# Depressive Disorder, Major trials: 380 new since Nov 2024

Updated November 9, 2026.

380 clinical studies in Depressive Disorder, Major were first posted on ClinicalTrials.gov from November 14, 2024 to November 9, 2026; 76 have an industry sponsor and 283 are recruiting or about to. The newest, NCT07925281, was posted on November 9, 2026: Emotional Reactivity in Severe Alcohol Use Disorder and Major Depressive Disorder Using Eye-tracking... (Université Catholique de Louvain).

## The full list

New Depressive Disorder, Major clinical trials: 380 rows for $19, first posted on ClinicalTrials.gov from November 12, 2024 to November 9, 2026. Columns: NCT ID, Title, Sponsor, Sponsor class, Phase, Status, Conditions, Condition groups (MeSH), Interventions, Start date, First posted, Enrollment, Enrollment type, Location countries, Central contact, Contact phone, Contact email, Last update posted, Read on, Source. The new rows each week by email, about 20 rows a month: $19 a month. Pay by card with no account. Prices exclude VAT. CSV and Excel files with the columns this page does not show (central contact, contact phone, contact email, sponsor class, condition groups (MeSH), interventions and 5 more), which open on your screen as soon as the payment clears and come by email. The rows on this page are a sample.

Buy: https://specstream.ai/data/clinical-trials/condition/depressive-disorder-major

SpecStream is the live web data engine for teams and agents. It reads every new study on ClinicalTrials.gov each morning, and this page is that reading. Ask for the conditions, phases or countries you follow and each new trial arrives in your sheet, CRM, Slack or agent with the sponsor, the sites and the listed contact.

- New trials: 380
- Industry sponsored: 76
- Recruiting or not yet: 283
- Latest posted: November 9, 2026

## Newest trials

The newest 100 of 380, each linked to its record. The full list holds every one with the sponsor class, interventions, start date and the central contact as the record prints it.

