiting | Opioid Use Disorders, Cannabis Use | 100 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07661446) |
| June 16, 2026 | NCT07649278 | The ENHANCE Project Toolkit | University of Wisconsin, Madison | Not applicable | Recruiting | Substance Related Disorder, Drug Overdose, eHealth | 40 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07649278) |
| June 10, 2026 | NCT07637994 | Improving Jail Response to the Overdose Crisis: A Hybrid Trial of Jail ECHO to Improve MOUD Implementation and Public Health Outcomes | University of Massachusetts, Worcester | Not applicable | Recruiting | Opioid Abuse (Disorder) | 100 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07637994) |
| June 8, 2026 | NCT07632053 | Postpartum Intervention for Mothers With Opioid Use Disorders (R33) | Stony Brook University | Not applicable | Recruiting | Opioid Use Disorder, Parent-Child Relations | 80 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07632053) |
| June 8, 2026 | NCT07631598 | Buprenorphine Implementation at Syringe Service Programs to Reduce Overdoses | Montefiore Medical Center | Not applicable | Recruiting | Opioid Use Disorder, Opioid Use Disorder, Severe, Opioid Use Disorder, Moderate | 512 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07631598) |
| June 8, 2026 | NCT07631559 | Pilot Study of an Adapted Partner Navigation Intervention Booster Session for Sustained Healthcare Engagement Among People Who Inject Drugs | University of California, San Francisco | Not applicable | Not yet recruiting | HEPATITIS C (HCV), Opioid Use Disorder, Substance Use Disorder (SUD), Drug Use Disorders, Healthcare Access, Harm... | 50 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07631559) |
| June 5, 2026 | NCT07630428 | Testing STAR and TextSTAR: A Randomized Controlled Trial | University of Wisconsin, Madison | Not applicable | Enrolling by invitation | Sexual Violence, Posttraumatic Stress Disorder (PTSD), Opioid Misuse | 394 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07630428) |
| June 2, 2026 | NCT07620171 | Peer Recovery Support for Opioid Use Disorder Treatment Retention | University of Pennsylvania | Not applicable | Enrolling by invitation | Opioid Use Disorder, Peer Recovery Supporters, Peer Recovery Coaching, Primary Care, Buprenorphine | 15 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07620171) |
| May 28, 2026 | NCT07610746 | Cerebral Physiology of NOWS | Indiana University | Not applicable | Recruiting | Neonatal Opioid Withdrawal, Neonatal Opioid Withdrawal Syndrome, Opioid Use Disorder, Intrauterine Exposure | 46 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07610746) |
| May 26, 2026 | NCT07607743 | Behavioral Optimization for Overcoming Suboptimal Treatment Retention (BUP-BOOSTeR) | Boston University | Not applicable | Not yet recruiting | Opioid Use Disorder | 240 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07607743) |
| May 22, 2026 | NCT07602335 | Safety, Tolerability, and Pharmacokinetics of MCAM in Healthy Adult Participants | The University of Texas Health Science Center at San Antonio | Early phase 1 | Not yet recruiting | Opioid Use Disorder | 24 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07602335) |
| May 22, 2026 | NCT07602218 | Adaptive Decision Support for Addiction Treatment (ADAPT) Serial Randomized Testing for Usability, Round 2 | Yale University | Not applicable | Completed | Opioid Use Disorder, Clinical Decision Support | 379 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07602218) |
| May 20, 2026 | NCT07600307 | Evaluating a Digital Toolkit for IPV | Medical University of South Carolina | Not applicable | Not yet recruiting | Opioid Use Disorder | 792 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07600307) |
| May 19, 2026 | NCT07594717 | Effects of E-Cigarette Flavors on Adult E-Cigarette Users With Opioid Use Disorder | Prisma Health-Upstate | Observational | Completed | Nicotine Use Disoder, Opioid Use Disorder | 70 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07594717) |
