# New Frailty clinical trials: 345 posted since Nov 2024

Updated November 6, 2026.

345 clinical studies in frailty were first posted on ClinicalTrials.gov from November 13, 2024 to November 6, 2026; 13 have an industry sponsor and 220 are recruiting or about to. The newest, NCT07923188, was posted on November 6, 2026: Online Exercise Program for Transplant Patients: A Pilot Study (Cardenal Herrera University).

## The full list

New Frailty clinical trials: 345 rows for $17.25, first posted on ClinicalTrials.gov from November 12, 2024 to November 9, 2026. Columns: NCT ID, Title, Sponsor, Sponsor class, Phase, Status, Conditions, Condition groups (MeSH), Interventions, Start date, First posted, Enrollment, Enrollment type, Location countries, Central contact, Contact phone, Contact email, Last update posted, Read on, Source. The new rows each week by email, about 15 rows a month: $19 a month. Pay by card with no account. Prices exclude VAT. CSV and Excel files with the columns this page does not show (central contact, contact phone, contact email, sponsor class, condition groups (MeSH), interventions and 5 more), which open on your screen as soon as the payment clears and come by email. The rows on this page are a sample.

Buy: https://specstream.ai/data/clinical-trials/condition/frailty

SpecStream is the live web data engine for teams and agents. It reads every new study on ClinicalTrials.gov each morning, and this page is that reading. Ask for the conditions, phases or countries you follow and each new trial arrives in your sheet, CRM, Slack or agent with the sponsor, the sites and the listed contact.

- New trials: 345
- Industry sponsored: 13
- Recruiting or not yet: 220
- Latest posted: November 6, 2026

## Newest trials

The newest 100 of 345, each linked to its record. The full list holds every one with the sponsor class, interventions, start date and the central contact as the record prints it.