| First posted | NCT ID | Title | Sponsor | Phase | Status | Conditions | Enrollment | Countries | Source |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| November 9, 2026 | NCT07925281 | Emotional Reactivity in Severe Alcohol Use Disorder and Major Depressive Disorder Using Eye-tracking, Physiological, and Interoceptive... | Université Catholique de Louvain | Observational | Recruiting | Alcohol Use Disorder, Major Depressive Disorder (MDD) | 280 | Belgium | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07925281) |
| November 9, 2026 | NCT07925047 | Individualized Temporal Interference Stimulation for Reward Processing in Late-Life Depression | Beijing HuiLongGuan Hospital | Not applicable | Not yet recruiting | Major Depressive Disorder (MDD | 70 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07925047) |
| November 9, 2026 | NCT07924917 | Individualized Temporally Interfering Electrical Stimulation in Major Depressive Disorder | Tianjin Medical University General Hospital | Not applicable | Recruiting | Major Depressive Disorder (MDD) | 75 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07924917) |
| November 9, 2026 | NCT07924852 | Neuromodulation of Motivation and Reward Oscillations | Florida State University | Not applicable | Recruiting | Cannabis Use Disorder, Major Depression, Anhedonia, Transcranial Alternating Current Stimulation | 54 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07924852) |
| November 6, 2026 | NCT07921654 | Acute Intermittent Hypoxia Therapy for Depression | Capital Medical University | Not applicable | Not yet recruiting | Major Depressive Disorder (MDD) | 156 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07921654) |
| November 6, 2026 | NCT07921446 | Preventive and Personalized Digital Emotion Regulation Skills Intervention to Reduce Depression and Anxiety in Youths With Adverse... | Institute of Mental Health, Singapore | Not applicable | Not yet recruiting | Adverse Childhood Experience, Depression / Major Depressive Disorder, Anxiety Depression, Anxiety | 140 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07921446) |
| November 5, 2026 | NCT07920302 | Affective Cognitive Training in Mood Disorders and High-risk Relatives | Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital | Not applicable | Recruiting | Major Depressive Disorder (MDD), Bipolar Disorder (BD) | 100 | Denmark | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07920302) |
| November 2, 2026 | NCT07910318 | Neurostructural and Biochemical Signatures of Tobacco Smoking in Mood Disorders | Assiut University | Observational | Not yet recruiting | Major Depressive Disorder, Bipolar Disorder, Tobacco Use Disorder, Mood Disorders | 240 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07910318) |
| November 2, 2026 | NCT07908563 | Dupilumab in Major Depressive Disorder | Icahn School of Medicine at Mount Sinai | Phase 2 | Recruiting | Major Depressive Disorder | 34 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07908563) |
| October 30, 2026 | NCT07906496 | Acceptance and Committment Therapy Combined With Ketamine in Difficult-to-Treat Depression. | University of British Columbia | Not applicable | Not yet recruiting | Major Depressive Disorder (MDD) | 50 | Canada | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07906496) |
| October 29, 2026 | NCT07905378 | Validation of Wearable Core Body Temperature-Based Circadian Rhythm Digital Biomarkers | Korea University Anam Hospital | Observational | Not yet recruiting | Mood Disorders, Major Depressive Diorder, Bipolar Disorders, Mental Disorder | 200 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07905378) |
| October 28, 2026 | NCT07901179 | A Study to Evaluate the Safety and Efficacy of ALKS 7290 as an Adjunctive Therapy to Antidepressants in Adult Participants With Major... | Alkermes, Inc. | Phase 2 | Recruiting | Major Depressive Disorder (MDD) | 180 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07901179) |
| October 26, 2026 | NCT07895134 | Psilocybin for Depression in Veterans | VA Office of Research and Development | Phase 2 | Not yet recruiting | Major Depression | 150 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07895134) |
| October 23, 2026 | NCT07891806 | REM Sleep Disruption and Its Potential Uses in Depression Management | WAKEZ HEALTH TECH ECOSYSTEM SRL | Not applicable | Completed | Depression / Major Depressive Disorder, Depressed Mood | 208 | Romania | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07891806) |
| October 23, 2026 | NCT07891624 | Neural Mechanisms of Real-world Emotions and Internalizing | University of Miami | Not applicable | Recruiting | Major Depression, Generalized Anxiety, Emotions | 144 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07891624) |
| October 22, 2026 | NCT07889908 | Testing a Non-Deceptive Placebo Intervention for Subclinical Depressive Symptoms | Miami University | Not applicable | Not yet recruiting | Depression - Major Depressive Disorder, Psychological Distress, Depression / Major Depressive Disorder | 330 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07889908) |
| October 22, 2026 | NCT07888387 | Temporal Interference Stimulation in Major Depressive Disorder: A Pilot Feasibility Study | Ruijin Hospital | Not applicable | Completed | Major Depressive Disorder (MDD) | 15 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07888387) |
| October 21, 2026 | NCT07885722 | Evaluation of a Multi-Layered Digital Phenotyping, Digital Safety Plan, and Pharmacogenomic Intervention for Suicide Prevention in Adults... | Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz | Not applicable | Recruiting | Depressive Disorder, Major Depressive Disorder, Suicidal Ideation, Suicide, Attempted, Suicide Prevention | 525 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07885722) |
| October 19, 2026 | NCT07881016 | French Minds Cohort: a French Longitudinal and Multimodal Cohort of Patients With Major Mood Disorders, Psychotic Disorders, Autism... | Fondation FondaMental | Not applicable | Recruiting | Schizophrenia / Schizoaffective Disorder, First Episode Psychosis (FEP), Bipolar Disorder (BD), Major Depressive... | 3,000 | France | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07881016) |