| May 14, 2026 | NCT07587359 | A Unique, Co-Designed Family-Based Therapy | Ohio State University | Not applicable | Recruiting | Opioid Abuse (Disorder) | 120 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07587359) |
| May 14, 2026 | NCT07586917 | Optimizing Pregnancy and Treatment Interventions for Moms 3.0 | University of Utah | Not applicable | Recruiting | Opioid Abuse (Disorder), Stimulant Use Disorders | 429 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07586917) |
| May 6, 2026 | NCT07569211 | Simplified HCV Integrated Management Model in Methadone Clinics in Ukraine | Ukrainian Institute on Public Health Policy | Not applicable | Completed | HCV, Opioid Use Disorder | 616 | Ukraine | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07569211) |
| May 6, 2026 | NCT07568847 | Improving Hospital-To-Methadone Clinic Connection Using Implementation Support for Patients With Opioid Use Disorder | University of Colorado, Denver | Not applicable | Not yet recruiting | Opioid Use Disorder | 1,440 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07568847) |
| April 30, 2026 | NCT07558187 | Systematic Examination of Health Inequalities: Documentation, Patterns, and Determinants | University of Thessaly | Observational | Recruiting | Non-communicable Diseases (NCD), Addiction to Opioids, Incarceration, Opioid-use Disorders | 2,000 | Greece | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07558187) |
| April 23, 2026 | NCT07549126 | Adaptive Decision Support for Addiction Treatment (ADAPT) Serial Randomized Testing for Usability, Round 1 | Yale University | Not applicable | Completed | Opioid Use Disorder, Clinical Decision Support | 267 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07549126) |
| April 22, 2026 | NCT07546396 | Methadone Rapid Restart | Pouya Azar | Phase 4 | Not yet recruiting | Opioid Use Disorder | 25 | Canada | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07546396) |
| April 21, 2026 | NCT07541417 | Building Retention and Initiation Through Delivery of Peer-Guided Evidence-Based Practices | Prisma Health-Upstate | Not applicable | Recruiting | Opioid Use Disorder | 750 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07541417) |
| April 13, 2026 | NCT07524738 | Telemedicine XR-B for Individuals in Jail | Friends Research Institute, Inc. | Phase 3 | Active not recruiting | Opioid Use Disorder | 30 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07524738) |
| March 27, 2026 | NCT07498322 | Chicago Data-driven Opioid Use Disorder Screening, Engagement, Treatment and Planning System | University of Illinois Chicago | Not applicable | Not yet recruiting | Opiod Use Disorder | 271,031 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07498322) |
| March 24, 2026 | NCT07490717 | Developing and Testing Innovative Care Pathways for Screening and Treatment of OUD/PTSD in Jails | University of Arkansas | Not applicable | Enrolling by invitation | Post-traumatic Stress Disorder (PTSD), Post-traumatic Stress Symptoms, Opioid Use Disorder (OUD), Stimulant Use... | 338 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07490717) |
| March 20, 2026 | NCT07485335 | A Bundled Intervention to End Opioid Overdoses | University of Alabama at Birmingham | Phase 4 | Recruiting | Opioid Use Disorder, Opioid Overdose | 160 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07485335) |
| March 16, 2026 | NCT07475728 | EMS-Initiated Buprenorphine | Yale University | Observational | Recruiting | Opioid Use Disorder | 495 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07475728) |
| March 13, 2026 | NCT07469501 | Comparing Outpatient Treatment Retention Among Individuals Using Fentanyl Randomized to Low-dose and Direct-to-inject Buprenorphine... | University of California, San Francisco | Phase 4 | Not yet recruiting | Opioid Use Disorder, Fentanyl | 50 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07469501) |