| First posted | NCT ID | Title | Sponsor | Phase | Status | Conditions | Enrollment | Countries | Source |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| November 6, 2026 | NCT07923188 | Online Exercise Program for Transplant Patients: A Pilot Study | Cardenal Herrera University | Not applicable | Enrolling by invitation | Kidney Transplantation, Physical Function, Muscle Weakness Condition, Physical Activity | 20 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07923188) |
| November 6, 2026 | NCT07922499 | Adapting an Evidence-Based Physical Activity Intervention to Prevent Frailty and Functional Decline in Older Women Living With HIV | University of Illinois Chicago | Not applicable | Not yet recruiting | Mobility Impairment, Frailty | 210 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07922499) |
| November 6, 2026 | NCT07921758 | The Role of Multidimensional Prognostic Index (MPI) in the Assessment of Elderly Patients underGoING Cardiac REHABilitation | Istituti Clinici Scientifici Maugeri SpA | Observational | Completed | Heart Failure, Acute Coronary Syndromes (ACS), Cardiac Surgery | 202 | Italy | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07921758) |
| November 5, 2026 | NCT07920575 | Assessment of Transnational Performance of the Universal Cardiac Surgical Risk Score Across International Sites | Union Health System | Observational | Not yet recruiting | Heart Valve Diseases, Cardiac Surgical Procedures, Coronary Artery Disease | 5,000 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07920575) |
| November 4, 2026 | NCT07916935 | Eccentric Exercise in Community-dwelling Older Adults | The University of Northampton | Not applicable | Not yet recruiting | Ageing Well | 30 | United Kingdom | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07916935) |
| November 4, 2026 | NCT07916675 | Preoperative Frailty and Suboptimal Mask Ventilation in Cardiac Surgery Patients | Ankara City Hospital Bilkent | Observational | Not yet recruiting | Frailty, Suboptimal Mask Ventilation | 450 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07916675) |
| November 4, 2026 | NCT07914920 | Postprandial Hypotension, Frailty and Post-Induction Hypotension in Older Patients Undergoing Noncardiac Surgery | Konya City Hospital | Observational | Not yet recruiting | Post-induction Hypotension (PIH), Postprandial Hypotension, Frailty | 200 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07914920) |
| October 29, 2026 | NCT07903584 | Personalized Drug Treatment of Frail Patients: Integrated Care and Real-Time Home Monitoring | Istituti Clinici Scientifici Maugeri SpA | Not applicable | Completed | Frailty, Polypharmacy (People Under Treatment With 5 or More Drugs), Multimorbidity | 40 | Italy | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07903584) |
| October 28, 2026 | NCT07902206 | Creatine and Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation Plus Home-Based Exercise for Sarcopenia in Huntington's Disease | Universidad de Burgos | Not applicable | Not yet recruiting | Huntington Disease, Sarcopenia, Frailty | 88 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07902206) |
| October 27, 2026 | NCT07898345 | Prognostic Value of Functional-Nutritional Status in Older Adults With Acute Coronary Syndrome | Samara State Medical University | Observational | Not yet recruiting | Acute Coronary Syndromes (ACS) | 270 | Russia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07898345) |
| October 27, 2026 | NCT07896876 | Selenium, Sarcopenia, and Frailty in Hemodialysis | Ankara City Hospital Bilkent | Observational | Completed | Frailty, Sarcopenia, Selenium | 78 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07896876) |
| October 26, 2026 | NCT07896174 | Resistance vs Aerobic Prehabilitation Before Colorectal Cancer Surgery | Semmelweis University | Not applicable | Recruiting | Colorectal Cancer, Colorectal Neoplasms, Postoperative Complications | 480 | Hungary | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07896174) |
| October 26, 2026 | NCT07893665 | PROfiles of FGF-19 Post-prandial Secretion in Older Adults With Frailty and Without Frailty | Hospices Civils de Lyon | Not applicable | Not yet recruiting | Frailty, Sarcopenia | 30 | France | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07893665) |
| October 23, 2026 | NCT07892612 | Frailty Training for Emergency Nurses: A Cluster RCT in Morocco | Cadi Ayyad University | Not applicable | Recruiting | Frail Elderly, Frailty | 144 | Morocco | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07892612) |
| October 21, 2026 | NCT07887334 | Hypoglycemia Risk Assessment in Elderly and Senile Female Patients With Type 2 Diabetes Mellitus | Samara State Medical University | Observational | Completed | Type 2 Diabetes Mellitus, Hypoglycemia, Frailty, Sarcopenia | 200 | Russia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07887334) |
| October 21, 2026 | NCT07886164 | Whole-Body Point-of-Care Ultrasound in Older Adults Presenting to the Emergency Department After a Fall | Kocaeli City Hospital | Observational | Recruiting | Accidental Falls, Aged, Syncope | 105 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07886164) |
| October 19, 2026 | NCT07880054 | Sleep Quality and Frailty Among People Living With HIV | National Sun Yat-sen University | Observational | Completed | HIV Infections, Frailty, Sleep Quality, Oral Frailty | 130 | Taiwan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07880054) |
| October 14, 2026 | NCT07872787 | NURSE-led Geriatric Assessment in Older Colorectal Cancer Patients | Helse Stavanger HF | Not applicable | Not yet recruiting | Colo-rectal Cancer | 50 | Norway | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07872787) |
| October 8, 2026 | NCT07864831 | Community-Based Multicomponent Exercise and Recreational Programme for Older Adults | Universidad de Murcia | Not applicable | Completed | Frailty, Aging, Physical Functional Performance, Postural Balance | 184 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07864831) |
| October 7, 2026 | NCT07862933 | AI-Based Conversational Social Support for Older Adults With Heart Failure | Chang Gung University of Science and Technology | Not applicable | Recruiting | Heart Failure | 174 | Taiwan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07862933) |