| October 19, 2026 | NCT07880015 | Digital Phenotypes for Predicting Depression\_Validation | Korea University Anam Hospital | Observational | Enrolling by invitation | Major Depressive Disorder, Bipolar I Disorder, Bipolar II Disorder, Mood Disorders | 200 | South Korea | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07880015) |
| October 19, 2026 | NCT07879924 | Dual Neuromodulation for Depression: Boosting TMS With tES | Mersey Care NHS Trust | Not applicable | Not yet recruiting | Depression - Major Depressive Disorder | 60 | United Kingdom | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07879924) |
| October 16, 2026 | NCT07879131 | A Mobile App to Support Mood, Daily Routines and Medication Adherence in Adults With Severe Mental Illness | Alexandria University | Not applicable | Not yet recruiting | Severe Mental Illness, Bipolar Disorder, Schizophrenia, Schizoaffective Disorder, Major Depressive Disorder | 60 | Bahrain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07879131) |
| October 15, 2026 | NCT07876453 | Feasibility and Preliminary Outcomes of Compassion-Focused Group Therapy for Depression and Anxiety | Karolinska Institutet | Not applicable | Completed | Depression / Major Depressive Disorder, Anxiety Disorder (Panic Disorder or GAD) | 21 | Sweden | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07876453) |
| October 14, 2026 | NCT07873905 | Digital Single-Session Cognitive Behavioural Therapy in Healthy Adults | Brunel University | Not applicable | Completed | Depression / Major Depressive Disorder, Anxiety, Anxiety Disorder Generalized | 110 | United Kingdom | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07873905) |
| October 14, 2026 | NCT07873060 | Comparing 10 Hz rTMS and iTBS for Adolescent Depression | Qilu Hospital of Shandong University | Not applicable | Recruiting | Depressive Disorder, Major Depressive Disorder, Adolescence | 80 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07873060) |
| October 7, 2026 | NCT07862205 | EEG-Guided Transcranial Magnetic Stimulation for Adults With Depression | Mayo Clinic | Not applicable | Recruiting | Major Depressive Disorder (MDD), Treatment Resistant Depression, Major Depression | 60 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07862205) |
| October 5, 2026 | NCT07857629 | Brief Psychoanalytic Therapy Versus Cognitive Behavioral Therapy for Major Depressive Disorder | Istanbul Nisantasi University | Not applicable | Not yet recruiting | Major Depressive Disorder (MDD | 90 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07857629) |
| October 2, 2026 | NCT07853989 | Effect of TMS Treatment on Defense Mechanisms and Functionality in Patients With Depression | Namik Kemal University | Observational | Not yet recruiting | Major Depressive Disorder (MDD) | 50 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07853989) |
| October 1, 2026 | NCT07853365 | Predictors of Treatment Outcome in Major Depressive Disorder | Assiut University | Observational | Not yet recruiting | Major Depressive Disorder | 100 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07853365) |
| October 1, 2026 | NCT07852065 | iTBS Versus Standard 10 Hz rTMS for Treatment-Resistant Depression (TRD) | Kafrelsheikh University | Not applicable | Active not recruiting | Major Depression | 182 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07852065) |
| September 29, 2026 | NCT07845604 | Precision Depression Adalimumab Trial | Daniel Moriarity | Phase 2 | Recruiting | Major Depressive Disorder (MDD) | 60 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07845604) |
| September 28, 2026 | NCT07843875 | Personalized Accelerated iTBS Versus Sham for Major Depressive Disorder | Capital Medical University | Not applicable | Not yet recruiting | Major Depressive Disorder (MDD) | 90 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07843875) |
| September 25, 2026 | NCT07842601 | Helping Kentuckians Overcome Depression and Opioid Addiction With Brain Stimulation | University of Kentucky | Not applicable | Not yet recruiting | Opioid Use Disorder, Major Depressive Disorder (MDD) | 60 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07842601) |
| September 22, 2026 | NCT07834762 | Home-Based Randomized Trial of Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression | University of California, San Diego | Not applicable | Not yet recruiting | Treatment Resistant Depression (TRD), Major Depressive Disorder (MDD) | 74 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07834762) |
| September 21, 2026 | NCT07829575 | Amygdala-Targeted Transcranial Temporal Interference Stimulation for Major Depressive Disorder: A Randomized Sham-Controlled Trial of... | Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University | Not applicable | Not yet recruiting | Major Depressive Disorder (MDD | 60 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07829575) |
| September 16, 2026 | NCT07823218 | Longitudinal Effects of Brain Stimulation on Decision-Making and Reward Learning | University of Bonn | Observational | Not yet recruiting | Depression / Major Depressive Disorder | 100 | Germany | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07823218) |
| September 10, 2026 | NCT07813169 | Study on iTBS Regulating the Reward Circuit Function to Improve Anhedonia in Depression | Guo Wenbin | Not applicable | Recruiting | Major Depression, Anhedonia, Melancholic Depression, Theta Burst Stimulation | 60 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07813169) |
| September 9, 2026 | NCT07810023 | Intramuscular Ketamine for Suicidal Patients in the Evanston Hospital Emergency Department for Suicidal Distress | Endeavor Health | Not applicable | Enrolling by invitation | Suicidal, Suicidal Ideation, Suicidal Ideation and Behavior, Depression / Major Depressive Disorder | 8 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07810023) |
| September 8, 2026 | NCT07807930 | Individual Narratives of Stimulation (ECT and TMS) | University of Nottingham | Observational | Not yet recruiting | Major Depression | 12 | United Kingdom | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07807930) |