| March 12, 2026 | NCT07466784 | CEDRN: Opioid Registry | University of British Columbia | Observational | Recruiting | Opioid Use Disorder, Opioid Abuse or Dependence, Opioid Withdrawal, Polysubstance Drug Use (Indiscriminate Drug Use)... | 7,200 | Canada | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07466784) |
| March 9, 2026 | NCT07457489 | Vanderbilt Integrated Community TMS for Opioid Recovery | Vanderbilt University Medical Center | Not applicable | Recruiting | Opiod Use Disorder | 100 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07457489) |
| March 9, 2026 | NCT07456930 | Real-World Evaluation of Compl-AI for Predicting Early Medication Dropout in Opioid Use Disorder Treatment | Tools4Patient | Observational | Not yet recruiting | Opioid Use Disorder | 295 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07456930) |
| March 5, 2026 | NCT07451197 | Family-Focused Study to Support Medication for Opioid Use Disorder | University of Wisconsin, Madison | Not applicable | Not yet recruiting | Opioid Use Disorder, Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe | 338 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07451197) |
| February 27, 2026 | NCT07439783 | Testing the CrOss Systems Technical Assistance for Retaining Staff (COSTARS) Model for Improving Staff Retention Among Child Welfare... | Alicia Bunger | Not applicable | Enrolling by invitation | Substance Use Disorder, Opioid Use Disorder, Child Maltreatment, Implementation, Peer Recovery Supporters | 200 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07439783) |
| February 27, 2026 | NCT07439549 | Symptom-Inhibited Naloxone Induction (SINI) for Buprenorphine Initiation: A Feasibility Trial | Pouya Azar | Phase 4 | Recruiting | Opioid Use Disorder | 12 | Canada | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07439549) |
| February 27, 2026 | NCT07435077 | Examining Analgesic Synergy and Efficacy in Trauma Care | Wake Forest University Health Sciences | Phase 4 | Not yet recruiting | Opioid Use Disorder | 282 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07435077) |
| February 19, 2026 | NCT07421102 | Pilot of Mailing Buprenorphine | Medical University of South Carolina | Early phase 1 | Recruiting | Opioid Use Disorder | 20 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07421102) |
| February 19, 2026 | NCT07420283 | A Study of Brenipatide in Participants With Opioid Use Disorder | Eli Lilly and Company | Phase 2 | Recruiting | Opioid Use Disorder | 465 | Canada, Puerto Rico, United Kingdom, United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07420283) |
| February 13, 2026 | NCT07408193 | The Role of Coadministration of Lidocaine and Ketamine in Opioid-Refractory Chronic Cancer-Related Pain. | National and Kapodistrian University of Athens | Early phase 1 | Recruiting | Opioid-Refractory Chronic Cancer-Related Pain | 24 | Greece | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07408193) |
| January 27, 2026 | NCT07369089 | Targeting Treatment-Resistant OUD With Ketamine-Assisted Mindfulness Oriented Recovery Enhancement | University of California, San Diego | Phase 2 | Recruiting | Opioid Use Disorder | 88 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07369089) |
| January 23, 2026 | NCT07362082 | A Clinical Trial of Telehealth Treatment for Opioid Use Disorders | Yale University | Not applicable | Recruiting | Opioid Use Disorder | 470 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07362082) |
| January 23, 2026 | NCT07361731 | Evaluating the Feasibility, Acceptability, and Preliminary Outcomes of Heart Rate Variability Biofeedback for Individuals With Opioid Use... | Arizona State University | Not applicable | Completed | Autonomic Nervous System Imbalance, Heart Rate Variability (HRV), Opioid Use Disorder, Breathing Techniques, Opioid... | 32 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07361731) |
| January 23, 2026 | NCT07361432 | Digital Treatment for Chronic Pain and Addiction in Veterans With Opioid Use Disorder Receiving Buprenorphine | VA Office of Research and Development | Phase 3 | Not yet recruiting | Opioid Use Disorder, Chronic Pain | 250 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07361432) |
