# Aortic Valve Stenosis trials: 152 new since Nov 2024

Updated November 9, 2026.

152 clinical studies in Aortic Valve Stenosis were first posted on ClinicalTrials.gov from November 15, 2024 to November 9, 2026; 31 have an industry sponsor and 120 are recruiting or about to. The newest, NCT07926022, was posted on November 9, 2026: TAVI and PCI in Comparison to SAVR and CABG in Low and Intermediate Risk Patients With Severe Aortic Stenosis (Alexandria University).

## The full list

New Aortic Valve Stenosis clinical trials: 152 rows for $7.60, first posted on ClinicalTrials.gov from November 12, 2024 to November 9, 2026. Columns: NCT ID, Title, Sponsor, Sponsor class, Phase, Status, Conditions, Condition groups (MeSH), Interventions, Start date, First posted, Enrollment, Enrollment type, Location countries, Central contact, Contact phone, Contact email, Last update posted, Read on, Source. The new rows each week by email, about 4 rows a month: $19 a month. Pay by card with no account. Prices exclude VAT. CSV and Excel files with the columns this page does not show (central contact, contact phone, contact email, sponsor class, condition groups (MeSH), interventions and 5 more), which open on your screen as soon as the payment clears and come by email. The rows on this page are a sample.

Buy: https://specstream.ai/data/clinical-trials/condition/aortic-valve-stenosis

SpecStream is the live web data engine for teams and agents. It reads every new study on ClinicalTrials.gov each morning, and this page is that reading. Ask for the conditions, phases or countries you follow and each new trial arrives in your sheet, CRM, Slack or agent with the sponsor, the sites and the listed contact.

- New trials: 152
- Industry sponsored: 31
- Recruiting or not yet: 120
- Latest posted: November 9, 2026

## Newest trials

The newest 100 of 152, each linked to its record. The full list holds every one with the sponsor class, interventions, start date and the central contact as the record prints it.