| October 6, 2026 | NCT07861997 | ENRICH Study: A Mixed-methods Feasibility Study of a Nurse-led Model of Care for Social Frailty in Philippine Primary Care | The Hong Kong Polytechnic University | Not applicable | Not yet recruiting | Frailty, Frailty in Older Adults, Frailty in Aging | 30 | Philippines | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07861997) |
| October 6, 2026 | NCT07860892 | VOCALE: A Digital Intervention to Improve Quality of Life and Reduce Frailty Among Older Adults in Retirement Communities | University of Washington | Not applicable | Not yet recruiting | Frailty, Quality of Life | 128 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07860892) |
| October 5, 2026 | NCT07857707 | AI-Supported Physiotherapy After Hip Fracture in Frail Older Adults | Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal | Not applicable | Not yet recruiting | Hip Fractures, Frailty | 48 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07857707) |
| October 2, 2026 | NCT07856602 | Safety and Preliminary Efficacy of Adipose-Derived Stem Cell Secretome in Frailty (VinVital) | Vinmec Research Institute of Stem Cell and Gene Technology | Phase 1 | Not yet recruiting | Frailty Syndrome, Aging | 20 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07856602) |
| October 2, 2026 | NCT07854275 | Biomarkers, Abdominal Muscle, and Frailty in CKD | Ankara City Hospital Bilkent | Observational | Completed | Chronic Kidney Disease, Abdominal Muscles/Ultrasonography, Frailty | 88 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07854275) |
| October 1, 2026 | NCT07851974 | Patients With Long-stay at ICU: Factors and Evaluation - Feasibility Study | Uppsala University | Observational | Not yet recruiting | Frailty, Delirium Confusional State, Persistent Critical Illness, Post-Intensive Care Syndrome, Health-related Quality... | 300 | Sweden | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07851974) |
| September 30, 2026 | NCT07848802 | Physical Function and Fall Risk in Older Adults in the Lalín Frailty Prevention Program | University of Vigo | Observational | Recruiting | Frailty, Fall Risk, Fall Prevention | 56 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07848802) |
| September 29, 2026 | NCT07845656 | A Home-based Multicomponent Exercise Intervention Program Based on the Fogg Behavior Model (FBM) for Older Adults With Osteosarcopenia and... | Jiawei Jiang | Not applicable | Recruiting | Osteosarcopenia; Frailty; Older Adults | 70 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07845656) |
| September 23, 2026 | NCT07837505 | Integrating Geriatric 8 (G8) Screening and Cancer and Age Research Group (CARG) Toxicity Assessment Score Into Routine Care for Older... | Assiut University | Observational | Not yet recruiting | Solid Neoplasms, Solid Tumors, Chemotherapy-Induced Toxicity | 100 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07837505) |
| September 23, 2026 | NCT07837219 | Frailty and Outcomes in Critically Ill Patients Receiving CRRT | Karolinska Institutet | Observational | Not yet recruiting | Acute Kidney Injury | 22,000 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07837219) |
| September 23, 2026 | NCT07836465 | A Pilot Study to Explore the Feasibility of Navigator and Coach Support for Community Participation by Older People | Bastiaan Van Grootven | Not applicable | Not yet recruiting | Frailty, Social Isolation in Older Adults, Frailty in Older Adults | 45 | Switzerland | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07836465) |
| September 23, 2026 | NCT07836127 | Human Albumin Combined With Plasma Exchange for Frailty Intervention | Institute of Hematology & Blood Diseases Hospital, China | Not applicable | Not yet recruiting | Frailty, Plasma Exchange | 34 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07836127) |
| September 21, 2026 | NCT07829484 | VIVI-OLIVE: Multicomponent Exercise and Extra Virgin Olive Oil in Older Adults at High Risk of Falls | Fundacion Miguel Servet | Not applicable | Recruiting | Falls, Frailty | 140 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07829484) |
| September 18, 2026 | NCT07829172 | Immediate Effects of Vojta Therapy on Postural Control in Older Adults | Marianela Alejandra Valenzuela Sandoval | Not applicable | Completed | Postural Balance, Aging, Frailty | 33 | Chile | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07829172) |
| September 18, 2026 | NCT07828886 | Immune Aging and Advanced Therapy Outcomes in Older Adults With IBD | First Affiliated Hospital, Sun Yat-Sen University | Observational | Not yet recruiting | Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Frailty, Immunosenescence | 300 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07828886) |
| September 18, 2026 | NCT07828847 | Involvement of Muscle Mitochondrial Dysfunction in Frailty in Older Adults. Role of Exercise | Fundación para la Investigación del Hospital Clínico de Valencia | Not applicable | Recruiting | Diabetes Type 2, Frail Elderly Syndrome, Mitochondrial Function, Bioenergetics, Functionality | 120 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07828847) |
| September 17, 2026 | NCT07826871 | Targeting HealthY Eating to Maintain Energy While Living With Cancer | University of Maryland, Baltimore | Phase 2 | Recruiting | Fatigue in Cancer Survivors | 132 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07826871) |
| September 17, 2026 | NCT07825090 | Association of ICU Admission Time, Age Stratification, and Clinical Frailty Scale With 30-Day Mortality in Geriatric Oncology Patients | Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital | Observational | Active not recruiting | Cancer, Frailty, Mortality | 150 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07825090) |
| September 17, 2026 | NCT07824700 | A Frailty-specific Prehabilitation Program for Mild to Moderately Frail Patients Undergoing Cardiac Surgeries/Procedures | The University of Hong Kong | Not applicable | Recruiting | Frailty, Thoracic Surgery | 144 | Hong Kong | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07824700) |
| September 17, 2026 | NCT07824141 | Fall Prevention Pathways | Emory University | Not applicable | Recruiting | Old Age; Debility | 50 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07824141) |