| January 20, 2026 | NCT07350148 | Opioid Adherence and Support Through Innovative Texting Strategies | University of New Mexico | Not applicable | Recruiting | Opioid Use Disorder (OUD), Chronic Pain | 60 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07350148) |
| January 16, 2026 | NCT07348796 | Real World Evaluation of the Effectiveness and Implementation of a Digital Health Therapeutic for OUD | The University of Texas Health Science Center at San Antonio | Not applicable | Not yet recruiting | Opioid Use Disorder | 134 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07348796) |
| January 15, 2026 | NCT07344233 | Neurofeedback During Naturalistic Stimuli to Reduce Craving in Heroin Addiction | Icahn School of Medicine at Mount Sinai | Not applicable | Completed | Opioid Use Disorder, Substance Use Disorder, Heroin Use Disorder | 28 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07344233) |
| January 15, 2026 | NCT07342504 | Better Experiences in Substance Treatment: A Brief Alcohol-focused Intervention Tailored for Patients in Opioid Agonist Treatment | University of Notre Dame | Not applicable | Recruiting | Alcohol Use Disorder, Opioid Use Disorder, Alcohol Use, Opioid Use | 60 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07342504) |
| January 8, 2026 | NCT07325279 | Nalmefene Implant in Healthy Subjects | ReacX Pharmaceuticals, Inc. | Phase 1 | Recruiting | Opioid Abuse and Addiction | 24 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07325279) |
| January 7, 2026 | NCT07322588 | Reentry Incentives and Support for Engagement With Contingency Management | Oregon Health and Science University | Not applicable | Not yet recruiting | Opioid Use Disorder | 75 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07322588) |
| January 6, 2026 | NCT07318480 | Transcranial Direct Current Stimulation (tDCS) for Treatment of Substance Use Disorder | Icahn School of Medicine at Mount Sinai | Not applicable | Recruiting | Cocaine Use Disorder, Cocaine Dependence, Substance Use Disorder (SUD), Opioid Use Disorder, Opioid Dependence | 240 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07318480) |
| December 19, 2025 | NCT07294118 | Infusion of Lidocaine and Steroids in Middle Meningeal Artery for Pain in Subarachnoid Hemorrhage | The University of Texas Medical Branch, Galveston | Phase 2 | Recruiting | Subarachnoid Hemorrhage, Aneurysmal, Headache, Opiate Dependence, Opioid Use | 15 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07294118) |
| December 12, 2025 | NCT07278518 | Evaluation of a Patient Decision Aid for Emergency Department Initiated Buprenorphine | Medical University of South Carolina | Not applicable | Recruiting | Opioid Use Disorder | 20 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07278518) |
| December 8, 2025 | NCT07269873 | Safety and PK Study of BICX104 With or Without Bupropion Compared to Vivitrol | BioCorRx Pharmaceuticals Inc | Phase 1 | Recruiting | Healthy Adult Male and Female Volunteers | 30 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07269873) |
| December 3, 2025 | NCT07262190 | NavSTAR Implementation Effectiveness Trial Across a Health System | Friends Research Institute, Inc. | Not applicable | Recruiting | Opioid Use Disorder | 720 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07262190) |
| November 18, 2025 | NCT07232641 | Impact of Federal and State Medications for Opioid Use Disorder (MOUD) Policy Changes During the Pandemic | Boston University | Observational | Recruiting | Substance Use Disorders, Alcohol Use Disorder, Opioid Use Disorder | 185,810 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07232641) |
| November 10, 2025 | NCT07226570 | Mapping Ibogaine Neural Dynamics in Opioid Use Disorder | University of California, Irvine | Observational | Recruiting | Opioid Use Disorder (OUD) | 20 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07226570) |