| First posted | NCT ID | Title | Sponsor | Phase | Status | Conditions | Enrollment | Countries | Source |
| --- | --- | --- | --- | --- | --- | --- | --- | --- | --- |
| November 9, 2026 | NCT07926022 | TAVI and PCI in Comparison to SAVR and CABG in Low and Intermediate Risk Patients With Severe Aortic Stenosis | Alexandria University | Observational | Recruiting | Aortic Stenosis Disease, Coronary Artery Disease (CAD) | 100 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07926022) |
| November 3, 2026 | NCT07912905 | Effect of Double-Tap Optimization on Valve Expansion and Hemodynamics in Balloon-expandable Transcatheter Aortic Valve Implantation: A... | Yonsei University | Not applicable | Not yet recruiting | Severe Aortic Stenosis | 250 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07912905) |
| November 2, 2026 | NCT07908355 | Society of Thoracic Surgeons and American College of Cardiology Transcatheter Valve Therapy Registry (STS/ACC TVT Registry™): Registry... | American College of Cardiology | Observational | Recruiting | Aortic Valve Stenosis | 50,000 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07908355) |
| November 2, 2026 | NCT07908225 | Target Value Study to Evaluate the Safety and Efficacy of the Taurus NXT® Transcatheter Aortic Valve System for the Treatment of Severe... | Peijia Medical Technology (Suzhou) Co., Ltd. | Not applicable | Active not recruiting | Aortic Stenosis | 150 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07908225) |
| October 26, 2026 | NCT07895719 | Exercise and Diet Supplements for Older Patients Undergoing TAVI: the IRON-TAVI Trial | University Hospital of Ferrara | Not applicable | Recruiting | Aortic Stenosis Disease, Aortic Stenosis Symptomatic, Aortic Stenosis | 450 | Italy | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07895719) |
| October 13, 2026 | NCT07872020 | SYMmetric Valve fraME Expansion To Reduce hYpoattenuated Leaflet Thickening After Balloon-expandable TAVI: the SYMMETRY Trial | Erasmus Medical Center | Not applicable | Recruiting | Aortic Valve Stenosis and/or Insufficiency, Hypoattenuated Leaflet Thickening, Valve Expansion, Transcatheter Aortic... | 422 | Germany, Netherlands | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07872020) |
| September 18, 2026 | NCT07828730 | Sparrow App Guided Evaluation (SAGE) Vanguard Trial for Aortic Stenosis in Adults Aged Seventy and Older | Sunnybrook Health Sciences Centre | Not applicable | Not yet recruiting | Moderate or Severe Aortic Stenosis | 1,000 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07828730) |
| September 18, 2026 | NCT07827105 | ECG-based AI Screening for Cases of Undiagnosed Moderate-to-Severe Aortic Stenosis in the Primary Care Setting | AccurKardia, Inc. | Observational | Enrolling by invitation | Aortic Stenosis | 4,000 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07827105) |
| September 14, 2026 | NCT07819344 | Molecular Imaging to Identify Predictors of Aortic Valve Disease Activity | Massachusetts General Hospital | Observational | Not yet recruiting | AORTIC VALVE DISEASES, Calcification; Heart | 100 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07819344) |
| September 10, 2026 | NCT07813273 | Coronary Access After Evolut FX Plus TAVI: Impact of Commissural Alignment and the Large-Cell Frame Design: ACCESS-FX+ Registry | Yonsei University | Observational | Not yet recruiting | Severe Aortic Stenosis | 122 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07813273) |
| September 8, 2026 | NCT07806409 | Safety and Clinical Performance of the Next-Generation SAFESYNC Transcatheter Heart Valve in Patients With Severe Aortic Stenosis | Braile Biomedica Ind. Com. e Repr. Ltda. | Not applicable | Not yet recruiting | Aortic Stenosis Senile, Aortic Stenosis Symptomatic, Aortic Stenosis | 40 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07806409) |
| September 1, 2026 | NCT07798713 | Quality of Life After Transcatheter Aortic Valve Implantation | Aalborg University Hospital | Observational | Active not recruiting | Aortic Stenosis, Heart Failure, Angina Pectoris, TAVI(Transcatheter Aortic Valve Implantation) | 200 | Denmark | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07798713) |
| August 31, 2026 | NCT07794436 | Association Between Changes in Aortic Valve Area and Pulmonary Congestion After Transcatheter Aortic Valve Implantation | Istanbul University - Cerrahpasa | Observational | Recruiting | Aortic Stenosis | 52 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07794436) |
| August 31, 2026 | NCT07794306 | Balloon- Versus Self-Expanding Intraannular TAVI in Small Aortic Annuli | Universitätsklinikum Hamburg-Eppendorf | Not applicable | Not yet recruiting | Aortic Valve Stenosis | 510 | Germany | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07794306) |
| August 10, 2026 | NCT07756398 | Importance of Point-of-Care Ultrasound for Early Detection of Valvular and Cardiac Diseases (IMPROVE) | University of Texas Southwestern Medical Center | Not applicable | Not yet recruiting | Valvular Heart Disease Patients, Aortic Stenosis, Mitral Regurgitation, Left Ventricular Diastolic Dysfunction | 1,088 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07756398) |
| August 7, 2026 | NCT07752732 | Non-Interventional Study on the Prevalence of Cardiac Amyloidosis in Patients With Higher-Grade Aortic Valve Stenosis - Evaluation Using... | University Hospital Tuebingen | Observational | Recruiting | Amyloidosis Cardiac, Stenosis Coronary, TAVI(Transcatheter Aortic Valve Implantation) | 600 | Germany | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07752732) |
| August 4, 2026 | NCT07743697 | Comparing Suture vs. Combined Closure Strategies for Large Blood Vessel Access in Patients Undergoing Transcatheter Aortic Valve... | University Hospital, Basel, Switzerland | Not applicable | Not yet recruiting | Aortic Valve Stenosis, Postoperative Complications, Vascular System Injuries, Hemorrhage | 705 | Switzerland | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07743697) |
| July 31, 2026 | NCT07739316 | Systematic Ambulatory ECG Monitoring Following TAVI | Institut universitaire de cardiologie et de pneumologie de Québec, University Laval | Not applicable | Recruiting | Aortic Stenosis, Conduction Disturbances | 754 | Canada | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07739316) |
| July 31, 2026 | NCT07738575 | Same-Day Versus Standard Hospital Discharge After TAVI (HOME-TAVI) | Hospital Clinic of Barcelona | Not applicable | Not yet recruiting | Aortic Stenosis, Severe, Aortic Stenosis | 764 | Canada, Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07738575) |