| September 11, 2026 | NCT07815392 | Preoperative Frailty and Postoperative Outcomes in Older Patients Undergoing Surgery for Gastrointestinal Cancer | Van Training and Research Hospital | Observational | Recruiting | Gastrointestinal Cancer, Frailty | 100 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07815392) |
| September 11, 2026 | NCT07815158 | Multi-Component Nutrition, Intrinsic Capacity, and Physical Function in Older Adults | National Yang Ming Chiao Tung University | Not applicable | Not yet recruiting | Sarcopenia, Intrinsic Capacity | 70 | Taiwan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07815158) |
| September 10, 2026 | NCT07813702 | URINARY INCONTINENCE AND GERIATRIC SYNDROMES | MERT UYSAL | Observational | Recruiting | Urinary Incontinence (UI), Urinary Incontinence, Urinary Incontinence in Old Age, Urinary Incontinence in Geriatric... | 120 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07813702) |
| September 9, 2026 | NCT07808619 | Longevity Metrics AI/ML Development Study | Longevity Metrics, Inc. | Observational | Recruiting | Aging, Mortality, Cardiovascular Disease Prevention, Metabolic Syndrome, Cognitive Dysfunction, Frailty... | 1,000,000 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07808619) |
| September 4, 2026 | NCT07803900 | Effect of Synchronized Transcutaneous Electrical Diaphragm Stimulation Using Surged Faradic Current Combined With Inspiratory Muscle... | Maharashtra University of Health Sciences | Not applicable | Completed | Chronic Kidney Disease, Frailty | 42 | India | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07803900) |
| August 31, 2026 | NCT07794657 | Brief Training Program for General Practitioners on Malnutrition and Adapted Physical Activity | Nantes University Hospital | Not applicable | Completed | Malnutrition Elderly, Primary Care, General Practitioner Education, Older Adults (65 Years and Older), Frailty, Adapted... | 40 | France | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07794657) |
| August 28, 2026 | NCT07793708 | Older Adults' Recovery Dynamics After Cardiac Surgery | University of Chile | Observational | Not yet recruiting | Frailty, Resilience, Cardiac Surgery Recovery | 75 | Chile | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07793708) |
| August 26, 2026 | NCT07787663 | Promoting Autonomy Through ExerCisE (PACE) in Outpatient Geriatric Clinics | Université du Québec a Montréal | Not applicable | Completed | Frailty, Sarcopenia | 162 | Canada | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07787663) |
| August 24, 2026 | NCT07783204 | ERAS Compliance and Hospital Stay After Open Heart Surgery | Bursa City Hospital | Observational | Completed | Cardiac Surgery, Nutritional Risk, Frailty | 120 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07783204) |
| August 20, 2026 | NCT07776184 | Multi-Component Delirium Prevention Bundle in Older Cardiac Intensive Care Unit Patients | Tel Aviv Medical Center | Not applicable | Active not recruiting | Delirium in Old Age, Delirium in the Intensive Care Unit, Delirium Confusional State, Delirium, Cardiac Intensive Care... | 200 | Israel | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07776184) |
| August 19, 2026 | NCT07772336 | MItochondrial Intervention for Resilience in Older Adults With Coenzyme Q10 | University Medical Centre Ljubljana | Not applicable | Not yet recruiting | Frailty, Aging, Mitochondria Health, Skin Aging, Mitochondrial Dysfunction | 100 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07772336) |
| August 3, 2026 | NCT07742475 | Funcional Recovery After Minithoracotomy or Sternotomy for CABG in Frail Patients | University of Sao Paulo General Hospital | Not applicable | Not yet recruiting | Frailty, Coronary Artery Disease, Coronary Artery Bypass Graft (CABG) | 194 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07742475) |
| August 3, 2026 | NCT07741292 | Niaoduqing Granules in Older Adults With Impaired Kidney Function | Huashan Hospital | Phase 4 | Recruiting | Chronic Kidney Disease | 300 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07741292) |
| July 31, 2026 | NCT07740031 | Development of a Frailty Risk Prediction Model and Preliminary Evaluation of a Risk-stratified Social Robot-assisted Intervention in... | The Hong Kong Polytechnic University | Not applicable | Not yet recruiting | Frailty | 60 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07740031) |
| July 31, 2026 | NCT07738393 | In-Person, Online, and Hybrid Healthy-Aging Education for Pre-Frailty and Frailty in Older Adults | University of Cadiz | Not applicable | Not yet recruiting | Frailty, Pre-Frailty | 276 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07738393) |
| July 29, 2026 | NCT07732530 | Acupoint Stimulation and Exercise for Taiwanese Pre-frail Older Adults | Tainan Hospital, Ministry of Health and Welfare | Not applicable | Recruiting | Frailty, Sleep Quality, Aging | 30 | Taiwan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07732530) |
| July 29, 2026 | NCT07732478 | Effects of a Community-based Multicomponent Physical Exercise Program on Physical Function, Frailty, and Sarcopenia in Older Adults From... | Universidad de Granada | Not applicable | Recruiting | Frailty/Sarcopenia, Frailty in Older Adults, Sarcopenia | 300 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07732478) |
| July 28, 2026 | NCT07731529 | Vivifrail Exercise Program in Nonagenarians: Effects on Function, Muscle, and Cognition | Federal University of Rio Grande do Sul | Not applicable | Enrolling by invitation | Frailty, Aging, Cognitive Decline | 54 | Brazil | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07731529) |
| July 27, 2026 | NCT07727876 | Ready for Safe Cancer Treatment (RESET): A Comprehensive Perioperative Program for Surgical Oncology | Regional Specialist Hospital in Wroclaw | Not applicable | Recruiting | Neoplasms, Frailty, Surgical Procedures, Operative | 12,800 | Poland | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07727876) |
| July 27, 2026 | NCT07727811 | Frailty Syndrome and Its Associated Factors Among Elderly Patients | Assiut University | Observational | Not yet recruiting | Geriatric Assessment | 175 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07727811) |
| July 24, 2026 | NCT07726498 | STRIDE: Strength of The Calf Muscles and Their Role In Declining Effectiveness of Movement With Aging | University of Leicester | Observational | Not yet recruiting | Sarcopenia, Aging, Muscle Weakness or Atrophy, Frailty | 200 | United Kingdom | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07726498) |