| September 8, 2026 | NCT07807735 | Evaluation of an 8-week Behavior Skills-based Virtual Reality Program for Adolescents With Depression. (MDD) | Edward Via Virginia College of Osteopathic Medicine | Not applicable | Not yet recruiting | Major Depression | 10 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07807735) |
| September 8, 2026 | NCT07806825 | Evaluation of the Acceptability, Feasibility and Exploration of the Efficacy of an Integrated Care Pathway CARIBOU | Universidad de los Andes, Chile | Not applicable | Not yet recruiting | Major Depressive Disorder (MDD) | 72 | Chile | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07806825) |
| September 4, 2026 | NCT07804979 | Comparison of Efficacy of Minocyclin and Celecoxib as Adjunctive Treatment in Treatment Resistant Cases of Major Depressive Disorder | Lahore General Hospital | Not applicable | Completed | Major Depressive Disorder (MDD), Treatment-resistant Depression (TRD) | 78 | Pakistan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07804979) |
| September 4, 2026 | NCT07804459 | Individualized fMRI-guided TMS for Depression | University of Pennsylvania | Early phase 1 | Not yet recruiting | Depression, Major Depressive Disorder (MDD), Depression - Major Depressive Disorder, Persistent Depressive Disorder... | 60 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07804459) |
| September 3, 2026 | NCT07801703 | Behavioural Activation Therapy and Ketamine for Treatment-Resistant Depression | The Royal's Institute of Mental Health Research | Phase 2/3 | Recruiting | Treatment Resistant Depression, Major Depressive Disorder (MDD) | 60 | Canada | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07801703) |
| September 1, 2026 | NCT07796295 | Prescribing the Right Agent for Depression in Adults | University of Oxford | Not applicable | Not yet recruiting | Major Depressive Disorder (MDD) | 2,142 | Ethiopia, Pakistan, United Kingdom | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07796295) |
| August 28, 2026 | NCT07793071 | Oral Thiamine (Vitamin B1) for Depression in Children and Adolescents | Massachusetts General Hospital | Phase 2 | Not yet recruiting | Major Depressive Disorder (MDD), Thiamine, Vitamin B1, Thiamine Diphosphate (TDP), Pediatrics | 40 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07793071) |
| August 28, 2026 | NCT07792252 | REWIRE: Real-world Engagement With Interventional and Rejoyn Effectiveness | Yale University | Observational | Not yet recruiting | Major Depressive Disorder (MDD) | 50 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07792252) |
| August 27, 2026 | NCT07789808 | Activating Voice Journaling for Mental Health With Voice Biomarkers | Kintsugi Mindful Wellness, Inc. | Observational | Completed | Depression / Major Depressive Disorder, Anxiety | 50,000 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07789808) |
| August 25, 2026 | NCT07786285 | Adjunctive Probiotic Therapy in Major Depressive Disorder (ProMOOD) | University Maribor | Not applicable | Not yet recruiting | Depression / Major Depressive Disorder | 200 | Slovenia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07786285) |
| August 25, 2026 | NCT07785102 | Single Day of Ultra-accelerated TMS With a Single Dose of NRX-101 | Mclean Hospital | Early phase 1 | Recruiting | Major Depression | 30 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07785102) |
| August 25, 2026 | NCT07784244 | Early Detection of Perinatal Depression With Wearable Technology | Women's College Hospital | Not applicable | Not yet recruiting | Perinatal Depression | 10 | Canada | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07784244) |
| August 25, 2026 | NCT07783906 | Precision Closed-loop Brain-Computer Interface Neuromodulation for Treatment-Resistant Depression | Shanghai Mental Health Center | Not applicable | Not yet recruiting | Treatment-Resistant Major Depressive Disorder, Major Depressive Disorder | 70 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07783906) |
| August 25, 2026 | NCT07783633 | Identifying Biomarkers of Response to Digital Interventions for Mood Disorders | Centre for Addiction and Mental Health | Not applicable | Enrolling by invitation | Depression / Major Depressive Disorder, Bipolar Disorder (BD) | 200 | Canada | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07783633) |
| August 24, 2026 | NCT07781293 | Study of Lurasidone as Adjunctive Treatment in Patients With Major Depressive Disorder With Inadequate Response to Antidepressant... | Bukwang Pharmaceutical | Phase 3 | Not yet recruiting | Major Depressive Disorder (MDD), Major Depressive Disorder With Psychotic Features | 364 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07781293) |
| August 21, 2026 | NCT07779707 | The Medically Tailored Groceries and Mental Health Study | University of Massachusetts, Worcester | Not applicable | Recruiting | Depression / Major Depressive Disorder, Food Insecurity | 300 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07779707) |
| August 20, 2026 | NCT07775586 | Home-Based Wearable rTMS Therapy for Moderate to Severe Depression | Shanghai Mental Health Center | Not applicable | Not yet recruiting | Major Depressive Disorder | 124 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07775586) |
| August 20, 2026 | NCT07775300 | A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder | Eli Lilly and Company | Phase 3 | Recruiting | Depressive Disorder, Major | 1,000 | Australia, Brazil, Canada, China, Germany, Greece, Japan, Mexico, Poland... | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07775300) |
| August 19, 2026 | NCT07772531 | A Study to Evaluate BMS-986511 in Adults With Major Depressive Disorder | Bristol-Myers Squibb | Phase 2 | Not yet recruiting | Major Depressive Disorder | 200 | Czechia, United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07772531) |
| August 18, 2026 | NCT07771517 | Role of Kynurenine Pathway and Its Metabolites in Depressive Disorders, Major Depressive Disorder is Suspected to Have the Greatest Burden... | Sohag University | Observational | Not yet recruiting | Major Depressive Disorder (MDD) | 90 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07771517) |
| August 17, 2026 | NCT07768397 | Accelerated Versus Standard Intermittent Theta Burst Stimulation for Major Depressive Disorder | Military Hospital 175 | Not applicable | Recruiting | Major Depressive Disorder | 80 | Vietnam | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07768397) |