| July 29, 2026 | NCT07735130 | Angiotensin Receptor Blocker After TAVR in Severe Aortic Stenosis With Left Ventricular Hypertrophy (ARBITAR) | Seoul National University Hospital | Phase 4 | Not yet recruiting | Transcatheter Aortic Valve Replacement (TAVR), Left Ventricular Hypertrophy, Severe Aortic Stenosis | 632 | South Korea | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07735130) |
| July 29, 2026 | NCT07734025 | A Prospective, Multi-centre, Single Arm, Pivotal Clinical Study to Determine the Safety and Effectiveness of Crea Aortic Valve for Use as a... | Onecrea Medical Inc. | Not applicable | Not yet recruiting | Aortic Valve Stenosis, Severe Aortic Stenosis | 30 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07734025) |
| July 20, 2026 | NCT07715279 | Vericiguat for the Inhibition of Calcific Aortic Valve Stenosis Progression | West China Hospital | Phase 2 | Recruiting | Calcific Aortic Valve Disease, AORTIC VALVE DISEASES, Aortic Valve Stenosis | 238 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07715279) |
| July 17, 2026 | NCT07709858 | CHATEAU Registry: Clinical Outcomes After Transcatheter Aortic Valve Replacement | Eunpyeong St. Mary's Hospital | Observational | Recruiting | Aortic Valve Stenosis, Transcatheter Aortic Valve Replacement (TAVR) | 4,000 | South Korea | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07709858) |
| July 8, 2026 | NCT07690748 | Remote Monitoring for Patients With Aortic Stenosis | Baker Heart and Diabetes Institute | Observational | Not yet recruiting | Aortic Stenosis | 160 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07690748) |
| July 8, 2026 | NCT07689279 | Selection of Transcatheter Heart vaLve With Intermediate Sizing in Patients With Severe Aortic Stenosis Treated With Transcatheter Aortic... | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Phase 4 | Not yet recruiting | Aortic Stenosis, Severe | 604 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07689279) |
| June 4, 2026 | NCT07626710 | Impact of Trans-catheter Aortic Valve Implantation on Renal Function | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Observational | Recruiting | Aortic Valve Stenosis, Chronic Kidney Diseases, Renal Failure Acute Chronic | 1,000 | Italy | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07626710) |
| June 4, 2026 | NCT07626567 | Prospective Neuropsychological Evaluation of the Implementation of a Heart Valve Unit (HVU-NEURO) | Heart and Brain Research Group, Germany | Observational | Not yet recruiting | Aortic Valve Stenosis, Postoperative Cognitive Dysfunction (POCD), Delirium - Postoperative, Neurocognitive Disorders | 500 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07626567) |
| June 3, 2026 | NCT07623083 | Evaluation of a Management Algorithm for TAVI Patients With Concomitant Mitral or Tricuspid Regurgitation | Josep Rodes-Cabau | Observational | Not yet recruiting | Aortic Stenosis, Mitral Regurgitation, Tricuspid Regurgitation, Transcatheter Aortic Valve Implantation (TAVI) | 300 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07623083) |
| June 2, 2026 | NCT07620925 | Derivation and Validation of the Aortic Valve Echocardiographic Calcium Score to Confirm Severe Aortic Stenosis: the Echo-AVCS Study | Azienda Ospedaliera "Sant'Andrea" | Observational | Recruiting | Aortic Stenosis, Chronic Coronary Syndrome, Calcific Aortic Valve Disease, Calcific Aortic Stenosis | 250 | Italy | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07620925) |
| May 29, 2026 | NCT07614100 | Cerebral Microembolization During Transcatheter Aortic Valve Implantation: Comparing Balloon-expandable and Self-expanding Valves | Ivan Zeljkovic | Not applicable | Not yet recruiting | Aortic Stenosis | 80 | Croatia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07614100) |
| May 26, 2026 | NCT07605780 | TAVI in LOW RISK in the REAL WORLD | Centro Cardiologico Monzino | Observational | Completed | Aortic Valve Stenosis | 650 | Italy | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07605780) |
| May 26, 2026 | NCT07605624 | Active Post-Market Surveillance of Innovative Devices for Valvular Heart Disease | Beijing Anzhen Hospital | Observational | Not yet recruiting | Aortic Stenosis, Aortic Regurgitation, Mitral Regurgitation, Tricuspid Regurgitation | 5,500 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07605624) |
| May 22, 2026 | NCT07604402 | TRanscatheter Aortic-Valve Implantation Without On-site Cardiac Surgery | University Hospital of Ferrara | Not applicable | Recruiting | Aortic Stenosis | 1,612 | Italy | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07604402) |
| May 19, 2026 | NCT07596394 | A Registry to Assess the Efficacy and Safety of Transcatheter Treatment for Aortic Valve Disease at the IRCCS Policlinico San Matteo... | Fondazione IRCCS Policlinico San Matteo di Pavia | Observational | Recruiting | Severe Aortic Stenosis | 500 | Italy | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07596394) |
| May 5, 2026 | NCT07566624 | Spanish Prospective Registry of Hydra THV for Transcatheter Aortic Valve Implantation | Fundación EPIC | Observational | Recruiting | Severe Aortic Valve Stenosis, Valvular Heart Disease, Aortic Valve Stenosis | 100 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07566624) |
| April 29, 2026 | NCT07556523 | Patient Quality of Recovery After TAVR With Different Sedation Regimens | David Lyubashevsky | Phase 4 | Recruiting | Transcatheter Aortic Valve Replacement (TAVR), Aortic Valve Stenosis | 126 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07556523) |
| April 22, 2026 | NCT07545369 | ULTRA-EVOLUT RCT: A Comparison of Latest-Generation TAVR Valves | Assiut University | Not applicable | Not yet recruiting | Severe Aortic Valve Stenosis | 200 | Egypt | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07545369) |
| April 20, 2026 | NCT07539909 | Alternative Peripheral TAVI Accesses | Medical University of Silesia | Observational | Not yet recruiting | Aortic Stenosis | 600 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07539909) |
| April 20, 2026 | NCT07539259 | Regression in Left Ventricular Hypertrophy and Fibrosis in Aortic Stenosis | University College, London | Phase 2 | Not yet recruiting | Aortic Stenosis | 445 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07539259) |
| April 9, 2026 | NCT07520656 | Impact of Transcatheter Aortic Valve Implantation and Mitral Valve Repair on Sleep-Disordered Breathing | Aristides Plaitis | Observational | Recruiting | Sleep-disordered Breathing (SDB), Aortic Valve Stenosis, Mitral Valve Regurgitation | 150 | Greece | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07520656) |