| July 23, 2026 | NCT07723339 | BIOANCIENT\_EX: Effects of a Physical Exercise Program in Centenarians of the BIOANCIENT Cohort: A Randomized Clinical Trial. | Fundacion Miguel Servet | Not applicable | Enrolling by invitation | Aging, Cellular Senescence, Biomarkers / Blood, Exercise, Frailty | 60 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07723339) |
| July 17, 2026 | NCT07712276 | The Effect of Teleconsultation, on the Reversibility of Frailty in Geriatric Patients Post Hospitalization | Universitas Indonesia | Not applicable | Not yet recruiting | Prefrail Elderly, Frail Elderly | 116 | Indonesia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07712276) |
| July 17, 2026 | NCT07710456 | Nutritional Status in Hospitalized Patients Over 65 Years of Age With Mental Disorders | University Psychiatric Clinic Ljubljana | Observational | Not yet recruiting | Malnutrition, Sarcopenia, Obesity, Sarcopenic Obesity, Frailty, Dysphagia, Mental Disorder | 450 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07710456) |
| July 17, 2026 | NCT07709975 | Analgesia Methods and Early Mobilization in Geriatric ICU Patients After Major Surgery | Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization | Observational | Recruiting | Postoperative Pain, Delirium - Postoperative, Frailty, Postoperative Care in Geriatric Intensive Care Patients | 90 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07709975) |
| July 16, 2026 | NCT07707297 | BIOANCIENT: Cohort of Centenarians in Navarra (1926-1927) | Fundacion Miguel Servet | Observational | Recruiting | Aging, Cellular Senescence, Biomarkers / Blood, Age-Related Diseases, Frailty | 333 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07707297) |
| July 15, 2026 | NCT07705802 | Outcome of Patients With Severe Mental Illness in the Intensive Care Unit | Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer | Observational | Not yet recruiting | Severe Mental Illness, Severe Mental Disorder | 2,000 | France | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07705802) |
| July 15, 2026 | NCT07705464 | Safety Study of Intravenous MiraMSC in Older Adults With Mild to Moderate Frailty Syndrome | Miracle Biomedical Co., Ltd. | Phase 1 | Not yet recruiting | Frailty | 12 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07705464) |
| July 14, 2026 | NCT07701538 | Frailty and Ultrasound-Guided Central Venous Catheterization Difficulty in Adult Cardiac Surgery Patients | Ankara City Hospital Bilkent | Observational | Recruiting | Frailty, Cardiac Surgery, Central Venous Catheter | 280 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07701538) |
| July 14, 2026 | NCT07701382 | Remote vs In-Person Prehabilitation for Kidney Transplant Candidates | Hospital Clinic of Barcelona | Not applicable | Not yet recruiting | Chronic Kidney Disease (CKD), Kidney Transplant, Frailty, Prehabilitation | 84 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07701382) |
| July 13, 2026 | NCT07698912 | The Effects of an AIoT-Based Exercise System on Frail Older Adults | National Cheng Kung University | Not applicable | Completed | Frail Older Adults | 376 | Taiwan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07698912) |
| July 10, 2026 | NCT07696078 | Frailty is a Risk Factor Postcholecystectomy | Zagazig University | Not applicable | Completed | Frailty, Gallbladder Diseases | Not listed |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07696078) |
| July 7, 2026 | NCT07687108 | Improving Shared DECISion-making in oldEr Hip Fracture Patients Living With Frailty | University of Southampton | Observational | Not yet recruiting | Hip Fractures (i.e. Femoral Neck or Intertrochanteric Hip Fractures), Hip Fractures (ICD-10 72.01-72.2), Hip Fracture... | 42 | United Kingdom | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07687108) |
| July 7, 2026 | NCT07686146 | Multicomponent Exercise and Frailty in Nursing Home Residents | Escoles Universitaries Gimbernat | Not applicable | Completed | Balance Impairment, Sarcopenia in Elderly, Frailty at Older Adults, Functional Decline, Fall Risk | 66 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07686146) |
| June 30, 2026 | NCT07677319 | SAGE-Heart : Senior Assessment fraGility and Post-opErative QALYs 1 Year After Emergency HEART Surgery for Patients Aged 75 and Older | University Hospital, Bordeaux | Not applicable | Recruiting | Frailty, Cardiac Surgery, QALYs | 265 | France | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07677319) |
| June 30, 2026 | NCT07677085 | Effects of a Nurse-Led Comprehensive Intervention on Frailty and Self-Management Behaviors in Patients Undergoing Peritoneal Dialysis | Henan University | Not applicable | Completed | Peritoneal Dialysis (PD), Frailty Syndrome | 72 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07677085) |
| June 30, 2026 | NCT07677072 | Can Serum Lumican Level Identify a Hidden Fragility Phenotype Beyond Bone Mineral Density in Postmenopausal Women? | Kanuni Sultan Suleyman Training and Research Hospital | Observational | Recruiting | Osteoporosis, Postmenopausal Osteoporosis, Frailty, Fragility Fractures | 98 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07677072) |
| June 25, 2026 | NCT07669168 | Health Ahead Comparative Effectiveness Study | William Brandenburg, MD | Not applicable | Recruiting | Health Services Accessibility, Rural Health, Medically Underserved Area, Preventive Health Services, Patient... | 1,000,000 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07669168) |
| June 25, 2026 | NCT07667764 | P-POSSUM for Outcomes After Abdominal Surgery | Bach Mai Hospital | Observational | Active not recruiting | Abdominal Surgery, Postoperative Complications, Surgical Risk Prediction, Postoperative Mortality, Frailty | 3,000 | Vietnam | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07667764) |
| June 23, 2026 | NCT07663955 | The SHAPE Project (Hospital System for Physical Activity and Active Participation) After Hospitalized Decompensation of Respiratory Chronic... | Hospital Universitari de Bellvitge | Not applicable | Not yet recruiting | Frailty, Sarcopenia, Hospital Discharge, Physical Activity, Acute Exacerbation Chronic Pulmonary Disease | 90 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07663955) |