| August 6, 2026 | NCT07749521 | Optimizing Treatment for Depressed Parents of Children With Emotional and Behavioural Problems | University of Toronto | Not applicable | Recruiting | Depression / Major Depressive Disorder, Conduct Disorders in Children, Disruptive Behaviour in Children, Parenting... | 210 | Canada | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07749521) |
| August 6, 2026 | NCT07748845 | Gottman Couple Therapy Program in Treatment of Depressed Female Partners | Tanta University | Not applicable | Completed | Major Depressive Disorder (MDD), Female | 40 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07748845) |
| August 5, 2026 | NCT07748091 | EEG Microstate Parameters and Neuroinflammatory Biomarkers in Patients With Treatment-Resistant Major Depressive Disorder Receiving ECT | Istanbul University - Cerrahpasa | Observational | Recruiting | Major Depression Moderate, Major Depression Severe, Major Depression With Comorbid Anxiety Symptoms, Major Depression... | 62 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07748091) |
| August 5, 2026 | NCT07747389 | A Study of Lumateperone Versus Placebo in Participants With Major Depressive Disorder | Intra-Cellular Therapies, Inc. | Phase 3 | Not yet recruiting | Depressive Disorder, Major | 585 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07747389) |
| August 4, 2026 | NCT07745569 | Assessing of Behavioral Risk and Response to Electromagnetic and Psychedelic Therapies | University of New Mexico | Phase 2 | Not yet recruiting | PTSD, PTSD - Post Traumatic Stress Disorder, Major Depression, Suicidality | 150 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07745569) |
| August 4, 2026 | NCT07744490 | Tracking Risk in Adolescents and Children for Early Identification of Common Mental Disorders | Shanghai Mental Health Center | Observational | Not yet recruiting | High Risk, Depression / Major Depressive Disorder, Anxiety Disease, Obsessive - Compulsive Disorder | 200 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07744490) |
| August 3, 2026 | NCT07743398 | Context-Guided Personalized iTBS for Depression | Capital Medical University | Not applicable | Not yet recruiting | Major Depressive Disorder (MDD) | 60 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07743398) |
| August 3, 2026 | NCT07741331 | Compare the Efficacy and Safety of KH607 Tablets Versus Vortioxetine Hydrobromide Tablets in Adult Patients With Major Depressive Disorder | Chengdu Kanghong Pharmaceutical Group Co., Ltd. | Phase 3 | Not yet recruiting | Major Depressive Disorder (MDD) | 326 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07741331) |
| August 3, 2026 | NCT07741240 | A Study of KH607 as Monotherpy in Adults Participants With Major Depressive Disorder | Chengdu Kanghong Pharmaceutical Group Co., Ltd. | Phase 3 | Not yet recruiting | Major Depressive Disorder (MDD) | 232 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07741240) |
| July 31, 2026 | NCT07740694 | EEG Microstate and Neuroinflammatory Biomarkers in Older Age Patients With Major Depressive Disorder Receiving ECT | Istanbul University - Cerrahpasa | Observational | Recruiting | Major Depression Moderate, Major Depression Severe, Major Depression With Comorbid Anxiety Symptoms, Major Depression... | 62 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07740694) |
| July 31, 2026 | NCT07738497 | Biomarkers and Pharmacogenomics for Precision Depression Therapy | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | Not applicable | Not yet recruiting | Depression / Major Depressive Disorder | 220 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07738497) |
| July 29, 2026 | NCT07735143 | iMORE+ Study: A Multi-Omics Cohort Study of Major Depressive Disorder | Shanghai Mental Health Center | Observational | Not yet recruiting | Major Depressive Disorder (MDD) | 150 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07735143) |
| July 29, 2026 | NCT07734701 | Pregnenolone Treatment for Alcohol Use Disorder and Major Depressive Disorder | Sherwood Brown, MD, PhD | Phase 2 | Not yet recruiting | Alcohol Use Disorder (AUD), Major Depressive Disorder (MDD) | 100 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07734701) |
| July 29, 2026 | NCT07733310 | Augmented Depression Therapy (ADepT) Case Series | Ohio State University | Not applicable | Not yet recruiting | Depression / Major Depressive Disorder | 40 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07733310) |
| July 27, 2026 | NCT07728253 | Probiotic IBNI617 for Moderate to Severe Depression | IBIOME BIOTECHNOLOGY CO., LTD | Not applicable | Not yet recruiting | Major Depressive Disorder (MDD), IBNI617 | 148 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07728253) |
| July 27, 2026 | NCT07727005 | Effectiveness of Clustered Versus Tapered Repetitive Transcranial Magnetic Stimulation (rTMS) as Maintenance Therapy Following Successful... | Technical University of Munich | Not applicable | Not yet recruiting | Major Depressive Disorder (MDD), Depressive Episodes, Depressive Syndrome | 100 | Germany | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07727005) |
| July 17, 2026 | NCT07712159 | Temporal Interference Transcranial Alternating Current Stimulation for Major Depressive Disorder | Central South University | Not applicable | Not yet recruiting | Major Depressive Disorder (MDD) | 102 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07712159) |
| July 14, 2026 | NCT07703722 | Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Major Depressive Disorder | Khyber Medical University Peshawar | Phase 3 | Recruiting | Major Depressive Disorder, Post-Traumatic Stress Disorder (PTSD) | 60 | Pakistan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07703722) |
| July 10, 2026 | NCT07696871 | Cannabidiol Oil for Treatment-Resistant Major Depression | Universidade do Sul de Santa Catarina | Phase 1/2 | Recruiting | Major Depressive Disorder (MDD), Treatment-resistant Depression (TRD) | 120 | Brazil | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07696871) |