| April 9, 2026 | NCT07520591 | Valvosoft Outcomes Registry for Real-World Evidence | Cardiawave SA | Observational | Not yet recruiting | Aortic Valve Disease, Aortic Stenosis, Severe, Aortic Valve Calcification, Ultrasound Therapy, Heart Failure | 200 | France, Germany, Netherlands | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07520591) |
| April 7, 2026 | NCT07515768 | TAVI Without On-Site Cardiac Surgery in Poland: A Randomized Multicenter Trial Protocol | Medical University of Warsaw | Not applicable | Not yet recruiting | Aortic Stenosis | 404 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07515768) |
| April 3, 2026 | NCT07509554 | PRessure-based Evaluation of Disease Improvement in the Course of TAVI | Istanbul Mehmet Akif Ersoy Educational and Training Hospital | Observational | Not yet recruiting | Aortic Stenosis | 100 | Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07509554) |
| March 18, 2026 | NCT07479992 | Multicenter Study for the Validation of Willem AI: Aortic StenoSis Early Diagnosis With AI-electrocardiogram Study | Idoven 1903 S.L. | Observational | Recruiting | Aortic Stenosis | 5,000 | Germany | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07479992) |
| March 17, 2026 | NCT07477002 | Post-Dilatation in Balloon-Expandable TAVI Prostheses | Medical University of Vienna | Not applicable | Active not recruiting | Aortic Valve Stenosis | 146 | Austria | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07477002) |
| March 13, 2026 | NCT07469371 | CLEAR-AS: CT-FFR-Guided Revascularization in Patients With Severe Aortic Stenosis | Yan'an Affiliated Hospital of Kunming Medical University | Not applicable | Recruiting | Severe Aortic Stenosis | 300 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07469371) |
| March 6, 2026 | NCT07456280 | Pilot Study to Evaluate a Noninvasive Electrocardiographic Monitoring Strategy Associated With Early Discharge in Patients With Conduction... | Hospital Universitari Vall d'Hebron Research Institute | Not applicable | Recruiting | Severe Aortic Valve Stenosis, Cardiovascular Diseases | 100 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07456280) |
| March 6, 2026 | NCT07455292 | Phenotyping Left Ventricle Failure With Hemodynamic Biomarkers From 4D Flow Magnetic Resonance Imaging | IRCCS Policlinico S. Donato | Not applicable | Recruiting | Left Ventricle Function, Transcatheter Aortic Valve Replacement (TAVR), Aortic Valve Stenosis | 190 | Italy | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07455292) |
| March 4, 2026 | NCT07450196 | A Prospective, Multicenter, Observational Study Evaluating Safety and Effectiveness of SAPIEN 3 Transcatheter Aortic Valve Replacement for... | Chinese Academy of Medical Sciences, Fuwai Hospital | Observational | Not yet recruiting | Aortic Stenosis, AORTIC VALVE DISEASES | 170 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07450196) |
| March 2, 2026 | NCT07442357 | The Per-procedural Antibiotic Prophylaxis in Patients Undergoing Transcatheter Aortic Valve Implantation Trial | Copenhagen University Hospital, Rigshospitalet | Not applicable | Recruiting | Aortic Valve Stenosis | 1,986 | Denmark, Sweden | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07442357) |
| February 24, 2026 | NCT07430267 | Dilation Optimisation for Uniform Bioprosthetic Leaflet Expansion | The Alfred | Not applicable | Not yet recruiting | Aortic Stenosis, TAVI(Transcatheter Aortic Valve Implantation) | 250 | Australia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07430267) |
| February 19, 2026 | NCT07420907 | Study of the Progression of Chronic Cardiovascular Conditions | Prolaio | Observational | Recruiting | Cardiovascular Disease (CVD), Heart Failure, Aortic Stenosis, Aortic Stenosis Disease, Hypertension, Hypertension... | 5,000 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07420907) |
| February 17, 2026 | NCT07414342 | Safety and Efficacy of the RENATUS® Transcatheter Aortic Valve System for the Treatment of Severe Aortic Stenosis | Beijing Balance Medical Technology Co., Ltd | Not applicable | Recruiting | Severe Aortic Stenosis | 800 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07414342) |
| February 5, 2026 | NCT07390513 | Electrophysiological Outcomes After Transcatheter Aortic Valve Replacement | Chinese Academy of Medical Sciences, Fuwai Hospital | Observational | Active not recruiting | Aortic Valve Stenosis, Arrhythmia | 1,000 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07390513) |
| January 27, 2026 | NCT07370688 | Iron Infusion in Patients Undergoing Transcatheter Aortic Valve Implantation | Erasmus Medical Center | Phase 4 | Recruiting | Aortic Valve Stenosis, Iron Deficiency, TAVI(Transcatheter Aortic Valve Implantation), Cardiovascular Diseases | 402 | Netherlands | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07370688) |
| January 22, 2026 | NCT07359898 | International Multicenter Study of the Navitor/Navitor Vision Transcatheter Aortic Valve Platform | IRCCS Policlinico S. Donato | Observational | Recruiting | Severe Native Aortic Stenosis | 1,000 | Italy | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07359898) |
| January 15, 2026 | NCT07343674 | PERFECT - Portuguese Evolut Registry Studying the Outcomes of Medtronic Evolut™ FX+ TAVI System by Evaluating an Optimal Care Pathway for... | Portuguese Association of Interventional Cardiology | Observational | Recruiting | Severe Symptomatic Aortic Stenosis (Defined as New York Heart Association (NYHA) Class ≥ II) | 500 | Portugal | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07343674) |
| January 13, 2026 | NCT07335900 | A Clinical Study Using FAPI-PET Imaging to Assess the Postoperative Effects of TAVI in Patients With Aortic Stenosis | RenJi Hospital | Not applicable | Recruiting | Severe Aortic Valve Stenosis | 25 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07335900) |
| January 9, 2026 | NCT07331116 | Echocardiography Findings in Patients With Myocardial Fibrosis and Severe Aortic Stenosis | Norwegian University of Science and Technology | Observational | Completed | Aortic Valve Stenosis, Myocardial Fibrosis | 22 | Norway | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07331116) |
| January 5, 2026 | NCT07317804 | Echo-Guided vs Fluoroscopy-Guided Transcatheter Aortic Valve Replacement in Patients With Aortic Stenosis（ECHO-TAVR） | China National Center for Cardiovascular Diseases | Phase 4 | Not yet recruiting | Aortic Stenosis, TAVI, TAVI(Transcatheter Aortic Valve Implantation) | 212 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07317804) |