| June 22, 2026 | NCT07660653 | Resistance-Based Multicomponent Training Plus Nutrition Supplementation for Intrinsic Capacity and Disability Risk in Chinese Rural Older... | Capital University of Physical Education and Sports, China | Not applicable | Completed | Frailty, Sarcopenia, Mobility Limitation, Nutritional Risk | 220 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07660653) |
| June 16, 2026 | NCT07649525 | Personalising Treatment for Myeloma Patients Based on Initial Response to NHS Treatment and Their Overall Fitness Level | University of Leeds | Phase 3 | Recruiting | Multiple Myeloma (MM), Plasma Cell Leukemia (PCL) | 1,226 | United Kingdom | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07649525) |
| June 15, 2026 | NCT07646782 | Human Observatory Study | Longevity Metrics, Inc. | Observational | Recruiting | Aging, Mortality, All-cause Mortality, Life Expectancy, Cardiovascular Diseases, Neoplasms, Cognitive Dysfunction... | 1,000,000 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07646782) |
| June 12, 2026 | NCT07646405 | Combined Effects of NMES and LIRT on Muscle Strength, Girth, and Physical Endurance in the Geriatric Population | Riphah International University | Not applicable | Recruiting | Old Age; Debility | 44 | Pakistan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07646405) |
| June 11, 2026 | NCT07643064 | Multicomponent Exercise and Comprehensive Geriatric Assessment Program (FRAIL+AP) for Frail Older Adults in Primary Care | Alberto Bermejo Franco | Not applicable | Recruiting | Frail Elderly | 200 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07643064) |
| June 11, 2026 | NCT07642765 | EASIX Score and Post-Induction Hypotension in Frail Patients Undergoing Non-Cardiac Surgery | Konya City Hospital | Observational | Recruiting | Hypotension on Induction, Frailty, Anesthesia, General | 160 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07642765) |
| June 11, 2026 | NCT07642726 | Change in Cognition and Frailty After Shunt Surgery in Idiopathic Normal Pressure Hydrocephalus (iNPH) | Oslo University Hospital | Observational | Completed | Idiopathic Normal Pressure Hydrocephalus (INPH) | 276 | Norway | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07642726) |
| June 10, 2026 | NCT07638449 | Silkworm Pupa Powder Improves Alzheimer's Disease | Zhejiang Provincial Tongde Hospital | Not applicable | Not yet recruiting | Alzheimer Disease, Sarcopenia, Asthenia, Frailty | 100 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07638449) |
| June 10, 2026 | NCT07637890 | Designing a Multicomponent Intervention for Improving Frailty. A Pilot Study in the Basque Country | Biogipuzkoa Health Research Institute | Not applicable | Completed | Frailty | 32 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07637890) |
| June 9, 2026 | NCT07637383 | IMPACT OF A MULTICOMPONENT PHYSICAL EXERCISE PROGRAM ON THE FUNCTIONAL CAPACITY OF PATIENTS ADMITTED TO AN INTERMEDIATE CARE HOSPITAL.... | Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina | Not applicable | Recruiting | Functionality, Fragility | 120 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07637383) |
| June 8, 2026 | NCT07634406 | Nurse-Led Telehealth Frailty Management in Older Adults | Kutahya Health Sciences University | Not applicable | Completed | Frailty | 122 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07634406) |
| June 8, 2026 | NCT07633964 | An Study Looking at Percutaneous Coronary Intervention Outcomes for Octogenarians | Gloucestershire Hospitals NHS Foundation Trust | Observational | Not yet recruiting | Cardio Vascular Disease | 850 | United Kingdom | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07633964) |
| June 3, 2026 | NCT07624370 | Frailty in the Elderly Oncological and Oncohematological Patient. | Azienda Socio Sanitaria Territoriale Ovest Milanese, Ospedale di Legnano | Observational | Enrolling by invitation | Sarcopenia in Elderly, Frailty/Sarcopenia, Oncological Patients, Hematologic Disease | 160 | Italy | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07624370) |
| June 3, 2026 | NCT07623694 | Clinical and Functional Effectiveness Assessment of Personalized Management Programs for Patients With Frailty | Pirogov Russian National Research Medical University | Not applicable | Active not recruiting | Frailty, Frailty/Sarcopenia | 115 | Russia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07623694) |
| June 3, 2026 | NCT07623122 | Characterisation of Functional and Cognitive Responses Following Olfactory Stimulation and/or Functional Training in Older Adults. | Fundacion Miguel Servet | Not applicable | Completed | Healthy Aging, Frailty, Cognitive Decline, Olfactory Dysfunction, Physical Performance Decline in Older Adults | 120 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07623122) |
| June 2, 2026 | NCT07621276 | Frailty and Severity as Determinants of Hospital Cost in the ICU | Hospital H+ Queretaro | Observational | Completed | Frailty, Critical Illness, Hospital Costs | 142 | Mexico | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07621276) |
| June 1, 2026 | NCT07616219 | Exergaming-based Sitting Tai Chi for Sarcopenia and/or Frailty | Hong Kong Metropolitan University | Not applicable | Enrolling by invitation | Sarcopenia in Elderly, Frailty at Older Adults | 152 | Hong Kong | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07616219) |
| May 26, 2026 | NCT07607236 | Muscle Ultrasound for Sarcopenia Assessment in Kidney Transplant Recipients | Sichuan Provincial People's Hospital | Observational | Not yet recruiting | Sarcopenia, Kidney Transplantation, Muscle Wasting | 140 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07607236) |
| May 26, 2026 | NCT07607041 | Evolution of Physical Frailty and Patient-Reported Outcome Measures in Kidney Transplant Candidates: A Mixed-Methods Longitudinal Study... | Hospital del Mar | Observational | Not yet recruiting | Kidney Failure, Chronic, Frailty, Quality of Life, Kidney Transplantation, Patient Reported Outcome Measures | 150 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07607041) |
| May 26, 2026 | NCT07605936 | Frailty in Older Adults With Prostate Cancer: a Prospective Cohort Study | University of Limerick | Observational | Recruiting | Frailty at Older Adults, Prostate Cancer | 80 | Ireland | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07605936) |