| July 9, 2026 | NCT07694076 | Mechanisms of Repeated Real-time Biofeedback With 7-Tesla MRI in Depression | University of Oxford | Not applicable | Recruiting | Major Depressive Disorder (MDD) | 60 | United Kingdom | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07694076) |
| July 9, 2026 | NCT07691749 | Effect of Psychobiotics With Standard Antiddepressants in Treatment of Major Depressive Disorder | Dr Sadia yasir | Not applicable | Recruiting | Major Depression | 86 | Pakistan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07691749) |
| July 6, 2026 | NCT07685964 | Pregnenolone for Cannabis Use Disorder and Depression | University of Texas Southwestern Medical Center | Phase 1/2 | Not yet recruiting | Cannabis Use Disorder, Major Depressive Disorder (MDD) | 20 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07685964) |
| July 6, 2026 | NCT07685925 | Intern Health Study 2026 | University of Michigan | Not applicable | Enrolling by invitation | Depression / Major Depressive Disorder, Mood, Sleep, Physical Activity | 1,000 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07685925) |
| July 6, 2026 | NCT07684911 | Longitudinal Study on the Sustainability of Transcranial Magnetic Stimulation Protocols - Biomarkers | Hospital Center Guillaume Régnier | Observational | Recruiting | Depression - Major Depressive Disorder, Depression Bipolar, Depression Unipolar | 30 | France | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07684911) |
| July 6, 2026 | NCT07684794 | Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium - Maintenance | Motif Neurotech, Inc. | Not applicable | Not yet recruiting | Major Depressive Disorder (MDD) | 10 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07684794) |
| July 6, 2026 | NCT07684677 | Effect of Participating in a Study of Causes of Pregnancy Loss on Mental Health Outcomes: A Target Trial Emulation Using the COPL Cohort... | Amager Hospital | Not applicable | Active not recruiting | Pregnancy Loss, Early, Major Depression, Anxiety, Stress (Psychology) | 30,000 | Denmark | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07684677) |
| July 2, 2026 | NCT07682207 | Accelerated iTBS for PTSD and Depression | Lawson Research Institute of St. Joseph's | Not applicable | Recruiting | Post Traumatic Stress Disorder PTSD, Major Depressive Disorder (MDD) | 16 | Canada | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07682207) |
| July 1, 2026 | NCT07679204 | Type D Personality and Life Satisfaction in Bipolar Disorder Type 2 and Major Depressive Disorder | Elazığ Mental Health and Diseases Hospital | Observational | Recruiting | Bipolar Disorder II, Major Depressive Disorder (MDD) | 180 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07679204) |
| June 29, 2026 | NCT07673913 | Relationship of Peripheral Inflammatory and Neuroprotective Biomarkers With Response to Intermittent Theta Burst Stimulation in... | Gulhane Training and Research Hospital | Not applicable | Recruiting | Treatment-resistant Depression (TRD), Major Depression | 100 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07673913) |
| June 16, 2026 | NCT07651293 | Using Fenfluramine to Test the Serotonin Deficiency Theory of Depression | Imperial College Healthcare NHS Trust | Not applicable | Not yet recruiting | Depression - Major Depressive Disorder | 46 | United Kingdom | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07651293) |
| June 16, 2026 | NCT07649993 | Non-Coding RNAs Gene Expression in Psychiatric Disorders | Carmen Concerto | Observational | Not yet recruiting | Schizophrenia Disorders, Major Depression, Bipolar Affective Disorders, Obsessive Compulsive Disorder (OCD), Anxiety... | 384 | Italy | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07649993) |
| June 12, 2026 | NCT07645157 | Sertraline Combined With Multi-Strain Probiotics for Adolescent Depression | First Affiliated Hospital of Chongqing Medical University | Phase 2 | Recruiting | Major Depressive Disorder (MDD), Probiotic Intervention | 120 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07645157) |
| June 10, 2026 | NCT07639164 | Stronger Together: Antenatal Depressive Symptoms - Prevalence and Digital Treatment | University of Turku | Not applicable | Not yet recruiting | Depression / Major Depressive Disorder, Antenatal Depression | 1,000 | Finland | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07639164) |
| June 10, 2026 | NCT07638202 | Transcranial Magnetic Stimulation in Depression. | Instituto Mexicano del Seguro Social | Not applicable | Completed | Major Depressive Disorder (MDD) | 40 | Mexico | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07638202) |
| June 8, 2026 | NCT07634458 | Serotonin Variants & Gut Microbiota in Mental Health | Neurobiologix | Observational | Not yet recruiting | Major Depressive Disorder (MDD, Anxiety Disorder, Generalized, Stress Disorders, Post-Traumatic, Panic Disorder | 30 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07634458) |
| June 8, 2026 | NCT07633080 | Magnesium Bisglycinate in Major Depressive Disorder | All India Institute of Medical Sciences, Bhubaneswar | Not applicable | Recruiting | Major Depressive Disorder | 84 | India | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07633080) |
| June 5, 2026 | NCT07629050 | Functional Electrical Stimulation for MDD | Unity Health Toronto | Not applicable | Not yet recruiting | MDD | 60 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07629050) |
| June 4, 2026 | NCT07628192 | Youth Suicide Prevention: CAMS-BI vs. Safety Planning in a Randomized Trial | The Cleveland Clinic | Not applicable | Not yet recruiting | Suicidal Ideation, Suicide Attempt, Safety Plan, Depression / Major Depressive Disorder, Hopelessness | 118 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07628192) |
| June 4, 2026 | NCT07625163 | The Effects of Aerobic Exercise and Mindful Breathing on Individuals With Major Depressive Disorder in Saudi Arabia | University of Pretoria | Not applicable | Not yet recruiting | Major Depressive Disorder (MDD) | 60 | Saudi Arabia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07625163) |
| June 3, 2026 | NCT07623135 | Lumateperone for Late-Life Depression | Eric Lenze | Phase 3 | Recruiting | Treatment Resistant Depression (TRD), Late Life Depression (LLD), Depression / Major Depressive Disorder | 100 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07623135) |