| October 28, 2025 | NCT07221786 | Preoperative Opioid Tapering Before Spine Surgery | Thomas Jefferson University | Not applicable | Recruiting | Opioid Consumption, Postoperative, Pain After Surgery, Opioid Dependency | 45 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07221786) |
| October 20, 2025 | NCT07218562 | PATH to Reducing Burnout Among Peers Who Deliver Overdose Prevention Services (R61 Phase Pilot) | Chestnut Health Systems | Phase 2 | Completed | Burnout, Compassion Satisfaction, Secondary Trauma | 18 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07218562) |
| October 15, 2025 | NCT07216963 | The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study | Duke University | Not applicable | Not yet recruiting | Opioid Use Disorder, Overdose, Drug, Overdose, Substance Use (Drugs, Alcohol) | 400 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07216963) |
| October 9, 2025 | NCT07214467 | Individualized Adaptive Deep Brain Stimulation in Opioid Use Disorder | University of California, San Francisco | Not applicable | Recruiting | Substance Use Disorder (SUD), Opioid Use Disorder (OUD) | 6 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07214467) |
| October 9, 2025 | NCT07214389 | PRoducing Outcome Measures for OTP Quality Improvement | RTI International | Not applicable | Recruiting | Opioid Use Disorder | 4,500 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07214389) |
| October 8, 2025 | NCT07211399 | Transition From Acute to Chronic Opioid Use and Chronic Pain | Jacques E. Chelly | Early phase 1 | Withdrawn | Opioid Use Disorder | 0 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07211399) |
| October 6, 2025 | NCT07208266 | Contingency Management for Opioid Use Disorder in Inpatients at Assiut University Hospital | Assiut University | Not applicable | Not yet recruiting | Opioid Use Disorder (OUD) | 55 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07208266) |
| October 2, 2025 | NCT07204171 | Phase 1 Study of Oral MG001 | National Institute on Drug Abuse (NIDA) | Phase 1 | Not yet recruiting | Safety and Tolerability in Healthy Subjects | 32 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07204171) |
| October 1, 2025 | NCT07202039 | Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine | Prisma Health-Upstate | Not applicable | Recruiting | Tobacco-flavored EC, Sweet-Cooling EC, Sweet Non-cooling EC | 90 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07202039) |
| September 29, 2025 | NCT07197801 | Evaluation of a Peer Recovery Support Program Adapted to Target Retention in Clinic-based Medication for Opioid Use Disorder Treatment | Geisinger Clinic | Not applicable | Recruiting | Opioid Use Disorder | 218 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07197801) |
| September 18, 2025 | NCT07179614 | Kentucky Women's Justice Community Overdose Innovation Network - Phase II | Michele Staton | Not applicable | Recruiting | Overdose Risk, Opioid Use Disorder, Stimulant Use Disorders | 300 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07179614) |
| September 17, 2025 | NCT07178990 | Mobile Platform for Optimizing Wellness and Engagement in Recovery | University of Michigan | Not applicable | Active not recruiting | Opioid Agonist Treatment, Alcohol Use Disorder, Opioid Use Disorder | 50 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07178990) |
| September 16, 2025 | NCT07176351 | Acceptability and Feasibility of Extended-Release Subcutaneous Buprenorphine on a Mobile Pharmacy Clinic | Yale University | Phase 4 | Recruiting | Opioid Use Disorder | 60 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07176351) |
| September 12, 2025 | NCT07171359 | TMS to Improve Recovery Outcomes Among Patients With Opioid Use Disorder (OUD) and Alcohol Use Disorder (AUD) | Washington State University | Not applicable | Recruiting | Alcohol Use Disorder, Opioid Use Disorder | 60 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07171359) |

## Sponsors posting most

| Sponsor | New trials | Latest |
| --- | --- | --- |
| Yale University | 12 | October 21, 2026 |