## Sponsors posting most

| Sponsor | New trials | Latest |
| --- | --- | --- |
| Ankara City Hospital Bilkent | 6 | November 4, 2026 |
| Fundacion Miguel Servet | 6 | September 21, 2026 |
| Assiut University | 5 | September 23, 2026 |
| National Taiwan University Hospital | 5 | March 19, 2025 |
| The University of Hong Kong | 4 | September 17, 2026 |
| Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina | 4 | June 9, 2026 |
| Cardenal Herrera University | 3 | November 6, 2026 |
| Universidad de Burgos | 3 | October 28, 2026 |
| The Hong Kong Polytechnic University | 3 | October 6, 2026 |
| Fundación para la Investigación del Hospital Clínico de Valencia | 3 | September 18, 2026 |
| Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital | 3 | September 17, 2026 |
| Longevity Metrics, Inc. | 3 | September 9, 2026 |
| University of Limerick | 3 | May 26, 2026 |
| Universidad Francisco de Vitoria | 3 | April 29, 2026 |
| National University of Singapore | 3 | April 9, 2026 |
| University of Iceland | 3 | March 11, 2026 |
| Chinese PLA General Hospital | 3 | January 7, 2026 |
| Istituti Clinici Scientifici Maugeri SpA | 2 | November 6, 2026 |
| Konya City Hospital | 2 | November 4, 2026 |
| Samara State Medical University | 2 | October 27, 2026 |