## Sponsors posting most

| Sponsor | New trials | Latest |
| --- | --- | --- |
| Stanford University | 7 | April 14, 2026 |
| Centre for Addiction and Mental Health | 6 | August 25, 2026 |
| Neurocrine Biosciences | 6 | September 29, 2025 |
| University of California, San Diego | 5 | September 22, 2026 |
| Shanghai Mental Health Center | 5 | August 25, 2026 |
| Sunnybrook Health Sciences Centre | 5 | January 29, 2026 |
| VA Office of Research and Development | 4 | October 26, 2026 |
| Mclean Hospital | 4 | August 25, 2026 |
| Istanbul University - Cerrahpasa | 4 | August 5, 2026 |
| Central South University | 4 | July 17, 2026 |
| Janssen Research & Development, LLC | 4 | May 7, 2026 |
| Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 4 | January 2, 2026 |
| Capital Medical University | 3 | November 6, 2026 |
| Ruijin Hospital | 3 | October 22, 2026 |
| University of Pennsylvania | 3 | September 4, 2026 |
| Tanta University | 3 | August 6, 2026 |
| Chengdu Kanghong Pharmaceutical Group Co., Ltd. | 3 | August 3, 2026 |
| Unity Health Toronto | 3 | June 5, 2026 |
| The Second Hospital of Anhui Medical University | 3 | April 28, 2026 |
| Peking University Sixth Hospital | 3 | April 2, 2026 |