| December 30, 2025 | NCT07309029 | Pre-Emptive LAVA-ECMO for Complex High-Risk TAVR | Atlantic Health System | Observational | Recruiting | Severe Aortic Stenosis, Cardiogenic Shock, Cardiogenic Shock, ECMO, Trans-catheter Aortic Valve Implantation | 30 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07309029) |
| December 26, 2025 | NCT07304427 | Alwide Plus China Post-market Clinical Investigation | Shanghai MicroPort CardioFlow Medtech Co., Ltd. | Observational | Completed | Severe Aortic Stenosis, Transcatheter Aortic Valve Replacemen | 75 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07304427) |
| December 16, 2025 | NCT07284550 | Smartphone Based Digital Screening for Aortic Valve Stenosis | Medical University Innsbruck | Observational | Recruiting | Aortic Valve Stenosis, Artifical Intelligence | 500 | Austria | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07284550) |
| December 12, 2025 | NCT07278310 | STAR Trial (Siegel Transcatheter Aortic Valve Replacement in Patients With Symptomatic Severe Aortic Stenosis) | MiRus | Not applicable | Recruiting | Symptomatic Severe Native Aortic Stenosis, Aortic Stenosis | 1,025 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07278310) |
| December 11, 2025 | NCT07276711 | CAPTURE-2: Controlled Arterial Protection to Ultimately Remove Embolic Material | EmStop Inc | Not applicable | Recruiting | Aortic Valve Stenosis, Aortic Stenosis, Aortic Valve Disease | 663 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07276711) |
| December 5, 2025 | NCT07267117 | Cohort Observing Mechanisms, Progression and Sequelae of Valvular Heart Disease | Second Affiliated Hospital, Zhejiang University, School of Medicine | Observational | Recruiting | Heart Valve Disease, Mitral Valve (MV) Regurgitation, Mitral Valve Disease, Mitral Valve Stenosis, Aortic Valve... | 10,000 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07267117) |
| December 2, 2025 | NCT07258706 | Demographic and Interpopulation Variations in Evaluation and Results of TAVI | Poznan University of Medical Sciences | Observational | Enrolling by invitation | Aortic Stenosis, TAVI(Transcatheter Aortic Valve Implantation), Computed Tomography, Inflammatory Response During... | 800 | Italy, Poland, Serbia, Thailand, Turkey (Türkiye) | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07258706) |
| November 26, 2025 | NCT07251660 | Comparison of Early Postoperative Outcomes Between Minimally Invasive Valve Surgery Via Right Thoracotomy and Conventional Valve Surgery... | Chaudhry Pervaiz Elahi Institute of Cardiology | Not applicable | Not yet recruiting | Heart Valve Diseases or Prosthesis, Aortic Valve Stenosis, Aortic Valve Insufficiency, Valvular Heart Disease Stenosis... | 32 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07251660) |
| November 20, 2025 | NCT07240025 | Anatomical Determinants and Outcomes of Small Annulus Patients Undergoing TAVR in Different ASIAN Ethnicity | Prince of Wales Hospital, Shatin, Hong Kong | Observational | Enrolling by invitation | Aortic Stenosis | 31 | Hong Kong | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07240025) |
| November 17, 2025 | NCT07230964 | Correlation Between an Impedance Cardiography Test for Decompensation and the Development of Left Ventricular Replacement Fibrosis | Dermed Diagnostics, Inc. | Not applicable | Recruiting | Aortic Stenosis | 6 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07230964) |
| October 16, 2025 | NCT07217691 | Optimization of Commissural Alignment During Transcatheter Aortic Valve Implantation With Evolut FX+ | Oslo University Hospital | Not applicable | Not yet recruiting | Aortic Stenosis, Trans-catheter Aortic Valve Implantation, Commissural Alignment | 40 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07217691) |
| October 10, 2025 | NCT07215143 | Observational Study to Collect Data of Patient Which Recieving a TAVI in TAVI Procedure | IHF GmbH - Institut für Herzinfarktforschung | Observational | Recruiting | Aortic Valve Stenosis | 300 | Germany | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07215143) |
| October 3, 2025 | NCT07205341 | Detecting Changes in Arterial Blood Volume and Cardiac Efficiency | HemoCept Inc. | Observational | Recruiting | Aortic Valve Stenosis | 20 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07205341) |
| October 3, 2025 | NCT07205068 | Improved Outcomes With Pre-Procedure Shockwave IVL of Common Femoral Artery Access Site Prior to Large Bore Access and Pre-Closure | University of Tennessee Graduate School of Medicine | Not applicable | Recruiting | Aortic Stenosis | 100 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07205068) |
| October 1, 2025 | NCT07201363 | Biomarkers of Inflammation and Fibrosis in Conduction Disorders After TAVI | Clinical Hospital Center Rijeka | Observational | Recruiting | TAVI(Transcatheter Aortic Valve Implantation), Conduction Disorder, Aortic Stenosis, Permanent Pacemaker Implantation | 102 | Croatia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07201363) |
| September 29, 2025 | NCT07197736 | DELINEATE-Prospective | Columbia University | Observational | Recruiting | Valve Disease, Aortic, Mitral Regurgitation (MR), Aortic Stenosis, Valvular Heart Disease, Tricuspid Regurgitation... | 50 | United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07197736) |
| September 26, 2025 | NCT07194265 | A Clinical Trial Assessing the Safety and Effectiveness of the DurAVR® THV System | Anteris Technologies Ltd. | Not applicable | Recruiting | Severe Aortic Stenosis, Valve-in-valve Procedures | 1,650 | Denmark | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07194265) |
| September 26, 2025 | NCT07193888 | Navitor Japan Study | Abbott Medical Devices | Observational | Recruiting | Severe Aortic Stenosis | 100 | Japan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07193888) |
| September 17, 2025 | NCT07179302 | Pre- and Post-TAVI Patient Assessment: Advancing Outcome Precision in Aortic Valve Therapy | Damanhour University | Observational | Completed | Aortic Valve Stenosis | 100 | Egypt, Saudi Arabia | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07179302) |
| September 12, 2025 | NCT07170306 | Cardiac Amyloidosis in Patients With Aortic Stenosis | Shanghai Zhongshan Hospital | Observational | Not yet recruiting | Aortic Stenosis, Transthyretin Amyloid Cardiomyopathy | 143 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07170306) |