## By phase

| Phase | New trials | Latest |
| --- | --- | --- |
| [Not applicable](https://specstream.ai/data/clinical-trials/phase/not-applicable) | 188 | November 6, 2026 |
| [Observational](https://specstream.ai/data/clinical-trials/phase/observational) | 143 | November 6, 2026 |
| [Phase 2](https://specstream.ai/data/clinical-trials/phase/phase-2) | 5 | September 17, 2026 |
| [Phase 1](https://specstream.ai/data/clinical-trials/phase/phase-1) | 4 | October 2, 2026 |
| [Phase 4](https://specstream.ai/data/clinical-trials/phase/phase-4) | 2 | August 3, 2026 |
| [Phase 3](https://specstream.ai/data/clinical-trials/phase/phase-3) | 1 | June 16, 2026 |
| [Phase 1/2](https://specstream.ai/data/clinical-trials/phase/phase-1-2) | 1 | March 2, 2026 |
| [Early phase 1](https://specstream.ai/data/clinical-trials/phase/early-phase-1) | 1 | March 11, 2025 |

## By country

| Country | New trials | Latest |
| --- | --- | --- |
| [Spain](https://specstream.ai/data/clinical-trials/country/spain) | 53 | November 6, 2026 |
| [Turkey (Türkiye)](https://specstream.ai/data/clinical-trials/country/turkey-t-rkiye) | 43 | November 4, 2026 |
| [China](https://specstream.ai/data/clinical-trials/country/china) | 21 | September 29, 2026 |
| [United States](https://specstream.ai/data/clinical-trials/country/united-states) | 19 | September 17, 2026 |
| [Taiwan](https://specstream.ai/data/clinical-trials/country/taiwan) | 18 | October 19, 2026 |
| [France](https://specstream.ai/data/clinical-trials/country/france) | 14 | October 26, 2026 |
| [Italy](https://specstream.ai/data/clinical-trials/country/italy) | 13 | November 6, 2026 |
| [United Kingdom](https://specstream.ai/data/clinical-trials/country/united-kingdom) | 10 | November 4, 2026 |
| [Hong Kong](https://specstream.ai/data/clinical-trials/country/hong-kong) | 8 | September 17, 2026 |
| [Canada](https://specstream.ai/data/clinical-trials/country/canada) | 8 | August 26, 2026 |
| [Singapore](https://specstream.ai/data/clinical-trials/country/singapore) | 6 | April 13, 2026 |
| [Sweden](https://specstream.ai/data/clinical-trials/country/sweden) | 5 | October 1, 2026 |
| [Switzerland](https://specstream.ai/data/clinical-trials/country/switzerland) | 5 | September 23, 2026 |
| [Denmark](https://specstream.ai/data/clinical-trials/country/denmark) | 5 | April 6, 2026 |
| [Chile](https://specstream.ai/data/clinical-trials/country/chile) | 4 | September 18, 2026 |
| [Indonesia](https://specstream.ai/data/clinical-trials/country/indonesia) | 4 | July 17, 2026 |
| [Ireland](https://specstream.ai/data/clinical-trials/country/ireland) | 4 | May 26, 2026 |
| [Belgium](https://specstream.ai/data/clinical-trials/country/belgium) | 4 | March 25, 2026 |
| [Portugal](https://specstream.ai/data/clinical-trials/country/portugal) | 4 | March 23, 2026 |
| [Germany](https://specstream.ai/data/clinical-trials/country/germany) | 4 | March 11, 2026 |
| [South Korea](https://specstream.ai/data/clinical-trials/country/south-korea) | 4 | September 23, 2025 |
| [Russia](https://specstream.ai/data/clinical-trials/country/russia) | 3 | October 27, 2026 |
| [Vietnam](https://specstream.ai/data/clinical-trials/country/vietnam) | 3 | June 25, 2026 |
| [Mexico](https://specstream.ai/data/clinical-trials/country/mexico) | 3 | June 2, 2026 |
| [Iceland](https://specstream.ai/data/clinical-trials/country/iceland) | 3 | March 11, 2026 |

## Where the register publishes

- [ClinicalTrials.gov](https://clinicaltrials.gov/)
- [ClinicalTrials.gov API](https://clinicaltrials.gov/data-api/api)

Source: [ClinicalTrials.gov API v2 (U.S. National Library of Medicine)](https://clinicaltrials.gov/data-api/api). U.S. government data; ClinicalTrials.gov terms of use. Studies are as their sponsors registered them on ClinicalTrials.gov, read through its API. Condition groups are the MeSH terms ClinicalTrials.gov assigns to each study's conditions; a study with several is in several groups. Sponsor class is the register's class of the lead sponsor. The central contact is in the full list only as the record prints it.

Free to reuse with credit to SpecStream under [CC BY 4.0](https://creativecommons.org/licenses/by/4.0/).