## By phase

| Phase | New trials | Latest |
| --- | --- | --- |
| [Not applicable](https://specstream.ai/data/clinical-trials/phase/not-applicable) | 200 | November 9, 2026 |
| [Observational](https://specstream.ai/data/clinical-trials/phase/observational) | 65 | November 9, 2026 |
| [Phase 2](https://specstream.ai/data/clinical-trials/phase/phase-2) | 41 | November 2, 2026 |
| [Phase 3](https://specstream.ai/data/clinical-trials/phase/phase-3) | 37 | August 24, 2026 |
| [Phase 1](https://specstream.ai/data/clinical-trials/phase/phase-1) | 11 | April 24, 2026 |
| [Phase 4](https://specstream.ai/data/clinical-trials/phase/phase-4) | 10 | April 29, 2026 |
| [Early phase 1](https://specstream.ai/data/clinical-trials/phase/early-phase-1) | 7 | September 4, 2026 |
| [Phase 1/2](https://specstream.ai/data/clinical-trials/phase/phase-1-2) | 7 | July 10, 2026 |
| [Phase 2/3](https://specstream.ai/data/clinical-trials/phase/phase-2-3) | 2 | September 3, 2026 |

## By country

| Country | New trials | Latest |
| --- | --- | --- |
| [United States](https://specstream.ai/data/clinical-trials/country/united-states) | 128 | November 9, 2026 |
| [China](https://specstream.ai/data/clinical-trials/country/china) | 48 | November 9, 2026 |
| [Canada](https://specstream.ai/data/clinical-trials/country/canada) | 35 | October 30, 2026 |
| [Spain](https://specstream.ai/data/clinical-trials/country/spain) | 19 | October 21, 2026 |
| [France](https://specstream.ai/data/clinical-trials/country/france) | 16 | October 19, 2026 |
| [Turkey (Türkiye)](https://specstream.ai/data/clinical-trials/country/turkey-t-rkiye) | 15 | October 5, 2026 |
| [Germany](https://specstream.ai/data/clinical-trials/country/germany) | 15 | September 16, 2026 |
| [United Kingdom](https://specstream.ai/data/clinical-trials/country/united-kingdom) | 14 | October 19, 2026 |
| [Poland](https://specstream.ai/data/clinical-trials/country/poland) | 12 | August 20, 2026 |
| [Czechia](https://specstream.ai/data/clinical-trials/country/czechia) | 10 | August 19, 2026 |
| [Pakistan](https://specstream.ai/data/clinical-trials/country/pakistan) | 9 | September 4, 2026 |
| [Australia](https://specstream.ai/data/clinical-trials/country/australia) | 9 | August 20, 2026 |
| [Taiwan](https://specstream.ai/data/clinical-trials/country/taiwan) | 9 | August 20, 2026 |
| [Italy](https://specstream.ai/data/clinical-trials/country/italy) | 9 | June 16, 2026 |
| [Brazil](https://specstream.ai/data/clinical-trials/country/brazil) | 8 | August 20, 2026 |
| [Bulgaria](https://specstream.ai/data/clinical-trials/country/bulgaria) | 8 | March 5, 2026 |
| [Denmark](https://specstream.ai/data/clinical-trials/country/denmark) | 7 | November 5, 2026 |
| [Switzerland](https://specstream.ai/data/clinical-trials/country/switzerland) | 7 | January 16, 2026 |
| [Romania](https://specstream.ai/data/clinical-trials/country/romania) | 6 | October 23, 2026 |
| [South Korea](https://specstream.ai/data/clinical-trials/country/south-korea) | 6 | October 19, 2026 |
| [Egypt](https://specstream.ai/data/clinical-trials/country/egypt) | 6 | October 1, 2026 |
| [Belgium](https://specstream.ai/data/clinical-trials/country/belgium) | 5 | November 9, 2026 |
| [Finland](https://specstream.ai/data/clinical-trials/country/finland) | 5 | June 10, 2026 |
| [Israel](https://specstream.ai/data/clinical-trials/country/israel) | 5 | February 10, 2026 |
| [Hungary](https://specstream.ai/data/clinical-trials/country/hungary) | 5 | November 12, 2025 |

## Where the register publishes

- [ClinicalTrials.gov](https://clinicaltrials.gov/)
- [ClinicalTrials.gov API](https://clinicaltrials.gov/data-api/api)

Source: [ClinicalTrials.gov API v2 (U.S. National Library of Medicine)](https://clinicaltrials.gov/data-api/api). U.S. government data; ClinicalTrials.gov terms of use. Studies are as their sponsors registered them on ClinicalTrials.gov, read through its API. Condition groups are the MeSH terms ClinicalTrials.gov assigns to each study's conditions; a study with several is in several groups. Sponsor class is the register's class of the lead sponsor. The central contact is in the full list only as the record prints it.

Free to reuse with credit to SpecStream under [CC BY 4.0](https://creativecommons.org/licenses/by/4.0/).