| August 28, 2025 | NCT07145463 | Prospective, Multicenter, Randomized Controlled Clinical Study Evaluating the VitaFlow Liberty® Flex Transcatheter Aortic Valve Delivery... | Shanghai Zhongshan Hospital | Not applicable | Recruiting | Aortic Valve Stenosis | 232 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07145463) |
| August 27, 2025 | NCT07144189 | AI Assessment of Low-Gradient Aortic Stenosis Severity Based on Echocardiography | National Institute of Cardiology, Warsaw, Poland | Observational | Recruiting | Low-gradient Aortic Stenosis, Aortic Stenosis | 300 | Poland | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07144189) |
| August 14, 2025 | NCT07123766 | Clinical Investigation for the PoliaValve Aortic Heart Valve- India | Suzhou Hearthill Medical Technology Co.,LTD | Not applicable | Not yet recruiting | AORTIC VALVE DISEASES, Aortic Valve Stenosis, Aortic Valve Regurgitation | 50 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07123766) |
| August 11, 2025 | NCT07116551 | Early Feasibility Study (EFS) of Abbott's Balloon-expandable (BE) TAVI System for the Treatment of Severe, Symptomatic Aortic Stenosis | Abbott Medical Devices | Not applicable | Active not recruiting | Symptomatic Severe Aortic Stenosis | 11 | France, United States | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07116551) |
| August 11, 2025 | NCT07116265 | Perceval Aortic Bioprostheses : Durability Study. | University Hospital, Montpellier | Observational | Completed | Stenoses, Aortic Valve, Aortic Insufficiency, Aortic Diseases | 192 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07116265) |
| August 7, 2025 | NCT07108478 | A Prospective, Multicenter, Observational Study of the Safety and Efficacy of Emergency Transcatheter Aortic Valve Replacement in Patients... | Qilu Hospital of Shandong University | Observational | Not yet recruiting | Severe Aortic Valve Stenosis | 35 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07108478) |
| August 6, 2025 | NCT07107568 | Assessment of Coronary Artery Disease Before Transcatheter Aortic Valve Replacement: A Randomized, Multicenter, Non-Inferiority Trial | Medical University Innsbruck | Not applicable | Recruiting | Aortic Valve Stenosis and Insufficiency, Coronary Artery Disease(CAD), Transcatheter Aortic Valve Replacement (TAVR) | 700 | Austria | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07107568) |
| August 6, 2025 | NCT07105501 | Atrial Amyloid May Influence Outcomes in Patients Undergoing Surgical Aortic Valve Replacement | Germans Trias i Pujol Hospital | Observational | Completed | Aortic Stenosis, Amyloid | 110 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07105501) |
| July 31, 2025 | NCT07097740 | Early Feasibility Study of Surgical Implantation of a Polymer Prosthetic Mitral and Aortic Valve | Mitrassist Lifesciences Limited Co., Ltd. | Not applicable | Recruiting | AORTIC VALVE DISEASES, Mitral Valve Disease, Aortic Stenosis, Aortic Regurgitation, Mitral Stenosis, Mitral... | 10 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07097740) |
| July 29, 2025 | NCT07090343 | Semaglutide in Patients Undergoing Transcatether Aortic Valve Replacement | Leiden University Medical Center | Phase 3 | Not yet recruiting | Aortic Stenosis, Heart Failure | 826 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07090343) |
| July 28, 2025 | NCT07087379 | Perioperative Intensive Statin Therapy for Neuroprotection in TAVR（PISTNT） | Pan Xiangbin | Phase 4 | Not yet recruiting | Aortic Stenosis, Cerebral Ischaemic Injury | 500 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07087379) |
| July 25, 2025 | NCT07086989 | Cardiovascular Risk in Children With Chronic Conditions Study | Semmelweis University | Observational | Recruiting | Kidney Transplant, Familial Hypercholesterolaemia, Type 1 Diabetes Mellitus (T1DM), Type 2 Diabetes Mellitus (T2DM)... | 300 | Hungary | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07086989) |
| July 24, 2025 | NCT07082426 | Early System Experience With the Abbott Balloon-expandable TAVI System: First-In-Human Study | Abbott Medical Devices | Not applicable | Active not recruiting | Symptomatic Severe Aortic Stenosis | 8 | Georgia, Uzbekistan | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07082426) |
| July 16, 2025 | NCT07068633 | Korea VHD Echo Study: Surveillance of Aortic, Mitral & Tricuspid Patients - Insights From Real-world Practice | Yonsei University | Observational | Recruiting | Heart Valve Diseases, Aortic Valve Stenosis, Aortic Valve Insufficiency, Mitral Valve Insufficiency, Mitral Valve... | 30,000 | South Korea | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07068633) |
| July 15, 2025 | NCT07065123 | Study on Heart Block Risks Using Outcome-Based Modeling | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Observational | Completed | Left Bundle-Branch Block, Aortic Stenosis | 112 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07065123) |
| July 11, 2025 | NCT07059728 | High Flow Nasal Oxygenation in Transcatheter Aortic Valve Replacement Procedures. TAVR-Highflow II | Hospital Clinic of Barcelona | Not applicable | Not yet recruiting | Aortic Stenosis Treated With TAVI, Sedation; Aged; Hemodynamics | 452 | Spain | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07059728) |
| July 4, 2025 | NCT07052071 | Impact of Transcatheter Aortic Valve Implantation (TAVI) on the Gut Microbiota in Patients With Aortic Valve Stenosis | Hippocration General Hospital | Observational | Recruiting | Aortic Stenosis, Gut Microbiome, Gut Microbiota, TAVI, TAVI(Transcatheter Aortic Valve Implantation) | 40 | Greece | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07052071) |
| June 29, 2025 | NCT07043075 | First-in-Human (FIH) Study on the Feasibility and Safety of the TaviPilot Augmented Reality Guidance Software | Caranx Medical | Not applicable | Not yet recruiting | Aortic Valve Stenosis | 10 |  | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07043075) |
| June 29, 2025 | NCT07042529 | Optimized Expansion of the Implanted Transcatheter Aortic Valve | Ole De Backer | Not applicable | Recruiting | Aortic Stenosis Disease, Valvular Heart Disease | 1,010 | Belgium, Denmark, Finland, Netherlands, Norway, Sweden | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07042529) |
| June 25, 2025 | NCT07035847 | Transaxillary TAVR With Solely Echocardiography Guidance | Chinese Academy of Medical Sciences, Fuwai Hospital | Not applicable | Recruiting | Aortic Stenosis | 20 | China | [clinicaltrials.gov](https://clinicaltrials.gov/study/NCT07035847) |