| University of Pittsburgh | 6 | July 20, 2025 |
| Medical University of South Carolina | 5 | May 20, 2026 |
| Ohio State University | 4 | October 26, 2026 |
| Chestnut Health Systems | 4 | October 21, 2026 |
| University of California, San Francisco | 4 | June 8, 2026 |
| University of Pennsylvania | 4 | June 2, 2026 |
| University of Maryland, Baltimore | 4 | September 3, 2025 |
| Johns Hopkins University | 3 | October 28, 2026 |
| Duke University | 3 | September 9, 2026 |
| University of Michigan | 3 | August 31, 2026 |
| Friends Research Institute, Inc. | 3 | August 26, 2026 |
| University of Wisconsin, Madison | 3 | June 16, 2026 |
| Montefiore Medical Center | 3 | June 8, 2026 |
| Prisma Health-Upstate | 3 | May 19, 2026 |
| University of Alabama at Birmingham | 3 | March 20, 2026 |
| Icahn School of Medicine at Mount Sinai | 3 | January 15, 2026 |
| University of Utah | 2 | October 8, 2026 |
| University of Kentucky | 2 | September 25, 2026 |
| Vanderbilt University Medical Center | 2 | September 24, 2026 |

## By phase

| Phase | New trials | Latest |
| --- | --- | --- |
| [Not applicable](https://specstream.ai/data/clinical-trials/phase/not-applicable) | 116 | October 28, 2026 |
| [Observational](https://specstream.ai/data/clinical-trials/phase/observational) | 15 | October 15, 2026 |
| [Phase 2](https://specstream.ai/data/clinical-trials/phase/phase-2) | 13 | October 15, 2026 |
| [Phase 1](https://specstream.ai/data/clinical-trials/phase/phase-1) | 12 | September 2, 2026 |
| [Phase 4](https://specstream.ai/data/clinical-trials/phase/phase-4) | 12 | August 6, 2026 |
| [Early phase 1](https://specstream.ai/data/clinical-trials/phase/early-phase-1) | 8 | October 26, 2026 |
| [Phase 3](https://specstream.ai/data/clinical-trials/phase/phase-3) | 5 | October 14, 2026 |
| [Phase 1/2](https://specstream.ai/data/clinical-trials/phase/phase-1-2) | 2 | October 13, 2026 |

## By country

| Country | New trials | Latest |
| --- | --- | --- |
| [United States](https://specstream.ai/data/clinical-trials/country/united-states) | 160 | October 28, 2026 |
| [Canada](https://specstream.ai/data/clinical-trials/country/canada) | 5 | July 24, 2026 |
| [Greece](https://specstream.ai/data/clinical-trials/country/greece) | 3 | April 30, 2026 |
| [Turkey (Türkiye)](https://specstream.ai/data/clinical-trials/country/turkey-t-rkiye) | 2 | May 13, 2025 |
| [Switzerland](https://specstream.ai/data/clinical-trials/country/switzerland) | 1 | August 21, 2026 |
| [Taiwan](https://specstream.ai/data/clinical-trials/country/taiwan) | 1 | July 29, 2026 |
| [Ukraine](https://specstream.ai/data/clinical-trials/country/ukraine) | 1 | May 6, 2026 |
| [Puerto Rico](https://specstream.ai/data/clinical-trials/country/puerto-rico) | 1 | February 19, 2026 |
| [United Kingdom](https://specstream.ai/data/clinical-trials/country/united-kingdom) | 1 | February 19, 2026 |
| [France](https://specstream.ai/data/clinical-trials/country/france) | 1 | July 25, 2025 |
| [South Korea](https://specstream.ai/data/clinical-trials/country/south-korea) | 1 | July 22, 2025 |
| [China](https://specstream.ai/data/clinical-trials/country/china) | 1 | June 11, 2025 |
| [Spain](https://specstream.ai/data/clinical-trials/country/spain) | 1 | May 9, 2025 |

## Where the register publishes

- [ClinicalTrials.gov](https://clinicaltrials.gov/)
- [ClinicalTrials.gov API](https://clinicaltrials.gov/data-api/api)

Source: [ClinicalTrials.gov API v2 (U.S. National Library of Medicine)](https://clinicaltrials.gov/data-api/api). U.S. government data; ClinicalTrials.gov terms of use. Studies are as their sponsors registered them on ClinicalTrials.gov, read through its API. Condition groups are the MeSH terms ClinicalTrials.gov assigns to each study's conditions; a study with several is in several groups. Sponsor class is the register's class of the lead sponsor. The central contact is in the full list only as the record prints it.

Free to reuse with credit to SpecStream under [CC BY 4.0](https://creativecommons.org/licenses/by/4.0/).