## Sponsors posting most

| Sponsor | New trials | Latest |
| --- | --- | --- |
| Yonsei University | 3 | November 3, 2026 |
| IRCCS Policlinico S. Donato | 3 | March 6, 2026 |
| Chinese Academy of Medical Sciences, Fuwai Hospital | 3 | March 4, 2026 |
| Abbott Medical Devices | 3 | September 26, 2025 |
| Peijia Medical Technology (Suzhou) Co., Ltd. | 2 | November 2, 2026 |
| University Hospital of Ferrara | 2 | October 26, 2026 |
| Erasmus Medical Center | 2 | October 13, 2026 |
| Braile Biomedica Ind. Com. e Repr. Ltda. | 2 | September 8, 2026 |
| Istanbul University - Cerrahpasa | 2 | August 31, 2026 |
| Hospital Clinic of Barcelona | 2 | July 31, 2026 |
| Eunpyeong St. Mary's Hospital | 2 | July 17, 2026 |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 2 | June 4, 2026 |
| Beijing Anzhen Hospital | 2 | May 26, 2026 |
| Portuguese Association of Interventional Cardiology | 2 | January 15, 2026 |
| China National Center for Cardiovascular Diseases | 2 | January 5, 2026 |
| Medical University Innsbruck | 2 | December 16, 2025 |
| Shanghai Zhongshan Hospital | 2 | September 12, 2025 |
| Suzhou Hearthill Medical Technology Co.,LTD | 2 | August 14, 2025 |
| University Hospital, Montpellier | 2 | August 11, 2025 |
| Semmelweis University | 2 | July 25, 2025 |

## By phase

| Phase | New trials | Latest |
| --- | --- | --- |
| [Observational](https://specstream.ai/data/clinical-trials/phase/observational) | 72 | November 9, 2026 |
| [Not applicable](https://specstream.ai/data/clinical-trials/phase/not-applicable) | 68 | November 3, 2026 |
| [Phase 4](https://specstream.ai/data/clinical-trials/phase/phase-4) | 7 | July 29, 2026 |
| [Phase 2](https://specstream.ai/data/clinical-trials/phase/phase-2) | 2 | July 20, 2026 |
| [Phase 3](https://specstream.ai/data/clinical-trials/phase/phase-3) | 1 | July 29, 2025 |
| [Phase 2/3](https://specstream.ai/data/clinical-trials/phase/phase-2-3) | 1 | June 3, 2025 |
| [Early phase 1](https://specstream.ai/data/clinical-trials/phase/early-phase-1) | 1 | May 30, 2025 |

## By country

| Country | New trials | Latest |
| --- | --- | --- |
| [United States](https://specstream.ai/data/clinical-trials/country/united-states) | 22 | November 2, 2026 |
| [China](https://specstream.ai/data/clinical-trials/country/china) | 21 | November 2, 2026 |
| [Germany](https://specstream.ai/data/clinical-trials/country/germany) | 13 | October 13, 2026 |
| [Italy](https://specstream.ai/data/clinical-trials/country/italy) | 12 | October 26, 2026 |
| [Spain](https://specstream.ai/data/clinical-trials/country/spain) | 8 | July 31, 2026 |
| [Netherlands](https://specstream.ai/data/clinical-trials/country/netherlands) | 6 | October 13, 2026 |
| [Turkey (Türkiye)](https://specstream.ai/data/clinical-trials/country/turkey-t-rkiye) | 6 | August 31, 2026 |
| [Canada](https://specstream.ai/data/clinical-trials/country/canada) | 6 | July 31, 2026 |
| [Egypt](https://specstream.ai/data/clinical-trials/country/egypt) | 5 | November 9, 2026 |
| [France](https://specstream.ai/data/clinical-trials/country/france) | 5 | April 9, 2026 |
| [Denmark](https://specstream.ai/data/clinical-trials/country/denmark) | 4 | September 1, 2026 |
| [Switzerland](https://specstream.ai/data/clinical-trials/country/switzerland) | 4 | August 4, 2026 |
| [South Korea](https://specstream.ai/data/clinical-trials/country/south-korea) | 4 | July 29, 2026 |
| [Austria](https://specstream.ai/data/clinical-trials/country/austria) | 4 | March 17, 2026 |
| [Australia](https://specstream.ai/data/clinical-trials/country/australia) | 4 | February 24, 2026 |
| [Sweden](https://specstream.ai/data/clinical-trials/country/sweden) | 3 | March 2, 2026 |
| [Poland](https://specstream.ai/data/clinical-trials/country/poland) | 3 | December 2, 2025 |
| [Croatia](https://specstream.ai/data/clinical-trials/country/croatia) | 2 | May 29, 2026 |
| [Greece](https://specstream.ai/data/clinical-trials/country/greece) | 2 | April 9, 2026 |
| [Portugal](https://specstream.ai/data/clinical-trials/country/portugal) | 2 | January 15, 2026 |
| [Norway](https://specstream.ai/data/clinical-trials/country/norway) | 2 | January 9, 2026 |
| [Thailand](https://specstream.ai/data/clinical-trials/country/thailand) | 2 | December 2, 2025 |
| [Japan](https://specstream.ai/data/clinical-trials/country/japan) | 2 | September 26, 2025 |
| [Hungary](https://specstream.ai/data/clinical-trials/country/hungary) | 2 | July 25, 2025 |
| [Belgium](https://specstream.ai/data/clinical-trials/country/belgium) | 2 | June 29, 2025 |

## Where the register publishes

- [ClinicalTrials.gov](https://clinicaltrials.gov/)
- [ClinicalTrials.gov API](https://clinicaltrials.gov/data-api/api)

Source: [ClinicalTrials.gov API v2 (U.S. National Library of Medicine)](https://clinicaltrials.gov/data-api/api). U.S. government data; ClinicalTrials.gov terms of use. Studies are as their sponsors registered them on ClinicalTrials.gov, read through its API. Condition groups are the MeSH terms ClinicalTrials.gov assigns to each study's conditions; a study with several is in several groups. Sponsor class is the register's class of the lead sponsor. The central contact is in the full list only as the record prints it.

Free to reuse with credit to SpecStream under [CC BY 4.0](https://creativecommons.org/licenses/by/4.0/).